YU8301A - Postupak dobijanja n,n,6-trimetil-2-(4-metilfenil)-imidazo- (1,2-a)-piridin-3-acetamida i njegovih soli - Google Patents
Postupak dobijanja n,n,6-trimetil-2-(4-metilfenil)-imidazo- (1,2-a)-piridin-3-acetamida i njegovih soliInfo
- Publication number
- YU8301A YU8301A YU8301A YU8301A YU8301A YU 8301 A YU8301 A YU 8301A YU 8301 A YU8301 A YU 8301A YU 8301 A YU8301 A YU 8301A YU 8301 A YU8301 A YU 8301A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- formula
- imidazo
- acetamide
- methylphenyl
- trimethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Sastoji se od redukcije hidroksiestra formule (X) njegovom reakcijom u DMF i zatim sa iminijum soli formule (XIII) nastale in situ sa tionilhloridom i dimetilformamidom, i zatim redukcije sa odgovarajućim redukcionim sredstvom da bi nastao estar formule (XII), koji zatim reaguje sa dimetilaminom u polihidroksilovanom rastvaraču kao medijumu na odgovarajućoj temperaturi.[The process comprises reducing the hydroxyester of formula (X) by making it react in DMF successively with an imine salt of formula (XIII) formed "in situ" with thionyl chloride and dimethylformamide, and subsequent reduction with an appropriate reducer in order to form the ester of formula (XII) which is then reacted with dimethylamine in a polyhydroxylated solvent medium in appropriate temperature conditions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009801694A ES2151834B1 (es) | 1998-08-06 | 1998-08-06 | Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU8301A true YU8301A (sh) | 2003-10-31 |
| RS50103B RS50103B (sr) | 2009-01-22 |
Family
ID=8304817
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6407240B1 (sh) |
| EP (1) | EP1104765B2 (sh) |
| JP (1) | JP3544944B2 (sh) |
| KR (1) | KR100492054B1 (sh) |
| AT (1) | ATE234836T1 (sh) |
| AU (1) | AU750302B2 (sh) |
| CA (1) | CA2339594C (sh) |
| CZ (1) | CZ292446B6 (sh) |
| DE (1) | DE69906088T3 (sh) |
| DK (1) | DK1104765T4 (sh) |
| ES (2) | ES2151834B1 (sh) |
| HK (1) | HK1037624A1 (sh) |
| HR (1) | HRP20010158B1 (sh) |
| HU (1) | HUP0102936A3 (sh) |
| IL (1) | IL141133A (sh) |
| IS (1) | IS5839A (sh) |
| NO (1) | NO319780B1 (sh) |
| NZ (1) | NZ510310A (sh) |
| PL (1) | PL195888B1 (sh) |
| PT (1) | PT1104765E (sh) |
| RS (1) | RS50103B (sh) |
| RU (1) | RU2221797C2 (sh) |
| SI (1) | SI1104765T2 (sh) |
| SK (1) | SK283652B6 (sh) |
| WO (1) | WO2000008021A2 (sh) |
| ZA (1) | ZA200101294B (sh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2151834B1 (es) † | 1998-08-06 | 2001-08-16 | Sint Quimica Sa | Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales. |
| CN1227252C (zh) * | 1999-11-22 | 2005-11-16 | 埃吉斯药物工厂 | 制备6－甲基－2－(4－甲基－苯基)－咪唑并[1,2－a]吡啶－3－(N,N－二甲基－乙酰胺)和中间体的方法 |
| IT1318624B1 (it) * | 2000-07-14 | 2003-08-27 | Dinamite Dipharma S P A In For | Processo per la preparazione di 2-fenil-imidazo (1,2-a)piridin-3-acetammidi. |
| US6596731B2 (en) | 2001-03-27 | 2003-07-22 | Hoffmann-La Roche Inc. | Substituted imidazo[1,2-A] pyridine derivatives |
| CN100408577C (zh) * | 2002-07-15 | 2008-08-06 | 台湾神隆股份有限公司 | 咪唑并(1,2-a)吡啶-3-乙酰胺类的制备方法 |
| CA2509561A1 (en) | 2002-12-18 | 2004-07-15 | Mallinckrodt Inc. | Synthesis of heteroaryl acetamides |
| CA2571491A1 (en) * | 2004-06-22 | 2006-01-19 | Mallinckrodt, Inc. | Synthesis of heteroaryl acetamides from reaction mixtures having reduced water content |
| US20080293946A1 (en) * | 2005-10-03 | 2008-11-27 | Cheng Brian K | Process for Preparing Zolpidem Hemitartrate and Tartrate Polymorphs |
| EP1803722A1 (en) * | 2006-01-03 | 2007-07-04 | Ferrer Internacional, S.A. | Imidazo[1,2-a]pyridin-3-yl-acetic acid hydrazides, processes for their preparation and pharmaceutical uses thereof |
| US20080145425A1 (en) * | 2006-12-15 | 2008-06-19 | Pliva Research & Development Limited | Pharmaceutical composition of zolpidem |
| CN103360387B (zh) * | 2012-03-28 | 2016-12-14 | 江苏豪森药业集团有限公司 | 一种制备化合物唑吡坦的方法 |
| CN104610253B (zh) * | 2015-01-26 | 2016-11-16 | 郑州大学 | 2‑三氟甲基‑2‑羟基‑2‑(2‑芳基吡啶并[1,2‑α]咪唑)乙酸酯类化合物 |
