CN1521180A - 介导除虫菌素b2：b1比例的除虫链霉菌基因 - Google Patents

介导除虫菌素b2：b1比例的除虫链霉菌基因 Download PDF

Info

Publication number
CN1521180A
CN1521180A CNA2004100054154A CN200410005415A CN1521180A CN 1521180 A CN1521180 A CN 1521180A CN A2004100054154 A CNA2004100054154 A CN A2004100054154A CN 200410005415 A CN200410005415 A CN 200410005415A CN 1521180 A CN1521180 A CN 1521180A
Authority
CN
China
Prior art keywords
avec
avermectin
cell
nucleotide sequence
deinsectization streptomycete
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004100054154A
Other languages
English (en)
Chinese (zh)
Inventor
��J��ʩͼ����-�����ֶ�
金·J·施图茨曼-恩格沃尔
加藤芳弘
��A��I����˰�ɪ
哈米什·A·I·麦克阿瑟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of CN1521180A publication Critical patent/CN1521180A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CNA2004100054154A 1998-02-13 1999-01-25 介导除虫菌素b2：b1比例的除虫链霉菌基因 Pending CN1521180A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7463698P 1998-02-13 1998-02-13
US60/074,636 1998-02-13

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN99805027A Division CN1297485A (zh) 1998-02-13 1999-01-25 介导除虫菌素b2:b1比例的除虫链霉菌基因

Publications (1)

Publication Number Publication Date
CN1521180A true CN1521180A (zh) 2004-08-18

Family

ID=22120706

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2004100054154A Pending CN1521180A (zh) 1998-02-13 1999-01-25 介导除虫菌素b2：b1比例的除虫链霉菌基因
CN99805027A Pending CN1297485A (zh) 1998-02-13 1999-01-25 介导除虫菌素b2:b1比例的除虫链霉菌基因

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN99805027A Pending CN1297485A (zh) 1998-02-13 1999-01-25 介导除虫菌素b2:b1比例的除虫链霉菌基因

Country Status (32)

Country Link
EP (1) EP1053335A1 (ko)
JP (2) JP2002503473A (ko)
KR (3) KR20040099389A (ko)
CN (2) CN1521180A (ko)
AP (1) AP9901463A0 (ko)
AR (1) AR018085A1 (ko)
AU (1) AU752343C (ko)
BG (1) BG64911B1 (ko)
BR (1) BR9907893A (ko)
CA (2) CA2521289A1 (ko)
CO (1) CO5070698A1 (ko)
DZ (1) DZ2720A1 (ko)
EA (1) EA003905B1 (ko)
GT (1) GT199900014A (ko)
HN (1) HN1999000008A (ko)
HR (1) HRP20000539A2 (ko)
HU (1) HUP0100784A3 (ko)
IL (2) IL137610A0 (ko)
IS (1) IS5567A (ko)
MA (1) MA24760A1 (ko)
NO (1) NO20004044L (ko)
NZ (2) NZ505676A (ko)
OA (1) OA11449A (ko)
PA (1) PA8467601A1 (ko)
PE (1) PE20000352A1 (ko)
PL (1) PL194270B1 (ko)
SK (1) SK11722000A3 (ko)
TN (1) TNSN99017A1 (ko)
TW (1) TW585910B (ko)
WO (1) WO1999041389A1 (ko)
YU (1) YU50900A (ko)
ZA (1) ZA991138B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9907893A (pt) * 1998-02-13 2000-11-14 Pfizer Prod Inc Gene de streptomyces avermitilis que dirige a proporção de avermectinas b2:b1
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
JP3884651B2 (ja) * 1999-08-12 2007-02-21 ファイザー・プロダクツ・インク Ｂ２アベルメクチン：ｂ１アベルメクチンの比を指示するストレプトミセス・アベルミティリス遺伝子
US7630836B2 (en) * 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
RU2293117C2 (ru) * 2002-02-12 2007-02-10 Пфайзер Продактс Инк. Ген streptomyces avermitilis и его применение для изменения соотношения авермектинов b2:b1
CN107338210B (zh) * 2017-09-05 2021-08-17 天津科技大学 一种阿维链霉菌合成培养基及其发酵液的制备方法
CN111269296B (zh) * 2020-03-06 2021-11-05 山东大学 一种nLsA蛋白及其结构基因和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
IN167980B (ko) * 1987-01-23 1991-01-19 Pfizer
ES2054822T3 (es) * 1987-10-23 1994-08-16 Pfizer Procedimiento para la produccion de agliconas de avermectinas y sus cultivos.
JPH0747171B2 (ja) * 1988-09-20 1995-05-24 株式会社東芝 圧延機の設定方法および装置
DE69023036T2 (de) * 1989-03-31 1996-06-13 Merck & Co Inc Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung.
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
JP2888586B2 (ja) * 1990-03-05 1999-05-10 社団法人北里研究所 エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法
FI942725A (fi) * 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
BR9907893A (pt) * 1998-02-13 2000-11-14 Pfizer Prod Inc Gene de streptomyces avermitilis que dirige a proporção de avermectinas b2:b1

