KR950011435A - 이미다졸-4-일 피페리딘 유도체, 이것의 제법 및 이것의 치료에의 이용 - Google Patents

이미다졸-4-일 피페리딘 유도체, 이것의 제법 및 이것의 치료에의 이용 Download PDF

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KR950011435A
KR950011435A KR1019940025222A KR19940025222A KR950011435A KR 950011435 A KR950011435 A KR 950011435A KR 1019940025222 A KR1019940025222 A KR 1019940025222A KR 19940025222 A KR19940025222 A KR 19940025222A KR 950011435 A KR950011435 A KR 950011435A
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South Korea
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group
dihydroimidazo
benzoxazine
dihydro
methyl
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KR1019940025222A
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English (en)
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제앙 사미르
데포스 제라르
앤드류 퍼셀 토마스
에방 뤽
Original Assignee
에. 뚜레 레메뜨르
신떼라보 소시에떼 아노님
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Publication of KR950011435A publication Critical patent/KR950011435A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

식(I)에 해당하는 화합물 및 약제학적으로 허용되는 산과는 이것의 부가염,
여기서, R1은 수소원자 또는 직쇄이거나 분지쇄인(C1-C4) 알킬기중의 하나를 나타내고, A는 페닐메틸기에 의해서 6- 위치에서 임의로 치환된 5,6-디히드로-4H-이미다조[4,5,1-ij]퀴놀-2-일기 또는 4,5-디히드로이미다조[1,5,4-de][1,4]벤족사진-2-일기 또는 4-메틸-4,5-디히드로이미다조[1,5,4-de][1,4]벤족사진-2-일기 또는 4-페닐-4,5-디히드로이미다조[1,5,4-de][1,4]벤족사진-2-일기 또는 4-페닐메틸-4,5-디히드로이미다조[1,5,4-de][1,4]벤족사진-2-일기 또는 5-메틸-4,5-디히드로이미다조[1,5,4-de][1,4]벤족사진-2-일기 또는 5,6-디히드로-4H-이미다조[1,5,4-de]퀴녹살린-2-일기 또는 6-옥소-5,6-디히드로-4H-이미다조-[4,5,1-ij]퀴놀-2일기 또는 5-메틸-4,5,6,7-테트라히드로이미다조[4,5,1-jk][1,4]벤조디아제핀-2-일기중의 하나를 나타낸다. 치료에의 이용.

Description

아미다졸-4-일 피페리딘 유도체, 이것의 제법 및 이것의 치료에의 이용
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 식(I)에 해당하는 화합물 및 약제학적으로 허용되는 산과의 이것의 부가염,
    여기서, R1은 수소원자 또는 직쇄이거나 분지쇄인(C1-C4) 알킬기중의 하나를 나타내고, A는 페닐메틸기에 의해서 6- 위치에서 임의로 치환된 5,6-디히드로-4H-이미다조[4,5,1-ij]퀴놀-2-일기 또는 4,5-디히드로이미다조[1,5,4-de][1,4]벤족사진-2-일기 또는 4-메틸-4,5-디히드로이미다조[1,5,4-de][1,4]벤족사진-2-일기 또는 4-페닐-4,5-디히드로이미다조[1,5,4-de][1,4]벤족사진-2-일기 또는 4-페닐메틸-4,5-디히드로이미다조[1,5,4-de][1,4]벤족사진-2-일기 또는 5-메틸-4,5-디히드로이미다조[1,5,4-de][1,4]벤족사진-2-일기 또는 5,6-디히드로-4H-이미다조[1,5,4-de]퀴녹살린-2-일기 또는 6-옥소-5,6-디히드로-4H-이미다조-[4,5,1-ij]퀴놀-2일기 또는 5-메틸-4,5,6,7-테트라히드로이미다조[4,5,1-jk][1,4]벤조디아제핀-2-일기중의 하나를 나타낸다.
  2. 식(II)
    A-Z (II)
    (여기서, Z는 할로겐원자, 바람직하게는 염소원자를 나타내고, A는 제1항에 정의된 것이다.)의 유도체를 식(III)
    (여기서, R1은 제1항에 정의된 것이다.)의 피페리딘과 용매안에서 뜨거울때 반응시키는 것을 특징으로 하는 제1항에 따르는 화합물의 제법.
  3. 제1항에 따르는 화합물을 함유하는 것을 특징으로 하는 의약.
  4. 약제학적으로 허용되는 부형제와 합하여 제1항에 따르는 화합물을 함유하는 것을 특징으로 하는 약제조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940025222A 1993-10-04 1994-10-01 이미다졸-4-일 피페리딘 유도체, 이것의 제법 및 이것의 치료에의 이용 KR950011435A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9311771A FR2710915B1 (fr) 1993-10-04 1993-10-04 Dérivés de pipéridine, leur préparation et leur utilisation en thérapeutique.
FR93.11771 1993-10-04

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KR950011435A true KR950011435A (ko) 1995-05-15

