RU94036003A - Производные имидазол-4-ил-пиперидина, их получение и содержащие их медикамент и фармацевтическая композиция - Google Patents
Производные имидазол-4-ил-пиперидина, их получение и содержащие их медикамент и фармацевтическая композицияInfo
- Publication number
- RU94036003A RU94036003A RU94036003/04A RU94036003A RU94036003A RU 94036003 A RU94036003 A RU 94036003A RU 94036003/04 A RU94036003/04 A RU 94036003/04A RU 94036003 A RU94036003 A RU 94036003A RU 94036003 A RU94036003 A RU 94036003A
- Authority
- RU
- Russia
- Prior art keywords
- group
- imidazo
- dihydroimidazo
- benzoxazin
- methyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 3
- 239000003814 drug Substances 0.000 title claims 2
- -1 4,5- dihydroimidazo [1,5,4-de][1,4]benzoxazin-2-yl group Chemical group 0.000 claims abstract 13
- 150000001875 compounds Chemical class 0.000 claims abstract 6
- 239000002253 acid Substances 0.000 claims abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004260 quinazolin-2-yl group Chemical group [H]C1=NC(*)=NC2=C1C([H])=C([H])C([H])=C2[H] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (4)
1. Соединения формулы (1)
(1)
в которой R1 представляет собой атом водорода или алкильную группу С1 -С6 нормального или разветвленного строения,
А представляет собой 5,6-дигидро-4Н-имидазо[4,5,1-ij]хинолин-2- -иловую группу, или 4,5-дигидроимидазо[1,5,4-dе] [1,4]бензоксазин-2-иловую группу, или 4-метил-4,5-дигидроимидазо[1,5,4-dе] [1,4] бензоксазин-2-иловую группу, или 4-фенил-4,5-дигидроимидазо[1,5,4-dе] [1,4] бензоксазин-2-иловую группу, или 4-(фенилметил)-4,5-дигидроимидазо[1,5,4- -dе][1,4]бензоксазин-2-иловую группу или 5-метил-4,5-дигидроимидазо[1,5,4-dе] [1,4] бензоксазин-2-иловую группу, или 5,6-дигидро-4Н-имидазо[1,5,4-dе]хиназолин -2-иловую группу или 6-оксо-5,6-дигидро-4Н-имидазо[4,5,1-ij] хинолин-2-иловую группу, или 5-метил-4,5,6,7-тетрагидроимидазо[4,5,1-ji] [1,4]бензодиазепин-2-иловую группу, которая может быть замещена в положение 6 фенилметильной группой,
а также их фармацевтически приемлемые соли, полученные присоединением кислот к указанным соединениям.
в которой R1 представляет собой атом водорода или алкильную группу С1 -С6 нормального или разветвленного строения,
А представляет собой 5,6-дигидро-4Н-имидазо[4,5,1-ij]хинолин-2- -иловую группу, или 4,5-дигидроимидазо[1,5,4-dе] [1,4]бензоксазин-2-иловую группу, или 4-метил-4,5-дигидроимидазо[1,5,4-dе] [1,4] бензоксазин-2-иловую группу, или 4-фенил-4,5-дигидроимидазо[1,5,4-dе] [1,4] бензоксазин-2-иловую группу, или 4-(фенилметил)-4,5-дигидроимидазо[1,5,4- -dе][1,4]бензоксазин-2-иловую группу или 5-метил-4,5-дигидроимидазо[1,5,4-dе] [1,4] бензоксазин-2-иловую группу, или 5,6-дигидро-4Н-имидазо[1,5,4-dе]хиназолин -2-иловую группу или 6-оксо-5,6-дигидро-4Н-имидазо[4,5,1-ij] хинолин-2-иловую группу, или 5-метил-4,5,6,7-тетрагидроимидазо[4,5,1-ji] [1,4]бензодиазепин-2-иловую группу, которая может быть замещена в положение 6 фенилметильной группой,
а также их фармацевтически приемлемые соли, полученные присоединением кислот к указанным соединениям.
2. Способ получения соединений по п.1, отличающийся тем, что производное формулы (II),
A-Z (II)
в которой
Z представляет собой атом галогена, преимущественно хлора, а
А группу, определенную в п.1,
подвергают взаимодействию при нагревании среде растворителя с пиперидином формулы (III)
(III)
в которой R1 представляет собой группу, определенную в п.1.
