HUP0102936A2 - Új eljárás N,N,6-trimetil-2-(4-metilfenil)imidazo[1,2-a]piridin-3-acetamid és sói előállítására - Google Patents

Új eljárás N,N,6-trimetil-2-(4-metilfenil)imidazo[1,2-a]piridin-3-acetamid és sói előállítására

Info

Publication number
HUP0102936A2
HUP0102936A2 HU0102936A HUP0102936A HUP0102936A2 HU P0102936 A2 HUP0102936 A2 HU P0102936A2 HU 0102936 A HU0102936 A HU 0102936A HU P0102936 A HUP0102936 A HU P0102936A HU P0102936 A2 HUP0102936 A2 HU P0102936A2
Authority
HU
Hungary
Prior art keywords
imidazo
acetamide
methylphenyl
trimethyl
pyridine
Prior art date
Application number
HU0102936A
Other languages
English (en)
Inventor
Rafael Labriola
Original Assignee
Quimica Sintetica S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8304817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0102936(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Quimica Sintetica S.A. filed Critical Quimica Sintetica S.A.
Publication of HUP0102936A2 publication Critical patent/HUP0102936A2/hu
Publication of HUP0102936A3 publication Critical patent/HUP0102936A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgya új eljárás (I) képletű N,N,6-trimetil-2-(4-metil-fenil)imidazo[1,2-a]piridin-3-acetamid előállítására. A találmányértelmében úgy járnak el, hogy a (XI) képletű hidroxi-észtert a (XIII)képletű tionil-kloriddal és dimetilformamiddal in situ képzettiminiumsóval reagáltatják és ezután egy alkalmas redukálószerrelredukálják, majd a kapott vegyületet dimetilaminnal reagáltatjákpolihidroxilezett oldószerben mint reakcióközegben alkalmashőmérsékleten. Ó
HU0102936A 1998-08-06 1999-08-04 New process for preparing n,n,6- trimethyl-2 -(4-methylphenyl)- imidazo-[1,2-a] -pyridine-3-acetamide and salts thereof HUP0102936A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009801694A ES2151834B1 (es) 1998-08-06 1998-08-06 Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales.
PCT/ES1999/000250 WO2000008021A2 (es) 1998-08-06 1999-08-04 Procedimiento para preparar n,n,6- trimetil-2- (4-metilfenil)- imidazo-[1,2-a] -piridina-3- acetamida y sus sales

Publications (2)

Publication Number Publication Date
HUP0102936A2 true HUP0102936A2 (hu) 2002-01-28
HUP0102936A3 HUP0102936A3 (en) 2002-09-30

Family

ID=8304817

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0102936A HUP0102936A3 (en) 1998-08-06 1999-08-04 New process for preparing n,n,6- trimethyl-2 -(4-methylphenyl)- imidazo-[1,2-a] -pyridine-3-acetamide and salts thereof

Country Status (26)

