ES2151834A1 - Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales. - Google Patents

Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales.

Info

Publication number
ES2151834A1
ES2151834A1 ES009801694A ES9801694A ES2151834A1 ES 2151834 A1 ES2151834 A1 ES 2151834A1 ES 009801694 A ES009801694 A ES 009801694A ES 9801694 A ES9801694 A ES 9801694A ES 2151834 A1 ES2151834 A1 ES 2151834A1
Authority
ES
Spain
Prior art keywords
imidazo
acetamide
methylphenyl
trimethyl
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009801694A
Other languages
English (en)
Other versions
ES2151834B1 (es
Inventor
Rafael Labriola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quimica Sintetica SA
Original Assignee
Quimica Sintetica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8304817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2151834(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Quimica Sintetica SA filed Critical Quimica Sintetica SA
Priority to ES009801694A priority Critical patent/ES2151834B1/es
Priority to PCT/ES1999/000250 priority patent/WO2000008021A2/es
Priority to YUP-83/01A priority patent/RS50103B/sr
Priority to JP2000563654A priority patent/JP3544944B2/ja
Priority to US09/762,205 priority patent/US6407240B1/en
Priority to DE69906088T priority patent/DE69906088T3/de
Priority to CA002339594A priority patent/CA2339594C/en
Priority to IL14113399A priority patent/IL141133A/xx
Priority to PT99938403T priority patent/PT1104765E/pt
Priority to RU2001106627/04A priority patent/RU2221797C2/ru
Priority to AT99938403T priority patent/ATE234836T1/de
Priority to AU52912/99A priority patent/AU750302B2/en
Priority to PL99346158A priority patent/PL195888B1/pl
Priority to EP99938403A priority patent/EP1104765B2/en
Priority to HU0102936A priority patent/HUP0102936A3/hu
Priority to SI9930286T priority patent/SI1104765T2/sl
Priority to NZ510310A priority patent/NZ510310A/xx
Priority to SK159-2001A priority patent/SK283652B6/sk
Priority to CZ2001360A priority patent/CZ292446B6/cs
Priority to KR10-2001-7001385A priority patent/KR100492054B1/ko
Priority to ES99938403T priority patent/ES2195598T5/es
Priority to DK99938403T priority patent/DK1104765T4/da
Publication of ES2151834A1 publication Critical patent/ES2151834A1/es
Priority to NO20010613A priority patent/NO319780B1/no
Priority to IS5839A priority patent/IS5839A/is
Priority to ZA200101294A priority patent/ZA200101294B/en
Priority to HR20010158A priority patent/HRP20010158B1/xx
Publication of ES2151834B1 publication Critical patent/ES2151834B1/es
Application granted granted Critical
Priority to HK01108425A priority patent/HK1037624A1/xx
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)- imidazo-[1,2-a]-piridina-3-acetamida y sus sales. Comprende reducir el hidroxiéster de fórmula (X) haciéndolo reaccionar en DMF sucesivamente con una sal de iminio de fórmula (XIII) formada "in situ" con cloruro de tionilo y dimetilformamida, y reducción subsiguiente con un reductor apropiado para formar el éster de fórmula (XII), que después se hace reaccionar con dimetilamina en un medio solvente polihidroxilado y a una temperatura adecuada.
ES009801694A 1998-08-06 1998-08-06 Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales. Expired - Fee Related ES2151834B1 (es)

Priority Applications (27)