A-Z (II)
в которой
Z представляет собой атом галогена, преимущественно хлора, а
А группу, определенную в п.1,
подвергают взаимодействию при нагревании среде растворителя с пиперидином формулы (III)
в которой R1 представляет собой группу, определенную в п.1.
3. Медикамент, отличающийся тем, что он содержит соединение по п.1.
4. Фармацевтическая композиция, отличающаяся тем, что она содержит соединение по п.1 в сочетании с любым фармацевтически приемлемым эксипиентом.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR93.11771 | 1993-10-04 | ||
| FR9311771A FR2710915B1 (fr) | 1993-10-04 | 1993-10-04 | Dérivés de pipéridine, leur préparation et leur utilisation en thérapeutique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU94036003A true RU94036003A (ru) | 1996-08-10 |
Family
ID=9451496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94036003/04A RU94036003A (ru) | 1993-10-04 | 1994-10-03 | Производные имидазол-4-ил-пиперидина, их получение и содержащие их медикамент и фармацевтическая композиция |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5589476A (ru) |
| EP (1) | EP0646583A1 (ru) |
| JP (1) | JPH07179466A (ru) |
| KR (1) | KR950011435A (ru) |
| CN (1) | CN1109471A (ru) |
| AU (1) | AU7432994A (ru) |
| CA (1) | CA2133491A1 (ru) |
| CZ (1) | CZ241994A3 (ru) |
| FI (1) | FI944600A (ru) |
| FR (1) | FR2710915B1 (ru) |
| HU (1) | HUT71120A (ru) |
| IL (1) | IL111148A0 (ru) |
| NO (1) | NO943682L (ru) |
| NZ (1) | NZ264596A (ru) |
| PL (1) | PL305288A1 (ru) |
| RU (1) | RU94036003A (ru) |
| SK (1) | SK119494A3 (ru) |
| ZA (1) | ZA947710B (ru) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5500423A (en) * | 1994-09-09 | 1996-03-19 | Hoechst-Roussel Pharmaceuticals Inc. | 5,6-dihydro-4H-imidazo[4,5,1-ij]quinolines |
| FR2731708B1 (fr) * | 1995-03-13 | 1997-04-30 | Synthelabo | Derives de piperidine, leur procede de preparation et leur application en therapeutique |
| WO1997010823A1 (en) * | 1995-09-18 | 1997-03-27 | Glaxo Group Limited | 5-ht3 receptor antagonists for dyskinesia |
| FR2747678B1 (fr) * | 1996-04-22 | 1998-05-22 | Synthelabo | Composes derives d'imidazobenzoxazine, leurs procedes de preparation et leurs utilisations en therapeutique |
| FR2753196B1 (fr) * | 1996-09-12 | 1998-10-23 | Synthelabo | Derives d'indazole tricyclique, leur preparation et leur application en therapeutique |
| IL141236A0 (en) * | 1998-08-21 | 2002-03-10 | Novartis Ag | New oral formulations for 5-ht4 agonists or antagonists |
| IT1303123B1 (it) | 1998-10-13 | 2000-10-30 | Rotta Research Lab | Derivati basici di benz(e)isoindol-1-oni e pirrolo(3,4-c)chinolin-1-oni ad attivita' 5ht3 antagonista, loro preparazione ed |
| GB9918425D0 (en) * | 1999-08-04 | 1999-10-06 | Novartis Ag | Organic compounds |
| FR2812878B1 (fr) * | 2000-08-08 | 2002-10-11 | Sanofi Synthelabo | Derives de benzimidazole, leur preparation et leur application en therapeutique |
| AU2001282267A1 (en) * | 2000-08-08 | 2002-02-18 | Sanofi-Aventis | Benzimidazole derivatives, preparation and therapeutic use thereof |
| FR2816619B1 (fr) * | 2000-11-15 | 2003-01-31 | Sanofi Synthelabo | Derives de benzimidazole, leur preparation et leur application en therapeutique |
| FR2816941B1 (fr) * | 2000-11-23 | 2003-01-31 | Sanofi Synthelabo | Derives de benzimidazole, leur preparation et leur application en therapeutique |
| FR2816942B1 (fr) | 2000-11-23 | 2003-05-09 | Sanofi Synthelabo | Derives de benzimidazole, leur preparation et leur application en therapeutique |
| US20040242635A1 (en) * | 2001-03-30 | 2004-12-02 | Painter Rachel J. | Encapsulated dyes in cosmetic compositions |
| AU2003240742A1 (en) * | 2002-06-07 | 2003-12-22 | Altana Pharma Ag | 4,5-dihydro-imidazo (4,5,1-ij) quinolin-6-ones derivatives and their use as poly (adp-ribosyl) transferase (parp) inhibitors |
| SG10201707487VA (en) | 2013-03-15 | 2017-10-30 | Incyte Corp | Tricyclic heterocycles as bet protein inhibitors |
| WO2015006193A1 (en) | 2013-07-08 | 2015-01-15 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
| WO2015081203A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
| US9315501B2 (en) | 2013-11-26 | 2016-04-19 | Incyte Corporation | Bicyclic heterocycles as BET protein inhibitors |
| WO2015095492A1 (en) | 2013-12-19 | 2015-06-25 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
| SG11201608843TA (en) | 2014-04-23 | 2016-11-29 | Incyte Corp | 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS |
| WO2016044130A1 (en) | 2014-09-15 | 2016-03-24 | Incyte Corporation | Tricyclic heterocycles for use as bet protein inhibitors |
| US20170121347A1 (en) | 2015-10-29 | 2017-05-04 | Incyte Corporation | Amorphous solid form of a bet protein inhibitor |
| IL263824B2 (en) | 2016-06-20 | 2023-10-01 | Incyte Corp | Crystals in solid form in the presence of an inhibitor |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4939138A (en) * | 1988-12-29 | 1990-07-03 | Sterling Drug Inc. | 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo(1,2,3-DE)-1,4-benzoxazines |
| FR2674855B1 (fr) * | 1991-04-03 | 1994-01-14 | Synthelabo | Derives de piperidine, leur preparation et leur application en therapeutique. |
-
1993
- 1993-10-04 FR FR9311771A patent/FR2710915B1/fr not_active Expired - Fee Related
-
1994
- 1994-09-23 EP EP94402114A patent/EP0646583A1/fr not_active Withdrawn
- 1994-10-01 KR KR1019940025222A patent/KR950011435A/ko not_active Application Discontinuation
- 1994-10-03 CZ CZ942419A patent/CZ241994A3/cs unknown
- 1994-10-03 RU RU94036003/04A patent/RU94036003A/ru unknown
- 1994-10-03 IL IL11114894A patent/IL111148A0/xx unknown
- 1994-10-03 SK SK1194-94A patent/SK119494A3/sk unknown
- 1994-10-03 HU HU9402832A patent/HUT71120A/hu unknown
- 1994-10-03 JP JP6238914A patent/JPH07179466A/ja active Pending
- 1994-10-03 FI FI944600A patent/FI944600A/fi not_active Application Discontinuation
- 1994-10-03 US US08/317,661 patent/US5589476A/en not_active Expired - Fee Related
- 1994-10-03 CN CN94117012A patent/CN1109471A/zh active Pending
- 1994-10-03 PL PL94305288A patent/PL305288A1/xx unknown
- 1994-10-03 NZ NZ264596A patent/NZ264596A/en unknown
- 1994-10-03 AU AU74329/94A patent/AU7432994A/en not_active Abandoned
- 1994-10-03 NO NO943682A patent/NO943682L/no unknown
- 1994-10-03 CA CA002133491A patent/CA2133491A1/en not_active Abandoned
- 1994-10-03 ZA ZA947710A patent/ZA947710B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2710915A1 (fr) | 1995-04-14 |
| JPH07179466A (ja) | 1995-07-18 |
| CN1109471A (zh) | 1995-10-04 |
| PL305288A1 (en) | 1995-04-18 |
| CZ241994A3 (en) | 1995-04-12 |
| HUT71120A (en) | 1995-11-28 |
| NO943682L (no) | 1995-04-05 |
| CA2133491A1 (en) | 1995-04-05 |
| FR2710915B1 (fr) | 1995-11-24 |
| EP0646583A1 (fr) | 1995-04-05 |
| FI944600A (fi) | 1995-04-05 |
| HU9402832D0 (en) | 1995-01-30 |
| IL111148A0 (en) | 1994-12-29 |
| FI944600A0 (fi) | 1994-10-03 |
| AU7432994A (en) | 1995-04-13 |
| KR950011435A (ko) | 1995-05-15 |
| US5589476A (en) | 1996-12-31 |
| SK119494A3 (en) | 1995-05-10 |
| NZ264596A (en) | 1995-11-27 |
| ZA947710B (en) | 1995-08-10 |
| NO943682D0 (no) | 1994-10-03 |
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