KR930016092A - 신속 용해형 정제 및 그의 제조법 - Google Patents

신속 용해형 정제 및 그의 제조법 Download PDF

Info

Publication number
KR930016092A
KR930016092A KR1019930001177A KR930001177A KR930016092A KR 930016092 A KR930016092 A KR 930016092A KR 1019930001177 A KR1019930001177 A KR 1019930001177A KR 930001177 A KR930001177 A KR 930001177A KR 930016092 A KR930016092 A KR 930016092A
Authority
KR
South Korea
Prior art keywords
carbohydrate
dissolving tablet
weight
water
active ingredient
Prior art date
Application number
KR1019930001177A
Other languages
English (en)
Other versions
KR100258223B1 (ko
Inventor
다다시 마끼노
마사유끼 야마다
준-이찌 기꾸따
Original Assignee
모리따 가쓰라
다께다야꾸힝고오교가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11835174&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR930016092(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 모리따 가쓰라, 다께다야꾸힝고오교가부시끼가이샤 filed Critical 모리따 가쓰라
Publication of KR930016092A publication Critical patent/KR930016092A/ko
Application granted granted Critical
Publication of KR100258223B1 publication Critical patent/KR100258223B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

약효성분, 탄수화물 및 상기 탄수화물의 입자표면이 습한 정도의 수분을 함유하는 조성물을 압축성형으로 타정한 신속 용해형 정제의 제조방법 및 상기 방법으로 수득될 수 있는 신속 용해형 정제.
약효성분은 예를 들면 비타민, 위장약 또는 해열 진통 소염약일 수 있다. 탄수화물은 당, 전분당, 락토스, 꿀, 당알콜 및 사탄당을 함유한다. 가할 물의 양은 약 0.3~10중량%이다.
상기 신속 용해형 정제는 적당한 강도 뿐만 아니라 우수한 붕괴성 및 용해성을 갖는 다공 구조를 갖는다.

Description

신속 용해형 정제 및 그의 제조법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (36)