Application Number Priority Date Filing Date Title
ES009801694A ES2151834B1 (es) 1998-08-06 1998-08-06 Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales.
HU0102936A HUP0102936A3 (en) 1998-08-06 1999-08-04 New process for preparing n,n,6- trimethyl-2 -(4-methylphenyl)- imidazo-[1,2-a] -pyridine-3-acetamide and salts thereof
SK159-2001A SK283652B6 (sk) 1998-08-06 1999-08-04 Spôsob prípravy N,N,6-trimetyl-2-(4-metylfenyl)imidazo-[1,2- a]pyridín-3-acetamidu a jeho solí
SI9930286T SI1104765T2 (sl) 1998-08-06 1999-08-04 Postopek za pripravo n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridin-3-acetamida in njegovih soli
US09/762,205 US6407240B1 (en) 1998-08-06 1999-08-04 Process for preparing N,N,6- trimethyl-2-(4-methylphenyl)-imidazo- [1,2-a]-pyridine- 3-acetamide and salts thereof
DE69906088T DE69906088T3 (de) 1998-08-06 1999-08-04 Verfahren zur herstellung von n,n,6-trimethyl-2-(4-methylphenyl)-imidazo-[1,2-a]-pridin-3-acetamid und salzen davon
CA002339594A CA2339594C (en) 1998-08-06 1999-08-04 Process for preparing n,n,6- trimethyl-2 -(4-methylphenyl)- imidazo-[1,2-a] -pyridine-3- acetamide and salts thereof
IL14113399A IL141133A (en) 1998-08-06 1999-08-04 Process for preparing N,N,6-trimethyl-2-(4-methylphenyl)-imidazo-Ä1,2-AÜ- pyridine-3-acetamide and salts thereof
PT99938403T PT1104765E (pt) 1998-08-06 1999-08-04 Processo para a preparacao da n,n,6-trimetil-2-(4-metilfenil)-imidazo-¬1,2-a|-piridina-3-acetamida e dos respectivos sais
RU2001106627/04A RU2221797C2 (ru) 1998-08-06 1999-08-04 Способ получения n,n,6-триметил-2-(4-метилфенил)-имидазо-[1,2-а]-пиридин-3-ацетамида и его солей
AT99938403T ATE234836T1 (de) 1998-08-06 1999-08-04 Verfahren zur herstellung von n,n,6-trimethyl-2- (4-methylphenyl)-imidazo-(1,2-a)-pridin-3- acetamid und salzen davon
AU52912/99A AU750302B2 (en) 1998-08-06 1999-08-04 Process for preparing N,N,6- trimethyl-2 -(4-methylphenyl)- imidazo-(1,2-A) -pyridine-3- acetamide and salts thereof
YUP-83/01A RS50103B (sr) 1998-08-06 1999-08-04 Postupak dobijanja n,n,6-trimetil-2-(4-metilfenil)-imidazo- (1,2-a)-piridin-3-acetamida i njegovih soli
EP99938403A EP1104765B2 (en) 1998-08-06 1999-08-04 Process for preparing n,n,6- trimethyl-2 -(4-methylphenyl)- imidazo-[1,2-a] -pyridine-3- acetamide and salts thereof
PCT/ES1999/000250 WO2000008021A2 (es) 1998-08-06 1999-08-04 Procedimiento para preparar n,n,6- trimetil-2- (4-metilfenil)- imidazo-[1,2-a] -piridina-3- acetamida y sus sales
JP2000563654A JP3544944B2 (ja) 1998-08-06 1999-08-04 Ｎ，Ｎ，６−トリメチル−２−（４−メチルフェニル）−イミダゾ−［１，２−ａ］−ピリジン−３−アセトアミドおよびその塩の製造方法
NZ510310A NZ510310A (en) 1998-08-06 1999-08-04 Process for preparing N,N,6- trimethyl-2-(4-methylphenyl)-imidazo[1,2-a]-pyridine-3-acetamide and its salts
PL99346158A PL195888B1 (pl) 1998-08-06 1999-08-04 Sposób wytwarzania N,N-6-trimetylo-2-(4-metylofenylo)-imidazo-[1,2-a]-pirydyno-3-acetamidu i jego soli
CZ2001360A CZ292446B6 (cs) 1998-08-06 1999-08-04 Způsob přípravy N,N,6-trimethyl-2-(4-methylfenyl)imidazo[1,2-a]pyridin-3-acetamidu a jeho solí
KR10-2001-7001385A KR100492054B1 (ko) 1998-08-06 1999-08-04 Ｎ,Ｎ,6-트리메틸-2-(4-메틸페닐)-이미다조-[1,2-ａ]-피리딘-3-아세트아미드 및 이의 염의 제조방법
ES99938403T ES2195598T5 (es) 1998-08-06 1999-08-04 Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo(1,2-a)piridina-3-acetamida y sus sales.
DK99938403T DK1104765T4 (da) 1998-08-06 1999-08-04 Fremgangsmåde til fremstilling af N,N,6-trimethyl-2-(4-methylphenyl)-imidazo-[1,2-a]-pyridin-3-acetamid og salte deraf
IS5839A IS5839A (is) 1998-08-06 2001-02-05 Aðferð við að framleiða N,N 6-trímetýl-2-(4-metýlfenýl)-imídasó-[1,2-A]-pýridín-3-asetamíð og sölt þess
NO20010613A NO319780B1 (no) 1998-08-06 2001-02-05 Fremgangsmate til fremstilling av N,N,6-trimetyl-2-(4-metylfenyl)-imidazo-[1,2-A]-pyridin-3-acetamid og salter derav
ZA200101294A ZA200101294B (en) 1998-08-06 2001-02-15 Process for preparing N,N,6- trimethyl-2-(4-methylphenyl)-imidazo-[1,2-A]-pyridine-3-acetamide and salts thereof.
HR20010158A HRP20010158B1 (en) 1998-08-06 2001-03-06 PROCESS FOR PREPARING N,N,6- TRIMETHYL-2-(4-METHYLPHENYL)-IMIDAZO-[1,2-a]-PYRIDINE-3-ACETAMIDE AND SALTS THEREOF
HK01108425A HK1037624A1 (en) 1998-08-06 2001-11-30 Process for preparing n,n,6-trimethyl-2-(4-methylphenyl)-imidazo-[1,2-a]-pyridine-3-acetamide and salts thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009801694A ES2151834B1 (es) 1998-08-06 1998-08-06 Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales.

