KR920021517A - 중축 신경계에 활성인 신규의 3-아미노피리다진 유도체, 그의 제조방법 및 이들의 존재하는 약제학적 조성물 - Google Patents

중축 신경계에 활성인 신규의 3-아미노피리다진 유도체, 그의 제조방법 및 이들의 존재하는 약제학적 조성물 Download PDF

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KR920021517A
KR920021517A KR1019920008304A KR920008304A KR920021517A KR 920021517 A KR920021517 A KR 920021517A KR 1019920008304 A KR1019920008304 A KR 1019920008304A KR 920008304 A KR920008304 A KR 920008304A KR 920021517 A KR920021517 A KR 920021517A
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hydrogen
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alkyl
pharmaceutically acceptable
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KR1019920008304A
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뵈르귀그논 쟝-쟈끄
캉 쟝-뽈
죠르쥐 베르무드 까밀레
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삐에르 마레스떼
엘프 사노피
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Publication of KR920021517A publication Critical patent/KR920021517A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

중축 신경계에 활성인 신규의 3-아미노피리다진 유도체, 그의 제조방법 및 이들이 존재하는 약제학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 일반식(Ⅰ)의 화합물 및 그의 유기산 또는 무기산과의 염.
    상기 식에서, Rv는 직쇄 또는 측쇄 C1-C4알킬기이고; -R6은 수소, C1∼3알콕시 또는 히드록실기이며; -Z는 하기 일반식의 기이다.
    (상기 식에서,*n1및 n2는 각각 0 또는 1이고,*Y1및 Y2는 각각 수소 또는 C1∼C3알킬기이며;*Y1또는 Y2가 수소 이외의 기라면 T는 알킬이 C1∼C3인 디알킬아미노기이거나, 다음과 같이 선택되는 헤테로사이클이다;
    a)n1=n2=1 Y1=CH3이고 Y2=H 또는 Y1=H이고 Y2=CH3및 W가 산소 또는 황 원자인 경우.
    b)n1=n2=1 Y1=Y2=H 및 p가 2 또는 3인 경우.
    c)n1=n2=0 p가 2 또는 3 및 R=C1∼C3알킬인 경우.
    d)n1=1, n2=0 Y1=H p' 및 p"가 3 또는 4인 경우.
  2. 제1항에 있어서, n1및 n2가 1이고, T가 디알킬아미노기(알킬은 C1∼C3이다)이며, Y1또는 Y2가 수소이외의 기인 화합물 또는 그의 약제학적 허용 가능염.
  3. 제1항에 있어서, n1및 n2가 1이고, Y1이 메틸이고, Y2가 수소이거나, Y1이 수소이고, Y2가 메틸이며, T가 모르폴리노기 또는 티오모르폴리노기인 화합물 또는 그의 약제학적 허용 가능염.
  4. 제1항에 있어서, Z-NH-가 N-8-아자비시클로[3,2,1]옥틸에틸아미노기를 나타내는 화합물 또는 그의 약제학적 허용 가능염.
  5. 제1항에 있어서. Z-NH-가 N-8-에틸 아자비시클로[3,2,1]옥틸-37아미노기를 나타내는 화합물 또는 그의 약제학적 허용 가능염.
  6. 제1항에 있어서, Z-NH-가 1-아자비시클로[3,3,0]옥틸-2-메틸아미노기를 나타내는 화합물 또는 그의 약제학적 허용 가능염.
  7. 하기 일반식(Ⅱ)의 아민을 하기 일반식(Ⅲ)의 3-클로로피리다진과 반응시키고,
    (상기식에서, Z, Rv및 R6은 제1항에서 정의한 바와 같다) 원한다면, 생성된 화합물을 무기산 또는 유기산과의 염으로 전환시킴을 특징으로 하는, 제1항에 따른 화합물의 제조방법.
  8. 제1항 내지 6항에 따른 일반식(Ⅰ)의 화합물을 활성 성분으로서 약제학적 조성물.
  9. 제8항에 있어서, 활성 성분을 하나 이상의 약제학적 부형제와 혼합한 사용단위 형태인 약제학적 조성물.
  10. 제9항에 있어서, 0.5∼100mg의 활성 성분을 함유하는 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920008304A 1991-05-16 1992-05-16 중축 신경계에 활성인 신규의 3-아미노피리다진 유도체, 그의 제조방법 및 이들의 존재하는 약제학적 조성물 KR920021517A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9105973A FR2676444B1 (fr) 1991-05-16 1991-05-16 Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant.
FR9105973 1991-05-16

Publications (1)

Publication Number Publication Date
KR920021517A true KR920021517A (ko) 1992-12-18

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KR1019920008304A KR920021517A (ko) 1991-05-16 1992-05-16 중축 신경계에 활성인 신규의 3-아미노피리다진 유도체, 그의 제조방법 및 이들의 존재하는 약제학적 조성물

Country Status (23)