  1. 약효 성분, 탄수화물 및 상기 탄수화물의 입자표면이 습한 정도의 수분을 함유하는 조성물을 압축 성형하여 타정하는 것을 포함하는 신속 용해형 정제의 제조방법.
  2. 제1항에 있어서, 상기 약효성분 및 상기 탄수화물을 함유하는 혼합물에 상기 탄수화물의 입자표면이 습한 정도의 수분으로 수분을 함유시킨 후 압축 성형하여 타정하는 신속 용해형 정제의 제조방법.
  3. 제1항에 있어서, 상기 조성물의 상기 약효 성분을 0.05~90중량%의 비율로 함유하는 신속 용해형 정제의 제조방법.
  4. 제1항에 있어서, 상기 약효 성분으로서 비타민, 생약, 해열진통 소염약, 항불안약, 최면 진정약, 위장약, 진해 거담제, 혈압강하제, 당뇨병용제, 골다공증제, 또는 골격 근육 이완제를 사용한 신속 용해형 정제의 제조방법.
  5. 제4항에 있어서, 상기 비타민이 비타민 A, 아세트산 d-α-토코페롤, 디벤조일티아민, 염산 푸르술티아민, 리보플라빈 부틸레이트, 염산 리독신, 아스코르빈산, L-아스코르빈산 나트륨 및 아세트산 히드록소코발아민으로 이루어진 군으로 부터 선택된 1종 이상인 신속 용해형 정제의 제조방법.
  6. 제1항에 있어서, 상기 조성물이 상기 탄수화물을 10~90중량%함유하는 신속 용해형 정제의 제조방법.
  7. 제1항에 있어서, 상기 탄수화물이 수용성이 신속 용해형 정제의 제조방법.
  8. 제1항에 있어서, 상기 탄수화물이 당, 전분당, 락토스, 꿀 당알콜 및 사탄당으로 이루어진 군으로 부터 선택된 1종 이상인 신속 용해형 정제의 제조방법.
  9. 제1항에 있어서, 상기 탄수화물이 슈크로스, 글루코스, 말티톨크실리톨 및 에리트리톨로 이루어진 군으로부터 선택된 1종 이상인 신속 용해형 정제의 제조방법.
  10. 제1항에 있어서, 상기 탄수화물의 평균입자 크가가 1~100㎛의 범위에 있는 신속 용해형 정제의 제조방법.
  11. 제1항에 있어서, 상기 조성물이 추가로 붕괴제, 결합제, 산, 발포제, 인공감미료, 향료, 윤활제 및 착색제로 이루어진 군으로 부터 선택된 첨가제를 1종 이상 함유하는 신속 용해형 정제의 제조방법.
  12. 제1항에 있어서, 상기 조성물이 수분을 0.3~10중량%의 비율로 함유하는 신속 용해형 정제의 제조방법.
  13. 제1항에 있어서, 상기 조성물의 3~160kg/㎠의 압력에서 압축 성형하여 타정하는 신속 용해형 정제의 제조방법.
  14. 제1항에 있어서, 상기 약효성분의 유효량, 수용성 탄수화물 및 0.3~7중량%의 수분을 함유하는 조성물을 5~130kg/㎠의 압력에서 압축 성형하여 타정한후 건조시켜 20~80%의 공간율을 갖는 다공성 정제를 제조하는 신속 용해형 정제의 제조방법.
  15. 제14항에 있어서, 상기 조성물이 0.1~10중량%의 상기 약효 성분 및 50~85중량%의 상기 수용성 탄수화물을 함유하는 신속 용해형 정제의 제조방법.
  16. 제14항에 있어서, 상기 조성물이 10~30중량%의 상기 약효 성분 및 20~80중량%의 상기 수용성 탄수화물을 함유하는 신속 용해형 정제의 제조방법.
  17. 제14항에 있어서, 상기 조성물이 30~70중량%의 상기 약효 성분 및 1575중량%의 상기 수용성 탄수화물을 함유하는 신속 용해형 정제의 제조방법.
  18. 제14항에 있어서, 당, 전분당, 락토스, 꿀, 당알콜 및 사탄당으로 이루어진 군으로부터 선택된 수용성 탄수화물 1종 이상을 20~85 중량% 함유하는 조성물을 8~50kg/㎠의 압력에서 압축성형하여 타정하는 신속 용해형 정제의 제조방법.
  19. 제14항에 있어서, 0.5~3중량%의 물을 함유하는 조성물을 8~50kg/㎠의 압력에서 압축 성형하여 타정하는 신속 용해형 정제의 제조방법.
  20. 약효성분, 탄수화물 및 상기 탄수화물의 입자표면이 습한 정도의 수분을 함유하는 조성물을 압축성형하여 타정하는 것에 의해 수득할 수 있는 신속 용해형 정제.
  21. 제20항에 있어서, 공간율이 20~80%인 다공 구조를 갖는 신속 용해형 정제.
  22. 제21항에 있어서, 2~25kg의 경도를 갖는 신속 용해형 정제.
  23. 제20항에 있어서, 공간율이 30~70%이고, 경도가 3~20kg이며, 붕괴시간이 0.05~3.0인 다공구조를 갖는 신속 용해형 정제.
  24. 제20항에 있어서, 공간율이 30~70%이고, 경도가 3~20kg이며, 붕괴시간이 0.05~3.0 분이고, 낙하 충격 강도가 0~70%이며, 구강내 용해성이 0.05~3.0인 다공구조를 갖는 신속 용해형 정제.
  25. 제20항에 있어서, 0.05~90 중량%의 상기 약효성분 및 10~90중량%의 상기 탄수화물을 함유하는 신속 용해형 정제.
  26. 제20항에 있어서, 상기 약효 성분으로서 비타민, 생약, 해열진통 소염약, 항불안약, 최면 진정약, 위장약, 진해 거담제, 혈압강하제, 당뇨병용제, 골다공증제 또는 근육이완제를 함유하는 신속 용해형 정제.
  27. 제20항에 있어서, 상기 탄수화물로서 당, 전분당, 락토스, 꿀, 당알콜 및 사탄당으로 이루어진 군으로 부터 선택된 1종 이상을 함유하는 신속 용해형 정제.
  28. 제20항에 있어서, 붕괴제, 결합제, 산, 발포제, 인공감미료, 향료, 윤활제 및 착색제로 이루어진 군으로 부터 선택된 첨가제를 1종 이상 함유하는 신속 용해형 정제.
  29. 제20항에 있어서, 상기 약효성분의 유효량, 10~90중량%의 수용성 탄수화물을 함유하며, 공간율이 20~80%인 다공구조를 갖는 신속 용해형 정제.
  30. 제29항에 있어서, 0.1~10중량%의 상기 수용성 탄수화물을 함유하는 신속 용해형 정제.
  31. 제29항에 있어서, 10~30중량%의 상기 약효성분 및 30~80중량%의 상기 수용성 탄수화물을 함유하는 신속 용해형 정제.
  32. 제29항에 있어서, 30~70중량%의 상기 약효성분 및 15~75 중량%의 상기 수용성 탄수화물을 함유하는 신속 용해형 정제.
  33. 상기 약효성분의 유효량, 수용성 탄수화물 및 0.3~7중량%의 수분을 함유하는 조성물을 5~130kg/㎠의 압력에서 압축 성형하여 타정하고 생성된 정제를 건조하여 수득할 수 있는 제20항에 따른 신속 용해형 정제.
  34. 약효성분의 유효량 및 수용성 탄수화물을 함유하며 경도가 2~25kg이고 공간율이 20~80%인 다공구조를 갖는 신속 용해형 정제.
  35. 제34항에 있어서, 3~20kg의 경도 및 30~70%의 공간율을 갖는 신속 용해형 정제.
  36. 제34항에 있어서, 탄수화물의 입자 표면이 습한 정도의 수분과 경도 2~25kg을 갖게 하는 성형 압력으로 상기 탄수화물을 서로 접착시킨후, 상기 수분을 제거한 신속 용해형 정제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930001177A 1992-01-29 1993-01-29 신속 용해형 정제 및 그의 제조법 KR100258223B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1351192 1992-01-29
JP92-13511 1992-01-29

Publications (2)

Publication Number Publication Date
KR930016092A true KR930016092A (ko) 1993-08-26
KR100258223B1 KR100258223B1 (ko) 2000-08-01

Family

ID=11835174

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930001177A KR100258223B1 (ko) 1992-01-29 1993-01-29 신속 용해형 정제 및 그의 제조법

Country Status (8)

Country Link
US (2) US5501861A (ko)
EP (1) EP0553777B1 (ko)
JP (2) JP3069458B2 (ko)
KR (1) KR100258223B1 (ko)
AT (1) ATE216577T1 (ko)
CA (1) CA2088334C (ko)
DE (1) DE69331839T2 (ko)
TW (1) TW249756B (ko)

