NZ505676A - Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins - Google Patents

Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins

Info

Publication number
NZ505676A
NZ505676A NZ505676A NZ50567699A NZ505676A NZ 505676 A NZ505676 A NZ 505676A NZ 505676 A NZ505676 A NZ 505676A NZ 50567699 A NZ50567699 A NZ 50567699A NZ 505676 A NZ505676 A NZ 505676A
Authority
NZ
New Zealand
Prior art keywords
avermectins
ratio
streptomyces avermitilis
gene directing
avermitilis gene
Prior art date
Application number
NZ505676A
Inventor
Kim Jonelle Stutzman-Engwall
Hamish Alastair Irvin Mcarthur
Yoshihiro Katoh
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Priority to NZ518657A priority Critical patent/NZ518657A/en
Publication of NZ505676A publication Critical patent/NZ505676A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Abstract

Isolated polynucleotide molecules comprising nucleotide sequences encoding the complete aveC open-reading frame of Streptomyces avermitilis, which sequences further comprise mutations such that cells comprising the mutated sequence produce a reduced cyclohexyl B2:cyclohexyl B1 ratio of avermectins.
NZ505676A 1998-02-13 1999-01-25 Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins NZ505676A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ518657A NZ518657A (en) 1998-02-13 1999-01-25 Streptomyces hygroscopicus directing the ratio of B2:B1 avermectins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7463698P 1998-02-13 1998-02-13
PCT/IB1999/000130 WO1999041389A1 (en) 1998-02-13 1999-01-25 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Publications (1)

Publication Number Publication Date
NZ505676A true NZ505676A (en) 2003-02-28

Family

ID=22120706

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ518657A NZ518657A (en) 1998-02-13 1999-01-25 Streptomyces hygroscopicus directing the ratio of B2:B1 avermectins
NZ505676A NZ505676A (en) 1998-02-13 1999-01-25 Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NZ518657A NZ518657A (en) 1998-02-13 1999-01-25 Streptomyces hygroscopicus directing the ratio of B2:B1 avermectins

Country Status (32)

Country Link
EP (1) EP1053335A1 (en)
JP (2) JP2002503473A (en)
KR (3) KR20040099389A (en)
CN (2) CN1297485A (en)
AP (1) AP9901463A0 (en)
AR (1) AR018085A1 (en)
AU (1) AU752343C (en)
BG (1) BG64911B1 (en)
BR (1) BR9907893A (en)
CA (2) CA2320031A1 (en)
CO (1) CO5070698A1 (en)
DZ (1) DZ2720A1 (en)
EA (1) EA003905B1 (en)
GT (1) GT199900014A (en)
HN (1) HN1999000008A (en)
HR (1) HRP20000539A2 (en)
HU (1) HUP0100784A3 (en)
IL (2) IL137610A0 (en)
IS (1) IS5567A (en)
MA (1) MA24760A1 (en)
NO (1) NO20004044L (en)
NZ (2) NZ518657A (en)
OA (1) OA11449A (en)
PA (1) PA8467601A1 (en)
PE (1) PE20000352A1 (en)
PL (1) PL194270B1 (en)
SK (1) SK11722000A3 (en)
TN (1) TNSN99017A1 (en)
TW (1) TW585910B (en)
WO (1) WO1999041389A1 (en)
YU (1) YU50900A (en)
ZA (1) ZA991138B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ518657A (en) * 1998-02-13 2003-10-31 Pfizer Prod Inc Streptomyces hygroscopicus directing the ratio of B2:B1 avermectins
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
KR100489856B1 (en) * 1999-08-12 2005-05-17 화이자 프로덕츠 인코포레이티드 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
US7630836B2 (en) 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
MXPA04007777A (en) * 2002-02-12 2004-10-15 Pfizer Prod Inc Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins.
CN107338210B (en) * 2017-09-05 2021-08-17 天津科技大学 Abamectin streptomycete synthetic medium and preparation method of fermentation liquor thereof
CN111269296B (en) * 2020-03-06 2021-11-05 山东大学 nLsA protein, structural gene thereof and application thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (en) * 1976-04-19 1984-07-16 Merck & Co Inc SET TO MAKE NEW ANTIHELMINTICALLY EFFECTIVE ASSOCIATIONS BY CULTIVATING STREPTOMYCS AVERMITILIS
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
IN167980B (en) * 1987-01-23 1991-01-19 Pfizer
ATE89604T1 (en) * 1987-10-23 1993-06-15 Pfizer PROCESS FOR THE PREPARATION OF AGLYCONES OF AVERMECTIN AND CULTURES CONTAINING THEM.
JPH0747171B2 (en) * 1988-09-20 1995-05-24 株式会社東芝 Rolling mill setting method and device
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
DE69023036T2 (en) * 1989-03-31 1996-06-13 Merck & Co Inc Cloning of Streptomyces avermitilis genes for the biosynthesis of avermectin and method of using them.
JP2888586B2 (en) * 1990-03-05 1999-05-10 社団法人北里研究所 Microorganism for selective production of specific components of avermectin and its selective production method
FI942725A (en) * 1993-12-16 1995-06-17 Pfizer Genes encoding branched chain alpha-keto acid dehydrogenase complex from Streptomyces avermitilis
NZ518657A (en) * 1998-02-13 2003-10-31 Pfizer Prod Inc Streptomyces hygroscopicus directing the ratio of B2:B1 avermectins

Also Published As

Publication number Publication date
PL194270B1 (en) 2007-05-31
GT199900014A (en) 2000-07-25
AP9901463A0 (en) 1999-03-31
CO5070698A1 (en) 2001-08-28
IL183596A0 (en) 2007-09-20
KR100499214B1 (en) 2005-07-07
AU752343B2 (en) 2002-09-19
TW585910B (en) 2004-05-01
TNSN99017A1 (en) 2005-11-10
EP1053335A1 (en) 2000-11-22
DZ2720A1 (en) 2003-09-01
AR018085A1 (en) 2001-10-31
IL137610A0 (en) 2001-07-24
IS5567A (en) 2000-07-20
PA8467601A1 (en) 2000-09-29
CA2521289A1 (en) 1999-08-19
CN1297485A (en) 2001-05-30
KR20040053390A (en) 2004-06-23
BG104759A (en) 2001-04-30
KR20040099389A (en) 2004-11-26
HUP0100784A2 (en) 2001-06-28
BR9907893A (en) 2000-11-14
SK11722000A3 (en) 2001-04-09
EA200000758A1 (en) 2001-04-23
NZ518657A (en) 2003-10-31
PL342468A1 (en) 2001-06-04
PE20000352A1 (en) 2000-05-16
HN1999000008A (en) 1999-10-29
NO20004044D0 (en) 2000-08-11
MA24760A1 (en) 1999-10-01
KR20010052166A (en) 2001-06-25
WO1999041389A1 (en) 1999-08-19
AU752343C (en) 2005-11-03
JP2004283174A (en) 2004-10-14
JP4011036B2 (en) 2007-11-21
HRP20000539A2 (en) 2001-04-30
OA11449A (en) 2003-12-03
AU1887899A (en) 1999-08-30
ZA991138B (en) 2000-08-14
NO20004044L (en) 2000-10-11
HUP0100784A3 (en) 2004-10-28
JP2002503473A (en) 2002-02-05
CN1521180A (en) 2004-08-18
BG64911B1 (en) 2006-08-31
YU50900A (en) 2004-03-12
EA003905B1 (en) 2003-10-30
CA2320031A1 (en) 1999-08-19

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