Also Published As

Publication number Publication date
SK11722000A3 (sk) 2001-04-09
IL137610A0 (en) 2001-07-24
KR20040053390A (ko) 2004-06-23
GT199900014A (es) 2000-07-25
IS5567A (is) 2000-07-20
BG64911B1 (bg) 2006-08-31
NZ505676A (en) 2003-02-28
EA003905B1 (ru) 2003-10-30
WO1999041389A1 (en) 1999-08-19
YU50900A (sh) 2004-03-12
HN1999000008A (es) 1999-10-29
DZ2720A1 (fr) 2003-09-01
HUP0100784A2 (hu) 2001-06-28
BR9907893A (pt) 2000-11-14
ZA991138B (en) 2000-08-14
TW585910B (en) 2004-05-01
IL183596A0 (ko) 2007-09-20
PL194270B1 (pl) 2007-05-31
CA2521289A1 (en) 1999-08-19
OA11449A (en) 2003-12-03
AU1887899A (en) 1999-08-30
HUP0100784A3 (en) 2004-10-28
JP2004283174A (ja) 2004-10-14
EA200000758A1 (ru) 2001-04-23
PA8467601A1 (es) 2000-09-29
NO20004044L (no) 2000-10-11
HRP20000539A2 (en) 2001-04-30
KR20010052166A (ko) 2001-06-25
CO5070698A1 (es) 2001-08-28
PL342468A1 (en) 2001-06-04
KR20040099389A (ko) 2004-11-26
CA2320031A1 (en) 1999-08-19
CN1297485A (zh) 2001-05-30
AU752343C (en) 2005-11-03
EP1053335A1 (en) 2000-11-22
JP4011036B2 (ja) 2007-11-21
TNSN99017A1 (fr) 2005-11-10
MA24760A1 (fr) 1999-10-01
JP2002503473A (ja) 2002-02-05
NZ518657A (en) 2003-10-31
NO20004044D0 (no) 2000-08-11
AR018085A1 (es) 2001-10-31
AP9901463A0 (en) 1999-03-31
KR100499214B1 (ko) 2005-07-07
PE20000352A1 (es) 2000-05-16
BG104759A (en) 2001-04-30
AU752343B2 (en) 2002-09-19

Similar Documents

Publication Publication Date Title
CN1227362C (zh) 生产刺糖噻杀虫剂所用的生物合成基因
CN1206342C (zh) 生产l－赖氨酸的棒状菌和制备l－赖氨酸的方法
CN1415014A (zh) 通过基因扩增增加赖氨酸产量
CN1065277C (zh) 阿凡曼菌素的制备方法
CN1231574C (zh) 生产l－赖氨酸的棒状菌和制备赖氨酸的方法
CN1633237A (zh) 新的产生spinosyn的聚酮合酶
CN1717493A (zh) 大环内酯化合物的产生方法
CN1777681A (zh) Sqs基因
CN1263855C (zh) 来自淡青链霉菌的假寡糖生物合成基因的分离及其应用
CN1644696A (zh) 编码黄酮合酶的基因
CN1308457C (zh) 发酵生产s－腺苷甲硫氨酸的方法
CN1186447C (zh) 介导除虫菌素b2:b1比例的除虫链霉菌基因
CN1521180A (zh) 介导除虫菌素b2：b1比例的除虫链霉菌基因
CN1886505A (zh) 参与大环内酯类化合物的羟化作用的dna
CN1676607A (zh) 为抗生素的生物合成从蓝灰链霉菌非产蓝亚种中克隆基因及其使用方法
CN1231591C (zh) 通过发酵棒状细菌生产l－氨基酸的方法
CN1186446C (zh) 介导除虫菌素b2:b1比例的除虫链霉茵基因
CN1104502C (zh) 编码阿佛曼链霉菌支链α－酮酸脱氢酶复合体的基因
CN1252440A (zh) 用于提高除虫菌素产量的阿维链霉菌调节基因
CN1350586A (zh) 经扩增gnd基因发酵制备L－氨基酸的方法
CN1630712A (zh) 指导b2∶b1除虫菌素比例的除虫链霉菌基因
CN100347190C (zh) 编码rpsL基因的核苷酸序列
CN1387566A (zh) 环状缩肽合成酶及其基因、以及环状缩肽的大规模生产系统
CN1056189C (zh) 编码阿凡曼链霉菌支链α－酮酸脱氢酶复合物的基因
CN1092811A (zh) 新的thiomarinol衍生物及其制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1068894

Country of ref document: HK

AD01 Patent right deemed abandoned
C20 Patent right or utility model deemed to be abandoned or is abandoned
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1068894

Country of ref document: HK