Publications (2)

Publication Number Publication Date
ES2151834A1 true ES2151834A1 (es) 2001-01-01
ES2151834B1 ES2151834B1 (es) 2001-08-16

Family

ID=8304817

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009801694A Expired - Fee Related ES2151834B1 (es) 1998-08-06 1998-08-06 Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales.
ES99938403T Expired - Lifetime ES2195598T5 (es) 1998-08-06 1999-08-04 Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo(1,2-a)piridina-3-acetamida y sus sales.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES99938403T Expired - Lifetime ES2195598T5 (es) 1998-08-06 1999-08-04 Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo(1,2-a)piridina-3-acetamida y sus sales.

Country Status (26)

Country Link
US (1) US6407240B1 (es)
EP (1) EP1104765B2 (es)
JP (1) JP3544944B2 (es)
KR (1) KR100492054B1 (es)
AT (1) ATE234836T1 (es)
AU (1) AU750302B2 (es)
CA (1) CA2339594C (es)
CZ (1) CZ292446B6 (es)
DE (1) DE69906088T3 (es)
DK (1) DK1104765T4 (es)
ES (2) ES2151834B1 (es)
HK (1) HK1037624A1 (es)
HR (1) HRP20010158B1 (es)
HU (1) HUP0102936A3 (es)
IL (1) IL141133A (es)
IS (1) IS5839A (es)
NO (1) NO319780B1 (es)
NZ (1) NZ510310A (es)
PL (1) PL195888B1 (es)
PT (1) PT1104765E (es)
RS (1) RS50103B (es)
RU (1) RU2221797C2 (es)
SI (1) SI1104765T2 (es)
SK (1) SK283652B6 (es)
WO (1) WO2000008021A2 (es)
ZA (1) ZA200101294B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2151834B1 (es) † 1998-08-06 2001-08-16 Sint Quimica Sa Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales.
CN1227252C (zh) * 1999-11-22 2005-11-16 埃吉斯药物工厂 制备6－甲基－2－(4－甲基－苯基)－咪唑并[1,2－a]吡啶－3－(N,N－二甲基－乙酰胺)和中间体的方法
IT1318624B1 (it) * 2000-07-14 2003-08-27 Dinamite Dipharma S P A In For Processo per la preparazione di 2-fenil-imidazo (1,2-a)piridin-3-acetammidi.
US6596731B2 (en) 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
CN100408577C (zh) * 2002-07-15 2008-08-06 台湾神隆股份有限公司 咪唑并(1,2-a)吡啶-3-乙酰胺类的制备方法
CA2509561A1 (en) 2002-12-18 2004-07-15 Mallinckrodt Inc. Synthesis of heteroaryl acetamides
CA2571491A1 (en) * 2004-06-22 2006-01-19 Mallinckrodt, Inc. Synthesis of heteroaryl acetamides from reaction mixtures having reduced water content
US20080293946A1 (en) * 2005-10-03 2008-11-27 Cheng Brian K Process for Preparing Zolpidem Hemitartrate and Tartrate Polymorphs
EP1803722A1 (en) * 2006-01-03 2007-07-04 Ferrer Internacional, S.A. Imidazo[1,2-a]pyridin-3-yl-acetic acid hydrazides, processes for their preparation and pharmaceutical uses thereof
US20080145425A1 (en) * 2006-12-15 2008-06-19 Pliva Research & Development Limited Pharmaceutical composition of zolpidem
CN103360387B (zh) * 2012-03-28 2016-12-14 江苏豪森药业集团有限公司 一种制备化合物唑吡坦的方法
CN104610253B (zh) * 2015-01-26 2016-11-16 郑州大学 2‑三氟甲基‑2‑羟基‑2‑(2‑芳基吡啶并[1,2‑α]咪唑)乙酸酯类化合物
CN114105974A (zh) * 2020-08-27 2022-03-01 鲁南制药集团股份有限公司 一种唑吡坦的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2600650A1 (fr) * 1986-06-27 1987-12-31 Synthelabo Procede de preparation d'imidazopyridines et composes intermediaires