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US (1) US5589476A (ko)
EP (1) EP0646583A1 (ko)
JP (1) JPH07179466A (ko)
KR (1) KR950011435A (ko)
CN (1) CN1109471A (ko)
AU (1) AU7432994A (ko)
CA (1) CA2133491A1 (ko)
CZ (1) CZ241994A3 (ko)
FI (1) FI944600A (ko)
FR (1) FR2710915B1 (ko)
HU (1) HUT71120A (ko)
IL (1) IL111148A0 (ko)
NO (1) NO943682L (ko)
NZ (1) NZ264596A (ko)
PL (1) PL305288A1 (ko)
RU (1) RU94036003A (ko)
SK (1) SK119494A3 (ko)
ZA (1) ZA947710B (ko)

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FR2731708B1 (fr) * 1995-03-13 1997-04-30 Synthelabo Derives de piperidine, leur procede de preparation et leur application en therapeutique
DE69625819T2 (de) * 1995-09-18 2003-11-06 Glaxo Group Ltd Die verwendung von ondansetron zur herstellung eines medikamentes zur behandlung von tremor
FR2747678B1 (fr) * 1996-04-22 1998-05-22 Synthelabo Composes derives d'imidazobenzoxazine, leurs procedes de preparation et leurs utilisations en therapeutique
FR2753196B1 (fr) * 1996-09-12 1998-10-23 Synthelabo Derives d'indazole tricyclique, leur preparation et leur application en therapeutique
RS50104B (sr) * 1998-08-21 2009-01-22 Novartis Ag., Nova oralna formulacija za 5-th4 agoniste ili antagoniste
IT1303123B1 (it) 1998-10-13 2000-10-30 Rotta Research Lab Derivati basici di benz(e)isoindol-1-oni e pirrolo(3,4-c)chinolin-1-oni ad attivita' 5ht3 antagonista, loro preparazione ed
GB9918425D0 (en) * 1999-08-04 1999-10-06 Novartis Ag Organic compounds
PL365080A1 (en) * 2000-08-08 2004-12-27 Sanofi-Aventis Benzimidazole derivatives, preparation and therapeutic use thereof
FR2812878B1 (fr) * 2000-08-08 2002-10-11 Sanofi Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
FR2816619B1 (fr) * 2000-11-15 2003-01-31 Sanofi Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
FR2816942B1 (fr) * 2000-11-23 2003-05-09 Sanofi Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
FR2816941B1 (fr) * 2000-11-23 2003-01-31 Sanofi Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
US20040242635A1 (en) * 2001-03-30 2004-12-02 Painter Rachel J. Encapsulated dyes in cosmetic compositions
WO2003104233A1 (en) * 2002-06-07 2003-12-18 Altana Pharma Ag 4,5-dihydro-imidazo (4,5,1-ij) quinolin-6-ones derivatives and their use as poly (adp-ribosyl) transferase (parp) inhibitors
WO2014143768A1 (en) 2013-03-15 2014-09-18 Incyte Corporation Tricyclic heterocycles as bet protein inhibitors
CA2917319A1 (en) 2013-07-08 2015-01-15 Incyte Holdings Corporation Tricyclic heterocycles as bet protein inhibitors
US9399640B2 (en) 2013-11-26 2016-07-26 Incyte Corporation Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors
WO2015081189A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
US9309246B2 (en) 2013-12-19 2016-04-12 Incyte Corporation Tricyclic heterocycles as BET protein inhibitors
BR112016024626B1 (pt) 2014-04-23 2023-03-21 Incyte Holdings Corporation Compostos 1h-pirrolo[2,3-c]piridin-7(6h)-onas e pirazolo[3,4-c]piridin-7 (6h)-onas, uso dos mesmos, composição farmacêutica que os compreende e método de inibição de uma proteína bet
EP3194406B8 (en) 2014-09-15 2021-03-31 Incyte Corporation Tricyclic heterocycles for use as bet protein inhibitors
TW201722966A (zh) 2015-10-29 2017-07-01 英塞特公司 Bet蛋白質抑制劑之非晶固體形式
PE20190623A1 (es) 2016-06-20 2019-04-26 Incyte Corp Formas solidas cristalinas de un inhibidor de bet
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms

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US4939138A (en) * 1988-12-29 1990-07-03 Sterling Drug Inc. 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo(1,2,3-DE)-1,4-benzoxazines
FR2674855B1 (fr) * 1991-04-03 1994-01-14 Synthelabo Derives de piperidine, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
NZ264596A (en) 1995-11-27
CN1109471A (zh) 1995-10-04
HU9402832D0 (en) 1995-01-30
FI944600A0 (fi) 1994-10-03
NO943682L (no) 1995-04-05
JPH07179466A (ja) 1995-07-18
SK119494A3 (en) 1995-05-10
FR2710915B1 (fr) 1995-11-24
HUT71120A (en) 1995-11-28
CA2133491A1 (en) 1995-04-05
FI944600A (fi) 1995-04-05
AU7432994A (en) 1995-04-13
NO943682D0 (no) 1994-10-03
CZ241994A3 (en) 1995-04-12
FR2710915A1 (fr) 1995-04-14
PL305288A1 (en) 1995-04-18
IL111148A0 (en) 1994-12-29
US5589476A (en) 1996-12-31
RU94036003A (ru) 1996-08-10
ZA947710B (en) 1995-08-10
EP0646583A1 (fr) 1995-04-05

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