KR940007020A - 피레리딘 유도체, 이것의 제법 및 이것의 치료에의 이용 - Google Patents

피레리딘 유도체, 이것의 제법 및 이것의 치료에의 이용 Download PDF

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Publication number
KR940007020A
KR940007020A KR1019930019850A KR930019850A KR940007020A KR 940007020 A KR940007020 A KR 940007020A KR 1019930019850 A KR1019930019850 A KR 1019930019850A KR 930019850 A KR930019850 A KR 930019850A KR 940007020 A KR940007020 A KR 940007020A
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South Korea
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group
compound
optionally substituted
alkyl
alkyl group
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KR1019930019850A
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제강 사미르
앙겔 이쯔샥
푸르셀 또마스
슈에마께 죠안느
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에. 뚜레 레메뜨르
신떼라보 쏘시에떼 아노님
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Publication of KR940007020A publication Critical patent/KR940007020A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

식(Ⅰ)의 해당하는 화합물 및 이것의 약제학적으로 수용할 수 있는 산 부가염.
여기서 R은 수소원자 또는 비분지되거나 분지된 (C1-C6)알킬기를 나타내고 Ar은 할로겐 원자 및 아미노, (C1-C2)알콕시 및 (C3-C6)시클로알킬(C1-C2)알콕시기로부터 선택된 하나 또는 그 이상의 라디칼로 임의로 치환된 페닐기, 또는 헤테로아릴기로 나타내며, R이 수소원자이고 Ar이 페닐기 또는 4-클로로페닐기인 화합물을 제외한다.
재료에의 이용

Description

피레리딘 유도체, 이것의 제법 및 이것의 치료에의 이용
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 식(Ⅰ)에 해당하는 화합물 및 이것의 약제학적으로 수용할 수 있는 산 부가염.
    여기에서 R은 수소원자 또는 비분지되거나 분지된 (C1-C6)알킬기를 나타내고 Ar은 할로겐 원자 및 아미노, (C1-C2)알콕시 및 (C3-C6)시클로알킬(C1-C2)알콕시기로부터 선택된 하나 또는 그 이상의 라디칼로 임의로 치환된 페닐기, 또는 헤테로아릴기로 나타내며, R이 수소원자이고 Ar이 페닐기 또는 4-클로로페닐기인 화합물을 제외한다.
  2. 제1항에 있어서, R이 수소원자 또는 비분지되거나 분지된 (C1-C6)알킬기를 나타내고 Ar이 염소원자 및 아미노, 메톡시 및 시클로프로필메톡시기로 부터 선택된 하나 또는 그 이상 라디칼로 임의로 치환된 페닐기, 또는 아미다조[1, 2-a]피리딘-2-일 또는 3-인돌릴기, 또는 1위치에 (C1-C2)알킬 및 아릴(C1-C2)알킬기로부터 선택된 라디칼이 임의로 치환되고 5위치에 수소 및 할로겐원자 및 (C1-C2)알킬기로 부터 선택된 라디칼이 임의로 치환된 3-인다졸릴기를 나타내는 것을 특징으로 하는 화합물.
  3. 제2항에 있어서, R이 수소원자 또는 비분지되거나 분지된 (C1-C6)알킬기를 나타내고 Ar이 1위치에 (C1-C2)알킬 및 아릴(C1-C2)알킬기로부터 선택된 라디칼로 임의로 치환되고 5위치에 수소 및 할로겐원자 및 (C1-C2)알킬기로 부터 선택된 라디칼로 임의로 치환된 3-인다졸릴기를 나타내는 것을 특징으로 하는 화합물.
  4. 제1항에 있어서, 식(Ⅱ)
    (Ⅱ)
    (여기서, Ar은 제1항에서 정의된 것이고 X는 할로겐 원자 또는 히드록실기로 나타낸다.)의 화합물을 식(Ⅲ)
    (Ⅲ)
    (여기에서, R은 제1항에서 정의된 것이다.)의 피페리딘 유도체와 반응시키는 것을 특징으로 하는 화합물의 제조방법.
  5. 제1항 내지 제3항중의 어느 하나의 화합물을 함유하는 것을 특징으로 하는 의약 생성물.
  6. 적당한 부형제와 조합하여 제1항 내지 제3항의 어느 하나의 화합물을 함유하는 것을 특징으로 하는 약제적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930019850A 1992-09-28 1993-09-27 피레리딘 유도체, 이것의 제법 및 이것의 치료에의 이용 KR940007020A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR92-11551 1992-09-28
FR9211551A FR2696177B1 (fr) 1992-09-28 1992-09-28 Dérivés de pipéridine, leur préparation et leur application en thérapeutique.

