CO5560083A1 - Formas polimorficas de rifaximina, procesos para su produccion y uso de las mismas en preparaciones - Google Patents
Formas polimorficas de rifaximina, procesos para su produccion y uso de las mismas en preparacionesInfo
- Publication number
- CO5560083A1 CO5560083A1 CO04022467A CO04022467A CO5560083A1 CO 5560083 A1 CO5560083 A1 CO 5560083A1 CO 04022467 A CO04022467 A CO 04022467A CO 04022467 A CO04022467 A CO 04022467A CO 5560083 A1 CO5560083 A1 CO 5560083A1
- Authority
- CO
- Colombia
- Prior art keywords
- rifaximin
- water content
- polymorph
- purified
- antibiotic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B6/00—Heating by electric, magnetic or electromagnetic fields
- H05B6/02—Induction heating
- H05B6/10—Induction heating apparatus, other than furnaces, for specific applications
- H05B6/12—Cooking devices
- H05B6/1209—Cooking devices induction cooking plates or the like and devices to be used in combination with them
- H05B6/1236—Cooking devices induction cooking plates or the like and devices to be used in combination with them adapted to induce current in a coil to supply power to a device and electrical heating devices powered in this way
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B6/00—Heating by electric, magnetic or electromagnetic fields
- H05B6/02—Induction heating
- H05B6/10—Induction heating apparatus, other than furnaces, for specific applications
- H05B6/12—Cooking devices
- H05B6/1209—Cooking devices induction cooking plates or the like and devices to be used in combination with them
- H05B6/1245—Cooking devices induction cooking plates or the like and devices to be used in combination with them with special coil arrangements
- H05B6/1263—Cooking devices induction cooking plates or the like and devices to be used in combination with them with special coil arrangements using coil cooling arrangements
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Electromagnetism (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
Abstract
Una rifaximina a purificada, un polimorfo del antibiótico rifaximina, CARACTERIZADA PORQUE dicha rifaximina a presenta un contenido de agua menor que un 4,5% y produce un difractograma de polvo por rayos X que presenta picos en valores de ángulos de difracción 2T de 6,6°; 7,4°; 7,9°; 8,8°; 10,5°; 11,1°; 11,8°; 12,9°; 17,6°; 18,5°; 19,7°; 21,0°; 21,4°; 22,1°. La rifaximina a acorde con la cláusula 1, CARACTERIZADA PORQUE dicho contenido de agua comprende entre 2,0% y 3,0%. Una rifaximina ß purificada, un polimorfo del antibiótico rifaximina, CARACTERIZADA PORQUE dicha rifaximina ß presenta un contenido de agua mayor que un 4,5% y produce un difractograma de polvo por rayos X que presenta picos en valores de ángulos de difracción 2T de 5,4°; 6,4°; 7,0°; 7,8°; 9,0°; 10,4°; 13,1°, 14,4°; 17,1°; 17,9°; 18,3°; 20,9°.4. - La rifaximina ß acorde con la cláusula 3, CARACTERIZADA PORQUE dicho contenido de agua comprende entre 5,0% y 6,0%. Una rifaximina ? purificada, un polimorfo del antibiótico rifaximina, CARACTERIZADA PORQUE dicha rifaximina ? presenta un contenido de agua entre 1,0% y 2,0% y produce un difractograma de polvo por rayos X que presenta un perfil fundamentalmente amorfo y pocos picos significativos en valores de ángulos de difracción 2T de 5,0°; 7,1°; 8,4°. Un proceso para la producción de las rifaximinas a, ß, y ?, CARACTERIZADO PORQUE comprende:hacer reaccionar un equivalente molar de rifamicina O con un exceso de 2-amino-4-metilpiridina en una mezcla de solventes compuesta de agua y aIcohol etílico en una relación volumétrica que comprende entre 1:1 y 2:1, por un período de tiempo entre 2 y 8 horas, a una temperatura entre 40 °C y 60 °C, tratar la masa de reacción a temperatura ambiente con una solución de ácido ascórbico en una mezcla de agua, alcohol etílico y ácido clorhídrico acuoso concentrado, ajustar el pH de la masa de reacción en pH 2,0 con una solución acuosa concentrada de ácido clorhídrico, ...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT002144A ITMI20032144A1 (it) | 2003-11-07 | 2003-11-07 | Forme polimorfe di rifaximina, processi per ottenerle e |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5560083A1 true CO5560083A1 (es) | 2005-09-30 |
Family
ID=33187382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO04022467A CO5560083A1 (es) | 2003-11-07 | 2004-03-11 | Formas polimorficas de rifaximina, procesos para su produccion y uso de las mismas en preparaciones |
Country Status (38)
Country | Link |
---|---|
US (5) | US7045620B2 (es) |
EP (6) | EP1557421B1 (es) |
JP (5) | JP2005139161A (es) |
KR (4) | KR20050043589A (es) |
CN (4) | CN1613858A (es) |
AR (3) | AR043547A1 (es) |
AT (3) | ATE361927T1 (es) |
AU (2) | AU2004200964A1 (es) |
BR (2) | BRPI0402382A (es) |
CA (2) | CA2460384A1 (es) |
CL (1) | CL2004000498A1 (es) |
CO (1) | CO5560083A1 (es) |
CY (3) | CY1108017T1 (es) |
DE (4) | DE602004006367C5 (es) |
DK (3) | DK1676848T3 (es) |
ES (3) | ES2320161T3 (es) |
HK (3) | HK1092150A1 (es) |
HR (2) | HRP20040265A2 (es) |
IL (2) | IL160798A0 (es) |
IT (1) | ITMI20032144A1 (es) |
JO (1) | JO2470B1 (es) |
MA (1) | MA27069A1 (es) |
MD (1) | MD3653G8 (es) |
ME (1) | ME00424B (es) |
MX (2) | MXPA04002353A (es) |
NO (1) | NO334950B1 (es) |
NZ (1) | NZ531622A (es) |
PL (3) | PL1676848T3 (es) |
PT (3) | PT1557421E (es) |
RS (4) | RS54569B1 (es) |
RU (1) | RU2270200C2 (es) |
SI (3) | SI1557421T1 (es) |
TN (2) | TNSN04044A1 (es) |
TW (1) | TWI285107B (es) |
UA (1) | UA86384C2 (es) |
WO (1) | WO2005044823A2 (es) |
YU (1) | YU24804A (es) |
ZA (1) | ZA200401948B (es) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6861053B1 (en) * | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
ITMI20032144A1 (it) * | 2003-11-07 | 2005-05-08 | Alfa Wassermann Spa | Forme polimorfe di rifaximina, processi per ottenerle e |
US7923553B2 (en) * | 2003-11-07 | 2011-04-12 | Alfa Wassermann, S.P.A. | Processes for the production of polymorphic forms of rifaximin |
US7902206B2 (en) * | 2003-11-07 | 2011-03-08 | Alfa Wassermann, S.P.A. | Polymorphic forms α, β and γ of rifaximin |
US20080262024A1 (en) * | 2003-11-07 | 2008-10-23 | Giuseppe Claudio Viscomi | Rifaximin compositions and method of use |
US7906542B2 (en) * | 2004-11-04 | 2011-03-15 | Alfa Wassermann, S.P.A. | Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin |
DK1698630T3 (da) | 2005-03-03 | 2014-12-08 | Alfa Wassermann Spa | Nye polymorfe former af rifaximin, fremgangsmåde for deres fremstilling og anvendelse deraf i de medicinske præparater |
ITBO20050123A1 (it) * | 2005-03-07 | 2005-06-06 | Alfa Wassermann Spa | Formulazioni farmaceutiche gastroresistenti contenenti rifaximina |
CN104382900A (zh) | 2006-08-02 | 2015-03-04 | 萨利克斯药品公司 | 治疗放射性肠炎的组合物和方法 |
