HUP0100784A3 - Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins - Google Patents

Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Info

Publication number
HUP0100784A3
HUP0100784A3 HU0100784A HUP0100784A HUP0100784A3 HU P0100784 A3 HUP0100784 A3 HU P0100784A3 HU 0100784 A HU0100784 A HU 0100784A HU P0100784 A HUP0100784 A HU P0100784A HU P0100784 A3 HUP0100784 A3 HU P0100784A3
Authority
HU
Hungary
Prior art keywords
avermectins
ratio
streptomyces avermitilis
gene directing
avermitilis gene
Prior art date
Application number
HU0100784A
Other languages
Hungarian (hu)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of HUP0100784A2 publication Critical patent/HUP0100784A2/en
Publication of HUP0100784A3 publication Critical patent/HUP0100784A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/60Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HU0100784A 1998-02-13 1999-01-25 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins HUP0100784A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7463698P 1998-02-13 1998-02-13
PCT/IB1999/000130 WO1999041389A1 (en) 1998-02-13 1999-01-25 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Publications (2)

Publication Number Publication Date
HUP0100784A2 HUP0100784A2 (en) 2001-06-28
HUP0100784A3 true HUP0100784A3 (en) 2004-10-28

Family

ID=22120706

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0100784A HUP0100784A3 (en) 1998-02-13 1999-01-25 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Country Status (32)

Country Link
EP (1) EP1053335A1 (en)
JP (2) JP2002503473A (en)
KR (3) KR20040053390A (en)
CN (2) CN1297485A (en)
AP (1) AP9901463A0 (en)
AR (1) AR018085A1 (en)
AU (1) AU752343C (en)
BG (1) BG64911B1 (en)
BR (1) BR9907893A (en)
CA (2) CA2320031A1 (en)
CO (1) CO5070698A1 (en)
DZ (1) DZ2720A1 (en)
EA (1) EA003905B1 (en)
GT (1) GT199900014A (en)
HN (1) HN1999000008A (en)
HR (1) HRP20000539A2 (en)
HU (1) HUP0100784A3 (en)
IL (2) IL137610A0 (en)
IS (1) IS5567A (en)
MA (1) MA24760A1 (en)
NO (1) NO20004044L (en)
NZ (2) NZ518657A (en)
OA (1) OA11449A (en)
PA (1) PA8467601A1 (en)
PE (1) PE20000352A1 (en)
PL (1) PL194270B1 (en)
SK (1) SK11722000A3 (en)
TN (1) TNSN99017A1 (en)
TW (1) TW585910B (en)
WO (1) WO1999041389A1 (en)
YU (1) YU50900A (en)
ZA (1) ZA991138B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1297485A (en) * 1998-02-13 2001-05-30 辉瑞产品公司 i (streptomyces avermitilis) gene directing ratio of B2:B1 avermectins
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
MXPA02001513A (en) * 1999-08-12 2002-07-02 Pfizer Prod Inc Streptomyces avermitilis.
US7630836B2 (en) * 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
ES2321827T3 (en) * 2002-02-12 2009-06-12 Pfizer Products Inc. STREPTOMYCES GENE AVERMITILIS THAT RULES THE RELATIONSHIP OF AVERMECTINES B2-B1.
CN107338210B (en) * 2017-09-05 2021-08-17 天津科技大学 Abamectin streptomycete synthetic medium and preparation method of fermentation liquor thereof
CN111269296B (en) * 2020-03-06 2021-11-05 山东大学 nLsA protein, structural gene thereof and application thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (en) * 1976-04-19 1984-07-16 Merck & Co Inc SET TO MAKE NEW ANTIHELMINTICALLY EFFECTIVE ASSOCIATIONS BY CULTIVATING STREPTOMYCS AVERMITILIS
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
IN167980B (en) * 1987-01-23 1991-01-19 Pfizer
EP0313297B1 (en) * 1987-10-23 1993-05-19 Pfizer Inc. Process for production of avermectin aglycones and cultures therefor
JPH0747171B2 (en) * 1988-09-20 1995-05-24 株式会社東芝 Rolling mill setting method and device
EP0391594B1 (en) * 1989-03-31 1995-10-18 Merck & Co. Inc. Cloning genes from streptomyces avermitilis for avermectin biosynthesis and the methods for their use
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
JP2888586B2 (en) * 1990-03-05 1999-05-10 社団法人北里研究所 Microorganism for selective production of specific components of avermectin and its selective production method
FI942725A (en) * 1993-12-16 1995-06-17 Pfizer Genes encoding branched chain alpha-keto acid dehydrogenase complex from Streptomyces avermitilis
CN1297485A (en) * 1998-02-13 2001-05-30 辉瑞产品公司 i (streptomyces avermitilis) gene directing ratio of B2:B1 avermectins

Also Published As

Publication number Publication date
IL137610A0 (en) 2001-07-24
AR018085A1 (en) 2001-10-31
EP1053335A1 (en) 2000-11-22
EA003905B1 (en) 2003-10-30
PA8467601A1 (en) 2000-09-29
AU1887899A (en) 1999-08-30
NZ518657A (en) 2003-10-31
CA2521289A1 (en) 1999-08-19
IS5567A (en) 2000-07-20
HRP20000539A2 (en) 2001-04-30
IL183596A0 (en) 2007-09-20
JP2002503473A (en) 2002-02-05
BG64911B1 (en) 2006-08-31
NZ505676A (en) 2003-02-28
NO20004044D0 (en) 2000-08-11
AP9901463A0 (en) 1999-03-31
ZA991138B (en) 2000-08-14
EA200000758A1 (en) 2001-04-23
YU50900A (en) 2004-03-12
PL194270B1 (en) 2007-05-31
CN1521180A (en) 2004-08-18
CN1297485A (en) 2001-05-30
KR20040099389A (en) 2004-11-26
CO5070698A1 (en) 2001-08-28
WO1999041389A1 (en) 1999-08-19
KR20010052166A (en) 2001-06-25
AU752343B2 (en) 2002-09-19
HUP0100784A2 (en) 2001-06-28
AU752343C (en) 2005-11-03
HN1999000008A (en) 1999-10-29
DZ2720A1 (en) 2003-09-01
CA2320031A1 (en) 1999-08-19
PE20000352A1 (en) 2000-05-16
KR100499214B1 (en) 2005-07-07
GT199900014A (en) 2000-07-25
SK11722000A3 (en) 2001-04-09
BG104759A (en) 2001-04-30
OA11449A (en) 2003-12-03
KR20040053390A (en) 2004-06-23
JP4011036B2 (en) 2007-11-21
BR9907893A (en) 2000-11-14
JP2004283174A (en) 2004-10-14
TNSN99017A1 (en) 2005-11-10
MA24760A1 (en) 1999-10-01
NO20004044L (en) 2000-10-11
TW585910B (en) 2004-05-01
PL342468A1 (en) 2001-06-04

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Legal Events

Date Code Title Description
FC4A Lapse of provisional application due to refusal