Publications (1)

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KR940007020A true KR940007020A (ko) 1994-04-26

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KR1019930019850A KR940007020A (ko) 1992-09-28 1993-09-27 피레리딘 유도체, 이것의 제법 및 이것의 치료에의 이용

Country Status (24)

Country Link
US (1) US5434169A (ko)
EP (1) EP0591027A1 (ko)
JP (1) JPH06211838A (ko)
KR (1) KR940007020A (ko)
CN (1) CN1087339A (ko)
AP (1) AP424A (ko)
AU (1) AU658533B2 (ko)
CA (1) CA2107061A1 (ko)
CZ (1) CZ282080B6 (ko)
DZ (1) DZ1718A1 (ko)
FI (1) FI934221A (ko)
FR (1) FR2696177B1 (ko)
HU (2) HUT65303A (ko)
IL (1) IL107133A (ko)
MA (1) MA22981A1 (ko)
MX (1) MX9305932A (ko)
NO (1) NO933435L (ko)
NZ (1) NZ248776A (ko)
OA (1) OA09840A (ko)
PL (1) PL172860B1 (ko)
SK (1) SK103193A3 (ko)
TN (1) TNSN93107A1 (ko)
TW (1) TW272190B (ko)
ZA (1) ZA937156B (ko)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
WO1997010823A1 (en) * 1995-09-18 1997-03-27 Glaxo Group Limited 5-ht3 receptor antagonists for dyskinesia
AU714477B2 (en) * 1996-04-19 2000-01-06 Regents Of The University Of California, The Treatment of mood/affective disorders by glutamatergic upmodulators
FR2765221B1 (fr) * 1997-06-25 1999-07-30 Synthelabo Derives de 4-[(1h-imidazol-4-yl)piperidin-1-yl]anilide, leur preparation et leur application en therapeutique
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
GB9918425D0 (en) * 1999-08-04 1999-10-06 Novartis Ag Organic compounds
US6887870B1 (en) * 1999-10-12 2005-05-03 Bristol-Myers Squibb Company Heterocyclic sodium/proton exchange inhibitors and method
US7183305B2 (en) 2003-11-11 2007-02-27 Allergan, Inc. Process for the synthesis of imidazoles
US7880017B2 (en) 2003-11-11 2011-02-01 Allergan, Inc. Process for the synthesis of imidazoles
WO2007014851A2 (en) * 2005-07-29 2007-02-08 F. Hoffmann-La Roche Ag Indol-3-yl-carbonyl-piperidin and piperazin derivatives
FR2925902B1 (fr) * 2008-01-02 2011-01-07 Sanofi Aventis DERIVES D'IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
CA2746943A1 (en) 2008-12-18 2010-07-15 Boehringer Ingelheim International Gmbh Serotonin 5-ht2b receptor inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61210080A (ja) * 1985-03-13 1986-09-18 Chisso Corp アルデヒドラクトンの製造法
FR2579596B1 (fr) * 1985-03-26 1987-11-20 Inst Nat Sante Rech Med (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique
US5008390A (en) * 1985-05-23 1991-04-16 Smithkline Beckman Corporation Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiazoles and corresponding thiazines
IT1230703B (it) * 1989-01-26 1991-10-29 Luso Farmaco Inst Derivati imidazolonici ad attivita' antiipertensiva, loro metodi di preparazione e composizioni farmaceutiche che li contengono.
US4925851A (en) * 1989-05-23 1990-05-15 Sandoz Pharmaceuticals Corp. 2- or 4-substituted-[2-(1H-imidazol-1-yl)ethyl]piperidines
FR2671083B1 (fr) * 1990-12-31 1994-12-23 Inst Nat Sante Rech Med Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques.

Also Published As

Publication number Publication date
AP9300575A0 (en) 1993-10-31
AP424A (en) 1995-11-04
SK103193A3 (en) 1994-08-10
HUT65303A (en) 1994-05-02
ZA937156B (en) 1994-05-23
US5434169A (en) 1995-07-18
NZ248776A (en) 1995-09-26
CA2107061A1 (en) 1994-03-29
PL300515A1 (en) 1994-04-05
JPH06211838A (ja) 1994-08-02
NO933435L (no) 1994-03-29
CZ282080B6 (cs) 1997-05-14
FI934221A0 (fi) 1993-09-27
MA22981A1 (fr) 1994-04-01
HU9302727D0 (en) 1993-12-28
DZ1718A1 (fr) 2002-02-17
IL107133A0 (en) 1993-12-28
OA09840A (fr) 1994-08-15
PL172860B1 (pl) 1997-12-31
NO933435D0 (no) 1993-09-27
HU211249A9 (en) 1995-11-28
AU658533B2 (en) 1995-04-13
FR2696177A1 (fr) 1994-04-01
CN1087339A (zh) 1994-06-01
EP0591027A1 (fr) 1994-04-06
AU4860693A (en) 1994-04-14
TW272190B (ko) 1996-03-11
TNSN93107A1 (fr) 1994-03-17
IL107133A (en) 1998-03-10
FR2696177B1 (fr) 1995-05-12
FI934221A (fi) 1994-03-29
CZ9302015A3 (en) 1994-04-13
MX9305932A (es) 1994-04-29

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