KR920002550A - 6-알킬피리다진 유도체, 그의 제법 및 그를 함유하는 약학 조성물 - Google Patents

6-알킬피리다진 유도체, 그의 제법 및 그를 함유하는 약학 조성물 Download PDF

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KR920002550A
KR920002550A KR1019910013248A KR910013248A KR920002550A KR 920002550 A KR920002550 A KR 920002550A KR 1019910013248 A KR1019910013248 A KR 1019910013248A KR 910013248 A KR910013248 A KR 910013248A KR 920002550 A KR920002550 A KR 920002550A
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부아쥬그랭 로베르
브로댕 로제
뽈 깡 쟝
올리에로 도미니끄
죠르쥬 베르무트 까밀
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사노피
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    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
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    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

내용 없음

Description

6-알킬피리다진 유도체, 그의 제법 및 그를 함유하는 약한 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 하기 일반식(Ⅰ)의 화합물 및 그의 무기 또는 유기산과의 염.
    중,-Ar은 식의 페닐기, 피리딜기 또는 티에닐기이고;-R1및 R2는 각각 독립적으로 수소, 할로겐 원자, 히드록실기, C1~C4알킬기, C1~C4알콕시 또는 트리플루오로메틸기이며; -R3는 직쇄 또는 분지쇄C1~C5알킬, -CH2-C6H5기 또는 -CH2-CH2-C6H5기이고 ;
    의 기
    {식중,
    ·X는 직쇄 또는 분지쇄 C1~C6알킬렌이고,
    ·R5및 R6은 각각 독립적으로 수소 또는 직쇄 또는 분지쇄 C1~C4알킬이거나, 그들이 결합된 질소원자와 함께피롤리딘, 모프폴린 또는 피레리딘에서 선택된 헤테로 고리를 형성할 수 있다.};또는 -R4는
    (식중, n은 상기 정의된 바와 같고, R7은 수소 또는 C1∼C4, 바람직하게는 C1∼C2알킬기이다,) ;
    (식중, n은 상기 정의된 바와 같다.)
    또는
    에서 선택된 기이다.]
  2. 제1항에 있어서, R4가 -X-NR5R6
    {식중, X는 -(CH2)n-(n은 1~3의 정수)의 기 또는
    (n1은 0또는 1이고, X1은 C1~C3알킬기이다)의 기를 나타내고, R5및 R6는 제1항에 정의된 바와 같다.}를 나타내는 화합물.
  3. 하기식(Ⅳ)로 표시되는, 식(Ⅰ)화합물의 제조를 위한 중간체.
    (식중, Ar 및 R3는 R1=R2=H이고 R3=CH3인 화합물(Ⅳ)를 제외하고는 제 1 항에 정의된 바와 같다.)
  4. 하기식(Ⅲ)으로 표시되는, 식(Ⅰ) 화합물의 제조를 위한 중간체.
    (식중, Ar 및 R3는, R1=R2=H이고 R3=CH3인 화합물(Ⅲ)를 제외하고는 제1항에 정의된 바와 같다.)
  5. 하기식(Ⅱ)로 표시되는, 식(Ⅰ) 화합물의 제조를 위한 중간체.
    (식중, Ar 및 R3는 제1항에 정의된 바와 같다.)
  6. 식 H2N-R4(R4는 제1항에 정의된 바와 같다)의 아민을 하기식(Ⅱ)의 3-클로로피리다진 유도체와 반응시키고, 필요하다면 수득된 화합물을 무기 또는 유기산과의 염으로 전환시키는 것을 특징으로 하는, 제 1 항에 따르는 화합물의 제조방법.
    (식중, Ar 및 R3는 제 1 항에 정의된 바와 같다.)
  7. 제1항에 따르는 식(Ⅰ)의 화합물이 활성 성분으로 존재하는 약제학적 조성물.
  8. 제7항에 있어서, 활성성분이 1종 이상의 약제학적 부형제와 혼합되어 있는 투여 단위 형태의 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910013248A 1990-07-31 1991-07-31 6-알킬피리다진 유도체, 그의 제법 및 그를 함유하는 약학 조성물 KR920002550A (ko)

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FR9009777A FR2665442B1 (fr) 1990-07-31 1990-07-31 Derives d'alkyl-6 pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR9009777 1990-07-31

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EP (1) EP0469992B1 (ko)
JP (1) JPH04234369A (ko)
KR (1) KR920002550A (ko)
AT (1) ATE111900T1 (ko)
AU (1) AU638858B2 (ko)
CA (1) CA2048162A1 (ko)
DE (1) DE69104155T2 (ko)
FI (1) FI913656A (ko)
FR (1) FR2665442B1 (ko)
HU (2) HU213392B (ko)
IE (1) IE66376B1 (ko)
IL (1) IL99013A (ko)
NO (1) NO179905C (ko)
NZ (1) NZ239181A (ko)
PT (1) PT98474B (ko)
ZA (1) ZA916030B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676444B1 (fr) * 1991-05-16 1995-03-10 Sanofi Elf Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant.
JP2983141B2 (ja) * 1993-10-06 1999-11-29 株式会社三和化学研究所 新規化合物及び該化合物を有効成分とする脳機能改善剤
JP4017214B2 (ja) * 1996-06-11 2007-12-05 興和創薬株式会社 ５−フェニル−３−ピリダジノン誘導体

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2510998B1 (fr) * 1981-08-07 1986-01-10 Sanofi Sa Nouveaux derives amines de la pyridazine, leur procede de preparation et les medicaments, a action desinhibitrice, qui en comportent
FR2539742B1 (fr) * 1983-01-24 1986-09-05 Sanofi Sa Derives amines de la pyridazine substitues en position 6 par un heterocycle ou un alicycle, lesdits derives etant actifs sur le systeme nerveux central
FR2663326B2 (fr) * 1989-11-17 1992-10-16 Sanofi Sa Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.

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HU912555D0 (en) 1992-01-28
DE69104155T2 (de) 1995-05-04
IE66376B1 (en) 1995-12-27
EP0469992B1 (fr) 1994-09-21
FI913656A0 (fi) 1991-07-31
FR2665442A1 (fr) 1992-02-07
HU211645A9 (en) 1995-12-28
PT98474B (pt) 1997-10-31
NZ239181A (en) 1993-09-27
ATE111900T1 (de) 1994-10-15
NO179905C (no) 1997-01-08
AU638858B2 (en) 1993-07-08
FR2665442B1 (fr) 1992-12-04
NO912972L (no) 1992-02-03
HUT58706A (en) 1992-03-30
IE912658A1 (en) 1992-02-12
NO912972D0 (no) 1991-07-30
IL99013A0 (en) 1992-07-15
AU8147691A (en) 1992-02-06
ZA916030B (en) 1992-04-29
DE69104155D1 (de) 1994-10-27
FI913656A (fi) 1992-02-01
IL99013A (en) 1996-01-19
PT98474A (pt) 1992-05-29
NO179905B (no) 1996-09-30
EP0469992A1 (fr) 1992-02-05
CA2048162A1 (en) 1992-02-01
JPH04234369A (ja) 1992-08-24
HU213392B (en) 1997-06-30

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