KR900009060A - 트리메부틴 기재 서방형 조성물 및 그 제조 방법 - Google Patents

트리메부틴 기재 서방형 조성물 및 그 제조 방법 Download PDF

Info

Publication number
KR900009060A
KR900009060A KR1019890019616A KR890019616A KR900009060A KR 900009060 A KR900009060 A KR 900009060A KR 1019890019616 A KR1019890019616 A KR 1019890019616A KR 890019616 A KR890019616 A KR 890019616A KR 900009060 A KR900009060 A KR 900009060A
Authority
KR
South Korea
Prior art keywords
active agent
composition
hydroxypropylmethylcellulose
diluent
tartaric acid
Prior art date
Application number
KR1019890019616A
Other languages
English (en)
Other versions
KR0137270B1 (ko
Inventor
오마르 방케르루 루프티
카누완 프랑스와즈
실벵 프랑스 쟈크
쥐니엥 쟝-루이
오바르 질베르
Original Assignee
로저 한나
주베이날 에스. 에이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 로저 한나, 주베이날 에스. 에이. filed Critical 로저 한나
Publication of KR900009060A publication Critical patent/KR900009060A/ko
Application granted granted Critical
Publication of KR0137270B1 publication Critical patent/KR0137270B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Fats And Perfumes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.

Description

트리메부틴 기재 서방형 조성물 및 그 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 전체 조성물의 15 내지 20중량%를 구성하는 수용성 희석제 20 내지 25중량% 및 타르타르산 10 내지 25중량%를 추가로 포함하는 히드록시프로필메틸셀룰로오스로 된 친수성의 다공성 매트릭스(matrix)중에 균질하게 분산된 조성물의 35 내지 45중량%를 구성하는 활성제로 이루어지고, 상기 활성제가 다음식의 2-디메틸아미노-2-페닐-1-부틸 3,4,5-트리메톡시벤조에이트 또는 제약상 허용되는 아들의 산 부가염중의 1종인 것을 특징으로 하는 피복되지 않은 정제 형태의 제약 조성물.
  2. 제1항에 있어서, 수용성 희석제가 락토오스 또는 만니톨인 것을 특징으로 하는 조성물.
  3. 제1 또는 2항에 있어서, 히드록시프로필메틸셀룰로오스의 점도가 3000 내지 5000 mPa. S인 것을 특징으로 하는 조성물.
  4. 전항 중 어느 하나의 항에 있어서, 활성제가 말레이트인 것을 특징으로 하는 조성물.
  5. 전항 중 어느 하나의 항에 있어서, 정제 당 활성제를 175 내지 323㎎ 함유하는 것을 특징으로 하는 조성물.
  6. 활성제, 히드록시프로필메틸셀룰오스, 희석제 및 타르타르산을 혼합하고, 이 혼합물을 정제 형태로 압축시키는 것을 특징으로 하는 전항 중 어느 하나의 항에 의한 조성물의 제조 방법.
  7. 제6항에 있어서, 활성제, 희석제 및 타르타르산으로 된 혼합물을 습식 방법으로 조립하여 습윤 과립을 형성하고, 이 습윤 과립을 건조시켜 건조 과립을 얻고, 이 건조 과립을 히드록시프로필메틸셀룰로오스와 혼합하여 히드록시프로필메틸셀룰로오스를 함유하는 혼합물을 얻고, 이 히드록시프로필메틸셀룰로오스를 함유하는 혼합물을 압착하여 정제를 얻는 것으로 구성되는 제조 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890019616A 1988-12-28 1989-12-27 트리메부틴의 서방형 조성물 및 그 제조 방법 KR0137270B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8817303 1988-12-28
FR8817303A FR2640876B1 (ko) 1988-12-28 1988-12-28

Publications (2)

Publication Number Publication Date
KR900009060A true KR900009060A (ko) 1990-07-02
KR0137270B1 KR0137270B1 (ko) 1998-04-25

Family

ID=9373520

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890019616A KR0137270B1 (ko) 1988-12-28 1989-12-27 트리메부틴의 서방형 조성물 및 그 제조 방법

Country Status (14)

Country Link
JP (1) JP2745232B2 (ko)
KR (1) KR0137270B1 (ko)
AT (1) AT397461B (ko)
BE (1) BE1006002A4 (ko)
CA (1) CA2006184C (ko)
DE (1) DE3942131C2 (ko)
EG (1) EG19994A (ko)
ES (1) ES2019024A6 (ko)
FR (1) FR2640876B1 (ko)
GR (1) GR1000429B (ko)
GT (1) GT198900080A (ko)
IT (1) IT1236239B (ko)
MX (1) MX170641B (ko)
PT (1) PT92682B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05255125A (ja) * 1992-02-29 1993-10-05 Upjohn Co:The 徐放性製剤およびその製法
FR2730163B1 (fr) * 1995-02-03 1997-04-04 Jouveinal Lab Nouvelle composition pharmaceutique contenant la trimebutine et son procede de preparation
FR2752162B1 (fr) * 1996-08-07 1998-11-06 Jouveinal Lab Comprime de maleate de trimebutine pellicule
CN1927185B (zh) * 2006-10-19 2010-05-19 开开援生制药股份有限公司 具速释部分的马来酸曲美布汀缓释片及其制备工艺
KR101051630B1 (ko) * 2008-10-02 2011-07-26 한국유나이티드제약 주식회사 용출률과 복용편의성이 향상된 트리메부틴 서방정
FR2944971B1 (fr) * 2009-04-30 2012-09-07 Roquette Freres Coagglomerats de mannitol et d'amidon granulaire comprimables et a ecoulement libre