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2151834B1 (es) † 1998-08-06 2001-08-16 Sint Quimica Sa Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2600650A1 (fr) * 1986-06-27 1987-12-31 Synthelabo Procede de preparation d'imidazopyridines et composes intermediaires

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GEORGE P. et al. Imidazopyridines, towards novel hypnotic and anxiolytic drugs, Il Farmaco, 46 (1, suppl.) 277-288 (1991). *
GEORGE P. et al. Le zolpidem: un nouvel hypnotique de structure imidazo[1,2-a]pyridine. Actual Chim. Ther. (1991), 18 (Recontres Int. Chim. Ther. 26th, 1990), 215-39. *
TRAPANI G. et al. Synthesis and binding affinity of 2-phenylimidazo[1,2-a]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new series of high-affinity and selective ligands for the peripheral type, J. Med. Chem., 40, 3109-3118, (1997). *

Also Published As

Publication number Publication date
HUP0102936A3 (en) 2002-09-30
HUP0102936A2 (hu) 2002-01-28
US6407240B1 (en) 2002-06-18
NO319780B1 (no) 2005-09-12
ATE234836T1 (de) 2003-04-15
IS5839A (is) 2001-02-05
YU8301A (sh) 2003-10-31
KR100492054B1 (ko) 2005-05-31
WO2000008021A2 (es) 2000-02-17
KR20010072173A (ko) 2001-07-31
SI1104765T1 (en) 2003-08-31
JP2002522437A (ja) 2002-07-23
EP1104765B2 (en) 2007-11-14
NO20010613D0 (no) 2001-02-05
AU5291299A (en) 2000-02-28
CA2339594A1 (en) 2000-02-17
PT1104765E (pt) 2003-08-29
CZ292446B6 (cs) 2003-09-17
JP3544944B2 (ja) 2004-07-21
NZ510310A (en) 2002-11-26
ZA200101294B (en) 2002-02-15
RS50103B (sr) 2009-01-22
AU750302B2 (en) 2002-07-18
EP1104765B1 (en) 2003-03-19
SI1104765T2 (sl) 2008-04-30
SK283652B6 (sk) 2003-11-04
DE69906088T2 (de) 2003-12-24
CA2339594C (en) 2005-05-03
DK1104765T3 (da) 2003-06-30
CZ2001360A3 (cs) 2001-12-12
ES2195598T5 (es) 2008-05-01
IL141133A0 (en) 2002-02-10
NO20010613L (no) 2001-02-05
HRP20010158B1 (en) 2003-12-31
DE69906088T3 (de) 2008-04-30
ES2151834B1 (es) 2001-08-16
HK1037624A1 (en) 2002-02-15
IL141133A (en) 2005-11-20
WO2000008021A3 (es) 2000-07-06
HRP20010158A2 (en) 2002-02-28
DK1104765T4 (da) 2008-03-03
DE69906088D1 (de) 2003-04-24
ES2195598T3 (es) 2003-12-01
EP1104765A2 (en) 2001-06-06
PL346158A1 (en) 2002-01-28
SK1592001A3 (en) 2001-12-03
RU2221797C2 (ru) 2004-01-20
PL195888B1 (pl) 2007-11-30

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