EA200000758A1 - Ген streptomyces avermitilis, изменяющий соотношение в2:в1 - Google Patents
Ген streptomyces avermitilis, изменяющий соотношение в2:в1Info
- Publication number
- EA200000758A1 EA200000758A1 EA200000758A EA200000758A EA200000758A1 EA 200000758 A1 EA200000758 A1 EA 200000758A1 EA 200000758 A EA200000758 A EA 200000758A EA 200000758 A EA200000758 A EA 200000758A EA 200000758 A1 EA200000758 A1 EA 200000758A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- streptomyces avermitilis
- changing relation
- classes
- ratio
- change
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Настоящее изобретение относится к полинуклеотидным молекулам, содержащим нуклеотидные последовательности, кодирующие продукт гена aveC, причем эти полинуклеотидные молекулы можно использовать для изменения соотношения или количества авермектинов классов 2:1, продуцируемых в ферментационных культурах S.avermitilis. Кроме того, настоящее изобретение относится к векторам, клеткам-хозяевам и мутантным штаммам S.avermitilis, в которых ген aveC инактивирован или мутирован таким образом, чтобы изменить соотношение или количество продуцируемых авермектинов классов 2:1.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7463698P | 1998-02-13 | 1998-02-13 | |
| PCT/IB1999/000130 WO1999041389A1 (en) | 1998-02-13 | 1999-01-25 | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200000758A1 true EA200000758A1 (ru) | 2001-04-23 |
| EA003905B1 EA003905B1 (ru) | 2003-10-30 |
Family
ID=22120706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200000758A EA003905B1 (ru) | 1998-02-13 | 1999-01-25 | Ген streptomyces avermitilis, контролирующий соотношение авермектинов b2:b1 |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP1053335A1 (ru) |
| JP (2) | JP2002503473A (ru) |
| KR (3) | KR20040099389A (ru) |
| CN (2) | CN1521180A (ru) |
| AP (1) | AP9901463A0 (ru) |
| AR (1) | AR018085A1 (ru) |
| AU (1) | AU752343C (ru) |
| BG (1) | BG64911B1 (ru) |
| BR (1) | BR9907893A (ru) |
| CA (2) | CA2521289A1 (ru) |
| CO (1) | CO5070698A1 (ru) |
| DZ (1) | DZ2720A1 (ru) |
| EA (1) | EA003905B1 (ru) |
| GT (1) | GT199900014A (ru) |
| HN (1) | HN1999000008A (ru) |
| HR (1) | HRP20000539A2 (ru) |
| HU (1) | HUP0100784A3 (ru) |
| IL (2) | IL137610A0 (ru) |
| IS (1) | IS5567A (ru) |
| MA (1) | MA24760A1 (ru) |
| NO (1) | NO20004044L (ru) |
| NZ (2) | NZ505676A (ru) |
| OA (1) | OA11449A (ru) |
| PA (1) | PA8467601A1 (ru) |
| PE (1) | PE20000352A1 (ru) |
| PL (1) | PL194270B1 (ru) |
| SK (1) | SK11722000A3 (ru) |
| TN (1) | TNSN99017A1 (ru) |
| TW (1) | TW585910B (ru) |
| WO (1) | WO1999041389A1 (ru) |
| YU (1) | YU50900A (ru) |
| ZA (1) | ZA991138B (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111269296A (zh) * | 2020-03-06 | 2020-06-12 | 山东大学 | 一种nLsA蛋白及其结构基因和应用 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9907893A (pt) * | 1998-02-13 | 2000-11-14 | Pfizer Prod Inc | Gene de streptomyces avermitilis que dirige a proporção de avermectinas b2:b1 |
| US6248579B1 (en) * | 1998-02-13 | 2001-06-19 | Pfizer Inc | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins |
| JP3884651B2 (ja) * | 1999-08-12 | 2007-02-21 | ファイザー・プロダクツ・インク | Ｂ２アベルメクチン：ｂ１アベルメクチンの比を指示するストレプトミセス・アベルミティリス遺伝子 |
| US7630836B2 (en) * | 2001-05-30 | 2009-12-08 | The Kitasato Institute | Polynucleotides |
| RU2293117C2 (ru) * | 2002-02-12 | 2007-02-10 | Пфайзер Продактс Инк. | Ген streptomyces avermitilis и его применение для изменения соотношения авермектинов b2:b1 |
| CN107338210B (zh) * | 2017-09-05 | 2021-08-17 | 天津科技大学 | 一种阿维链霉菌合成培养基及其发酵液的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE434277B (sv) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| US4429042A (en) * | 1978-09-08 | 1984-01-31 | Merck & Co., Inc. | Strain of Streptomyces for producing antiparasitic compounds |
| IN167980B (ru) * | 1987-01-23 | 1991-01-19 | Pfizer | |