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065143A (en) * 1960-04-19 1962-11-20 Richardson Merrell Inc Sustained release tablet
JPS57197214A (en) * 1981-05-29 1982-12-03 Tanabe Seiyaku Co Ltd Rapid-releasing microcapsule and its preparation
JPS5858146A (ja) * 1981-10-05 1983-04-06 Tanabe Seiyaku Co Ltd 速放性マイクロカプセル
JPS5858145A (ja) * 1981-10-05 1983-04-06 Tanabe Seiyaku Co Ltd 速放性マイクロカプセル
JPS5916821A (ja) * 1982-07-16 1984-01-28 Tanabe Seiyaku Co Ltd 非凝集性マイクロカプセルの製法
IT1206166B (it) * 1984-07-26 1989-04-14 Sigma Tau Ind Farmaceuti Dispositivo per rilasciare una sostanza in un fluido di dissoluzione con cinetica di ordine zero e procedimento per la sua preparazione
GB8616669D0 (en) * 1986-07-09 1986-08-13 Merk Sharpe & Dohme Ltd Pharmaceutical compositions

Also Published As

Publication number Publication date
DE3942131A1 (de) 1990-07-05
JPH02184624A (ja) 1990-07-19
KR0137270B1 (ko) 1998-04-25
EG19994A (en) 1997-01-30
GR1000429B (el) 1992-07-30
IT8912615A0 (it) 1989-12-20
PT92682B (pt) 1997-01-31
CA2006184A1 (en) 1990-06-28
GR890100860A (en) 1991-03-15
JP2745232B2 (ja) 1998-04-28
PT92682A (pt) 1990-06-29
AT397461B (de) 1994-04-25
FR2640876B1 (ko) 1993-09-24
BE1006002A4 (fr) 1994-04-19
IT1236239B (it) 1993-01-27
CA2006184C (en) 1999-11-23
MX170641B (es) 1993-09-01
DE3942131C2 (de) 1998-09-17
IT8912615A1 (it) 1991-06-20
ATA294489A (de) 1993-09-15
GT198900080A (es) 1991-06-20
FR2640876A1 (ko) 1990-06-29
ES2019024A6 (es) 1991-05-16

Similar Documents

Publication Publication Date Title
CA1240925A (en) Controlled release solid drug dosage forms based on mixtures of water soluble nonionic cellulose ethers and anionic surfactants
KR890004685B1 (ko) 지효성 조성물
CA1316108C (en) Formulation for preparing sustained release drugs for oral administration
KR101367814B1 (ko) 위장체류 제제 및 이의 제조 방법
KR890001526A (ko) 경구용 서방성 아세트 아미노펜 제형 및 이의 제조방법
KR850007559A (ko) 조절 펩타이드의 삽입식 제형
KR930016092A (ko) 신속 용해형 정제 및 그의 제조법
KR880010757A (ko) 제약정제, 제약과립 및 그의 제조방법
US4849229A (en) Controlled release solid drug dosage forms based on mixtures of water soluble nonionic cellulose ethers and anionic surfactants
JPH08504214A (ja) 放出調整賦形剤として容易に入手できるコンニャクグルコマンナン
MXPA02001243A (es) Medios para crear una masa que tiene integridad estructural.
IL42232A (en) Dry medicines for oral administration
JPS62120323A (ja) ヒドロキシプロピルセルロースエーテルを含有する持効性組成物
CA2018167A1 (en) Sustained release pharmaceutical tablet
HUP0000141A2 (hu) Eljárás legfeljebb 90 tömeg% gyógyhatású anyagot tartalmazó pelletek előállítására
KR850001693A (ko) 아모술랄롤 하이드로클로라이드 지속성 제제의 제조방법
US4851233A (en) Sustained release formulations
US4143129A (en) Cephalexin tablets
KR870700354A (ko) 기포성 아세틸살리실산 정제의 개선
RU2002123182A (ru) Содержащая ибупрофен композиция
KR910011241A (ko) 정제로 직접 압착 가능한 약제학적 분말 조성물을 제조하기 위한 분무 건조법
KR900009060A (ko) 트리메부틴 기재 서방형 조성물 및 그 제조 방법
EP1501484A1 (en) A process for the preparation of tablets from pharmaceutically active substances having unfavourable tabletting properties with a granulating liquid comprising microcrystalline cellulose
US4973470A (en) Sustained release pharmaceutical compositions
JPS63290818A (ja) 高分子量ヒドロキシプロピルメチルセルロースを基剤にした徐放性錠剤

Legal Events

Date Code Title Description
A201 Request for examination
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20080110

Year of fee payment: 11

LAPS Lapse due to unpaid annual fee