CN1849135B - 治疗白介素-6相关疾病的方法 - Google Patents
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- CN1849135B CN1849135B CN2004800114011A CN200480011401A CN1849135B CN 1849135 B CN1849135 B CN 1849135B CN 2004800114011 A CN2004800114011 A CN 2004800114011A CN 200480011401 A CN200480011401 A CN 200480011401A CN 1849135 B CN1849135 B CN 1849135B
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Classifications
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- Health & Medical Sciences (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
2mg/kg MRA | 4mg/kg MRA | 8mg/kg MRA | MTX | |
ACR 20 | 30.8% | 61.1% | 62.7% | 40.8% |
ACR 50 | 5.8% | 27.8% | 41.2% | 28.6% |
ACR 70 | 1.9% | 5.6% | 15.7% | 16.3% |
2mg/kg MRA+MTX | 4mg/kg MRA+MTX | 8mg/kg MRA+MTX | ||
ACR 20 | 64.0% | 63.3% | 73.5% | |
ACR 50 | 32.0% | 36.7% | 53.1% | |
ACR 70 | 14.0% | 12.2% | 36.7% |
2mg/kgMRA | 4mg/kgMRA | 8mg/kgMRA | MTX | |
基线:N平均值±SD | 5211.6±4.6 | 5411.1±4.4 | 5112.2±5.2 | 4912.7±4.2 |
与基线相比的变化:第16周N平均值±SD | 42-4.5±5.7 | 43-5.8±4.1 | 43-8.4±4.6 | 39-5.7±6.1 |
2mg/kgMRA+MTX | 4mg/kgMRA+MTX | 8mg/kgMRA+MTX | ||
基线:N平均值±SD | 5011.9±4.3 | 4911.9±3.9 | 4911.8±3.9 | |
与基线相比的变化:第16周N平均值±SD | 46-6.2±4.6 | 42-6.8±5.4 | 44-9.4±4.0 |
Claims (18)
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CN202010040597.8A CN111068062B (zh) | 2003-04-28 | 2004-04-28 | 治疗白介素-6相关疾病的方法 |
CN201511004468.9A CN105617387B (zh) | 2003-04-28 | 2004-04-28 | 治疗白介素-6相关疾病的方法 |
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GB0309619A GB2401040A (en) | 2003-04-28 | 2003-04-28 | Method for treating interleukin-6 related diseases |
GB0309619.5 | 2003-04-28 | ||
PCT/JP2004/006211 WO2004096273A1 (en) | 2003-04-28 | 2004-04-28 | Methods for treating interleukin-6 related diseases |
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CN2011100777473A Division CN102172403A (zh) | 2003-04-28 | 2004-04-28 | 治疗白介素-6相关疾病的方法 |
CN202010040597.8A Division CN111068062B (zh) | 2003-04-28 | 2004-04-28 | 治疗白介素-6相关疾病的方法 |
CN201511004468.9A Division CN105617387B (zh) | 2003-04-28 | 2004-04-28 | 治疗白介素-6相关疾病的方法 |
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CN1849135A CN1849135A (zh) | 2006-10-18 |
CN1849135B true CN1849135B (zh) | 2011-06-15 |
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CN2004800114011A Expired - Lifetime CN1849135B (zh) | 2003-04-28 | 2004-04-28 | 治疗白介素-6相关疾病的方法 |
CN202010040597.8A Ceased CN111068062B (zh) | 2003-04-28 | 2004-04-28 | 治疗白介素-6相关疾病的方法 |
CN2011100777473A Pending CN102172403A (zh) | 2003-04-28 | 2004-04-28 | 治疗白介素-6相关疾病的方法 |
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CN2011100777473A Pending CN102172403A (zh) | 2003-04-28 | 2004-04-28 | 治疗白介素-6相关疾病的方法 |
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US (7) | US7521052B2 (zh) |
EP (5) | EP1617869A1 (zh) |
JP (9) | JP4869063B2 (zh) |
KR (4) | KR101385822B1 (zh) |
CN (4) | CN105617387B (zh) |
AR (1) | AR044104A1 (zh) |
AU (1) | AU2004233700B2 (zh) |
BR (1) | BRPI0409910A (zh) |
CA (2) | CA2865872A1 (zh) |
CL (2) | CL2004000896A1 (zh) |
CO (1) | CO5700791A2 (zh) |
GB (1) | GB2401040A (zh) |
HK (2) | HK1096859A1 (zh) |
IL (1) | IL171285A (zh) |
MX (1) | MXPA05011266A (zh) |
MY (1) | MY146986A (zh) |
NO (1) | NO336061B1 (zh) |
NZ (2) | NZ543073A (zh) |
RU (2) | RU2367471C2 (zh) |
TW (1) | TWI400086B (zh) |
UA (1) | UA86587C2 (zh) |
WO (1) | WO2004096273A1 (zh) |
ZA (1) | ZA200508427B (zh) |
Families Citing this family (115)