Country Link
US (1) US6407240B1 (hu)
EP (1) EP1104765B2 (hu)
JP (1) JP3544944B2 (hu)
KR (1) KR100492054B1 (hu)
AT (1) ATE234836T1 (hu)
AU (1) AU750302B2 (hu)
CA (1) CA2339594C (hu)
CZ (1) CZ292446B6 (hu)
DE (1) DE69906088T3 (hu)
DK (1) DK1104765T4 (hu)
ES (2) ES2151834B1 (hu)
HK (1) HK1037624A1 (hu)
HR (1) HRP20010158B1 (hu)
HU (1) HUP0102936A3 (hu)
IL (1) IL141133A (hu)
IS (1) IS5839A (hu)
NO (1) NO319780B1 (hu)
NZ (1) NZ510310A (hu)
PL (1) PL195888B1 (hu)
PT (1) PT1104765E (hu)
RS (1) RS50103B (hu)
RU (1) RU2221797C2 (hu)
SI (1) SI1104765T2 (hu)
SK (1) SK283652B6 (hu)
WO (1) WO2000008021A2 (hu)
ZA (1) ZA200101294B (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2151834B1 (es) † 1998-08-06 2001-08-16 Sint Quimica Sa Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales.
CN1227252C (zh) * 1999-11-22 2005-11-16 埃吉斯药物工厂 制备6－甲基－2－(4－甲基－苯基)－咪唑并[1,2－a]吡啶－3－(N,N－二甲基－乙酰胺)和中间体的方法
IT1318624B1 (it) * 2000-07-14 2003-08-27 Dinamite Dipharma S P A In For Processo per la preparazione di 2-fenil-imidazo (1,2-a)piridin-3-acetammidi.
US6596731B2 (en) 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
DE03764677T1 (de) * 2002-07-15 2007-01-04 Scinopharm Taiwan, Ltd. Verfahren zur herstellung von imidazo(1,2-a)pyridin-3-acetamiden
ES2320758T3 (es) 2002-12-18 2009-05-28 Mallinckrodt Inc. Sintesis de heteroaril acetamidas.
CN1972939A (zh) * 2004-06-22 2007-05-30 马林克罗特公司 由具有减少的水含量的反应混合物合成杂芳基乙酰胺
JP2009510163A (ja) * 2005-10-03 2009-03-12 マリンクロッド・インコーポレイテッド ヘミ酒石酸および酒石酸ゾルピデム多形の製造方法
EP1803722A1 (en) * 2006-01-03 2007-07-04 Ferrer Internacional, S.A. Imidazo[1,2-a]pyridin-3-yl-acetic acid hydrazides, processes for their preparation and pharmaceutical uses thereof
US20080145425A1 (en) * 2006-12-15 2008-06-19 Pliva Research & Development Limited Pharmaceutical composition of zolpidem
CN103360387B (zh) * 2012-03-28 2016-12-14 江苏豪森药业集团有限公司 一种制备化合物唑吡坦的方法
CN104610253B (zh) * 2015-01-26 2016-11-16 郑州大学 2‑三氟甲基‑2‑羟基‑2‑(2‑芳基吡啶并[1,2‑α]咪唑)乙酸酯类化合物
CN114105974A (zh) * 2020-08-27 2022-03-01 鲁南制药集团股份有限公司 一种唑吡坦的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2600650B1 (fr) * 1986-06-27 1988-09-09 Synthelabo Procede de preparation d'imidazopyridines et composes intermediaires
ES2151834B1 (es) † 1998-08-06 2001-08-16 Sint Quimica Sa Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales.

Also Published As

Publication number Publication date
CZ292446B6 (cs) 2003-09-17
IL141133A (en) 2005-11-20
KR20010072173A (ko) 2001-07-31
CA2339594A1 (en) 2000-02-17
JP3544944B2 (ja) 2004-07-21
DK1104765T4 (da) 2008-03-03
DE69906088D1 (de) 2003-04-24
KR100492054B1 (ko) 2005-05-31
EP1104765B1 (en) 2003-03-19
ATE234836T1 (de) 2003-04-15
ES2151834B1 (es) 2001-08-16
CZ2001360A3 (cs) 2001-12-12
CA2339594C (en) 2005-05-03
HK1037624A1 (en) 2002-02-15
NO20010613L (no) 2001-02-05
ES2195598T3 (es) 2003-12-01
PL195888B1 (pl) 2007-11-30
AU5291299A (en) 2000-02-28
EP1104765A2 (en) 2001-06-06
ZA200101294B (en) 2002-02-15
DE69906088T3 (de) 2008-04-30
IS5839A (is) 2001-02-05
IL141133A0 (en) 2002-02-10
ES2151834A1 (es) 2001-01-01
SK283652B6 (sk) 2003-11-04
SI1104765T1 (en) 2003-08-31
WO2000008021A2 (es) 2000-02-17
EP1104765B2 (en) 2007-11-14
NO319780B1 (no) 2005-09-12
SI1104765T2 (sl) 2008-04-30
AU750302B2 (en) 2002-07-18
NO20010613D0 (no) 2001-02-05
YU8301A (sh) 2003-10-31
WO2000008021A3 (es) 2000-07-06
HUP0102936A3 (en) 2002-09-30
NZ510310A (en) 2002-11-26
DE69906088T2 (de) 2003-12-24
PT1104765E (pt) 2003-08-29
ES2195598T5 (es) 2008-05-01
DK1104765T3 (da) 2003-06-30
JP2002522437A (ja) 2002-07-23
US6407240B1 (en) 2002-06-18
HRP20010158B1 (en) 2003-12-31
RS50103B (sr) 2009-01-22
HRP20010158A2 (en) 2002-02-28
PL346158A1 (en) 2002-01-28
RU2221797C2 (ru) 2004-01-20
SK1592001A3 (en) 2001-12-03

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