Country Link
US (1) US5276036A (ko)
EP (1) EP0514277B1 (ko)
JP (1) JPH0673021A (ko)
KR (1) KR920021517A (ko)
AT (1) ATE115569T1 (ko)
AU (1) AU656770B2 (ko)
BR (1) BR9201854A (ko)
CA (1) CA2068770A1 (ko)
CZ (1) CZ282531B6 (ko)
DE (1) DE69200895T2 (ko)
DK (1) DK0514277T3 (ko)
ES (1) ES2065755T3 (ko)
FI (1) FI922235A (ko)
FR (1) FR2676444B1 (ko)
GR (1) GR3015389T3 (ko)
HU (2) HUT61305A (ko)
IE (1) IE66926B1 (ko)
IL (1) IL101885A (ko)
MX (1) MX9202282A (ko)
NO (1) NO180233C (ko)
NZ (1) NZ242760A (ko)
RU (1) RU2088577C1 (ko)
TW (1) TW227997B (ko)

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US5461053A (en) * 1989-02-07 1995-10-24 Sanofi Pyridazine derivatives
US5656631A (en) * 1989-02-07 1997-08-12 Sanofi Pyridazine derivatives
JP2983141B2 (ja) * 1993-10-06 1999-11-29 株式会社三和化学研究所 新規化合物及び該化合物を有効成分とする脳機能改善剤
GB9707693D0 (en) * 1997-04-16 1997-06-04 Smithkline Beecham Plc Novel method of treatment
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
JP3693957B2 (ja) * 2000-05-26 2005-09-14 ファイザー・インク 療法において有用なトロパン誘導体
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
US8265724B2 (en) * 2007-03-09 2012-09-11 Nellcor Puritan Bennett Llc Cancellation of light shunting
EP2560488B1 (en) 2010-04-23 2015-10-28 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
AR081626A1 (es) * 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
CN111499615B (zh) 2017-08-04 2024-02-02 斯基霍克疗法公司 用于调节剪接的方法和组合物
AU2019216492A1 (en) * 2018-02-02 2020-08-20 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
JP2022519311A (ja) * 2019-02-05 2022-03-22 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
CN114126613A (zh) * 2019-02-05 2022-03-01 斯基霍克疗法公司 用于调节剪接的方法和组合物
JP2022521467A (ja) 2019-02-05 2022-04-08 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
EP3920920A4 (en) * 2019-02-05 2022-09-28 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATING SPLICE
CN113677344A (zh) 2019-02-06 2021-11-19 斯基霍克疗法公司 用于调节剪接的方法和组合物
AR119731A1 (es) 2019-05-17 2022-01-05 Novartis Ag Inhibidores del inflamasoma nlrp3
US11129829B2 (en) 2019-06-17 2021-09-28 Skyhawk Therapeutics, Inc. Methods for modulating splicing
EP4289823A1 (en) * 2021-02-08 2023-12-13 Medshine Discovery Inc. Substituted pyridazine phenol derivatives

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FR2510998B1 (fr) * 1981-08-07 1986-01-10 Sanofi Sa Nouveaux derives amines de la pyridazine, leur procede de preparation et les medicaments, a action desinhibitrice, qui en comportent
FR2539741A1 (fr) * 1983-01-21 1984-07-27 Sanofi Sa Composes a noyau heterocyclique diazote, leur procede de preparation et les medicaments, actifs sur le systeme nerveux central, qui en contiennent
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
FR2665442B1 (fr) * 1990-07-31 1992-12-04 Sanofi Sa Derives d'alkyl-6 pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
PT93060B (pt) * 1989-02-07 1995-12-29 Sanofi Sa Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem
FR2642648B1 (fr) * 1989-02-07 1991-06-21 Sanofi Sa Utilisation de derives d'alkyl-5 pyridazine comme medicaments actifs sur le systeme cholinergique
FR2663326B2 (fr) * 1989-11-17 1992-10-16 Sanofi Sa Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
GB8911158D0 (en) * 1989-05-16 1989-07-05 Janssen Pharmaceutica Nv Antiviral pyridazinamines

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IE66926B1 (en) 1996-02-07
ES2065755T3 (es) 1995-02-16
CZ282531B6 (cs) 1997-08-13
DK0514277T3 (da) 1995-05-01
AU656770B2 (en) 1995-02-16
CZ147392A3 (en) 1993-03-17
RU2088577C1 (ru) 1997-08-27
FI922235A0 (fi) 1992-05-15
FI922235A (fi) 1992-11-17
DE69200895D1 (de) 1995-01-26
FR2676444A1 (fr) 1992-11-20
MX9202282A (es) 1992-12-01
JPH0673021A (ja) 1994-03-15
NZ242760A (en) 1994-12-22
DE69200895T2 (de) 1995-06-29
US5276036A (en) 1994-01-04
BR9201854A (pt) 1993-01-05
HU211920A9 (en) 1996-01-29
IL101885A0 (en) 1992-12-30
TW227997B (ko) 1994-08-11
GR3015389T3 (en) 1995-06-30
IE921557A1 (en) 1992-11-18
NO921949L (no) 1992-11-17
NO921949D0 (no) 1992-05-15
EP0514277B1 (fr) 1994-12-14
EP0514277A1 (fr) 1992-11-19
HUT61305A (en) 1992-12-28
CA2068770A1 (en) 1992-11-17
NO180233C (no) 1997-03-12
NO180233B (no) 1996-12-02
FR2676444B1 (fr) 1995-03-10
HU9201626D0 (en) 1992-08-28
AU1627492A (en) 1992-11-19
IL101885A (en) 1996-08-04
ATE115569T1 (de) 1994-12-15

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