Publication number | Priority date | Publication date | Assignee | Title |
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US8017121B2 (en) | 1994-06-30 | 2011-09-13 | Chugai Seiyaku Kabushika Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
EP0791359A4 (en) * | 1994-10-21 | 2002-09-11 | Chugai Pharmaceutical Co Ltd | MEDICINE AGAINST IL-6 PRODUCTION IN DISEASES |
DE69839992D1 (de) | 1997-03-21 | 2008-10-23 | Chugai Pharmaceutical Co Ltd | Vorbeugende- oder Heilmittel zur Behandlung von Multipler Sklerose, mit antagonistischen anti-IL6-Rezeptor Antikörpern als Wirkstoff |
PL201461B1 (pl) | 1998-03-17 | 2009-04-30 | Chugai Pharmaceutical Co Ltd | Czynnik zapobiegający lub terapeutyczny do leczenia zapalenia jelita, zawierający antagonistę IL-6 jako składnik aktywny |
UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
EP3192528A1 (en) | 2002-02-14 | 2017-07-19 | Chugai Seiyaku Kabushiki Kaisha | Formulation of anti-il6r antibody-containing solutions comprising a sugar as a stabilizer |
GB2401040A (en) * | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
NZ546557A (en) | 2003-10-17 | 2010-01-29 | Chugai Pharmaceutical Co Ltd | Therapeutic agent for mesothelioma comprising interleukin-6 |
AR048210A1 (es) * | 2003-12-19 | 2006-04-12 | Chugai Pharmaceutical Co Ltd | Un agente preventivo para la vasculitis. |
US8617550B2 (en) | 2003-12-19 | 2013-12-31 | Chugai Seiyaku Kabushiki Kaisha | Treatment of vasculitis with IL-6 antagonist |
US8398980B2 (en) | 2004-03-24 | 2013-03-19 | Chugai Seiyaku Kabushiki Kaisha | Subtypes of humanized antibody against interleuken-6 receptor |
JP4911894B2 (ja) * | 2004-12-01 | 2012-04-04 | アサマ化成株式会社 | 関節リウマチを予防するための経口投与用組成物 |
JP5620626B2 (ja) | 2005-03-31 | 2014-11-05 | 中外製薬株式会社 | 会合制御によるポリペプチド製造方法 |
PE20061324A1 (es) | 2005-04-29 | 2007-01-15 | Centocor Inc | Anticuerpos anti-il-6, composiciones, metodos y usos |
AU2006300234B2 (en) * | 2005-10-14 | 2013-01-10 | Chugai Seiyaku Kabushiki Kaisha | Agents for suppressing damage to transplanted islets after islet transplantation |
KR101239051B1 (ko) * | 2005-10-21 | 2013-03-04 | 추가이 세이야쿠 가부시키가이샤 | 심장질환 치료제 |
AR057582A1 (es) | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | Agentes para suprimir la induccion de linfocitos t citotoxicos |
TW200803894A (en) * | 2005-11-25 | 2008-01-16 | Univ Keio | Prostate cancer therapeutic agents |
CN104189907A (zh) * | 2006-01-27 | 2014-12-10 | 学校法人庆应义塾 | 伴有脉络膜血管生成的疾病的治疗药 |
EP4001409A1 (en) | 2006-03-31 | 2022-05-25 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
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Commission number: 4W113883 Conclusion of examination: On the basis of claims 1-9 submitted by the patentee on April 6, 2022, the validity of invention patent right No. 200480011401.1 is maintained. The modification was made by deleting claims 1-9 from the authorization announcement text, and changing the "drug complex", "use of claim 30", and "use of claim 31" in claims 10, 12, and 13 to "drug combination", "use of claim 2", and "use of claim 3", respectively. At the same time, the numbering and citation relationships of each claim were adjusted accordingly Decision date of declaring invalidation: 20230322 Decision number of declaring invalidation: 560071 Denomination of invention: Methods for treating interleukin-6 related diseases Granted publication date: 20110615 Patentee: Chugai Pharmaceutical Co.,Ltd. |
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