TW227997B - - Google Patents

Info

Publication number
TW227997B
TW227997B TW081103670A TW81103670A TW227997B TW 227997 B TW227997 B TW 227997B TW 081103670 A TW081103670 A TW 081103670A TW 81103670 A TW81103670 A TW 81103670A TW 227997 B TW227997 B TW 227997B
Authority
TW
Taiwan
Prior art keywords
image
group
hydrogen
represent
alkyl
Prior art date
Application number
TW081103670A
Other languages
English (en)
Original Assignee
Sanofi Elf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Elf filed Critical Sanofi Elf
Application granted granted Critical
Publication of TW227997B publication Critical patent/TW227997B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
TW081103670A 1991-05-16 1992-05-12 TW227997B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9105973A FR2676444B1 (fr) 1991-05-16 1991-05-16 Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant.

Publications (1)

Publication Number Publication Date
TW227997B true TW227997B (zh) 1994-08-11

Family

ID=9412856

Family Applications (1)

Application Number Title Priority Date Filing Date
TW081103670A TW227997B (zh) 1991-05-16 1992-05-12

Country Status (23)

Country Link
US (1) US5276036A (zh)
EP (1) EP0514277B1 (zh)
JP (1) JPH0673021A (zh)
KR (1) KR920021517A (zh)
AT (1) ATE115569T1 (zh)
AU (1) AU656770B2 (zh)
BR (1) BR9201854A (zh)
CA (1) CA2068770A1 (zh)
CZ (1) CZ282531B6 (zh)
DE (1) DE69200895T2 (zh)
DK (1) DK0514277T3 (zh)
ES (1) ES2065755T3 (zh)
FI (1) FI922235A (zh)
FR (1) FR2676444B1 (zh)
GR (1) GR3015389T3 (zh)
HU (2) HUT61305A (zh)
IE (1) IE66926B1 (zh)
IL (1) IL101885A (zh)
MX (1) MX9202282A (zh)
NO (1) NO180233C (zh)
NZ (1) NZ242760A (zh)
RU (1) RU2088577C1 (zh)
TW (1) TW227997B (zh)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5656631A (en) * 1989-02-07 1997-08-12 Sanofi Pyridazine derivatives
US5461053A (en) * 1989-02-07 1995-10-24 Sanofi Pyridazine derivatives
JP2983141B2 (ja) * 1993-10-06 1999-11-29 株式会社三和化学研究所 新規化合物及び該化合物を有効成分とする脳機能改善剤
GB9707693D0 (en) * 1997-04-16 1997-06-04 Smithkline Beecham Plc Novel method of treatment
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
AP1965A (en) * 2000-05-26 2009-03-04 Pfizer Tropane derivatives useful in therapy.
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
US8265724B2 (en) * 2007-03-09 2012-09-11 Nellcor Puritan Bennett Llc Cancellation of light shunting
US9133123B2 (en) 2010-04-23 2015-09-15 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
SG10202002990XA (en) * 2017-08-04 2020-05-28 Skyhawk Therapeutics Inc Methods and compositions for modulating splicing
WO2019152809A1 (en) * 2018-02-02 2019-08-08 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
CN114007612A (zh) * 2019-02-05 2022-02-01 斯基霍克疗法公司 用于调节剪接的方法和组合物
CN114007613A (zh) 2019-02-05 2022-02-01 斯基霍克疗法公司 用于调节剪接的方法和组合物
JP2022523148A (ja) * 2019-02-05 2022-04-21 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
WO2020163541A1 (en) * 2019-02-05 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
EP3920928A4 (en) 2019-02-06 2022-09-28 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATION OF SPLICING
AR119731A1 (es) 2019-05-17 2022-01-05 Novartis Ag Inhibidores del inflamasoma nlrp3
US11129829B2 (en) 2019-06-17 2021-09-28 Skyhawk Therapeutics, Inc. Methods for modulating splicing
EP4289823A1 (en) * 2021-02-08 2023-12-13 Medshine Discovery Inc. Substituted pyridazine phenol derivatives

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2510998B1 (fr) * 1981-08-07 1986-01-10 Sanofi Sa Nouveaux derives amines de la pyridazine, leur procede de preparation et les medicaments, a action desinhibitrice, qui en comportent
FR2539741A1 (fr) * 1983-01-21 1984-07-27 Sanofi Sa Composes a noyau heterocyclique diazote, leur procede de preparation et les medicaments, actifs sur le systeme nerveux central, qui en contiennent
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
PT93060B (pt) * 1989-02-07 1995-12-29 Sanofi Sa Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem
FR2663326B2 (fr) * 1989-11-17 1992-10-16 Sanofi Sa Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR2665442B1 (fr) * 1990-07-31 1992-12-04 Sanofi Sa Derives d'alkyl-6 pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR2642648B1 (fr) * 1989-02-07 1991-06-21 Sanofi Sa Utilisation de derives d'alkyl-5 pyridazine comme medicaments actifs sur le systeme cholinergique
GB8911158D0 (en) * 1989-05-16 1989-07-05 Janssen Pharmaceutica Nv Antiviral pyridazinamines

Also Published As

Publication number Publication date
CZ147392A3 (en) 1993-03-17
AU656770B2 (en) 1995-02-16
HU211920A9 (en) 1996-01-29
AU1627492A (en) 1992-11-19
HU9201626D0 (en) 1992-08-28
ATE115569T1 (de) 1994-12-15
EP0514277A1 (fr) 1992-11-19
KR920021517A (ko) 1992-12-18
IL101885A (en) 1996-08-04
FI922235A (fi) 1992-11-17
FR2676444B1 (fr) 1995-03-10
IL101885A0 (en) 1992-12-30
RU2088577C1 (ru) 1997-08-27
NO180233C (no) 1997-03-12
IE921557A1 (en) 1992-11-18
IE66926B1 (en) 1996-02-07
EP0514277B1 (fr) 1994-12-14
HUT61305A (en) 1992-12-28
DK0514277T3 (da) 1995-05-01
BR9201854A (pt) 1993-01-05
DE69200895T2 (de) 1995-06-29
US5276036A (en) 1994-01-04
DE69200895D1 (de) 1995-01-26
ES2065755T3 (es) 1995-02-16
NZ242760A (en) 1994-12-22
GR3015389T3 (en) 1995-06-30
JPH0673021A (ja) 1994-03-15
FR2676444A1 (fr) 1992-11-20
NO921949L (no) 1992-11-17
CZ282531B6 (cs) 1997-08-13
CA2068770A1 (en) 1992-11-17
NO921949D0 (no) 1992-05-15
NO180233B (no) 1996-12-02
FI922235A0 (fi) 1992-05-15
MX9202282A (es) 1992-12-01

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