ITMI20061692A1 (it) * | 2006-09-05 | 2008-03-06 | Alfa Wassermann Spa | Uso di polioli per ottenere forme polimorfe stabili di rifaximina |
US8633234B2 (en) * | 2006-09-22 | 2014-01-21 | Cipla Limited | Rifaximin |
US20080159987A1 (en) * | 2007-01-03 | 2008-07-03 | Leonard Weinstock | Use of Rifaximin for the Treatment of Restless Legs Syndrome |
US20080161337A1 (en) * | 2007-01-03 | 2008-07-03 | Leonard Weinstock | Use of Rifaximin for the Treatment of Chronic Prostatitis |
ITMI20071241A1 (it) * | 2007-06-20 | 2008-12-21 | Solmag S P A | Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta |
WO2009008005A1 (en) * | 2007-07-06 | 2009-01-15 | Lupin Limited | Pharmaceutical compositions of rifaximin |
AU2016203925B2 (en) * | 2007-07-06 | 2016-10-20 | Lupin Limited | Pharmaceutical compositions of rifaximin |
SI2011486T1 (sl) * | 2007-07-06 | 2012-10-30 | Lupin Ltd | Farmacevtski sestavki rifaksimina |
US7709634B2 (en) * | 2007-09-20 | 2010-05-04 | Apotex Pharmachem Inc. | Amorphous form of rifaximin and processes for its preparation |
UA101829C2 (uk) * | 2008-02-25 | 2013-05-13 | Саликс Фармасьютикалз, Лтд. | ФОРМА η РИФАКСИМІНУ І ЇЇ ЗАСТОСУВАННЯ В ТЕРАПЕВТИЧНІЙ ПРАКТИЦІ |
US8486956B2 (en) | 2008-02-25 | 2013-07-16 | Salix Pharmaceuticals, Ltd | Forms of rifaximin and uses thereof |
US11779571B2 (en) | 2008-02-26 | 2023-10-10 | Salix Pharmaceuticals, Inc. | Methods for treating irritable bowel syndrome (IBS) |
PL2252148T3 (pl) * | 2008-02-26 | 2019-09-30 | Salix Pharmaceuticals, Ltd. | Sposoby leczenia zespołu jelita drażliwego |
SI2294012T1 (sl) | 2008-05-07 | 2014-11-28 | Salix Pharmaceuticals, Ltd. | Dajanje ÄŤistila za ÄŤrevo in antibiotika za zdravljenje ÄŤrevesne bolezni |
KR20110071096A (ko) | 2008-09-26 | 2011-06-28 | 아스카 세이야쿠 가부시키가이샤 | 기능성 소화관 장해의 예방 및/또는 치료제 |
US7928115B2 (en) | 2008-10-02 | 2011-04-19 | Salix Pharmaceuticals, Ltd. | Methods of treating travelers diarrhea and hepatic encephalopathy |
US20100317681A1 (en) * | 2009-06-15 | 2010-12-16 | Salix Pharmaceuticals, Ltd. | Modulation of systemic exposure to rifaximin |
US20110035232A1 (en) | 2008-10-02 | 2011-02-10 | Salix Pharmaceuticals, Ltd. | Methods of treating hepatic encephalopathy |
WO2010040020A1 (en) | 2008-10-02 | 2010-04-08 | Salix Pharmaceuticals, Ltd. | Methods of treating hepatic encephalopathy |
WO2010067072A1 (en) | 2008-12-10 | 2010-06-17 | Cipla Limited | Rifaximin complexes |
IT1397617B1 (it) * | 2009-04-20 | 2013-01-18 | Alfa Wassermann Spa | Nuovi derivati della rifamicina |
EP3964066A1 (en) | 2009-06-02 | 2022-03-09 | Salix Pharmaceuticals, Ltd. | Methods of treating hepatic encephalopathy |
JP2013504597A (ja) | 2009-09-13 | 2013-02-07 | サリックス ファーマスーティカルズ,リミテッド | 過敏性腸症候群(ibs)の治療方法 |
MX346660B (es) * | 2009-10-27 | 2017-03-28 | Lupin Ltd | Dispersion solida de rifaximina. |
WO2011061748A1 (en) * | 2009-11-19 | 2011-05-26 | Strides Arcolab Limited | Rifaximin premix |
MX2012005883A (es) | 2009-11-23 | 2012-10-09 | Cipla Ltd | Composicion topica en espuma. |
US8952159B2 (en) † | 2009-12-28 | 2015-02-10 | Silvio Massimo Lavagna | Method for the production of amorphous rifaximin |
WO2011103246A1 (en) | 2010-02-18 | 2011-08-25 | Salix Pharmaceuticals, Ltd. | Methods for treating infection |
IT1398550B1 (it) | 2010-03-05 | 2013-03-01 | Alfa Wassermann Spa | Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo |
BR112012030783A2 (pt) * | 2010-06-03 | 2015-09-29 | Salix Pharmaceuticals Ltd | formas de rifaximina e seus usos |
EP2582707A4 (en) * | 2010-06-16 | 2014-01-08 | Apotex Pharmachem Inc | POLYMORPHIC FORMS OF RIFAXIMINE |
WO2012009388A1 (en) * | 2010-07-12 | 2012-01-19 | Salix Pharmaceuticals, Ltd | Formulations of rifaximin and uses thereof |
US8759513B2 (en) | 2010-09-13 | 2014-06-24 | Sequent Scientific Limited | Polymorphic form of rifaximin and process for its preparation |
IT1403847B1 (it) | 2010-09-22 | 2013-11-08 | Alfa Wassermann Spa | Composizioni farmaceutiche comprendenti rifaximina e loro uso. |
WO2012060675A1 (es) * | 2010-11-05 | 2012-05-10 | Interquim, S.A. De C.V. | Proceso para la preparación de rifaximina amorfa |
WO2012076832A1 (en) * | 2010-12-09 | 2012-06-14 | Cipla Limited | Suppositories comprising rifaximin |
CA2825964A1 (en) * | 2011-02-11 | 2012-08-16 | Salix Pharmaceuticals, Ltd. | Forms of rifaximin and uses thereof |
CA2834829A1 (en) | 2011-05-02 | 2012-11-08 | Ranbaxy Laboratories Limited | Rifaximin dimethylformamide solvate |
WO2012155981A1 (en) | 2011-05-19 | 2012-11-22 | Friulchem Spa | New process for the synthesis of rifaximin and a new pseudo-crystalline form of rifaximin obtained thereby |
ITMI20110890A1 (it) * | 2011-05-19 | 2012-11-20 | A M S A Anonima Materie Sint & Affini S P A | Polimorfo di rifaximina e processo per la sua preparazione |
ITBO20110461A1 (it) | 2011-07-29 | 2013-01-30 | Alfa Wassermann Spa | Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali. |
WO2013067394A1 (en) | 2011-11-02 | 2013-05-10 | Salix Pharmaceuticals, Ltd | Methods for treating irritable bowel syndrome (ibs) and infections |
JP2013184902A (ja) * | 2012-03-06 | 2013-09-19 | Aska Pharmaceutical Co Ltd | リファキシミン含有結晶 |
CA2876737A1 (en) * | 2012-06-13 | 2013-12-19 | Apotex Pharmachem Inc. | Polymorphic forms of rifaximin |
ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
US9849090B2 (en) | 2012-12-12 | 2017-12-26 | Sun Pharmaceutical Industries Limited | Pharmaceutical compositions of rifaximin |
WO2014140995A2 (en) | 2013-03-15 | 2014-09-18 | Alfa Wassermann S.P.A. | Method for diagnosing vaginal infections |
EA201591267A1 (ru) | 2013-03-15 | 2016-03-31 | Альфа Вассерманн С.П.А. | Рифаксимин для применения в лечении вагинальных инфекций |
ES2829285T3 (es) | 2013-04-12 | 2021-05-31 | Alfasigma Spa | Administración de AINE y composiciones, métodos y sistemas relacionados |
US9018225B1 (en) | 2013-07-26 | 2015-04-28 | Novel Laboratories | Rifaximin crystalline forms and methods of preparation thereof |
ES2621557T3 (es) * | 2014-03-31 | 2017-07-04 | Euticals S.P.A. | Mezcla polimórfica de rifaximina y su uso para la preparación de formulaciones sólidas |
WO2015159275A2 (en) * | 2014-04-19 | 2015-10-22 | Granules India Limited | An improved process for the preparation of rifamycin derivatives |
CA2947962C (en) | 2014-05-04 | 2024-01-16 | Salix Pharmaceuticals, Inc. | Ibs microbiota and uses thereof |
ES2810010T3 (es) | 2014-05-12 | 2021-03-08 | Alfasigma Spa | Preparación y uso de la forma cristalina tau de rifaximina solvatada con DEGME |
WO2016003536A1 (en) * | 2014-06-30 | 2016-01-07 | Salix Pharmaceuticals, Inc. | Methods for retreating irritable bowel syndrome (ibs) |
CN104083324B (zh) * | 2014-07-10 | 2017-05-10 | 青岛动保国家工程技术研究中心有限公司 | 一种利福昔明的兽用悬乳剂及其制备方法和应用 |
