UY25611A1 - Formas solidas de dosificacion oral para el tratamiento de diabetes no dependiente de insulina - Google Patents
Formas solidas de dosificacion oral para el tratamiento de diabetes no dependiente de insulinaInfo
- Publication number
- UY25611A1 UY25611A1 UY25611A UY25611A UY25611A1 UY 25611 A1 UY25611 A1 UY 25611A1 UY 25611 A UY25611 A UY 25611A UY 25611 A UY25611 A UY 25611A UY 25611 A1 UY25611 A1 UY 25611A1
- Authority
- UY
- Uruguay
- Prior art keywords
- glibenclamide
- metformin
- oral dosage
- micrometers
- particles
- Prior art date
Links
- 239000007787 solid Substances 0.000 title abstract 3
- 239000006186 oral dosage form Substances 0.000 title abstract 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title 1
- 229960004580 glibenclamide Drugs 0.000 abstract 9
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 abstract 9
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 abstract 6
- 229960003105 metformin Drugs 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 3
- 239000002245 particle Substances 0.000 abstract 3
- SODPIMGUZLOIPE-UHFFFAOYSA-N (4-chlorophenoxy)acetic acid Chemical compound OC(=O)COC1=CC=C(Cl)C=C1 SODPIMGUZLOIPE-UHFFFAOYSA-N 0.000 abstract 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 229950005627 embonate Drugs 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 238000001033 granulometry Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
- 238000005550 wet granulation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a una forma sólida de dosificación oral que comprende una combinación de metformina y glibenclamida (también denominada gliburida) en que la granulometría de la glibenclamida es tal que la biodisponibilidad de glibenclamida es comparable a la biodisponibilidad de glibenclamida obtenida con un administración separada de metformina y glibenclamida. La metformina puede ser utilizada como sal de metformina, tal como clorhidrato, fumarato, bromhidrato, p-clorofenoxi acetato o embonato. La relación ponderal de sal de metformina a glibenclamida preferiblemente será entre 50:1 a 250:1. En una primera realización la forma sólida de administarción oral contienen la combinación de estos principios activos en donde el tamano de la glibenclamida es tal que como máximo 10% de las partículas son menores a 2 micrometros y como máximo 10% de las partículas son mayores a 60 micrometros. Preferiblemente, el 50% de las partículas tienen tamano menor a 23 micrometros. La tableta según la presente invención pueder ser obtenida por un método que comprende: a) formar gránulos por granulación vía húmeda con una mezcla de metformina y glibenclamida; b) mezclas los gránulos con un auxiliar de tabletado y diluyente y c) comprimir la mezcla en tabletas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98401781A EP0974356B1 (en) | 1998-07-15 | 1998-07-15 | Tablets comprising a combination of metformin and glibenclamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY25611A1 true UY25611A1 (es) | 2000-08-21 |
Family
ID=8235441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY25611A UY25611A1 (es) | 1998-07-15 | 1999-07-15 | Formas solidas de dosificacion oral para el tratamiento de diabetes no dependiente de insulina |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US6303146B1 (es) |
| EP (4) | EP0974356B1 (es) |
| JP (2) | JP2002520371A (es) |
| KR (2) | KR100478347B1 (es) |
| CN (2) | CN1146427C (es) |
| AP (1) | AP1450A (es) |
| AR (2) | AR013052A1 (es) |
| AT (1) | ATE250418T1 (es) |
| AU (2) | AU753604B2 (es) |
| BR (1) | BR9906600A (es) |
| CA (1) | CA2303537C (es) |
| DE (1) | DE69818444T2 (es) |
| DK (1) | DK0974356T3 (es) |
| DZ (1) | DZ2846A1 (es) |
| ES (1) | ES2206868T3 (es) |
| ID (1) | ID25784A (es) |
| MA (1) | MA24930A1 (es) |
| MY (1) | MY129552A (es) |
| NZ (1) | NZ503248A (es) |
| OA (1) | OA11400A (es) |
| PT (1) | PT974356E (es) |
| RU (2) | RU2286788C2 (es) |
| SI (1) | SI0974356T1 (es) |
| TW (2) | TWI245632B (es) |
| UY (1) | UY25611A1 (es) |
| WO (1) | WO2000003742A2 (es) |
| ZA (1) | ZA200001159B (es) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040102486A1 (en) * | 1998-11-12 | 2004-05-27 | Smithkline Beecham Corporation | Novel method of treatment |
| US20040081697A1 (en) * | 1998-11-12 | 2004-04-29 | Smithkline Beecham P.L.C. | Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent |
| BR0015294A (pt) | 1999-11-03 | 2003-07-15 | Bristol Myers Squibb Co | Método para tratamento da diabetes |
| US6586438B2 (en) * | 1999-11-03 | 2003-07-01 | Bristol-Myers Squibb Co. | Antidiabetic formulation and method |
| US20010036479A1 (en) | 2000-01-14 | 2001-11-01 | Gillian Cave | Glyburide composition |
| FR2816840B1 (fr) | 2000-11-17 | 2004-04-09 | Flamel Tech Sa | Medicament a base de microcapsules d'anti-hyperclycemiant a liberation prolongee et son procede de preparation |
| FR2816841B1 (fr) * | 2000-11-22 | 2004-02-06 | Lipha | Nouvelles compositions pharmaceutiques a action antidiabetique et leur procede de preparation |
| WO2002055009A1 (en) * | 2001-01-12 | 2002-07-18 | Sun Pharmaceutical Industries Limited | Spaced drug delivery system |
| FR2825023B1 (fr) * | 2001-05-23 | 2005-04-15 | Flamel Tech Sa | Forme pharmaceutique orale antidiabetique "une prise par jour"comprenant une biguanide et au moins un autre principe actif |
| US20050271737A1 (en) * | 2001-06-07 | 2005-12-08 | Chinea Vanessa I | Application of a bioactive agent to a substrate |
| US7767249B2 (en) * | 2001-06-07 | 2010-08-03 | Hewlett-Packard Development Company, L.P. | Preparation of nanoparticles |
| US8206753B2 (en) * | 2001-06-20 | 2012-06-26 | Metaproteomics, Llc | Anti-inflammatory botanical products for the treatment of metabolic syndrome and diabetes |
| ES2295369T3 (es) * | 2001-07-30 | 2008-04-16 | Mitsubishi Pharma Corporation | Farmacos para mejorar la hiperglucemia postcibal. |
| US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| ITFI20010230A1 (it) * | 2001-11-29 | 2003-05-29 | Menarini Int Operations Lu Sa | Composizioni farmaceutiche per il trattamento del diabete mellito di tipo ii |
| US7183321B2 (en) * | 2001-12-17 | 2007-02-27 | Bristol-Myers Squibb Company | Antidiabetic formulation and method |
| ES2284829T3 (es) * | 2002-01-25 | 2007-11-16 | Laboratorios Silanes, S.A. De C.V. | Composicion farmaceutica que se usa para controlar la glucosa en sangre en pacientes con diabetes de tipo 2. |
| NZ535456A (en) * | 2002-02-21 | 2006-08-31 | Biovail Lab Int Srl | Modified release formulations of at least one form of tramadol for oral administration |
| US20030187074A1 (en) * | 2002-03-04 | 2003-10-02 | Javed Hussain | Oral compositions for treatment of diabetes |
| US20030219482A1 (en) * | 2002-03-21 | 2003-11-27 | Chaudhari Sunil Sudhakar | Multiparticulate compositions for once-a-day administration |
| IL164221A0 (en) | 2002-04-09 | 2005-12-18 | Flamel Tech Sa | Oral pharmaceutical formulation in the form of aqueous suspension of microcapsules for modified release of amoxicillim |
| CA2480826C (fr) | 2002-04-09 | 2012-02-07 | Flamel Technologies | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s) |
| KR100897890B1 (ko) | 2002-06-17 | 2009-05-18 | 인벤티아 헬스케어 피브이티. 엘티디. | 티아졸리딘디온 및 바이구아나이드를 함유하는 다층 정제및 그의 제조 방법 |
| US7445796B2 (en) * | 2002-08-19 | 2008-11-04 | L. Perrigo Company | Pharmaceutically active particles of a monomodal particle size distribution and method |
| CN1729005A (zh) * | 2002-11-15 | 2006-02-01 | 兰贝克赛实验室有限公司 | 含双胍－磺酰脲类组合的药物剂型 |
| FR2853831A1 (fr) * | 2003-03-05 | 2004-10-22 | Usv Ltd | Forme posologique solide a usage oral de metformine et de glyburide et son procede de preparation |
| TW200507875A (en) * | 2003-04-15 | 2005-03-01 | Chugai Pharmaceutical Co Ltd | Remedy for diabetes |
| US20060121108A1 (en) * | 2004-12-02 | 2006-06-08 | Prasad C K | System and method for producing a directly compressible, high-potency formulation of metformin hydrochloride |
| CN100341495C (zh) * | 2004-12-29 | 2007-10-10 | 三九医药股份有限公司 | 格列本脲固体分散体、口服组合物及其制备方法 |
| KR100760430B1 (ko) * | 2004-12-31 | 2007-10-04 | 한미약품 주식회사 | 당뇨병 치료제의 경구 투여용 서방성 복합 제제 및 이의제조 방법 |
| PE20061245A1 (es) * | 2005-03-30 | 2007-01-06 | Generex Pharm Inc | Composiciones para la transmision transmucosa oral de la metformina |
| US8529537B2 (en) * | 2005-08-05 | 2013-09-10 | Kimberly-Clark Worldwide, Inc. | Absorbent article with enclosures |
| MXPA05009633A (es) * | 2005-09-08 | 2007-03-07 | Silanes Sa De Cv Lab | Composicion farmaceutica estable de glimepirida de liberacion inmediata y metformina de liberacion prolongada. |
| US20080096900A1 (en) | 2006-06-26 | 2008-04-24 | Amgen Inc. | Methods for treating atherosclerosis |
| WO2008062273A2 (en) * | 2006-11-20 | 2008-05-29 | Cadila Pharmaceuticals Limited | Solid oral dosage form having antidiabetic drug combination |
| MY159203A (en) | 2007-07-19 | 2016-12-30 | Takeda Pharmaceuticals Co | Solid preparation comprising alogliptin and metformin hydrochloride |
| ES2449483T3 (es) | 2007-07-26 | 2014-03-19 | Amgen, Inc | Enzimas lecitina-colesterol aciltransferasa modificadas |
| US20110009347A1 (en) | 2009-07-08 | 2011-01-13 | Yin Liang | Combination therapy for the treatment of diabetes |
| US20130108699A1 (en) * | 2010-04-26 | 2013-05-02 | Jose Antonio Matji Tuduri | Highly dispersible granulate for the preparation of formulations of high dosage active substances and procedure for obtaining high dosage active substances thereof |
| RU2451506C1 (ru) | 2011-06-02 | 2012-05-27 | Сергей Юрьевич Лешков | Комбинация для лечения сахарного диабета и его осложнений |
| EP2788384B1 (en) | 2011-12-08 | 2017-08-09 | Amgen Inc. | Agonistic human lcat antigen binding proteins and their use in therapy |
| CN104127424A (zh) * | 2014-07-30 | 2014-11-05 | 沈阳药科大学 | 格列本脲衍生物及其制备方法和应用 |
| CN105030793A (zh) * | 2015-08-25 | 2015-11-11 | 瑞阳制药有限公司 | 二甲双胍格列本脲胶囊及其制备方法 |
| WO2019070109A1 (es) * | 2017-10-03 | 2019-04-11 | Infinite Clinical Research International, S.A. De C.V. | Triconjugado para el tratamiento de diabetes mellitus |
| KR102484756B1 (ko) * | 2020-11-13 | 2023-01-06 | 한국생산기술연구원 | 용해성 증대 및 취급용이성을 갖는 파우더 배지의 과립화 방법 |
| CN113143940A (zh) * | 2020-12-30 | 2021-07-23 | 成都恒瑞制药有限公司 | 一种抗糖尿病药物组合物的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE362704C (de) * | 1921-08-09 | 1922-11-02 | Naamlooze Vennootschap Interna | Vorrichtung zum Senken einer Last, insbesondere eines Rettungsbootes |
| US3174901A (en) | 1963-01-31 | 1965-03-23 | Jan Marcel Didier Aron Samuel | Process for the oral treatment of diabetes |
| DE2348334C2 (de) | 1973-09-26 | 1982-11-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue Zubereitungsform des N-4-[2-(5-Chlor-2-methoxybenzamido)äthyl]- phenyl-sulfonyl-N'-cyclohexylharnstoffs |
| US4060634A (en) * | 1973-09-26 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Rapidly resorbable glibenclamide |
| US4916163A (en) | 1985-06-04 | 1990-04-10 | The Upjohn Company | Spray-dried lactose formulation of micronized glyburide |
| DE3833439A1 (de) | 1988-10-01 | 1991-09-12 | Hoechst Ag | Verfahren zur mikronisierung von glibenclamid |
| DK36392D0 (da) | 1992-03-19 | 1992-03-19 | Novo Nordisk As | Anvendelse af kemisk forbindelse |
| DE4323636A1 (de) | 1993-07-15 | 1995-01-19 | Hoechst Ag | Arzneistoffzubereitungen aus umhüllten, schwerstwasserlöslichen Arzneistoffen für Inhalationsarzneiformen und Verfahren zu ihrer Herstellung |
| TW438587B (en) | 1995-06-20 | 2001-06-07 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| IT1276130B1 (it) * | 1995-11-14 | 1997-10-27 | Gentili Ist Spa | Associazione glibenclamide-metformina, composizioni farmaceutiche che la contengono e loro uso nel trattamento del diabete mellito di tipo |
| AU8539398A (en) | 1997-06-18 | 1999-01-04 | Smithkline Beecham Plc | Treatment of diabetes with thiazolidinedione and metformin |
| US6544564B1 (en) * | 2001-11-27 | 2003-04-08 | Michael Donald Farley | Cytotoxic pharmaceutical composition |
-
1998
- 1998-07-15 DE DE69818444T patent/DE69818444T2/de not_active Revoked
- 1998-07-15 EP EP98401781A patent/EP0974356B1/en not_active Revoked
- 1998-07-15 SI SI9830517T patent/SI0974356T1/xx unknown
- 1998-07-15 ES ES98401781T patent/ES2206868T3/es not_active Expired - Lifetime
- 1998-07-15 PT PT98401781T patent/PT974356E/pt unknown
- 1998-07-15 DK DK98401781T patent/DK0974356T3/da active
- 1998-07-15 AT AT98401781T patent/ATE250418T1/de not_active IP Right Cessation
-
1999
- 1999-07-12 RU RU2003126257/15A patent/RU2286788C2/ru active
- 1999-07-12 CN CNB998013625A patent/CN1146427C/zh not_active Expired - Lifetime
- 1999-07-12 AP APAP/P/2000/001757A patent/AP1450A/en active
- 1999-07-12 BR BR9906600-9A patent/BR9906600A/pt not_active Application Discontinuation
- 1999-07-12 AU AU54179/99A patent/AU753604B2/en not_active Expired
- 1999-07-12 RU RU2000109583/15A patent/RU2226396C2/ru active
- 1999-07-12 JP JP2000559876A patent/JP2002520371A/ja active Pending
- 1999-07-12 KR KR10-2000-7002714A patent/KR100478347B1/ko not_active IP Right Cessation
- 1999-07-12 KR KR10-2004-7005583A patent/KR20040053177A/ko active Search and Examination
- 1999-07-12 CA CA002303537A patent/CA2303537C/en not_active Expired - Lifetime
- 1999-07-12 EP EP10185329A patent/EP2269613A3/en not_active Ceased
- 1999-07-12 ID IDW20000482D patent/ID25784A/id unknown
- 1999-07-12 EP EP99940114A patent/EP1011684A2/en not_active Ceased
- 1999-07-12 EP EP04008415A patent/EP1435240A3/en not_active Ceased
- 1999-07-12 WO PCT/EP1999/005571 patent/WO2000003742A2/en active IP Right Grant
- 1999-07-12 CN CNA031092314A patent/CN1486698A/zh active Pending
- 1999-07-12 NZ NZ503248A patent/NZ503248A/xx not_active IP Right Cessation
- 1999-07-13 MA MA25681A patent/MA24930A1/fr unknown
- 1999-07-14 DZ DZ990146A patent/DZ2846A1/xx active
- 1999-07-14 US US09/353,141 patent/US6303146B1/en not_active Expired - Lifetime
- 1999-07-14 TW TW092113257A patent/TWI245632B/zh not_active IP Right Cessation
- 1999-07-14 MY MYPI99002968A patent/MY129552A/en unknown
- 1999-07-14 TW TW088111959A patent/TW555560B/zh not_active IP Right Cessation
- 1999-07-15 UY UY25611A patent/UY25611A1/es not_active Application Discontinuation
- 1999-07-15 AR ARP990103470A patent/AR013052A1/es not_active Application Discontinuation
-
2000
- 2000-03-07 ZA ZA200001159A patent/ZA200001159B/xx unknown
- 2000-03-15 OA OA1200000076A patent/OA11400A/en unknown
-
2002
- 2002-12-27 US US10/329,426 patent/USRE38629E1/en not_active Expired - Lifetime
-
2003
- 2003-03-31 JP JP2003094873A patent/JP2003292443A/ja active Pending
- 2003-11-11 AU AU2003261560A patent/AU2003261560A1/en not_active Abandoned
-
2008
- 2008-04-07 AR ARP080101435A patent/AR065970A2/es not_active Application Discontinuation
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