EA201290726A1 - NEW SALTS FOR PRODUCING PHARMACEUTICAL COMPOSITIONS - Google Patents

NEW SALTS FOR PRODUCING PHARMACEUTICAL COMPOSITIONS

Info

Publication number
EA201290726A1
EA201290726A1 EA201290726A EA201290726A EA201290726A1 EA 201290726 A1 EA201290726 A1 EA 201290726A1 EA 201290726 A EA201290726 A EA 201290726A EA 201290726 A EA201290726 A EA 201290726A EA 201290726 A1 EA201290726 A1 EA 201290726A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical compositions
producing pharmaceutical
new salts
salts
new
Prior art date
Application number
EA201290726A
Other languages
Russian (ru)
Other versions
EA022496B1 (en
Inventor
Имре Кирай
Петер Тринка
Балаж Вольк
Ласло Понго
Йожеф Баркоци
Петер Шлегель
Магдольна Обрецан
Андраш Данчо
Моника Мезёвари
Тибор Сабо
Дьёрдь Ружич
Ласло Славик
Дьюла Лукач
Андраш Боза
Original Assignee
Эгиш Дьёдьсердьяр Ньильваношан Мюкеде Ресвеньтаршашаг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эгиш Дьёдьсердьяр Ньильваношан Мюкеде Ресвеньтаршашаг filed Critical Эгиш Дьёдьсердьяр Ньильваношан Мюкеде Ресвеньтаршашаг
Publication of EA201290726A1 publication Critical patent/EA201290726A1/en
Publication of EA022496B1 publication Critical patent/EA022496B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к новым полиморфным солям дабигатрана этексилата формулы 11 и способу их получения.The invention relates to new polymorphic salts of dabigatran etexilate of formula 11 and a method for their preparation.

EA201290726A 2010-02-02 2011-02-02 Polymorphous form of dabigatran etexilate hydrochloride EA022496B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU1000069A HUP1000069A2 (en) 2010-02-02 2010-02-02 New salts for the preparation of pharmaceutical composition
PCT/HU2011/000014 WO2011110876A1 (en) 2010-02-02 2011-02-02 Novel salts for the manufacture of pharmaceutical compositions

Publications (2)

Publication Number Publication Date
EA201290726A1 true EA201290726A1 (en) 2013-07-30
EA022496B1 EA022496B1 (en) 2016-01-29

Family

ID=89989543

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201290726A EA022496B1 (en) 2010-02-02 2011-02-02 Polymorphous form of dabigatran etexilate hydrochloride

Country Status (5)

Country Link
CN (1) CN102858762A (en)
EA (1) EA022496B1 (en)
HU (1) HUP1000069A2 (en)
WO (1) WO2011110876A1 (en)
ZA (1) ZA201206254B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030181488A1 (en) 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof
WO2012027543A1 (en) * 2010-08-25 2012-03-01 Teva Pharmaceuticals Usa, Inc. Solid state forms of dabigatran etexilate, dabigatran etexilate mesylate and processes for preparation thereof
US9006448B2 (en) 2010-12-06 2015-04-14 Msn Laboratories Private Limited Process for the preparation of benzimidazole derivatives and its salts
CN102558153A (en) * 2012-02-08 2012-07-11 北京阜康仁生物制药科技有限公司 Novel pharmaceutical salt of dabigatran etexilate and preparation method thereof
EP2631234A1 (en) 2012-02-23 2013-08-28 Esteve Química, S.A. Solid forms of dabigatran etexilate mesylate and processes for their preparation
WO2013144971A1 (en) * 2012-03-27 2013-10-03 Cadila Healthcare Limited New solid forms of dabigatran etexilate bisulfate and mesylate and processes to prepare them
CN102633777B (en) * 2012-03-31 2014-04-16 天津药物研究院 Dabigatran etexilate 2-ketoglutarate as well as preparation method and application thereof
WO2013150545A2 (en) 2012-04-02 2013-10-10 Msn Laboratories Limited Process for the preparation of benzimidazole derivatives and salts thereof
CN103539779B (en) * 2012-07-13 2016-12-21 四川海思科制药有限公司 A kind of hydroxyl-substituted sulfonate of dabigatran etcxilate and its production and use
JP2015522596A (en) * 2012-07-16 2015-08-06 インテルキム、ソシエダッド アノニマ Process for preparing an intermediate for the synthesis of dabigatran etexilate and crystal forms of the intermediate
CA2886094A1 (en) 2012-09-28 2014-04-03 Ranbaxy Laboratories Limited Process for the preparation of dabigatran etexilate or pharmaceutically acceptable salt thereof
EP2900651A2 (en) 2012-09-28 2015-08-05 Ranbaxy Laboratories Limited Process for the preparation of dabigatran etexilate or pharmaceutically acceptable salt thereof
CN103864756B (en) * 2012-12-11 2018-06-15 四川海思科制药有限公司 Fourth disulfonic acid dabigatran etcxilate and its preparation method and application
WO2014178017A1 (en) 2013-04-30 2014-11-06 Ranbaxy Laboratories Limited Dabigatran etexilate impurity, process of its preparation, and its use as a reference standard
EP2835370A1 (en) 2013-08-08 2015-02-11 Medichem, S.A. New crystals of dabigatran etexilate mesylate
CN104418840A (en) * 2013-09-05 2015-03-18 天津汉瑞药业有限公司 Dabigatran etexilate mesylate anhydrous compound
WO2015071841A1 (en) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
CN104892574A (en) 2014-03-04 2015-09-09 浙江海正药业股份有限公司 Dabigatran etexilate mesylate crystal forms, preparation methods and uses thereof
CN108864049A (en) * 2014-04-04 2018-11-23 江苏天士力帝益药业有限公司 Dabigatran etcxilate mesylate novel crystal forms and preparation method thereof
WO2016009405A1 (en) * 2014-07-18 2016-01-21 Sifavitor S.R.L. Crystalline compounds of dabigatran etexilate
CN105348260A (en) * 2014-08-19 2016-02-24 天津药物研究院 Dabigatran etexilate hydrobromide, preparation method and applications thereof
CN106554370A (en) * 2015-09-25 2017-04-05 陕西合成药业股份有限公司 Dabigatran derivant containing phosphate ester and its production and use
CN116621815A (en) * 2023-07-21 2023-08-22 成都苑东生物制药股份有限公司 Industrial preparation method of dabigatran etexilate mesylate