EP2982764A1 (en) | 2014-08-05 | 2016-02-10 | ALFA WASSERMANN S.p.A. | Identification of vaginal bacteria |
CN104274391B (zh) * | 2014-10-08 | 2017-02-01 | 哈尔滨坤盟医药科技有限公司 | 一种含利福昔明的药物制剂 |
WO2017021975A1 (en) * | 2015-08-06 | 2017-02-09 | Msn Laboratories Private Limited | Process for the preparation of crystalline forms of rifaximin |
US10576065B2 (en) | 2016-03-24 | 2020-03-03 | Sandoz Ag | Pharmaceutical composition containing rifaximin alpha and delta |
EP3373914B2 (en) | 2016-03-24 | 2022-06-01 | Sandoz AG | Storage stable composition comprising rifaximin alpha |
US9988398B2 (en) * | 2016-06-07 | 2018-06-05 | Cadila Healthcare Limited | Crystalline form of rifaximin and process for its preparation |
EP4137132A1 (en) | 2016-09-30 | 2023-02-22 | Salix Pharmaceuticals, Inc. | Solid dispersion forms of rifaximin |
CN106632396B (zh) * | 2017-01-06 | 2019-01-11 | 成都樵枫科技发展有限公司 | γ晶型利福昔明的制备方法和用途 |
CA3013161C (en) * | 2017-04-26 | 2020-03-24 | Sandoz Ag | Oral dosage form comprising rifaximin in form beta |
PL3645539T3 (pl) | 2017-06-26 | 2021-10-25 | Biofer S.P.A. | Pochodne pirydoimidazoryfamycyny jako środek przeciwbakteryjny |
CA3142214A1 (en) | 2019-06-03 | 2020-12-10 | Bausch Health Ireland Limited | Use of methylnaltrexone and rifaximin for treatment of increased gut permeability or associated disorders |
AU2020355603A1 (en) | 2019-09-24 | 2022-03-17 | Bausch Health Ireland Limited | Rifaximin liquid formulations |
WO2021191312A1 (en) | 2020-03-24 | 2021-09-30 | Bausch Health Ireland Limited | Methods of treating covid-19 with rifaximin |
WO2021229480A1 (en) * | 2020-05-15 | 2021-11-18 | Atra Pharmaceuticals Limited | Polymorph of rifaximin, process for the preparation thereof and pharmaceutical composition containing rifaximin |
CA3184054A1 (en) | 2020-06-26 | 2021-12-30 | Jacob Cole | Targeted release rifaximin compositions |
WO2022090490A1 (en) | 2020-10-29 | 2022-05-05 | Bausch Health Ireland Limited | Rifaximin liquid formulations for use in the treatment of sickle cell disease |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4241785A (en) * | 1978-07-24 | 1980-12-30 | Peerless Of America, Inc. | Heat exchangers and method of making same |
IT1154655B (it) * | 1980-05-22 | 1987-01-21 | Alfa Farmaceutici Spa | Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica |
IT1199374B (it) | 1984-05-15 | 1988-12-30 | Alfa Farmaceutici Spa | Processo per la preparazione di pirido-imidazo-rifamicine |
CA1215976A (en) | 1984-05-15 | 1986-12-30 | Vincenzo Cannata | New process for the synthesis of imidazo rifamycins |
IT1199413B (it) | 1984-09-26 | 1988-12-30 | Alfa Farmaceutici Spa | Processo per la preparazione di pirido-imidazo-rifamicine |
GB8816620D0 (en) * | 1988-07-13 | 1988-08-17 | Lepetit Spa | Rifapentine hydrohalides |
CA2082809C (en) * | 1990-06-29 | 1995-10-17 | Marino Nebuloni | Pure crystalline form of rifapentine |
NZ519984A (en) * | 2000-01-07 | 2004-03-26 | Transform Pharmaceuticals Inc | High-throughput formation, identification, and analysis of diverse solid-forms |
UA75365C2 (en) * | 2000-08-16 | 2006-04-17 | Bristol Myers Squibb Co | Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon |
AU2002212340B2 (en) * | 2000-10-31 | 2006-12-14 | Sandoz Ag | Crystalline forms of venlafaxine hydrochloride |
IL156055A0 (en) * | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