Families Citing this family (212)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2650493B2 (ja) * 1992-02-18 1997-09-03 日本新薬株式会社 速溶錠
EP0627218B1 (en) * 1992-02-18 2001-12-19 Nippon Shinyaku Company, Limited Process for producing fast soluble tablets and fast soluble tablets comprising xylitol
CA2128820A1 (en) * 1993-07-27 1995-01-28 Walter G. Gowan, Jr. Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof
CA2179382C (en) * 1994-01-31 2009-11-10 Takao Mizumoto Intrabuccally dissolving compressed moldings and production process thereof
US5576014A (en) * 1994-01-31 1996-11-19 Yamanouchi Pharmaceutical Co., Ltd Intrabuccally dissolving compressed moldings and production process thereof
DE4403943A1 (de) * 1994-02-08 1995-08-10 Hexal Pharma Gmbh Orale Azrneimittelzubereitung mit Diclofenac-Natrium
US5567439A (en) * 1994-06-14 1996-10-22 Fuisz Technologies Ltd. Delivery of controlled-release systems(s)
US5837287A (en) * 1994-10-28 1998-11-17 R P Scherer Corporation Process for preparing solid pharmaceutical dosage forms
US5994348A (en) * 1995-06-07 1999-11-30 Sanofi Pharmaceutical compositions containing irbesartan
GB9517062D0 (en) * 1995-08-18 1995-10-25 Scherer Ltd R P Pharmaceutical compositions
US5762961A (en) * 1996-02-09 1998-06-09 Quadrant Holdings Cambridge Ltd. Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof
DK0890359T3 (da) * 1996-02-29 2002-07-01 Fujisawa Pharmaceutical Co Beta-Lactam-antibiotikumholdige tabletter og fremgangsmåde til fremstilling deraf
AU733032C (en) 1996-06-14 2002-01-03 Kyowa Hakko Kirin Co., Ltd. Intraorally rapidly disintegrable tablet
US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
GB9613470D0 (en) * 1996-06-27 1996-08-28 Ciba Geigy Ag Small solid oral dosage form
CN1222317C (zh) * 1996-07-12 2005-10-12 第一制药株式会社 可迅速崩解的压模物质及其生产方法
ZA976189B (en) * 1996-07-12 1999-01-11 Novartis Consumer Health Sa Oral pharmaceutical combinations
US5846568A (en) * 1996-09-19 1998-12-08 Xyrofin Oy Directly compressible lactitol and method
US5958453A (en) 1996-10-31 1999-09-28 Takeda Chemical Industries, Ltd. Solid pharmaceutical preparation with improved buccal disintegrability and/or dissolubility
KR100530508B1 (ko) * 1997-01-09 2005-11-23 모리나가 뉴교 가부시키가이샤 락토페린 정제
EP0974366B1 (en) 1997-03-28 2006-10-18 Eisai Co., Ltd. Oral pharmaceutical preparations decreased in bitterness by masking
US6024981A (en) * 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
US5939091A (en) * 1997-05-20 1999-08-17 Warner Lambert Company Method for making fast-melt tablets
TW580397B (en) 1997-05-27 2004-03-21 Takeda Chemical Industries Ltd Solid preparation
JP4939680B2 (ja) * 1997-05-27 2012-05-30 武田薬品工業株式会社 固形製剤
DE69834255T2 (de) * 1997-07-25 2006-09-28 Alpex Pharma S.A. Verfahren zur herstellung eines granulates, geeignet zur herstellung schnell-freisetzender, im mund löslicher tabletten
TW527195B (en) 1997-10-09 2003-04-11 Ssp Co Ltd Fast-soluble solid pharmaceutical combinations
JPH11137208A (ja) * 1997-11-14 1999-05-25 Nikken Chem Co Ltd 口腔内速溶性固形物及びその製造方法
NZ333474A (en) * 1998-01-02 1999-06-29 Mcneil Ppc Inc A chewable tablet containing ibuprofen, fumaric acid and a non hydrocolloid binder e.g. a wax or a fat
US6413541B1 (en) 1999-01-13 2002-07-02 Dainippon Pharmaceutical Co., Ltd. Disintegrating tablet in oral cavity and production thereof
US6432442B1 (en) 1998-02-23 2002-08-13 Mcneil-Ppc, Inc. Chewable product
PT1058538E (pt) * 1998-03-06 2002-11-29 Eurand Int Comprimidos de desintegracao rapida
US6465009B1 (en) 1998-03-18 2002-10-15 Yamanouchi Pharmaceutical Co., Ltd. Water soluble polymer-based rapidly dissolving tablets and production processes thereof
US6974590B2 (en) 1998-03-27 2005-12-13 Cima Labs Inc. Sublingual buccal effervescent
US20030118645A1 (en) * 1998-04-29 2003-06-26 Pather S. Indiran Pharmaceutical compositions for rectal and vaginal administration
US20030091629A1 (en) * 1998-03-27 2003-05-15 Cima Labs Inc. Sublingual buccal effervescent
US6328994B1 (en) 1998-05-18 2001-12-11 Takeda Chemical Industries, Ltd. Orally disintegrable tablets
WO2000003735A1 (fr) 1998-07-15 2000-01-27 Asahi Kasei Kogyo Kabushiki Kaisha Excipient
EP1561458B1 (en) 1998-07-28 2010-09-15 Takeda Pharmaceutical Company Limited Rapidly disintegrable solid preparation
WO2000012135A1 (fr) * 1998-08-28 2000-03-09 Eisai Co., Ltd Compositions medicales presentant une amertume, etc., reduite
US8231899B2 (en) 1998-09-10 2012-07-31 Nycomed Danmark Aps Quick release pharmaceutical compositions of drug substances
TR200100708T2 (tr) * 1998-09-10 2001-07-23 Nycomed Danmark A/S İlaç maddelerine mahsus çabuk salımlı farmasötik bileşimler.
EP1120120A4 (en) 1998-10-05 2009-04-29 Eisai R&D Man Co Ltd TABLETS DISSOLVING DIRECTLY IN MOUTH
JP2000178204A (ja) * 1998-10-05 2000-06-27 Eisai Co Ltd ホスフォジエステラ―ゼ阻害剤を含有する口腔内速崩壊性錠剤
US6322819B1 (en) * 1998-10-21 2001-11-27 Shire Laboratories, Inc. Oral pulsed dose drug delivery system
US6296868B1 (en) * 1998-11-19 2001-10-02 Advanced Technology Pharmaceuticals Corporation Chewable tablets containing mannitol and aspartame
US7163705B2 (en) * 1998-12-15 2007-01-16 Wm. Wrigley Jr. Company Coated chewing gum product and method of making
US6552024B1 (en) 1999-01-21 2003-04-22 Lavipharm Laboratories Inc. Compositions and methods for mucosal delivery
ATE283708T1 (de) * 1999-02-15 2004-12-15 Sumitomo Pharma Im mundraum schnellzerfallende tabletten
DE60020680T2 (de) * 1999-02-17 2006-05-04 Kyowa Hakko Kogyo Co., Ltd. Tabletten und verfahren zur tablettenherstellung
GB9910505D0 (en) 1999-05-06 1999-07-07 Electrosols Ltd A method and apparatus for manufacturing consumable tablets
DE19931708A1 (de) 1999-07-08 2001-01-18 Bayer Ag Verfahren zur Herstellung schnell zerfallender, fester pharmazeutischer Zubereitungen
US6384020B1 (en) * 1999-07-14 2002-05-07 Shire Laboratories, Inc. Rapid immediate release oral dosage form
US6284270B1 (en) * 1999-08-04 2001-09-04 Drugtech Corporation Means for creating a mass having structural integrity
JP4719899B2 (ja) * 2000-01-07 2011-07-06 大正製薬株式会社 口腔内速崩壊性錠剤
ATE437632T1 (de) 2000-03-01 2009-08-15 Eisai R&D Man Co Ltd Schnellzerfallende polyvinylhaltige tablette
US20020015730A1 (en) * 2000-03-09 2002-02-07 Torsten Hoffmann Pharmaceutical formulations and method for making
EP1133984B1 (en) 2000-03-17 2005-05-11 Shin-Etsu Chemical Co., Ltd. Solid preparation containing low-substituted hydroxypropyl cellulose and production process thereof
US20030104066A1 (en) * 2000-03-27 2003-06-05 Kouji Murai Easy-to-take granules
PL203804B1 (pl) 2000-06-27 2009-11-30 Hoffmann La Roche Sposób wytwarzania kompozycji farmaceutycznej w postaci spoistej, płytkowej, piankowej, gąbczastej lub ciastowatej struktury i kompozycja farmaceutyczna otrzymana tym sposobem
JP3415835B2 (ja) 2000-06-30 2003-06-09 山之内製薬株式会社 口腔内速崩壊錠およびその製造法
US6656492B2 (en) * 2000-06-30 2003-12-02 Yamanouchi Pharmaceutical Co., Ltd. Quick disintegrating tablet in buccal cavity and manufacturing method thereof
US20020071857A1 (en) * 2000-08-18 2002-06-13 Kararli Tugrul T. Rapidly disintegrating oral formulation of a cyclooxygenase-2 inhibitor
JP4886107B2 (ja) * 2000-10-13 2012-02-29 サンスター株式会社 歯周病予防用口腔内溶解錠
KR20030042006A (ko) * 2000-10-16 2003-05-27 다이이찌 세이야꾸 가부시기가이샤 구강내 속붕괴성 의약 조성물 및 그의 제조방법
US6733781B2 (en) 2000-12-06 2004-05-11 Wyeth Fast dissolving tablet
US7799342B2 (en) 2000-12-06 2010-09-21 Wyeth Llc Fast dissolving tablet
US6544552B2 (en) 2001-01-11 2003-04-08 Particle And Coating Technologies, Inc. Method of producing porous tablets with improved dissolution properties
MXPA03007081A (es) * 2001-02-08 2004-10-15 Pharmacia Corp Medicamento de accion rapida para el tratamiento de disfuncion sexual.
CN100372536C (zh) * 2001-02-15 2008-03-05 田边三菱制药株式会社 在口腔中迅速崩解的片剂
CA2440361A1 (en) * 2001-03-06 2002-09-12 Kyowa Hakko Kogyo Co. Ltd. Intraorally rapidly disintegrable preparation
US6706284B2 (en) 2001-03-15 2004-03-16 Yamanouchi Pharmaceutical Co., Ltd. Bitterness-reduced oral pharmaceutical composition
US20040131673A1 (en) * 2001-03-22 2004-07-08 Coffee Ronald Alan Manufacturing dissolvable dosage forms
KR100457458B1 (ko) * 2001-04-02 2004-11-17 삼아약품 주식회사 속용정 및 그의 제조방법
EP1405635A1 (en) * 2001-06-07 2004-04-07 Tanabe Seiyaku Co., Ltd. Functional grain-containing preparations quickly disintegrated in the oral cavity
BR0212807A (pt) * 2001-09-25 2004-10-05 Ranbaxy Lab Ltd Processo para a preparação de formas de dosagem de dissolução rápida
US20050053678A1 (en) * 2001-10-03 2005-03-10 Gow Robert T. Methods and compositions for betel nut chewing gum
US7291352B2 (en) 2001-10-03 2007-11-06 Herbalscience Llc Methods and compositions for oral delivery of Areca and mate' or theobromine
US20050069596A1 (en) * 2001-10-03 2005-03-31 Gow Robert T. Compositions and methods comprising kava and anti-anxiety compounds
US7037524B2 (en) * 2001-10-03 2006-05-02 Herbalscience, Llc Oral delivery of a botanical
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
US20040047904A1 (en) * 2001-11-13 2004-03-11 Motohiro Ohta Amino acid-containing tablets quickly disintegrating in the oral cavity and process for producing the same
MXPA04003807A (es) * 2001-11-30 2004-07-30 Pfizer Prod Inc Formulaciones farmaceuticas de 5, 7, 14-trianzatetraciclo [10.3.1.02, 11, 04, 9]-hexadeca -2 (11), 3, 5, 7, 9-pentaeno.
US7118765B2 (en) * 2001-12-17 2006-10-10 Spi Pharma, Inc. Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms
JP2003238393A (ja) * 2002-02-15 2003-08-27 Otsuka Pharmaceut Co Ltd 施錠性が改善された錠剤及びその製造方法
US20050147666A1 (en) * 2002-03-06 2005-07-07 Kyowa Hakko Kogyo Co., Ltd. Tablets quickly disintegrating in oral cavity
WO2003080023A2 (en) * 2002-03-20 2003-10-02 Elan Pharma International Limited Fast dissolving dosage forms having reduced friability
US20030215498A1 (en) * 2002-05-17 2003-11-20 Harland Ronald S. Rapidly disintegrating comressed tablets comprising biologically active compounds
JP4605977B2 (ja) * 2002-06-14 2011-01-05 日本ベーリンガーインゲルハイム株式会社 ブロチゾラムを含有する錠剤
US20040001885A1 (en) * 2002-06-27 2004-01-01 Unchalee Kositprapa Rapidly disintegrating antihistamine formulation
US20030017208A1 (en) * 2002-07-19 2003-01-23 Francis Ignatious Electrospun pharmaceutical compositions
GB0217056D0 (en) * 2002-07-23 2002-08-28 Ass Octel Use
US20060039967A1 (en) * 2002-08-12 2006-02-23 Motohiro Ohta Amino acid-containing chewable
US20050037025A1 (en) * 2002-10-03 2005-02-17 Gow Robert T. Methods and compositions comprising kava and mate' or theobromine
WO2004032853A2 (en) * 2002-10-04 2004-04-22 Pharmacia Corporation Compositions and methods for treating sexual dysfunction
UA80991C2 (en) * 2002-10-07 2007-11-26 Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes
FR2845914B1 (fr) * 2002-10-18 2005-11-04 Schwarz Pharma Lab Compose antiemetique a desagregation rapide
US8367111B2 (en) 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
US20040161459A1 (en) * 2002-12-31 2004-08-19 Ngoc Do Fast-dissolve tablet technology
WO2004098571A1 (en) * 2003-04-30 2004-11-18 Zicam, Llc Cold remedy composition comprising zinc salts
US7204986B2 (en) 2003-06-11 2007-04-17 Ultra Biotech Limited Method to prepare compositions comprising yeast treated with electromagnetic energy
US20050036977A1 (en) * 2003-08-11 2005-02-17 Dilip Gole Taste-masked resinate and preparation thereof
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
US7282217B1 (en) 2003-08-29 2007-10-16 Kv Pharmaceutical Company Rapidly disintegrable tablets
EP1670441A4 (en) * 2003-10-07 2012-05-02 Andrx Pharmaceuticals Llc FAST RESOLUTION FORMULATION
US8349361B2 (en) 2003-10-15 2013-01-08 Fuji Chemical Industry Co., Ltd. Composition for rapid disintegrating tablet in oral cavity
US8647668B2 (en) 2003-10-15 2014-02-11 Fuji Chemical Industry Co., Ltd. Tablet quickly disintegrating in oral cavity
JP3841804B2 (ja) 2003-10-15 2006-11-08 富士化学工業株式会社 口腔内速崩壊性錠剤用の組成物
EP1535700A1 (de) * 2003-11-25 2005-06-01 Sika Tivoli GmbH Schleifmittelverbundkörper
WO2005065317A2 (en) * 2003-12-31 2005-07-21 Cima Labs Inc. Effervescent oral fentanyl dosage form
US7862833B2 (en) * 2003-12-31 2011-01-04 Cima Labs, Inc. Effervescent oral opiate dosage forms and methods of administering opiates