| CN114105974A (zh) * | 2020-08-27 | 2022-03-01 | 鲁南制药集团股份有限公司 | 一种唑吡坦的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2600650B1 (fr) * | 1986-06-27 | 1988-09-09 | Synthelabo | Procede de preparation d'imidazopyridines et composes intermediaires |
| ES2151834B1 (es) † | 1998-08-06 | 2001-08-16 | Sint Quimica Sa | Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales. |
-
1998
- 1998-08-06 ES ES009801694A patent/ES2151834B1/es not_active Expired - Fee Related
-
1999
- 1999-08-04 HU HU0102936A patent/HUP0102936A3/hu unknown
- 1999-08-04 SK SK159-2001A patent/SK283652B6/sk not_active IP Right Cessation
- 1999-08-04 IL IL14113399A patent/IL141133A/xx not_active IP Right Cessation
- 1999-08-04 AU AU52912/99A patent/AU750302B2/en not_active Ceased
- 1999-08-04 DE DE69906088T patent/DE69906088T3/de not_active Expired - Lifetime
- 1999-08-04 PT PT99938403T patent/PT1104765E/pt unknown
- 1999-08-04 SI SI9930286T patent/SI1104765T2/sl unknown
- 1999-08-04 CZ CZ2001360A patent/CZ292446B6/cs not_active IP Right Cessation
- 1999-08-04 AT AT99938403T patent/ATE234836T1/de not_active IP Right Cessation
- 1999-08-04 US US09/762,205 patent/US6407240B1/en not_active Expired - Fee Related
- 1999-08-04 EP EP99938403A patent/EP1104765B2/en not_active Expired - Lifetime
- 1999-08-04 NZ NZ510310A patent/NZ510310A/xx unknown
- 1999-08-04 DK DK99938403T patent/DK1104765T4/da active
- 1999-08-04 JP JP2000563654A patent/JP3544944B2/ja not_active Expired - Fee Related
- 1999-08-04 KR KR10-2001-7001385A patent/KR100492054B1/ko not_active IP Right Cessation
- 1999-08-04 WO PCT/ES1999/000250 patent/WO2000008021A2/es active IP Right Grant
- 1999-08-04 RU RU2001106627/04A patent/RU2221797C2/ru not_active IP Right Cessation
- 1999-08-04 PL PL99346158A patent/PL195888B1/pl not_active IP Right Cessation
- 1999-08-04 RS YUP-83/01A patent/RS50103B/sr unknown
- 1999-08-04 ES ES99938403T patent/ES2195598T5/es not_active Expired - Lifetime
- 1999-08-04 CA CA002339594A patent/CA2339594C/en not_active Expired - Fee Related
-
2001
- 2001-02-05 NO NO20010613A patent/NO319780B1/no not_active IP Right Cessation
- 2001-02-05 IS IS5839A patent/IS5839A/is unknown
- 2001-02-15 ZA ZA200101294A patent/ZA200101294B/en unknown
- 2001-03-06 HR HR20010158A patent/HRP20010158B1/xx not_active IP Right Cessation
- 2001-11-30 HK HK01108425A patent/HK1037624A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| YU8301A (sh) | Postupak dobijanja n,n,6-trimetil-2-(4-metilfenil)-imidazo- (1,2-a)-piridin-3-acetamida i njegovih soli | |
| TW324028B (en) | A cleaner composition used in the process of producing semiconductor device | |
| DK119684A (da) | Quinoloncarboxylsyrer og disses anvendelse som baktericider | |
| JPS5551041A (en) | Phenyl-fatty acid derivative | |
| CA2091005A1 (en) | Microbiological process for hydroxylation of nitrogen-heterocyclic-carboxylic acids | |
| DE69119714D1 (de) | Verfahren zur Herstellung von Benzylphthalazinonderivaten und von deren Salzen | |
| SG81900A1 (en) | A method for making a, b-unsaturated-b-trifluoromethyl-carboxylates and related compounds | |
| WO2001042182A3 (de) | Verfahren zur herstellung von o-chlormethylbenzoesäurechloriden | |
| ATE251616T1 (de) | Verfahren zur herstellung von 5- hydroxymethylthiazole | |
| JPS5492925A (en) | Amine bearing vinylsilyl group and its salt | |
| JPS5785386A (en) | Novel quinolinic acid imide a compound | |
| TH3125A (th) | สารอนุพันธ์ของควิโนลีนคาร์บอกซิลิคแอซิด และกรรมวิธีในการเตรียมสารนั้น | |
| JP2000063336A5 (sh) | ||
| ZA200100566B (en) | Novel 6-deoxy erythromycin derivatives, method for preparing same and use as medicines. | |
| JPS56108777A (en) | Novel guanidinothiazole derivative and its preparation | |
| KR900004758A (ko) | 안트라 시클린 유도체 및 그의 제조 방법 | |
| JPS57159770A (en) | 1(2h)-isoquinolone derivative and its acid addition salt | |
| EA200200706A1 (ru) | Триазатринафтирины и способ их получения, их соль, комплекс металла, способ и композиция для экстрагирования переходного металла |