TNSN99017A1 - GENE OF AVERMITILIZED STREPTOMYCES CONTROLLING THE REPORT OF AVERMECTINS B2: B1 AND NEW PROCESS FOR THE PRODUCTION OF AVERMECTINS. - Google Patents

GENE OF AVERMITILIZED STREPTOMYCES CONTROLLING THE REPORT OF AVERMECTINS B2: B1 AND NEW PROCESS FOR THE PRODUCTION OF AVERMECTINS.

Info

Publication number
TNSN99017A1
TNSN99017A1 TNTNSN99017A TNSN99017A TNSN99017A1 TN SN99017 A1 TNSN99017 A1 TN SN99017A1 TN TNSN99017 A TNTNSN99017 A TN TNSN99017A TN SN99017 A TNSN99017 A TN SN99017A TN SN99017 A1 TNSN99017 A1 TN SN99017A1
Authority
TN
Tunisia
Prior art keywords
avermectins
gene
avermitilized
streptomyces
report
Prior art date
Application number
TNTNSN99017A
Other languages
French (fr)
Inventor
Jonelle Stutzman-Engwall Kim
Katoh Yoshihiro
Alastair Irvine Mcarthur Hamish
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TNSN99017A1 publication Critical patent/TNSN99017A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Abstract

L'INVENTION CONCERNE DES MOLECULES POLYNUCLEOTIDIQUES COMPRENANT DES SEQUENCES CODANT POUR UN PRODUIT DU GENE AveC, POUR MODIFIER LE RAPPORT DES CATEGORIES 2:1 DES AVERMECTINES DANS DES CULTURES DE S.AVERMITILIS PAR FERMENTATION. ELLE CONCERNE EGALEMENT DES VECTEURS, DES CELLULES HOTES ET DES SOUCHES MUTANTES DE S.AVERMITILIS DANS LESQUELS LE GENE AveC A ETE INACTIVE OU MUTE. APPLICATION : UTILISATION DE CES AVERMECTINES ET DE COMPOSITIONS LES CONTENANT COMME COMPOSES PARASITICIDES.THE INVENTION RELATES TO POLYNUCLEOTIDE MOLECULES COMPRISING SEQUENCES ENCODING A GENE PRODUCT WITH AVC, TO MODIFY THE RATIO OF 2: 1 CATEGORIES OF AVERMECTINES IN FERTILIZED S. AVERMECTIN CROPS. IT ALSO CONCERNS VECTORS, HOST CELLS AND MUTANT STRAINS OF S. AVERMMITIL IN WHICH THE GENE WITH HAS BEEN INACTIVE OR MUTE. APPLICATION: USE OF THESE AVERMECTINS AND COMPOSITIONS CONTAINING THEM AS PARASITICIDE COMPOUNDS.

TNTNSN99017A 1998-02-13 1999-02-10 GENE OF AVERMITILIZED STREPTOMYCES CONTROLLING THE REPORT OF AVERMECTINS B2: B1 AND NEW PROCESS FOR THE PRODUCTION OF AVERMECTINS. TNSN99017A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7463698P 1998-02-13 1998-02-13

Publications (1)

Publication Number Publication Date
TNSN99017A1 true TNSN99017A1 (en) 2005-11-10

Family

ID=22120706

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN99017A TNSN99017A1 (en) 1998-02-13 1999-02-10 GENE OF AVERMITILIZED STREPTOMYCES CONTROLLING THE REPORT OF AVERMECTINS B2: B1 AND NEW PROCESS FOR THE PRODUCTION OF AVERMECTINS.