ITMI20032144A1 (it) | 2003-11-07 | 2005-05-08 | Alfa Wassermann Spa | Forme polimorfe di rifaximina, processi per ottenerle e |
US20050262269A1 (en) | 2004-05-20 | 2005-11-24 | Pike Jimmy D | System and method for information handling system PCI express advanced switching |
DK1698630T3 (da) | 2005-03-03 | 2014-12-08 | Alfa Wassermann Spa | Nye polymorfe former af rifaximin, fremgangsmåde for deres fremstilling og anvendelse deraf i de medicinske præparater |
US8633234B2 (en) * | 2006-09-22 | 2014-01-21 | Cipla Limited | Rifaximin |
WO2008115572A1 (en) | 2007-03-21 | 2008-09-25 | Theraquest Biosciences, Inc. | Methods and compositions of nsaids |
ITMI20071241A1 (it) | 2007-06-20 | 2008-12-21 | Solmag S P A | Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta |
WO2009008005A1 (en) | 2007-07-06 | 2009-01-15 | Lupin Limited | Pharmaceutical compositions of rifaximin |
SI2011486T1 (sl) | 2007-07-06 | 2012-10-30 | Lupin Ltd | Farmacevtski sestavki rifaksimina |
US7709634B2 (en) * | 2007-09-20 | 2010-05-04 | Apotex Pharmachem Inc. | Amorphous form of rifaximin and processes for its preparation |
JP2011500552A (ja) | 2007-10-10 | 2011-01-06 | ルピン・リミテッド | 胃腸障害を処置するための医薬用組み合わせおよび組成物 |
UA101829C2 (uk) | 2008-02-25 | 2013-05-13 | Саликс Фармасьютикалз, Лтд. | ФОРМА η РИФАКСИМІНУ І ЇЇ ЗАСТОСУВАННЯ В ТЕРАПЕВТИЧНІЙ ПРАКТИЦІ |
-
2003
- 2003-11-07 IT IT002144A patent/ITMI20032144A1/it unknown
- 2003-12-05 US US10/728,090 patent/US7045620B2/en active Active
-
2004
- 2004-03-09 PL PL06004220T patent/PL1676848T3/pl unknown
- 2004-03-09 ES ES06004220T patent/ES2320161T3/es not_active Expired - Lifetime
- 2004-03-09 NZ NZ531622A patent/NZ531622A/en not_active IP Right Cessation
- 2004-03-09 ES ES04005541T patent/ES2244364T3/es not_active Expired - Lifetime
- 2004-03-09 PT PT04005541T patent/PT1557421E/pt unknown
- 2004-03-09 ES ES06004219T patent/ES2320160T4/es not_active Expired - Lifetime
- 2004-03-09 DK DK06004220T patent/DK1676848T3/da active
- 2004-03-09 PT PT06004220T patent/PT1676848E/pt unknown
- 2004-03-09 SI SI200430297T patent/SI1557421T1/sl unknown
- 2004-03-09 CA CA002460384A patent/CA2460384A1/en not_active Abandoned
- 2004-03-09 PL PL04005541T patent/PL1557421T3/pl unknown
- 2004-03-09 DK DK04005541T patent/DK1557421T3/da active
- 2004-03-09 PL PL06004219T patent/PL1676847T3/pl unknown
- 2004-03-09 SI SI200431074T patent/SI1676847T1/sl unknown
- 2004-03-09 EP EP04005541A patent/EP1557421B1/en not_active Expired - Lifetime
- 2004-03-09 AT AT04005541T patent/ATE361927T1/de active
- 2004-03-09 DK DK06004219T patent/DK1676847T3/da active
- 2004-03-09 PT PT06004219T patent/PT1676847E/pt unknown
- 2004-03-09 SI SI200431070T patent/SI1676848T1/sl unknown
- 2004-03-09 AT AT06004219T patent/ATE421965T1/de active
- 2004-03-09 EP EP06004220A patent/EP1676848B1/en not_active Expired - Lifetime
- 2004-03-09 EP EP06004219A patent/EP1676847B1/en not_active Expired - Lifetime
- 2004-03-09 DE DE602004006367.3T patent/DE602004006367C5/de not_active Expired - Lifetime
- 2004-03-09 DE DE04005541T patent/DE04005541T1/de active Pending
- 2004-03-09 DE DE602004019298T patent/DE602004019298D1/de not_active Expired - Lifetime
- 2004-03-09 DE DE602004019296T patent/DE602004019296D1/de not_active Expired - Lifetime
- 2004-03-09 IL IL16079804A patent/IL160798A0/xx unknown
- 2004-03-09 AT AT06004220T patent/ATE421966T1/de active
