AP1450A - Solid oral dosage form comprising a combination of metformin and glibenclamide. - Google Patents

Solid oral dosage form comprising a combination of metformin and glibenclamide.

Info

Publication number
AP1450A
AP1450A APAP/P/2000/001757A AP2000001757A AP1450A AP 1450 A AP1450 A AP 1450A AP 2000001757 A AP2000001757 A AP 2000001757A AP 1450 A AP1450 A AP 1450A
Authority
AP
ARIPO
Prior art keywords
glibenclamide
metformin
combination
dosage form
oral dosage
Prior art date
Application number
APAP/P/2000/001757A
Other languages
English (en)
Other versions
AP2000001757A0 (en
Inventor
Yves Bonhomme
Geoffrey Nicholson
Gillian Cave
Sarah J Nicholson
Original Assignee
Merck Sante Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8235441&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP1450(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sante Sas filed Critical Merck Sante Sas
Publication of AP2000001757A0 publication Critical patent/AP2000001757A0/xx
Application granted granted Critical
Publication of AP1450A publication Critical patent/AP1450A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
APAP/P/2000/001757A 1998-07-15 1999-07-12 Solid oral dosage form comprising a combination of metformin and glibenclamide. AP1450A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98401781A EP0974356B1 (en) 1998-07-15 1998-07-15 Tablets comprising a combination of metformin and glibenclamide
PCT/EP1999/005571 WO2000003742A2 (en) 1998-07-15 1999-07-12 Solid oral dosage form comprising a combination of metformin and glibenclamide

Publications (2)

Publication Number Publication Date
AP2000001757A0 AP2000001757A0 (en) 2000-03-31
AP1450A true AP1450A (en) 2005-07-25

Family

ID=8235441

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/2000/001757A AP1450A (en) 1998-07-15 1999-07-12 Solid oral dosage form comprising a combination of metformin and glibenclamide.

Country Status (27)

Country Link
US (2) US6303146B1 (cg-RX-API-DMAC7.html)
EP (4) EP0974356B1 (cg-RX-API-DMAC7.html)
JP (2) JP2002520371A (cg-RX-API-DMAC7.html)
KR (2) KR100478347B1 (cg-RX-API-DMAC7.html)
CN (2) CN1486698A (cg-RX-API-DMAC7.html)
AP (1) AP1450A (cg-RX-API-DMAC7.html)
AR (2) AR013052A1 (cg-RX-API-DMAC7.html)
AT (1) ATE250418T1 (cg-RX-API-DMAC7.html)
AU (2) AU753604B2 (cg-RX-API-DMAC7.html)
BR (1) BR9906600A (cg-RX-API-DMAC7.html)
CA (1) CA2303537C (cg-RX-API-DMAC7.html)
DE (1) DE69818444T2 (cg-RX-API-DMAC7.html)
DK (1) DK0974356T3 (cg-RX-API-DMAC7.html)
DZ (1) DZ2846A1 (cg-RX-API-DMAC7.html)
ES (1) ES2206868T3 (cg-RX-API-DMAC7.html)
ID (1) ID25784A (cg-RX-API-DMAC7.html)
MA (1) MA24930A1 (cg-RX-API-DMAC7.html)
MY (1) MY129552A (cg-RX-API-DMAC7.html)
NZ (1) NZ503248A (cg-RX-API-DMAC7.html)
OA (1) OA11400A (cg-RX-API-DMAC7.html)
PT (1) PT974356E (cg-RX-API-DMAC7.html)
RU (2) RU2226396C2 (cg-RX-API-DMAC7.html)
SI (1) SI0974356T1 (cg-RX-API-DMAC7.html)
TW (2) TWI245632B (cg-RX-API-DMAC7.html)
UY (1) UY25611A1 (cg-RX-API-DMAC7.html)
WO (1) WO2000003742A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200001159B (cg-RX-API-DMAC7.html)

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US6586438B2 (en) 1999-11-03 2003-07-01 Bristol-Myers Squibb Co. Antidiabetic formulation and method
ATE390140T1 (de) * 1999-11-03 2008-04-15 Bristol Myers Squibb Co Arzneimittel, umfassend eine kombination aus metformin und glibenclamide
US20010036479A1 (en) 2000-01-14 2001-11-01 Gillian Cave Glyburide composition
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FR2816841B1 (fr) * 2000-11-22 2004-02-06 Lipha Nouvelles compositions pharmaceutiques a action antidiabetique et leur procede de preparation
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FR2825023B1 (fr) * 2001-05-23 2005-04-15 Flamel Tech Sa Forme pharmaceutique orale antidiabetique "une prise par jour"comprenant une biguanide et au moins un autre principe actif
US20050271737A1 (en) * 2001-06-07 2005-12-08 Chinea Vanessa I Application of a bioactive agent to a substrate
US7767249B2 (en) * 2001-06-07 2010-08-03 Hewlett-Packard Development Company, L.P. Preparation of nanoparticles
US8206753B2 (en) * 2001-06-20 2012-06-26 Metaproteomics, Llc Anti-inflammatory botanical products for the treatment of metabolic syndrome and diabetes
DE60223551T2 (de) 2001-07-30 2008-10-23 Mitsubishi Pharma Corp. Mittel zu linderung von hyperglykämie nach dem essen
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
ITFI20010230A1 (it) * 2001-11-29 2003-05-29 Menarini Int Operations Lu Sa Composizioni farmaceutiche per il trattamento del diabete mellito di tipo ii
US7183321B2 (en) * 2001-12-17 2007-02-27 Bristol-Myers Squibb Company Antidiabetic formulation and method
ES2284829T3 (es) * 2002-01-25 2007-11-16 Laboratorios Silanes, S.A. De C.V. Composicion farmaceutica que se usa para controlar la glucosa en sangre en pacientes con diabetes de tipo 2.
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MXPA04009968A (es) 2002-04-09 2004-12-13 Flamel Tech Sa Formulacion farmaceutica oral bajo forma de suspension acuosa de microcapsulas que permiten la liberacion modificada de principio (s) activo (s).
KR20050005437A (ko) 2002-04-09 2005-01-13 플라멜 테크놀로지스 아목시실린의 변형 방출을 위한 마이크로캡슐 수성 현탁액형태의 경구 제약학적 제제
KR100897890B1 (ko) 2002-06-17 2009-05-18 인벤티아 헬스케어 피브이티. 엘티디. 티아졸리딘디온 및 바이구아나이드를 함유하는 다층 정제및 그의 제조 방법
US7445796B2 (en) * 2002-08-19 2008-11-04 L. Perrigo Company Pharmaceutically active particles of a monomodal particle size distribution and method
AU2003276572A1 (en) * 2002-11-15 2004-06-15 Ranbaxy Laboratories Limited Pharmaceutical dosage forms of biguanide-sulfonylurea combinations
FR2853831A1 (fr) * 2003-03-05 2004-10-22 Usv Ltd Forme posologique solide a usage oral de metformine et de glyburide et son procede de preparation
JPWO2004091661A1 (ja) * 2003-04-15 2006-07-06 中外製薬株式会社 糖尿病治療剤
US20060121108A1 (en) * 2004-12-02 2006-06-08 Prasad C K System and method for producing a directly compressible, high-potency formulation of metformin hydrochloride
CN100341495C (zh) * 2004-12-29 2007-10-10 三九医药股份有限公司 格列本脲固体分散体、口服组合物及其制备方法
KR100760430B1 (ko) * 2004-12-31 2007-10-04 한미약품 주식회사 당뇨병 치료제의 경구 투여용 서방성 복합 제제 및 이의제조 방법
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WO2008062273A2 (en) * 2006-11-20 2008-05-29 Cadila Pharmaceuticals Limited Solid oral dosage form having antidiabetic drug combination
CN101801351B (zh) 2007-07-19 2012-12-12 武田药品工业株式会社 包含阿格列汀和盐酸二甲双胍的固体制剂
SI2489731T1 (sl) 2007-07-26 2014-12-31 Amgen Inc. Patent Operations, M/S 28-2-C Modificirani encimi lecitin-holesterol aciltransferaze
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
WO2011135106A1 (es) * 2010-04-26 2011-11-03 Smart Pharma Solutions, S.L Granulado altamente dispersable para la preparación de formulaciones de sustancias activas de altas dosis y procedimiento de obtención del mismo
RU2451506C1 (ru) 2011-06-02 2012-05-27 Сергей Юрьевич Лешков Комбинация для лечения сахарного диабета и его осложнений
CA2858572C (en) 2011-12-08 2023-01-17 Amgen Inc. Human lcat antigen binding proteins and their use in therapy
CA2859174C (en) * 2011-12-12 2019-03-05 Orbis Biosciences, Inc. Sustained release particle formulations
CN104127424A (zh) * 2014-07-30 2014-11-05 沈阳药科大学 格列本脲衍生物及其制备方法和应用
CN105030793A (zh) * 2015-08-25 2015-11-11 瑞阳制药有限公司 二甲双胍格列本脲胶囊及其制备方法
WO2019070109A1 (es) * 2017-10-03 2019-04-11 Infinite Clinical Research International, S.A. De C.V. Triconjugado para el tratamiento de diabetes mellitus
CN115461344B (zh) 2020-04-01 2024-01-12 杭州中美华东制药有限公司 一种glp-1受体激动剂的晶型a及其制备方法
WO2021196951A1 (zh) 2020-04-01 2021-10-07 杭州中美华东制药有限公司 Glp-1受体激动剂游离碱的药学上可接受的酸式盐及其制备方法
KR102484756B1 (ko) * 2020-11-13 2023-01-06 한국생산기술연구원 용해성 증대 및 취급용이성을 갖는 파우더 배지의 과립화 방법
CN113143940A (zh) * 2020-12-30 2021-07-23 成都恒瑞制药有限公司 一种抗糖尿病药物组合物的制备方法