Country Status (32)

Country Link
EP (1) EP1053335A1 (en)
JP (2) JP2002503473A (en)
KR (3) KR20040099389A (en)
CN (2) CN1297485A (en)
AP (1) AP9901463A0 (en)
AR (1) AR018085A1 (en)
AU (1) AU752343C (en)
BG (1) BG64911B1 (en)
BR (1) BR9907893A (en)
CA (2) CA2320031A1 (en)
CO (1) CO5070698A1 (en)
DZ (1) DZ2720A1 (en)
EA (1) EA003905B1 (en)
GT (1) GT199900014A (en)
HN (1) HN1999000008A (en)
HR (1) HRP20000539A2 (en)
HU (1) HUP0100784A3 (en)
IL (2) IL137610A0 (en)
IS (1) IS5567A (en)
MA (1) MA24760A1 (en)
NO (1) NO20004044L (en)
NZ (2) NZ518657A (en)
OA (1) OA11449A (en)
PA (1) PA8467601A1 (en)
PE (1) PE20000352A1 (en)
PL (1) PL194270B1 (en)
SK (1) SK11722000A3 (en)
TN (1) TNSN99017A1 (en)
TW (1) TW585910B (en)
WO (1) WO1999041389A1 (en)
YU (1) YU50900A (en)
ZA (1) ZA991138B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ518657A (en) * 1998-02-13 2003-10-31 Pfizer Prod Inc Streptomyces hygroscopicus directing the ratio of B2:B1 avermectins
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
KR100489856B1 (en) * 1999-08-12 2005-05-17 화이자 프로덕츠 인코포레이티드 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
US7630836B2 (en) 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
MXPA04007777A (en) * 2002-02-12 2004-10-15 Pfizer Prod Inc Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins.
CN107338210B (en) * 2017-09-05 2021-08-17 天津科技大学 Abamectin streptomycete synthetic medium and preparation method of fermentation liquor thereof
CN111269296B (en) * 2020-03-06 2021-11-05 山东大学 nLsA protein, structural gene thereof and application thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (en) * 1976-04-19 1984-07-16 Merck & Co Inc SET TO MAKE NEW ANTIHELMINTICALLY EFFECTIVE ASSOCIATIONS BY CULTIVATING STREPTOMYCS AVERMITILIS
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
IN167980B (en) * 1987-01-23 1991-01-19 Pfizer
ATE89604T1 (en) * 1987-10-23 1993-06-15 Pfizer PROCESS FOR THE PREPARATION OF AGLYCONES OF AVERMECTIN AND CULTURES CONTAINING THEM.
JPH0747171B2 (en) * 1988-09-20 1995-05-24 株式会社東芝 Rolling mill setting method and device
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
DE69023036T2 (en) * 1989-03-31 1996-06-13 Merck & Co Inc Cloning of Streptomyces avermitilis genes for the biosynthesis of avermectin and method of using them.
JP2888586B2 (en) * 1990-03-05 1999-05-10 社団法人北里研究所 Microorganism for selective production of specific components of avermectin and its selective production method
FI942725A (en) * 1993-12-16 1995-06-17 Pfizer Genes encoding branched chain alpha-keto acid dehydrogenase complex from Streptomyces avermitilis
NZ518657A (en) * 1998-02-13 2003-10-31 Pfizer Prod Inc Streptomyces hygroscopicus directing the ratio of B2:B1 avermectins

Also Published As

Publication number Publication date
PL194270B1 (en) 2007-05-31
GT199900014A (en) 2000-07-25
AP9901463A0 (en) 1999-03-31
CO5070698A1 (en) 2001-08-28
IL183596A0 (en) 2007-09-20
KR100499214B1 (en) 2005-07-07
AU752343B2 (en) 2002-09-19
TW585910B (en) 2004-05-01
EP1053335A1 (en) 2000-11-22
DZ2720A1 (en) 2003-09-01
AR018085A1 (en) 2001-10-31
IL137610A0 (en) 2001-07-24
IS5567A (en) 2000-07-20
PA8467601A1 (en) 2000-09-29
CA2521289A1 (en) 1999-08-19
CN1297485A (en) 2001-05-30
KR20040053390A (en) 2004-06-23
BG104759A (en) 2001-04-30
KR20040099389A (en) 2004-11-26
HUP0100784A2 (en) 2001-06-28
BR9907893A (en) 2000-11-14
SK11722000A3 (en) 2001-04-09
EA200000758A1 (en) 2001-04-23
NZ518657A (en) 2003-10-31
PL342468A1 (en) 2001-06-04
PE20000352A1 (en) 2000-05-16
HN1999000008A (en) 1999-10-29
NO20004044D0 (en) 2000-08-11
MA24760A1 (en) 1999-10-01
KR20010052166A (en) 2001-06-25
WO1999041389A1 (en) 1999-08-19
AU752343C (en) 2005-11-03
JP2004283174A (en) 2004-10-14
JP4011036B2 (en) 2007-11-21
HRP20000539A2 (en) 2001-04-30
OA11449A (en) 2003-12-03
AU1887899A (en) 1999-08-30
ZA991138B (en) 2000-08-14
NO20004044L (en) 2000-10-11
NZ505676A (en) 2003-02-28
HUP0100784A3 (en) 2004-10-28
JP2002503473A (en) 2002-02-05
CN1521180A (en) 2004-08-18
BG64911B1 (en) 2006-08-31
YU50900A (en) 2004-03-12
EA003905B1 (en) 2003-10-30
CA2320031A1 (en) 1999-08-19

Similar Documents

Publication Publication Date Title
EA200602068A1 (en) Enzymatic preparation of thin chemical compounds
FR2540516A1 (en) PROCESS FOR THE PRODUCTION OF PROTEINS CORRESPONDING TO DIPHTERIC TOXIN
Jordan Effect of vancomycin on the synthesis of the cell wall mucopeptide of Staphylococcus aureus
TNSN99017A1 (en) GENE OF AVERMITILIZED STREPTOMYCES CONTROLLING THE REPORT OF AVERMECTINS B2: B1 AND NEW PROCESS FOR THE PRODUCTION OF AVERMECTINS.
EP0915981B1 (en) Isolation of the biosynthesis genes for pseudo-oligosaccharides from streptomyces glaucescens gla.o and their use
EP0990704A3 (en) Non-reducing saccharide-forming enzyme, trehalose-releasing enzyme, and process for producing saccharides using the enzymes
TNSN00170A1 (en) GENE OF AVERMITIL STREPTOMYCES DIRECTING THE REPORT OF AVERMECTINS B2: B1
US20210024939A1 (en) Development of technology for inducing over-expression of β-agarase daga enzyme
TNSN00171A1 (en) GENE OF AVERMITILATED STREPTOMYCES ORDERING AVERMECTINS B2: B1 REPORT
US20080166776A1 (en) Method for Preparing a Useful Secondary Metabolite by Effective Elimination of Biological By-Products
DE60127948T2 (en) PROCESS FOR THE PREPARATION OF AVERMECTIN DERIVATIVES
DE10109166A1 (en) Avilamycin derivatives
DE60029818T2 (en) NEW USE OF URIDINE PHOSPHATE-GLUCOSE 4-EPIMERASE
KR100321304B1 (en) Process for Purifying Teicoplanin
JPWO2008047674A1 (en) Β-Fructofuranosidase that selectively degrades nystose and method for producing 1-kestose high content solution using the same
FR2627507B1 (en) PROCESS FOR REDUCING THE VISCOSITY OF MEDIA IN THE EVENT OF EXCRETING VISCOSIFYING POLYMERS ATTACHED TO FERMENTATION PROCESSES
KR100197357B1 (en) A medium for producing microbial cellulose and a producing method of microbial cellulose
Jizba et al. Insecticidal activity of pyrrolizine derivatives isolated from Streptomyces griseus
US4535083A (en) Cleavage products of 4',6'-didesoxy-4'-thio-,6'-amino-hepturonic acid nucleosides
RS70004A (en) Streptomyces avermitilis gene directing the ratio of b2:b1 avermectin
Nonaka et al. Fermentative production of milbemycin α11 and α14: Appearance of morphological mutants during large-scale fermentation
Vanhooren L-fucose-rich extracellular polysaccharides from Clavibacter and Klebsiella species: Fermentation and rheological characterisation.
SU1557165A1 (en) Method of obtaining biologically active substances
RU2034924C1 (en) Strain of streptomyces ornatus - a producer of keratinase
KR830000618B1 (en) Preparation method of new antibiotic SF-2050B