- 2004-03-10 ZA ZA200401948A patent/ZA200401948B/xx unknown
- 2004-03-10 AU AU2004200964A patent/AU2004200964A1/en not_active Abandoned
- 2004-03-11 CO CO04022467A patent/CO5560083A1/es not_active Application Discontinuation
- 2004-03-11 MX MXPA04002353A patent/MXPA04002353A/es unknown
- 2004-03-11 AR ARP040100781A patent/AR043547A1/es not_active Application Discontinuation
- 2004-03-11 CL CL200400498A patent/CL2004000498A1/es unknown
- 2004-03-16 TW TW093106943A patent/TWI285107B/zh not_active IP Right Cessation
- 2004-03-16 CN CNA2004100477623A patent/CN1613858A/zh active Pending
- 2004-03-17 KR KR1020040017892A patent/KR20050043589A/ko not_active Application Discontinuation
- 2004-03-17 JP JP2004076458A patent/JP2005139161A/ja active Pending
- 2004-03-18 HR HRP20040265 patent/HRP20040265A2/hr not_active Application Discontinuation
- 2004-03-18 RU RU2004108953/04A patent/RU2270200C2/ru active
- 2004-03-18 JO JO200433A patent/JO2470B1/en active
- 2004-03-19 YU YU24804A patent/YU24804A/sh unknown
- 2004-03-19 BR BR0402382-0A patent/BRPI0402382A/pt not_active IP Right Cessation
- 2004-03-19 TN TNP2004000044A patent/TNSN04044A1/en unknown
- 2004-03-24 MA MA27590A patent/MA27069A1/fr unknown
- 2004-04-11 UA UAA200602354A patent/UA86384C2/uk unknown
- 2004-11-04 WO PCT/EP2004/012490 patent/WO2005044823A2/en active Application Filing
- 2004-11-04 ME MEP-2008-633A patent/ME00424B/me unknown
- 2004-11-04 KR KR1020057013910A patent/KR100855084B1/ko active IP Right Review Request
- 2004-11-04 CN CN2008100869308A patent/CN101260114B/zh active Active
- 2004-11-04 JP JP2006537252A patent/JP5199576B2/ja active Active
- 2004-11-04 CN CN2008100869327A patent/CN101260115B/zh active Active
- 2004-11-04 CN CN2004800030228A patent/CN1886408B/zh active Active
- 2004-11-04 RS RS20150291A patent/RS54569B1/en unknown
- 2004-11-04 MX MXPA06002644A patent/MXPA06002644A/es active IP Right Grant
- 2004-11-04 KR KR1020077026410A patent/KR100867751B1/ko active IP Right Grant
- 2004-11-04 EP EP10004589A patent/EP2210893A1/en not_active Withdrawn
- 2004-11-04 AU AU2004287601A patent/AU2004287601B8/en active Active
- 2004-11-04 BR BRPI0407149A patent/BRPI0407149A8/pt not_active Application Discontinuation
- 2004-11-04 EP EP10004590A patent/EP2208730A1/en not_active Withdrawn
- 2004-11-04 KR KR1020077026409A patent/KR100883216B1/ko active IP Right Grant
- 2004-11-04 CA CA2538546A patent/CA2538546C/en active Active
- 2004-11-04 EP EP04797615A patent/EP1682556A2/en not_active Withdrawn
- 2004-11-04 RS RS20060168A patent/RS54568B1/en unknown
- 2004-11-04 RS YUP-2006/0168A patent/RS20060168A/sr unknown
- 2004-11-04 MD MDA20060080A patent/MD3653G8/ro active IP Right Grant
- 2004-11-04 RS RS20150292A patent/RS54571B1/en unknown
-
2005
- 2005-05-24 US US11/135,651 patent/US20050272754A1/en not_active Abandoned
- 2005-08-04 HK HK06113863.1A patent/HK1092150A1/xx not_active IP Right Cessation
- 2005-08-04 HK HK06113864.0A patent/HK1092151A1/xx not_active IP Right Cessation
- 2005-08-04 HK HK05106702A patent/HK1073657A1/xx not_active IP Right Cessation
-
2006
- 2006-03-01 TN TNP2006000069A patent/TNSN06069A1/en unknown
- 2006-03-08 NO NO20061110A patent/NO334950B1/no unknown
- 2006-03-08 HR HRP20060093AA patent/HRP20060093B1/hr active IP Right Grant
- 2006-03-12 IL IL174271A patent/IL174271A/en active IP Right Grant
-
2007
- 2007-07-02 CY CY20071100875T patent/CY1108017T1/el unknown