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE121699A1 (en) 1997-02-18 1999-12-08 Boehringer Ingelheim Pharma BICYCLE HETERO CYCLES DISSTITUTED AS INHIBITORS OF THROMBIN
DE10337697A1 (en) * 2003-08-16 2005-03-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tablet containing 3 - [(2 - {[4- (hexyloxycarbonylamino-iminomethyl) -phenyl-amino] -methyl} -1-methyl-1H-benzimidazole-5-carbonyl) -pyridin-2-yl-amino] - propionic acid ethyl ester or its salts
DE10339862A1 (en) * 2003-08-29 2005-03-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg New crystalline forms of ethyl 3-(N-(2-(4-(hexyloxycarbonylamidino)phenylaminomethyl)-1-methyl-1H-benzimidazole-5-carbonyl)-N-(2-pyridyl)amino)propionate methanesulfonate used for post-operative prophylaxis of deep vein thrombosis
DE102005020002A1 (en) * 2005-04-27 2006-11-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg New hexyloxycarbonylamino-imino-methyl-phenylamino-methyl-benzimidazole-pyridine-propionic acid-ethyl ester salts such as hydrochloride useful for the prophylaxis of vein thrombosis and stroke
DE102005025728A1 (en) 2005-06-04 2006-12-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Polymorphs of 3 - [(2 - {[4- (hexyloxycarbonylamino-imino-methyl) -phenyl-amino] -methyl} -1-methyl-1H-benzimidazole-5-carbonyl) -pyridin-2-yl-amino] -propionic acid ethyl ester
DE102005061623A1 (en) * 2005-12-21 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Improved process for the preparation of 4- (benzimidazolylmethylamino) -benzamidines and their salts
WO2008009638A2 (en) * 2006-07-17 2008-01-24 Boehringer Ingelheim International Gmbh New indications for direct thrombin inhibitors in the cardiovascular field
WO2008043759A1 (en) * 2006-10-10 2008-04-17 Boehringer Ingelheim International Gmbh Physiologically acceptable salts of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1h-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester
DE102006054005A1 (en) 2006-11-16 2008-05-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg New polymorphs of 3 - [(2 - {[4- (hexyloxycarbonylamino-imino-methyl) -phenyl-amino] -methyl} -1-methyl-1H-benzimidazole-5-carbonyl) -pyridin-2-yl-amino] -propionic acid ethyl
CN100556642C (en) * 2007-06-06 2009-11-04 中国科学院化学研究所 The regulate and control method of aliphatic poly adipic acid fourth diester material degradation performance

Also Published As

Publication number Publication date
WO2011110876A1 (en) 2011-09-15
HU1000069D0 (en) 2010-04-28
ZA201206254B (en) 2013-10-30
WO2011110876A8 (en) 2012-07-05
HUP1000069A2 (en) 2012-05-02
CN102858762A (en) 2013-01-02
EA022496B1 (en) 2016-01-29

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU