ES2019024A6 - Procedimiento de preparar una composicion farmaceutica a base de trimebutina. - Google Patents

Procedimiento de preparar una composicion farmaceutica a base de trimebutina.

Info

Publication number
ES2019024A6
ES2019024A6 ES9000188A ES9000188A ES2019024A6 ES 2019024 A6 ES2019024 A6 ES 2019024A6 ES 9000188 A ES9000188 A ES 9000188A ES 9000188 A ES9000188 A ES 9000188A ES 2019024 A6 ES2019024 A6 ES 2019024A6
Authority
ES
Spain
Prior art keywords
sustained release
trimebutine
base
tablets
release composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9000188A
Other languages
English (en)
Inventor
Omar Loufty Benkerrour
Francoise Chanoine
Sylvain Jacques Frances
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jouveinal SA
Original Assignee
Jouveinal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jouveinal SA filed Critical Jouveinal SA
Publication of ES2019024A6 publication Critical patent/ES2019024A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)

Abstract

PROCEDIMIENTO DE PREPARAR UNA COMPOSICION FARMACEUTICA A BASE DE TRIMEBUTINA, EN FORMA DE UN COMPRIMIDO EXENTO DE REVESTIMIENTO QUE COMPRENDE TRIMETOXI-3,4,5 BENZOATO DE DIMETILAMINO-2-FENIL-2 BUTANOL-1 DE LA FORMULA INDICADA O UNA DE SUS SALES. EL PROCEDIMIENTO CONSISTE EN DISPERSAR DE MANERA HOMOGENEA EL PRINCIPIO ACTIVO EN UNA MATRIZ DE HIDROXIPROPILMETILCELULOSA, MEZCLANDO DICHOS COMPONENTES CON UN DILUYENTE HIDROSOLUBLE Y CON ACIDO TARTARICO, Y EN COMPRIMIR LA MEZCLA PARA FORMAR UN COMPRIMIDO, ELIGIENDOSE LAS CONDICIONES DE OPERACION DE MODO QUE, RESPECTO AL PESO DE LA COMPOSICION, EL PRINCIPIO ACTIVO REPRESENTE DEL 35 AL 45%, LA HIDROXIPROPILMETILCELULOSA REPRESENTE DEL 15 AL 20%, EL DILUYENTE HIDROSOLUBLE REPRESENTE DEL 20 AL 25% Y EL ACIDO TARTARICO REPRESENTE DEL 10 AL 20%. LAS COMPOSICIONES OBTENIDAS CON EL PROCEDIMIENTO SON DE LIBERACION PROLONGADA Y APLICABLES PARTICULARMENTE EN GASTROENTEROLOGIA.
ES9000188A 1988-12-28 1989-12-28 Procedimiento de preparar una composicion farmaceutica a base de trimebutina. Expired - Lifetime ES2019024A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8817303A FR2640876B1 (es) 1988-12-28 1988-12-28

Publications (1)

Publication Number Publication Date
ES2019024A6 true ES2019024A6 (es) 1991-05-16

Family

ID=9373520

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9000188A Expired - Lifetime ES2019024A6 (es) 1988-12-28 1989-12-28 Procedimiento de preparar una composicion farmaceutica a base de trimebutina.

Country Status (14)

Country Link
JP (1) JP2745232B2 (es)
KR (1) KR0137270B1 (es)
AT (1) AT397461B (es)
BE (1) BE1006002A4 (es)
CA (1) CA2006184C (es)
DE (1) DE3942131C2 (es)
EG (1) EG19994A (es)
ES (1) ES2019024A6 (es)
FR (1) FR2640876B1 (es)
GR (1) GR1000429B (es)
GT (1) GT198900080A (es)
IT (1) IT1236239B (es)
MX (1) MX170641B (es)
PT (1) PT92682B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2130081A1 (es) * 1996-08-07 1999-06-16 Jouveninal Laboratoires Comprimido de maleato de trimebutina con recubrimiento laminar.

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05255125A (ja) * 1992-02-29 1993-10-05 Upjohn Co:The 徐放性製剤およびその製法
FR2730163B1 (fr) * 1995-02-03 1997-04-04 Jouveinal Lab Nouvelle composition pharmaceutique contenant la trimebutine et son procede de preparation
CN1927185B (zh) * 2006-10-19 2010-05-19 开开援生制药股份有限公司 具速释部分的马来酸曲美布汀缓释片及其制备工艺
KR101051630B1 (ko) * 2008-10-02 2011-07-26 한국유나이티드제약 주식회사 용출률과 복용편의성이 향상된 트리메부틴 서방정
FR2944971B1 (fr) * 2009-04-30 2012-09-07 Roquette Freres Coagglomerats de mannitol et d'amidon granulaire comprimables et a ecoulement libre

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065143A (en) * 1960-04-19 1962-11-20 Richardson Merrell Inc Sustained release tablet
JPS57197214A (en) * 1981-05-29 1982-12-03 Tanabe Seiyaku Co Ltd Rapid-releasing microcapsule and its preparation
JPS5858145A (ja) * 1981-10-05 1983-04-06 Tanabe Seiyaku Co Ltd 速放性マイクロカプセル
JPS5858146A (ja) * 1981-10-05 1983-04-06 Tanabe Seiyaku Co Ltd 速放性マイクロカプセル
JPS5916821A (ja) * 1982-07-16 1984-01-28 Tanabe Seiyaku Co Ltd 非凝集性マイクロカプセルの製法
IT1206166B (it) * 1984-07-26 1989-04-14 Sigma Tau Ind Farmaceuti Dispositivo per rilasciare una sostanza in un fluido di dissoluzione con cinetica di ordine zero e procedimento per la sua preparazione
GB8616669D0 (en) * 1986-07-09 1986-08-13 Merk Sharpe & Dohme Ltd Pharmaceutical compositions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2130081A1 (es) * 1996-08-07 1999-06-16 Jouveninal Laboratoires Comprimido de maleato de trimebutina con recubrimiento laminar.

Also Published As

Publication number Publication date
KR900009060A (ko) 1990-07-02
FR2640876B1 (es) 1993-09-24
IT1236239B (it) 1993-01-27
GR1000429B (el) 1992-07-30
GT198900080A (es) 1991-06-20
FR2640876A1 (es) 1990-06-29
PT92682B (pt) 1997-01-31
IT8912615A1 (it) 1991-06-20
KR0137270B1 (ko) 1998-04-25
JPH02184624A (ja) 1990-07-19
DE3942131C2 (de) 1998-09-17
PT92682A (pt) 1990-06-29
GR890100860A (en) 1991-03-15
CA2006184A1 (en) 1990-06-28
IT8912615A0 (it) 1989-12-20
JP2745232B2 (ja) 1998-04-28
MX170641B (es) 1993-09-01
EG19994A (en) 1997-01-30
AT397461B (de) 1994-04-25
BE1006002A4 (fr) 1994-04-19
ATA294489A (de) 1993-09-15
DE3942131A1 (de) 1990-07-05
CA2006184C (en) 1999-11-23

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2009-12-28

FD1A Patent lapsed

Effective date: 20101018