CN1486698A - 含有二甲双胍和格列本脲的固体口服剂型 - Google Patents

含有二甲双胍和格列本脲的固体口服剂型 Download PDF

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Publication number
CN1486698A
CN1486698A CNA031092314A CN03109231A CN1486698A CN 1486698 A CN1486698 A CN 1486698A CN A031092314 A CNA031092314 A CN A031092314A CN 03109231 A CN03109231 A CN 03109231A CN 1486698 A CN1486698 A CN 1486698A
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CN
China
Prior art keywords
glibenclamide
dosage form
solid oral
metformin
oral dosage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA031092314A
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English (en)
Chinese (zh)
Inventor
Y�����ķ
Y·伯赫姆
�������ɭ
G·尼克尔森
G·卡维
S·J·尼克尔森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
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Merck Sante SAS
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8235441&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1486698(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sante SAS filed Critical Merck Sante SAS
Publication of CN1486698A publication Critical patent/CN1486698A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA031092314A 1998-07-15 1999-07-12 含有二甲双胍和格列本脲的固体口服剂型 Pending CN1486698A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98401781A EP0974356B1 (en) 1998-07-15 1998-07-15 Tablets comprising a combination of metformin and glibenclamide
EP98401781.4 1998-07-15

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB998013625A Division CN1146427C (zh) 1998-07-15 1999-07-12 含有二甲双胍和格列本脲的固体口服剂型

Publications (1)

Publication Number Publication Date
CN1486698A true CN1486698A (zh) 2004-04-07

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ID=8235441

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA031092314A Pending CN1486698A (zh) 1998-07-15 1999-07-12 含有二甲双胍和格列本脲的固体口服剂型
CNB998013625A Expired - Lifetime CN1146427C (zh) 1998-07-15 1999-07-12 含有二甲双胍和格列本脲的固体口服剂型

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB998013625A Expired - Lifetime CN1146427C (zh) 1998-07-15 1999-07-12 含有二甲双胍和格列本脲的固体口服剂型

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Country Link
US (2) US6303146B1 (cg-RX-API-DMAC7.html)
EP (4) EP0974356B1 (cg-RX-API-DMAC7.html)
JP (2) JP2002520371A (cg-RX-API-DMAC7.html)
KR (2) KR100478347B1 (cg-RX-API-DMAC7.html)
CN (2) CN1486698A (cg-RX-API-DMAC7.html)
AP (1) AP1450A (cg-RX-API-DMAC7.html)
AR (2) AR013052A1 (cg-RX-API-DMAC7.html)
AT (1) ATE250418T1 (cg-RX-API-DMAC7.html)
AU (2) AU753604B2 (cg-RX-API-DMAC7.html)
BR (1) BR9906600A (cg-RX-API-DMAC7.html)
CA (1) CA2303537C (cg-RX-API-DMAC7.html)
DE (1) DE69818444T2 (cg-RX-API-DMAC7.html)
DK (1) DK0974356T3 (cg-RX-API-DMAC7.html)
DZ (1) DZ2846A1 (cg-RX-API-DMAC7.html)
ES (1) ES2206868T3 (cg-RX-API-DMAC7.html)
ID (1) ID25784A (cg-RX-API-DMAC7.html)
MA (1) MA24930A1 (cg-RX-API-DMAC7.html)
MY (1) MY129552A (cg-RX-API-DMAC7.html)
NZ (1) NZ503248A (cg-RX-API-DMAC7.html)
OA (1) OA11400A (cg-RX-API-DMAC7.html)
PT (1) PT974356E (cg-RX-API-DMAC7.html)
RU (2) RU2226396C2 (cg-RX-API-DMAC7.html)
SI (1) SI0974356T1 (cg-RX-API-DMAC7.html)
TW (2) TWI245632B (cg-RX-API-DMAC7.html)
UY (1) UY25611A1 (cg-RX-API-DMAC7.html)
WO (1) WO2000003742A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200001159B (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN101094657B (zh) * 2004-12-31 2012-01-04 韩美药品株式会社 用于糖尿病药物的口服给药的控释复合制剂及其制备方法

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ATE390140T1 (de) * 1999-11-03 2008-04-15 Bristol Myers Squibb Co Arzneimittel, umfassend eine kombination aus metformin und glibenclamide
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JPWO2004091661A1 (ja) * 2003-04-15 2006-07-06 中外製薬株式会社 糖尿病治療剤
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CN100341495C (zh) * 2004-12-29 2007-10-10 三九医药股份有限公司 格列本脲固体分散体、口服组合物及其制备方法
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WO2008062273A2 (en) * 2006-11-20 2008-05-29 Cadila Pharmaceuticals Limited Solid oral dosage form having antidiabetic drug combination
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US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
WO2011135106A1 (es) * 2010-04-26 2011-11-03 Smart Pharma Solutions, S.L Granulado altamente dispersable para la preparación de formulaciones de sustancias activas de altas dosis y procedimiento de obtención del mismo
RU2451506C1 (ru) 2011-06-02 2012-05-27 Сергей Юрьевич Лешков Комбинация для лечения сахарного диабета и его осложнений
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CN104127424A (zh) * 2014-07-30 2014-11-05 沈阳药科大学 格列本脲衍生物及其制备方法和应用
CN105030793A (zh) * 2015-08-25 2015-11-11 瑞阳制药有限公司 二甲双胍格列本脲胶囊及其制备方法
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CN115461344B (zh) 2020-04-01 2024-01-12 杭州中美华东制药有限公司 一种glp-1受体激动剂的晶型a及其制备方法
WO2021196951A1 (zh) 2020-04-01 2021-10-07 杭州中美华东制药有限公司 Glp-1受体激动剂游离碱的药学上可接受的酸式盐及其制备方法
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CN113143940A (zh) * 2020-12-30 2021-07-23 成都恒瑞制药有限公司 一种抗糖尿病药物组合物的制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101094657B (zh) * 2004-12-31 2012-01-04 韩美药品株式会社 用于糖尿病药物的口服给药的控释复合制剂及其制备方法

Also Published As

Publication number Publication date
BR9906600A (pt) 2000-07-18
DZ2846A1 (fr) 2003-12-01
AP1450A (en) 2005-07-25
EP2269613A2 (en) 2011-01-05
AU753604B2 (en) 2002-10-24
SI0974356T1 (en) 2003-12-31
EP2269613A3 (en) 2012-10-17
KR20040053177A (ko) 2004-06-23
ATE250418T1 (de) 2003-10-15
ID25784A (id) 2000-11-02
CN1146427C (zh) 2004-04-21
EP1011684A2 (en) 2000-06-28
RU2226396C2 (ru) 2004-04-10
WO2000003742A2 (en) 2000-01-27
TW200303208A (en) 2003-09-01
DE69818444D1 (de) 2003-10-30
AU2003261560A1 (en) 2005-05-26
MY129552A (en) 2007-04-30
KR100478347B1 (ko) 2005-03-23
WO2000003742A3 (en) 2000-04-20
US6303146B1 (en) 2001-10-16
AR013052A1 (es) 2000-11-22
DE69818444T2 (de) 2004-05-06
JP2003292443A (ja) 2003-10-15
CN1275082A (zh) 2000-11-29
TW555560B (en) 2003-10-01
NZ503248A (en) 2002-09-27
RU2003126257A (ru) 2005-02-27
AR065970A2 (es) 2009-07-15
PT974356E (pt) 2004-02-27
UY25611A1 (es) 2000-08-21
EP1435240A3 (en) 2009-08-12
TWI245632B (en) 2005-12-21
RU2286788C2 (ru) 2006-11-10
DK0974356T3 (da) 2003-10-27
ZA200001159B (en) 2001-05-31
AP2000001757A0 (en) 2000-03-31
USRE38629E1 (en) 2004-10-19
EP1435240A2 (en) 2004-07-07
CA2303537A1 (en) 2000-01-27
EP0974356B1 (en) 2003-09-24
MA24930A1 (fr) 2000-04-01
EP0974356A1 (en) 2000-01-26
OA11400A (en) 2004-04-08
JP2002520371A (ja) 2002-07-09
AU5417999A (en) 2000-02-07
ES2206868T3 (es) 2004-05-16
KR20010030603A (ko) 2001-04-16
CA2303537C (en) 2005-12-06

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