| ES2054822T3 (es) * | 1987-10-23 | 1994-08-16 | Pfizer | Procedimiento para la produccion de agliconas de avermectinas y sus cultivos. |
| JPH0747171B2 (ja) * | 1988-09-20 | 1995-05-24 | 株式会社東芝 | 圧延機の設定方法および装置 |
| DE69023036T2 (de) * | 1989-03-31 | 1996-06-13 | Merck & Co Inc | Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung. |
| US5252474A (en) * | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
| JP2888586B2 (ja) * | 1990-03-05 | 1999-05-10 | 社団法人北里研究所 | エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法 |
| FI942725A (fi) * | 1993-12-16 | 1995-06-17 | Pfizer | Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta |
| BR9907893A (pt) * | 1998-02-13 | 2000-11-14 | Pfizer Prod Inc | Gene de streptomyces avermitilis que dirige a proporção de avermectinas b2:b1 |
-
1999
- 1999-01-25 BR BR9907893-7A patent/BR9907893A/pt not_active Application Discontinuation
- 1999-01-25 HU HU0100784A patent/HUP0100784A3/hu not_active Application Discontinuation
- 1999-01-25 EP EP99900270A patent/EP1053335A1/en not_active Withdrawn
- 1999-01-25 KR KR10-2004-7015691A patent/KR20040099389A/ko active Search and Examination
- 1999-01-25 YU YU50900A patent/YU50900A/sh unknown
- 1999-01-25 KR KR10-2000-7008870A patent/KR100499214B1/ko not_active IP Right Cessation
- 1999-01-25 NZ NZ505676A patent/NZ505676A/xx unknown
- 1999-01-25 KR KR10-2004-7008310A patent/KR20040053390A/ko active Search and Examination
- 1999-01-25 PL PL99342468A patent/PL194270B1/pl not_active IP Right Cessation
- 1999-01-25 CN CNA2004100054154A patent/CN1521180A/zh active Pending
- 1999-01-25 WO PCT/IB1999/000130 patent/WO1999041389A1/en not_active Application Discontinuation
- 1999-01-25 JP JP2000531570A patent/JP2002503473A/ja active Pending
- 1999-01-25 NZ NZ518657A patent/NZ518657A/en unknown
- 1999-01-25 CN CN99805027A patent/CN1297485A/zh active Pending
- 1999-01-25 IL IL13761099A patent/IL137610A0/xx unknown
- 1999-01-25 SK SK1172-2000A patent/SK11722000A3/sk unknown
- 1999-01-25 CA CA002521289A patent/CA2521289A1/en not_active Abandoned
- 1999-01-25 CA CA002320031A patent/CA2320031A1/en not_active Abandoned
- 1999-01-25 EA EA200000758A patent/EA003905B1/ru not_active IP Right Cessation
- 1999-01-25 AU AU18878/99A patent/AU752343C/en not_active Ceased
- 1999-01-26 PA PA19998467601A patent/PA8467601A1/es unknown
- 1999-02-01 GT GT199900014A patent/GT199900014A/es unknown
- 1999-02-05 HN HN1991000008A patent/HN1999000008A/es unknown
- 1999-02-08 PE PE1999000099A patent/PE20000352A1/es not_active Application Discontinuation
- 1999-02-09 TW TW088102005A patent/TW585910B/zh active
- 1999-02-10 TN TNTNSN99017A patent/TNSN99017A1/fr unknown
- 1999-02-10 MA MA25460A patent/MA24760A1/fr unknown
- 1999-02-10 DZ DZ990021A patent/DZ2720A1/xx active
- 1999-02-11 AR ARP990100571A patent/AR018085A1/es unknown
- 1999-02-11 AP APAP/P/1999/001463A patent/AP9901463A0/en unknown
- 1999-02-12 CO CO99008652A patent/CO5070698A1/es unknown
- 1999-02-12 ZA ZA9901138A patent/ZA991138B/xx unknown
-
2000
- 2000-07-20 IS IS5567A patent/IS5567A/is unknown
- 2000-08-04 OA OA1200000217A patent/OA11449A/en unknown
- 2000-08-11 NO NO20004044A patent/NO20004044L/no not_active Application Discontinuation
- 2000-08-11 HR HR20000539A patent/HRP20000539A2/hr not_active Application Discontinuation
- 2000-09-12 BG BG104759A patent/BG64911B1/bg unknown
-
2004
- 2004-04-27 JP JP2004130624A patent/JP4011036B2/ja not_active Expired - Fee Related
-
2007
- 2007-05-31 IL IL183596A patent/IL183596A0/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111269296A (zh) * | 2020-03-06 | 2020-06-12 | 山东大学 | 一种nLsA蛋白及其结构基因和应用 |
| CN111269296B (zh) * | 2020-03-06 | 2021-11-05 | 山东大学 | 一种nLsA蛋白及其结构基因和应用 |
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Legal Events
| Date | Code | Title | Description |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |