CN109923360B - 在受控环境中加速干燥软胶囊 - Google Patents

在受控环境中加速干燥软胶囊 Download PDF

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Publication number
CN109923360B
CN109923360B CN201780069164.1A CN201780069164A CN109923360B CN 109923360 B CN109923360 B CN 109923360B CN 201780069164 A CN201780069164 A CN 201780069164A CN 109923360 B CN109923360 B CN 109923360B
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Prior art keywords
relative humidity
drying
dryer
temperature
capsules
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English (en)
Chinese (zh)
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CN109923360A (zh
Inventor
N·理查德·哈特
L·大卫·弗普尔
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RP Scherer Technologies LLC
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RP Scherer Technologies LLC
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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/06—Controlling, e.g. regulating, parameters of gas supply
    • F26B21/10—Temperature; Pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/077—Manufacturing capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B11/00—Machines or apparatus for drying solid materials or objects with movement which is non-progressive
    • F26B11/02—Machines or apparatus for drying solid materials or objects with movement which is non-progressive in moving drums or other mainly-closed receptacles
    • F26B11/04—Machines or apparatus for drying solid materials or objects with movement which is non-progressive in moving drums or other mainly-closed receptacles rotating about a horizontal or slightly-inclined axis
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/004—Nozzle assemblies; Air knives; Air distributors; Blow boxes
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/02—Circulating air or gases in closed cycles, e.g. wholly within the drying enclosure
    • F26B21/04—Circulating air or gases in closed cycles, e.g. wholly within the drying enclosure partly outside the drying enclosure
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/06—Controlling, e.g. regulating, parameters of gas supply
    • F26B21/08—Humidity
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/06—Controlling, e.g. regulating, parameters of gas supply
    • F26B21/12—Velocity of flow; Quantity of flow, e.g. by varying fan speed, by modifying cross flow area
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • F26B3/06—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour flowing through the materials or objects to be dried
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S53/00—Package making
    • Y10S53/90—Capsules

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Drying Of Solid Materials (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Disintegrating Or Milling (AREA)
CN201780069164.1A 2016-12-08 2017-12-08 在受控环境中加速干燥软胶囊 Active CN109923360B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662431569P 2016-12-08 2016-12-08
US62/431,569 2016-12-08
PCT/US2017/065290 WO2018107019A1 (en) 2016-12-08 2017-12-08 Accelerated drying of soft capsules in a controlled environment

Publications (2)

Publication Number Publication Date
CN109923360A CN109923360A (zh) 2019-06-21
CN109923360B true CN109923360B (zh) 2022-02-11

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CN201780069164.1A Active CN109923360B (zh) 2016-12-08 2017-12-08 在受控环境中加速干燥软胶囊
CN201780070689.7A Expired - Fee Related CN110167510B (zh) 2016-12-08 2017-12-08 减轻胶囊壳中的应力以降低破裂倾向的方法

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CN201780070689.7A Expired - Fee Related CN110167510B (zh) 2016-12-08 2017-12-08 减轻胶囊壳中的应力以降低破裂倾向的方法

Country Status (14)

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US (3) US11026865B2 (enExample)
EP (2) EP3551158B1 (enExample)
JP (2) JP7129977B2 (enExample)
KR (2) KR102475555B1 (enExample)
CN (2) CN109923360B (enExample)
AU (2) AU2017374037B2 (enExample)
BR (1) BR112019010069A2 (enExample)
CA (2) CA3045127A1 (enExample)
CO (2) CO2019005095A2 (enExample)
ES (1) ES2927068T3 (enExample)
IL (2) IL266694B2 (enExample)
MX (2) MX2019005930A (enExample)
RU (2) RU2765074C2 (enExample)
WO (2) WO2018107019A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018107019A1 (en) 2016-12-08 2018-06-14 R.P. Scherer Technologies, Llc Accelerated drying of soft capsules in a controlled environment
US20220249368A1 (en) * 2019-08-30 2022-08-11 Procaps S.A. Heat resistant chewable oral form with an agar matrix and manufacturing process thereof
US20210154099A1 (en) * 2019-11-22 2021-05-27 Karl Wei Cao Top liquid fill method and apparatus for hard capsules
CN114787512B (zh) * 2019-12-11 2024-07-05 W.L.戈尔及同仁股份有限公司 用于评估蒸气泵性能的方法
CN115792141B (zh) * 2023-01-06 2023-05-02 广州兰泰仪器有限公司 一种提高水活度仪平衡检测效率的方法及系统

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JP7129977B2 (ja) 2022-09-02
RU2019112049A (ru) 2021-01-12
MX2019005930A (es) 2019-07-08
CO2019005238A2 (es) 2019-05-31
IL266694A (en) 2019-07-31
IL266694B (en) 2022-11-01
US12161605B2 (en) 2024-12-10
EP3551158B1 (en) 2024-07-10
AU2017371180B2 (en) 2023-05-11
NZ752946A (en) 2025-03-28
AU2017371180A1 (en) 2019-05-23
BR112019010644A2 (pt) 2019-10-01
US20200069524A1 (en) 2020-03-05
KR102328603B1 (ko) 2021-11-18
CN110167510B (zh) 2021-12-14
IL266695A (en) 2019-07-31
ES2927068T3 (es) 2022-11-02
EP3551158A1 (en) 2019-10-16
US11026865B2 (en) 2021-06-08
IL266695B (en) 2022-09-01
EP3551950A1 (en) 2019-10-16
US20200069525A1 (en) 2020-03-05
KR20190084990A (ko) 2019-07-17
WO2018107080A1 (en) 2018-06-14
IL266694B2 (en) 2023-03-01
CN110167510A (zh) 2019-08-23
RU2765074C2 (ru) 2022-01-25
JP7013465B2 (ja) 2022-01-31
WO2018107019A1 (en) 2018-06-14
MX2019005956A (es) 2019-07-10
US20250025377A1 (en) 2025-01-23
EP3551158A4 (en) 2020-06-03
EP3551950B1 (en) 2022-06-22
RU2019113369A3 (enExample) 2021-03-18
CA3045127A1 (en) 2018-06-14
JP2020500643A (ja) 2020-01-16
CO2019005095A2 (es) 2019-05-31
CA3041560A1 (en) 2018-06-14
CN109923360A (zh) 2019-06-21
RU2019112049A3 (enExample) 2021-01-21
BR112019010069A2 (pt) 2019-08-20
RU2745334C2 (ru) 2021-03-24
RU2745334C9 (ru) 2021-05-24
AU2017374037B2 (en) 2023-02-23
AU2017374037A1 (en) 2019-05-16
KR102475555B1 (ko) 2022-12-07
JP2020501101A (ja) 2020-01-16
RU2019113369A (ru) 2021-01-13
EP3551158C0 (en) 2024-07-10
EP3551950A4 (en) 2020-06-03
KR20190069576A (ko) 2019-06-19

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