US20050142197A1 (en) * 2003-12-31 2005-06-30 Cima Labs Inc. Generally linear effervescent oral fentanyl dosage form and methods of administering
US7670624B2 (en) * 2004-01-29 2010-03-02 Astella Pharma Inc. Gastrointestinal-specific multiple drug release system
TWI335227B (en) * 2004-02-25 2011-01-01 Medical & Pharm Ind Tech & Dev Pharmaceutical composition of taste masking and rapidly dissolving drug and method of preparing the same
US20090246288A1 (en) * 2004-02-25 2009-10-01 Pharmaceutical Industry Technology And Development Center Taste-masking oral dosage form and method of preparing the same
US8545881B2 (en) 2004-04-19 2013-10-01 Eurand Pharmaceuticals, Ltd. Orally disintegrating tablets and methods of manufacture
ATE493973T1 (de) 2004-06-04 2011-01-15 Teva Pharma Irbesartan enthaltende pharmazeutische zusammensetzung
US8747895B2 (en) 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
NZ589750A (en) 2004-10-21 2012-07-27 Aptalis Pharmatech Inc Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US20060105038A1 (en) * 2004-11-12 2006-05-18 Eurand Pharmaceuticals Limited Taste-masked pharmaceutical compositions prepared by coacervation
ITMI20042356A1 (it) * 2004-12-10 2005-03-10 Acraf Composizione farmaceutica orodisperdibile e procedimento per prepararla
NL1027807C1 (nl) * 2004-12-17 2006-06-20 4Sight Innovation Bv Inrichting voor het verrijken van een drank met additieven, en verpakking voor een dergelijke inrichting.
US20060240101A1 (en) * 2005-04-22 2006-10-26 Shubha Chungi Orally disintegrating pharmaceutical tablet formulations of olanzapine
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
CN101227894B (zh) * 2005-07-22 2013-01-09 田边三菱制药株式会社 口腔速崩片
US20070020186A1 (en) 2005-07-22 2007-01-25 Alpex Pharma S.A. Solid dosage formulations of narcotic drugs having improved buccal adsorption
ES2396913T3 (es) 2005-08-04 2013-03-01 Sirtris Pharmaceuticals, Inc. Compuestos moduladores de sirtuina
US20110142957A1 (en) * 2005-08-15 2011-06-16 Van Kempen Theo Method of treating parturient placental mammals in order to reduce maternal and/or uterine exhaustion
EP1942877A4 (en) * 2005-11-02 2011-09-14 Teikoku Pharma Usa Inc ORGANOLEPTICALLY ACCEPTABLE ORAL DOSAGE FORMS OF IBUPROFEN, MANUFACTURING METHOD AND APPLICATION
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
PE20070698A1 (es) 2005-11-14 2007-08-17 Teijin Pharma Ltd Comprimido de disgregacion rapida intraoral que contiene hidrocloruro de ambroxol
US7811604B1 (en) 2005-11-14 2010-10-12 Barr Laboratories, Inc. Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same
US8956677B2 (en) * 2005-11-23 2015-02-17 The Coca-Cola Company High-potency sweetener composition with glucosamine and compositions sweetened therewith
US8524304B2 (en) * 2005-11-23 2013-09-03 The Coca-Cola Company High-potency sweetener composition with probiotics/prebiotics and compositions sweetened therewith
US8956678B2 (en) * 2005-11-23 2015-02-17 The Coca-Cola Company High-potency sweetener composition with preservative and compositions sweetened therewith
US20070116825A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company Confection with High-Potency Sweetener
EP1965667A2 (en) * 2005-11-23 2008-09-10 The Coca-Cola Company Synthetic sweetener compositions with improved temporal profile and/or flavor profile, methods for their formulation, and uses
US20070116822A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company High-potency sweetener composition with saponin and compositions sweetened therewith
US9144251B2 (en) * 2005-11-23 2015-09-29 The Coca-Cola Company High-potency sweetener composition with mineral and compositions sweetened therewith
US8524303B2 (en) * 2005-11-23 2013-09-03 The Coca-Cola Company High-potency sweetener composition with phytosterol and compositions sweetened therewith
US8435587B2 (en) * 2005-11-23 2013-05-07 The Coca-Cola Company High-potency sweetener composition with long-chain primary aliphatic saturated alcohol and compositions sweetened therewith
US8993027B2 (en) * 2005-11-23 2015-03-31 The Coca-Cola Company Natural high-potency tabletop sweetener compositions with improved temporal and/or flavor profile, methods for their formulation, and uses
US20070116829A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company Pharmaceutical Composition with High-Potency Sweetener
US20070116839A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company High-Potency Sweetener Composition With C-Reactive Protein Reducing Substance and Compositions Sweetened Therewith
US20070116800A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company Chewing Gum with High-Potency Sweetener
US20070116836A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company High-Potency Sweetener Composition for Treatment and/or Prevention of Osteoporosis and Compositions Sweetened Therewith
US8512789B2 (en) * 2005-11-23 2013-08-20 The Coca-Cola Company High-potency sweetener composition with dietary fiber and compositions sweetened therewith
US8377491B2 (en) * 2005-11-23 2013-02-19 The Coca-Cola Company High-potency sweetener composition with vitamin and compositions sweetened therewith
US20070116833A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company High-Potency Sweetener Composition with Calcium and Compositions Sweetened Therewith
US20070116831A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company Dental Composition with High-Potency Sweetener
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US20070134391A1 (en) * 2005-11-23 2007-06-14 The Coca-Cola Company High-Potency Sweetener Composition for Treatment and/or Prevention of Autoimmune Disorders and Compositions Sweetened Therewith
MY149082A (en) 2005-12-28 2013-07-15 Meiji Co Ltd Solid milk and method of making the same
SG170766A1 (en) * 2006-03-24 2011-05-30 Kowa Co Oral fast-disintegrating tablet
US8846100B2 (en) * 2006-05-12 2014-09-30 Shire Llc Controlled dose drug delivery system
EP2043613A1 (en) * 2006-07-14 2009-04-08 Fmc Corporation Solid form
EP1891946A1 (en) * 2006-08-14 2008-02-27 Santhera Pharmaceuticals (Schweiz) AG Transmucosal administration of 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone
WO2008032767A1 (fr) 2006-09-14 2008-03-20 Astellas Pharma Inc. Comprimé se désintegrant oralement et procédé de fabrication de celui-ci
ES2370062T3 (es) * 2006-09-15 2011-12-12 Echo Pharmaceuticals B.V. Granulado que contiene una sustancia farmacéuticamente activa y un emulsionante y método para su producción.
US9101161B2 (en) * 2006-11-02 2015-08-11 The Coca-Cola Company High-potency sweetener composition with phytoestrogen and compositions sweetened therewith
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US20080107787A1 (en) * 2006-11-02 2008-05-08 The Coca-Cola Company Anti-Diabetic Composition with High-Potency Sweetener
US20100036002A1 (en) * 2006-12-26 2010-02-11 Medrx Co., Ltd. Pharmaceutical composition comprising porous dry matrix
JP5366558B2 (ja) 2006-12-28 2013-12-11 武田薬品工業株式会社 口腔内崩壊性固形製剤
ES2302650B1 (es) 2007-01-11 2009-02-16 Tedec-Meiji Farma, S.A. Composicion de rapida desintegracion en la cavidad bucal.
US20080187628A1 (en) * 2007-02-02 2008-08-07 Champion Melinda L Water-Soluble, Quick-Dissolve Flavor Tablets
US20080260823A1 (en) * 2007-04-20 2008-10-23 Sciele Pharma, Inc. Orally disintegrating tablet comprising glycopyrrolate for treating sialorrhea
US20080311162A1 (en) * 2007-05-16 2008-12-18 Olivia Darmuzey Solid form
JP4980144B2 (ja) * 2007-06-05 2012-07-18 日機装株式会社 固型化透析用剤の製造方法
JP2009035505A (ja) * 2007-08-01 2009-02-19 Takada Seiyaku Kk レボフロキサシン錠剤
US20090060983A1 (en) * 2007-08-30 2009-03-05 Bunick Frank J Method And Composition For Making An Orally Disintegrating Dosage Form
AU2008318851B2 (en) * 2007-10-31 2014-04-17 Mcneil-Ppc, Inc. Orally disintegrated dosage form
JP4832407B2 (ja) * 2007-11-19 2011-12-07 花王株式会社 コラーゲン含有組成物
CA2709709A1 (en) * 2007-12-21 2009-07-09 Mcneil-Ppc, Inc. Manufacture of tablet
JP5547096B2 (ja) * 2008-02-28 2014-07-09 アール．ピー． シェーラー テクノロジーズ エルエルシー 多型を最小化する方法
EP2100595A1 (en) * 2008-03-10 2009-09-16 The Procter and Gamble Company Compressed tablets
US20100075930A1 (en) * 2008-09-03 2010-03-25 Yoel Ovil Salicylic salt compositions and related method of treatment of cardiac conditions
EP2385769A4 (en) * 2008-12-15 2014-08-20 Valeant Pharmaceuticals Luxembourg S R L QUICKLY SOLUBLE VITAMIN FORMULATION AND METHOD FOR THEIR USE
US8303868B2 (en) 2009-01-26 2012-11-06 Shin-Etsu Chemical Co., Ltd. Wet granulation tableting method using aqueous dispersion of low-substituted hydroxypropyl cellulose
MX2011009053A (es) 2009-03-09 2012-04-02 Spi Pharma Inc Excipientes de compresion directa con alta capacidad de compactacion y durables y sistemas de excipiente.
EP2440210A4 (en) * 2009-06-12 2014-01-29 Meritage Pharma Inc METHOD FOR THE TREATMENT OF STOMACH DARM DISEASES
JP2011037767A (ja) * 2009-08-11 2011-02-24 Dainippon Sumitomo Pharma Co Ltd 薬物および噴霧乾燥粒子を含有する口腔内速崩壊錠
US20110318411A1 (en) 2010-06-24 2011-12-29 Luber Joseph R Multi-layered orally disintegrating tablet and the manufacture thereof
US20110070286A1 (en) * 2009-09-24 2011-03-24 Andreas Hugerth Process for the manufacture of nicotine-comprising chewing gum and nicotine-comprising chewing gum manufactured according to said process
US8313768B2 (en) 2009-09-24 2012-11-20 Mcneil-Ppc, Inc. Manufacture of tablet having immediate release region and sustained release region
US8784781B2 (en) 2009-09-24 2014-07-22 Mcneil-Ppc, Inc. Manufacture of chewing gum product with radiofrequency
ES2668203T3 (es) 2009-12-02 2018-05-17 Adare Pharmaceuticals S.R.L. Microcápsulas de fexofenadina y composiciones que las contienen
WO2011085181A1 (en) * 2010-01-08 2011-07-14 Eurand, Inc. Taste masked topiramate composition and an orally disintegrating tablet comprising the same
JP5513936B2 (ja) * 2010-03-10 2014-06-04 全星薬品工業株式会社 口腔内崩壊製剤
JP2010174028A (ja) * 2010-03-18 2010-08-12 Rohto Pharmaceut Co Ltd 苦味を有する薬物を含有する口中溶解型又は咀嚼型固形内服医薬組成物
KR101232088B1 (ko) * 2010-05-11 2013-02-08 박대철 용해성이 향상된 태블릿 제조방법
SG188363A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Fast-dissolve dosage forms of 5-ht2c agonists
AU2011336300B2 (en) 2010-12-02 2015-05-21 Adare Pharmaceuticals, Inc. Rapidly dispersing granules, orally disintegrating tablets and methods
SG10201602311XA (en) 2010-12-27 2016-04-28 Takeda Pharmaceutical Orally disintegrating tablet
MX2014007933A (es) 2011-12-26 2014-07-30 Novartis Ag Comprimidos y agentes recubiertos en seco.
KR20130076015A (ko) * 2011-12-28 2013-07-08 주식회사 삼양바이오팜 높은 경도를 갖는 속붕정 및 이의 제조 방법
US9233491B2 (en) 2012-05-01 2016-01-12 Johnson & Johnson Consumer Inc. Machine for production of solid dosage forms
US9445971B2 (en) 2012-05-01 2016-09-20 Johnson & Johnson Consumer Inc. Method of manufacturing solid dosage form
US9511028B2 (en) 2012-05-01 2016-12-06 Johnson & Johnson Consumer Inc. Orally disintegrating tablet
JP2013028647A (ja) * 2012-11-06 2013-02-07 Rohto Pharmaceutical Co Ltd 苦味を有する薬物を含有する口中溶解型又は咀嚼型固形内服医薬組成物
FR2999432B1 (fr) 2012-12-17 2014-12-12 Ethypharm Sa Comprimes orodispersibles obtenus par compression moulage
US20150098978A1 (en) * 2013-10-03 2015-04-09 Altria Client Services Inc. Dissolvable-chewable tablet
US20160296463A1 (en) 2013-11-11 2016-10-13 Impax Laboratories, Inc. Rapidly disintegrating formulations and methods thereof
MX368159B (es) 2014-01-10 2019-09-20 Johnson & Johnson Consumer Inc Proceso para elaborar tabletas con el uso de radiofrecuencia y partículas disipativas revestidas.
US9925138B2 (en) 2015-01-20 2018-03-27 Handa Pharmaceuticals, Llc Stable solid fingolimod dosage forms
CA2977168C (en) 2015-03-31 2020-01-28 Laboratorios Bago S.A. Enteric-coated pellets containing a proton pump inhibitor
JP6552088B2 (ja) * 2015-04-21 2019-07-31 ライオン株式会社 造粒顆粒およびその製造方法と、錠剤およびその製造方法
US10493026B2 (en) 2017-03-20 2019-12-03 Johnson & Johnson Consumer Inc. Process for making tablet using radiofrequency and lossy coated particles
CN113876725A (zh) * 2020-10-12 2022-01-04 北京中科利华医药研究院有限公司 一种维生素b6片剂及其制备方法
JP2023549568A (ja) * 2020-11-16 2023-11-27 オルコサ・インコーポレイテッド ヒトにおける治療的処置のための急速注入プラットフォーム及び組成物
US11672761B2 (en) 2020-11-16 2023-06-13 Orcosa Inc. Rapidly infusing platform and compositions for therapeutic treatment in humans

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2926121A (en) * 1957-03-20 1960-02-23 American Home Prod Therapeutic candy-like product and its preparation
GB1134097A (en) * 1965-11-25 1968-11-20 Internat Chemical Company Ltd Improvements in antacid tablets
DE2556561C2 (de) * 1975-12-16 1983-04-14 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur Herstellung von porösen Tabletten
JPS5824410A (ja) * 1981-08-06 1983-02-14 Toppan Printing Co Ltd チユ−ブの製造方法
GB2111423B (en) * 1981-12-02 1985-06-26 Wyeth John & Brother Ltd Making quick-dissolving pills
US4414198A (en) * 1982-04-23 1983-11-08 Joseph Michaelson Rapidly disintegrable tablet composition and method
EP0166440A3 (en) * 1984-06-28 1987-06-03 THE PROCTER & GAMBLE COMPANY Antacid composition
US4684534A (en) * 1985-02-19 1987-08-04 Dynagram Corporation Of America Quick-liquifying, chewable tablet
ATE108996T1 (de) * 1988-02-25 1994-08-15 Brocades Pharma Bv Verfahren zur herstellung eines pharmazeutischen granulats.
US5082667A (en) * 1988-06-07 1992-01-21 Abbott Laboratories Solid pharmaceutical dosage in tablet triturate form and method of producing same
US5112616A (en) * 1988-11-30 1992-05-12 Schering Corporation Fast dissolving buccal tablet
US5073374A (en) * 1988-11-30 1991-12-17 Schering Corporation Fast dissolving buccal tablet
US4946684A (en) * 1989-06-20 1990-08-07 American Home Products Corporation Fast dissolving dosage forms
US5079018A (en) * 1989-08-14 1992-01-07 Neophore Technologies, Inc. Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
US5215756A (en) * 1989-12-22 1993-06-01 Gole Dilip J Preparation of pharmaceutical and other matrix systems by solid-state dissolution
RU2109509C1 (ru) * 1991-12-24 1998-04-27 Яманути Фармасьютикал Ко., Лтд. Композиция для буккального введения лекарственного средства и способ ее получения
TW272942B (ko) * 1993-02-10 1996-03-21 Takeda Pharm Industry Co Ltd

Also Published As

Publication number Publication date
EP0553777B1 (en) 2002-04-24
CA2088334C (en) 2004-06-15
TW249756B (ko) 1995-06-21
JPH05271054A (ja) 1993-10-19
JP4336021B2 (ja) 2009-09-30
US5501861A (en) 1996-03-26
ATE216577T1 (de) 2002-05-15
DE69331839D1 (de) 2002-05-29
JP2000264836A (ja) 2000-09-26
EP0553777A2 (en) 1993-08-04
CA2088334A1 (en) 1993-07-30
US5720974A (en) 1998-02-24
DE69331839T2 (de) 2002-12-12
EP0553777A3 (en) 1994-12-14
JP3069458B2 (ja) 2000-07-24
KR100258223B1 (ko) 2000-08-01

Similar Documents

Publication Publication Date Title
KR930016092A (ko) 신속 용해형 정제 및 그의 제조법
US5939091A (en) Method for making fast-melt tablets
RU2227020C2 (ru) Быстрорастворяющиеся таблетки на основе полимеров и способы их приготовления
EP0914818B1 (en) Intraorally rapidly disintegrable tablet
US4708874A (en) Devices for the controlled release of active substances, as well as process for the preparation thereof
DE60028536T2 (de) In der Mundhöhle schnell zerfallende orale feste Verabreichungsform
US4880830A (en) Slow release formulation
DE69821553T2 (de) Granulatzubereitung enthaltend Simethicon und granuliertes wasserfreies Calciumphosphat
EP0272265B1 (de) Zerfallstablette und verfahren zu ihrer herstellung
CA2378578A1 (en) Means for creating a mass having structural integrity
EP0277092A1 (de) Therapeutisches System für schwerlösliche Wirkstoffe
KR20010024464A (ko) 신속 용해성 고형 제제
EP0804171B1 (de) Kautablette mit brausewirkung
Khanna et al. Fast dissolving tablets-A novel approach
KR890001526A (ko) 경구용 서방성 아세트 아미노펜 제형 및 이의 제조방법
CH655241A5 (de) Verfahren zur herstellung therapeutisch wirksamer praeparate mit anhaltendem verlauf der wirkstoff-freisetzung.
JP2001058944A (ja) 速崩壊性固形製剤
US3632778A (en) Tablets containing l-dopa
EP1198227A1 (de) Verfahren zur herstellung schnell zerfallender, fester pharmazeutischer zubereitungen
JP3418274B2 (ja) 口腔内感触の良好な錠剤
US3446899A (en) Vitamin compositions produced by direct compression
NO326259B1 (no) Faste oralt-dispergerbare farmasoytiske formuleringer
Roy et al. A comprehensive review on superdisintegrants used in orodispersible tablets
US6413541B1 (en) Disintegrating tablet in oral cavity and production thereof
JP4438121B2 (ja) 口腔内速崩錠及びその製造方法

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20120223

Year of fee payment: 13

EXPY Expiration of term