MX170641B - Procedimiento para preparar una composicion farmaceutica a base de trimebutina - Google Patents
Procedimiento para preparar una composicion farmaceutica a base de trimebutinaInfo
- Publication number
- MX170641B MX170641B MX018683A MX1868389A MX170641B MX 170641 B MX170641 B MX 170641B MX 018683 A MX018683 A MX 018683A MX 1868389 A MX1868389 A MX 1868389A MX 170641 B MX170641 B MX 170641B
- Authority
- MX
- Mexico
- Prior art keywords
- percent
- trimebutine
- preparing
- pharmaceutical composition
- based pharmaceutical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Fats And Perfumes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a procedimiento de preparar una composición farmacéutica a base de trimebutina, en forma de una comprimido exento de revestimiento que comprende, como principio activo, trimetoxi-3,4,5 benzoato de dimetilamino-2-fenil-2 butanol-1 (trimebutina) de fórmula: o una de sus sales de adición con un ácido farmacéuticamente aceptable, caracterizado porque consiste en dispersar de manera homogenea el principio activo en una matriz poroso hidrófilo de hidroxipropilmetilcelulosa, mezclando dichos componentes con un diluyente hidrosoluble y con ácido tartárico y en comprimir la mezcla para formar un comprimido, eligiendose las condiciones de operación de tal modo que, respecto al peso de la composición, el principio activo represente del 35 al 45 por ciento, la hidroxipropilmetilcelulosa represente del 15 al 20 por ciento, el diluyente hidrosoluble represente del 20 al 25 por ciento y el ácido tartárico represente del 10 al 20 por ciento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8817303A FR2640876B1 (es) | 1988-12-28 | 1988-12-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX170641B true MX170641B (es) | 1993-09-01 |
Family
ID=9373520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX018683A MX170641B (es) | 1988-12-28 | 1989-12-12 | Procedimiento para preparar una composicion farmaceutica a base de trimebutina |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JP2745232B2 (es) |
| KR (1) | KR0137270B1 (es) |
| AT (1) | AT397461B (es) |
| BE (1) | BE1006002A4 (es) |
| CA (1) | CA2006184C (es) |
| DE (1) | DE3942131C2 (es) |
| EG (1) | EG19994A (es) |
| ES (1) | ES2019024A6 (es) |
| FR (1) | FR2640876B1 (es) |
| GR (1) | GR1000429B (es) |
| GT (1) | GT198900080A (es) |
| IT (1) | IT1236239B (es) |
| MX (1) | MX170641B (es) |
| PT (1) | PT92682B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05255125A (ja) * | 1992-02-29 | 1993-10-05 | Upjohn Co:The | 徐放性製剤およびその製法 |
| FR2730163B1 (fr) * | 1995-02-03 | 1997-04-04 | Jouveinal Lab | Nouvelle composition pharmaceutique contenant la trimebutine et son procede de preparation |
| FR2752162B1 (fr) * | 1996-08-07 | 1998-11-06 | Jouveinal Lab | Comprime de maleate de trimebutine pellicule |
| CN1927185B (zh) * | 2006-10-19 | 2010-05-19 | 开开援生制药股份有限公司 | 具速释部分的马来酸曲美布汀缓释片及其制备工艺 |
| KR101051630B1 (ko) * | 2008-10-02 | 2011-07-26 | 한국유나이티드제약 주식회사 | 용출률과 복용편의성이 향상된 트리메부틴 서방정 |
| FR2944971B1 (fr) * | 2009-04-30 | 2012-09-07 | Roquette Freres | Coagglomerats de mannitol et d'amidon granulaire comprimables et a ecoulement libre |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3065143A (en) * | 1960-04-19 | 1962-11-20 | Richardson Merrell Inc | Sustained release tablet |
| JPS57197214A (en) * | 1981-05-29 | 1982-12-03 | Tanabe Seiyaku Co Ltd | Rapid-releasing microcapsule and its preparation |
| JPS5858145A (ja) * | 1981-10-05 | 1983-04-06 | Tanabe Seiyaku Co Ltd | 速放性マイクロカプセル |
| JPS5858146A (ja) * | 1981-10-05 | 1983-04-06 | Tanabe Seiyaku Co Ltd | 速放性マイクロカプセル |
| JPS5916821A (ja) * | 1982-07-16 | 1984-01-28 | Tanabe Seiyaku Co Ltd | 非凝集性マイクロカプセルの製法 |
| IT1206166B (it) * | 1984-07-26 | 1989-04-14 | Sigma Tau Ind Farmaceuti | Dispositivo per rilasciare una sostanza in un fluido di dissoluzione con cinetica di ordine zero e procedimento per la sua preparazione |
| GB8616669D0 (en) * | 1986-07-09 | 1986-08-13 | Merk Sharpe & Dohme Ltd | Pharmaceutical compositions |
-
1988
- 1988-12-28 FR FR8817303A patent/FR2640876B1/fr not_active Expired - Lifetime
-
1989
- 1989-06-22 JP JP1158445A patent/JP2745232B2/ja not_active Expired - Fee Related
- 1989-12-12 MX MX018683A patent/MX170641B/es unknown
- 1989-12-15 BE BE8901343A patent/BE1006002A4/fr not_active IP Right Cessation
- 1989-12-20 DE DE3942131A patent/DE3942131C2/de not_active Expired - Lifetime
- 1989-12-20 IT IT01261589A patent/IT1236239B/it active IP Right Grant
- 1989-12-20 CA CA002006184A patent/CA2006184C/en not_active Expired - Lifetime
- 1989-12-22 PT PT92682A patent/PT92682B/pt not_active IP Right Cessation
- 1989-12-27 AT AT0294489A patent/AT397461B/de not_active IP Right Cessation
- 1989-12-27 GT GT198900080A patent/GT198900080A/es unknown
- 1989-12-27 KR KR1019890019616A patent/KR0137270B1/ko not_active IP Right Cessation
- 1989-12-27 EG EG64189A patent/EG19994A/xx active
- 1989-12-27 GR GR890100860A patent/GR1000429B/el not_active IP Right Cessation
- 1989-12-28 ES ES9000188A patent/ES2019024A6/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| GT198900080A (es) | 1991-06-20 |
| EG19994A (en) | 1997-01-30 |
| KR0137270B1 (ko) | 1998-04-25 |
| PT92682B (pt) | 1997-01-31 |
| IT1236239B (it) | 1993-01-27 |
| JP2745232B2 (ja) | 1998-04-28 |
| AT397461B (de) | 1994-04-25 |
| ATA294489A (de) | 1993-09-15 |
| ES2019024A6 (es) | 1991-05-16 |
| GR1000429B (el) | 1992-07-30 |
| BE1006002A4 (fr) | 1994-04-19 |
| GR890100860A (en) | 1991-03-15 |
| JPH02184624A (ja) | 1990-07-19 |
| CA2006184A1 (en) | 1990-06-28 |
| IT8912615A0 (it) | 1989-12-20 |
| KR900009060A (ko) | 1990-07-02 |
| DE3942131C2 (de) | 1998-09-17 |
| FR2640876B1 (es) | 1993-09-24 |
| DE3942131A1 (de) | 1990-07-05 |
| FR2640876A1 (es) | 1990-06-29 |
| PT92682A (pt) | 1990-06-29 |
| CA2006184C (en) | 1999-11-23 |
| IT8912615A1 (it) | 1991-06-20 |
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