- 2007-10-17 US US11/873,841 patent/US7915275B2/en active Active
-
2009
- 2009-03-23 CY CY20091100319T patent/CY1108909T1/el unknown
- 2009-04-09 CY CY20091100414T patent/CY1108964T1/el unknown
-
2010
- 2010-11-19 JP JP2010259452A patent/JP2011057698A/ja not_active Withdrawn
- 2010-11-19 JP JP2010259453A patent/JP5635376B2/ja active Active
-
2011
- 2011-03-04 US US13/041,346 patent/US8173801B2/en active Active
- 2011-03-04 US US13/041,348 patent/US8404704B2/en active Active
- 2011-06-23 AR ARP110102194A patent/AR081992A2/es not_active Application Discontinuation
- 2011-06-23 AR ARP110102193A patent/AR081991A2/es not_active Application Discontinuation
-
2014
- 2014-07-04 JP JP2014138697A patent/JP2014177500A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO5560083A1 (es) | Formas polimorficas de rifaximina, procesos para su produccion y uso de las mismas en preparaciones | |
HUP0402485A2 (hu) | A clopidogrel hidrogénszulfát polimorf módosulatai | |
NO20035210D0 (no) | 2-anilino-pyrimidinderivater som cyklinavhengige kinaseinhibitorer | |
WO2007143507A3 (en) | Preparation and utility of substituted erythromycin analogs | |
TWI339659B (en) | Aqueous composition comprising thiazole derivative | |
HUP0004323A2 (hu) | 6,11-Áthidalt eritromicinszármazékok, azokat tartalmazó gyógyszerkészítmények, valamint eljárás ilyen származékok előállítására | |
YU94103A (sh) | Novi derivati sulfonske kiseline | |
HU9200204D0 (en) | Process for the production of benzyloxi-phenyl derivatives and medical preparations containing them | |
SI1572699T1 (sl) | Kristalne soli cefdinira | |
GB0205688D0 (en) | Chemical compounds | |
CA1303028C (en) | Metal complexes of n-methyl-11-aza-10-deoxo-10- dihydroerythromycina or 11-aza-10-deoxo-10- dihydroerythromycin a, method for the manufacture thereof and their use in the manufacture of pharmaceuticals | |
PE20070548A1 (es) | Formas cristalinas de la sal de di-sodio del acido n-(5-clorosaliciloil)-8-aminocaprilico | |
HUP0102936A2 (hu) | Új eljárás N,N,6-trimetil-2-(4-metilfenil)imidazo[1,2-a]piridin-3-acetamid és sói előállítására | |
WO2004009608A3 (en) | Novel amorphous 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a, process for preparing the same, and use thereof | |
PE20010151A1 (es) | Nuevas formas cristalinas de un antibiotico macrolido | |
TNSN05248A1 (en) | Crystalline n-formyl hydroxylamine compounds | |
DE3264906D1 (en) | Aminoglycoside derivatives, processes for their production, pharmaceutical compositions containing them and such derivatives for use as pharmaceuticals | |
CA2467249A1 (en) | Polyene polyketides, processes for their production and their use as pharmaceuticals | |
TW200602334A (en) | Method for the preparation of aryl ethers | |
AR047061A1 (es) | Sintesis de un polimorfo de clorhidrato hidratado de 4-amino-5-cloro-2-metoxi-n-(1-azabiciclo[3.3.1]non-4-il)benzamida | |
DK85490D0 (da) | Krystallinsk (5r,6s)-2-carbamoyloxymethyl-6-((1r)-hydroxyethyl)-2-penemcarboxylsyre og dens farmaceutiske formulering | |
IL40447A (en) | Delta3-cephalosporin compounds and process for their preparation from delta2-cephalosporin | |
EP0646586A4 (es) | ||
GB1387769A (en) | Butenoic acid derivatives and a process for the manufacture thereof | |
TH79586B (th) | สารประกอบอินทรีย์ |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Application withdrawn |