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WO1997017975A1 (en) * 1995-11-14 1997-05-22 Abiogen Pharma S.R.L. A glibenclamide-metformin combination for the treatment of diabetes mellitus of type ii

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Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US4060634A (en) * 1973-09-26 1977-11-29 Boehringer Mannheim G.M.B.H. Rapidly resorbable glibenclamide
WO1997017975A1 (en) * 1995-11-14 1997-05-22 Abiogen Pharma S.R.L. A glibenclamide-metformin combination for the treatment of diabetes mellitus of type ii

Also Published As

Publication number Publication date
BR9906600A (pt) 2000-07-18
DZ2846A1 (fr) 2003-12-01
EP2269613A2 (en) 2011-01-05
AU753604B2 (en) 2002-10-24
SI0974356T1 (en) 2003-12-31
EP2269613A3 (en) 2012-10-17
KR20040053177A (ko) 2004-06-23
ATE250418T1 (de) 2003-10-15
ID25784A (id) 2000-11-02
CN1146427C (zh) 2004-04-21
EP1011684A2 (en) 2000-06-28
RU2226396C2 (ru) 2004-04-10
WO2000003742A2 (en) 2000-01-27
TW200303208A (en) 2003-09-01
DE69818444D1 (de) 2003-10-30
AU2003261560A1 (en) 2005-05-26
MY129552A (en) 2007-04-30
KR100478347B1 (ko) 2005-03-23
WO2000003742A3 (en) 2000-04-20
US6303146B1 (en) 2001-10-16
AR013052A1 (es) 2000-11-22
DE69818444T2 (de) 2004-05-06
JP2003292443A (ja) 2003-10-15
CN1275082A (zh) 2000-11-29
TW555560B (en) 2003-10-01
NZ503248A (en) 2002-09-27
RU2003126257A (ru) 2005-02-27
AR065970A2 (es) 2009-07-15
PT974356E (pt) 2004-02-27
UY25611A1 (es) 2000-08-21
EP1435240A3 (en) 2009-08-12
TWI245632B (en) 2005-12-21
RU2286788C2 (ru) 2006-11-10
DK0974356T3 (da) 2003-10-27
ZA200001159B (en) 2001-05-31
CN1486698A (zh) 2004-04-07
AP2000001757A0 (en) 2000-03-31
USRE38629E1 (en) 2004-10-19
EP1435240A2 (en) 2004-07-07
CA2303537A1 (en) 2000-01-27
EP0974356B1 (en) 2003-09-24
MA24930A1 (fr) 2000-04-01
EP0974356A1 (en) 2000-01-26
OA11400A (en) 2004-04-08
JP2002520371A (ja) 2002-07-09
AU5417999A (en) 2000-02-07
ES2206868T3 (es) 2004-05-16
KR20010030603A (ko) 2001-04-16
CA2303537C (en) 2005-12-06

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