DZ2720A1 - Gène de streptomyces avermitilis commandant le rapport des avermectines b2:b1 et procédé nouveau pour la production d'avermectines. - Google Patents

Gène de streptomyces avermitilis commandant le rapport des avermectines b2:b1 et procédé nouveau pour la production d'avermectines.

Info

Publication number
DZ2720A1
DZ2720A1 DZ990021A DZ990021A DZ2720A1 DZ 2720 A1 DZ2720 A1 DZ 2720A1 DZ 990021 A DZ990021 A DZ 990021A DZ 990021 A DZ990021 A DZ 990021A DZ 2720 A1 DZ2720 A1 DZ 2720A1
Authority
DZ
Algeria
Prior art keywords
avermectins
production
ratio
new process
streptomyces avermitilis
Prior art date
Application number
DZ990021A
Other languages
English (en)
French (fr)
Inventor
Kim Jonelle Stutzman-Engwall
Yoshihiro Katoh
Hamish Alastair Irvine Mcarthur
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of DZ2720A1 publication Critical patent/DZ2720A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/60Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DZ990021A 1998-02-13 1999-02-10 Gène de streptomyces avermitilis commandant le rapport des avermectines b2:b1 et procédé nouveau pour la production d'avermectines. DZ2720A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7463698P 1998-02-13 1998-02-13

Publications (1)

Publication Number Publication Date
DZ2720A1 true DZ2720A1 (fr) 2003-09-01

Family

ID=22120706

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ990021A DZ2720A1 (fr) 1998-02-13 1999-02-10 Gène de streptomyces avermitilis commandant le rapport des avermectines b2:b1 et procédé nouveau pour la production d'avermectines.

Country Status (32)

Country Link
EP (1) EP1053335A1 (xx)
JP (2) JP2002503473A (xx)
KR (3) KR100499214B1 (xx)
CN (2) CN1521180A (xx)
AP (1) AP9901463A0 (xx)
AR (1) AR018085A1 (xx)
AU (1) AU752343C (xx)
BG (1) BG64911B1 (xx)
BR (1) BR9907893A (xx)
CA (2) CA2521289A1 (xx)
CO (1) CO5070698A1 (xx)
DZ (1) DZ2720A1 (xx)
EA (1) EA003905B1 (xx)
GT (1) GT199900014A (xx)
HN (1) HN1999000008A (xx)
HR (1) HRP20000539A2 (xx)
HU (1) HUP0100784A3 (xx)
IL (2) IL137610A0 (xx)
IS (1) IS5567A (xx)
MA (1) MA24760A1 (xx)
NO (1) NO20004044L (xx)
NZ (2) NZ505676A (xx)
OA (1) OA11449A (xx)
PA (1) PA8467601A1 (xx)
PE (1) PE20000352A1 (xx)
PL (1) PL194270B1 (xx)
SK (1) SK11722000A3 (xx)
TN (1) TNSN99017A1 (xx)
TW (1) TW585910B (xx)
WO (1) WO1999041389A1 (xx)
YU (1) YU50900A (xx)
ZA (1) ZA991138B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1521180A (zh) * 1998-02-13 2004-08-18 �Ʒ� 介导除虫菌素b2:b1比例的除虫链霉菌基因
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
WO2001012821A1 (en) * 1999-08-12 2001-02-22 Pfizer Products Inc. Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
US7630836B2 (en) * 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
JP2005517406A (ja) * 2002-02-12 2005-06-16 ファイザー・プロダクツ・インク B2:B1アベルメクチン比を支配するStreptomycesavermitilis遺伝子
CN107338210B (zh) * 2017-09-05 2021-08-17 天津科技大学 一种阿维链霉菌合成培养基及其发酵液的制备方法
CN111269296B (zh) * 2020-03-06 2021-11-05 山东大学 一种nLsA蛋白及其结构基因和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
IN167980B (xx) * 1987-01-23 1991-01-19 Pfizer
EP0313297B1 (en) * 1987-10-23 1993-05-19 Pfizer Inc. Process for production of avermectin aglycones and cultures therefor
JPH0747171B2 (ja) * 1988-09-20 1995-05-24 株式会社東芝 圧延機の設定方法および装置
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
NZ233116A (en) * 1989-03-31 1994-09-27 Merck & Co Inc Cloning genes from steptomyces avermitilis for avermectin biosynthesis
JP2888586B2 (ja) * 1990-03-05 1999-05-10 社団法人北里研究所 エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法
FI942725A (fi) * 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
CN1521180A (zh) * 1998-02-13 2004-08-18 �Ʒ� 介导除虫菌素b2:b1比例的除虫链霉菌基因

Also Published As

Publication number Publication date
BG64911B1 (bg) 2006-08-31
EA200000758A1 (ru) 2001-04-23
PA8467601A1 (es) 2000-09-29
JP4011036B2 (ja) 2007-11-21
PE20000352A1 (es) 2000-05-16
HN1999000008A (es) 1999-10-29
AU752343B2 (en) 2002-09-19
CA2320031A1 (en) 1999-08-19
CN1297485A (zh) 2001-05-30
IL137610A0 (en) 2001-07-24
BR9907893A (pt) 2000-11-14
HRP20000539A2 (en) 2001-04-30
SK11722000A3 (sk) 2001-04-09
KR20040053390A (ko) 2004-06-23
AP9901463A0 (en) 1999-03-31
AR018085A1 (es) 2001-10-31
BG104759A (en) 2001-04-30
TNSN99017A1 (fr) 2005-11-10
KR20010052166A (ko) 2001-06-25
TW585910B (en) 2004-05-01
CN1521180A (zh) 2004-08-18
CO5070698A1 (es) 2001-08-28
JP2002503473A (ja) 2002-02-05
NZ505676A (en) 2003-02-28
AU752343C (en) 2005-11-03
IS5567A (is) 2000-07-20
KR100499214B1 (ko) 2005-07-07
EP1053335A1 (en) 2000-11-22
YU50900A (sh) 2004-03-12
PL194270B1 (pl) 2007-05-31
IL183596A0 (xx) 2007-09-20
AU1887899A (en) 1999-08-30
HUP0100784A3 (en) 2004-10-28
EA003905B1 (ru) 2003-10-30
WO1999041389A1 (en) 1999-08-19
GT199900014A (es) 2000-07-25
OA11449A (en) 2003-12-03
PL342468A1 (en) 2001-06-04
MA24760A1 (fr) 1999-10-01
KR20040099389A (ko) 2004-11-26
CA2521289A1 (en) 1999-08-19
HUP0100784A2 (hu) 2001-06-28
ZA991138B (en) 2000-08-14
JP2004283174A (ja) 2004-10-14
NZ518657A (en) 2003-10-31
NO20004044L (no) 2000-10-11
NO20004044D0 (no) 2000-08-11

Similar Documents

Publication Publication Date Title
DZ1880A1 (fr) Forme posologique d'azithromycine et son procédé de production.
AU2705600A (en) Process and apparatus for the production of nanofibers
AU2717999A (en) Process for the production of gamma-butyrolactone
AU3546199A (en) Small molecule anticancer compounds and related production process
DZ2720A1 (fr) Gène de streptomyces avermitilis commandant le rapport des avermectines b2:b1 et procédé nouveau pour la production d'avermectines.
AU2515399A (en) Process for the production of gamma-butyrolactone
AU1036600A (en) Method for the production of quercetin and isoquercetin derivatives
HUP9903073A2 (en) Streptomyces avermitilis regulatory genes for increased avermectin production
AU3330699A (en) Process for the production of microcapsules
AU5160599A (en) Method for the production of n,n'-carbonyl diazoles
HK1027110A1 (en) Production of avermectin compounds.
HU9800369D0 (en) Pellet-based pharmaceutical composition of controlled release with high content of potassium-chloride, and process for it's production
IL147562A0 (en) Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
AU7773700A (en) Method for the production or preparation of 2,6-dichlorotoluol
IL147563A0 (en) Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
AU2002226018A1 (en) Process for the production of diaryl carbonates
FR2720406B1 (fr) Composition de microorganismes et procédé pour la production de xylitol.
AU2002216685A1 (en) Process for the production of diaryl carbonates
AU1432700A (en) Method and arrangement for the continuous production of lignocellulose-containing boards
AU2001262240A1 (en) Process for the production of 2,2,6-trimethylcyclohexane-1,4-dione
AU1684700A (en) Process for the production of optically active 3,4-dehydroprolines
AU3274099A (en) Process for producing avermectin b1 derivatives
AU5067399A (en) Process for the preparation of erythromycin derivatives
AU1063300A (en) Process for the production of trifluoromethyltropanone cyanohydrin
DE59608617D1 (de) 4a,5a,8a,8b-TETRAHYDRO-6H-PYRROLO 3',4':4,5]FURO 3,2-b]PYRIDIN-6,8(7H)-DION DERIVATE ZUR BEKÄMPFUNG VON ENDOPARASITEN UND VERFAHREN ZU IHRER HERSTELLUNG