JP7129977B2 - カプセルシェル応力を軽減してひび割れや損傷の可能性を減少させる方法 - Google Patents

カプセルシェル応力を軽減してひび割れや損傷の可能性を減少させる方法 Download PDF

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JP7129977B2
JP7129977B2 JP2019531045A JP2019531045A JP7129977B2 JP 7129977 B2 JP7129977 B2 JP 7129977B2 JP 2019531045 A JP2019531045 A JP 2019531045A JP 2019531045 A JP2019531045 A JP 2019531045A JP 7129977 B2 JP7129977 B2 JP 7129977B2
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capsule shell
capsule
hard capsule
shell
temperature
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JPWO2018107080A5 (enExample
JP2020500643A5 (enExample
JP2020500643A (ja
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デイビッド フルパー、レスター
ハート、ノートン
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アール．ピー．シェーラー テクノロジーズ、エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/077—Manufacturing capsule shells
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/06—Controlling, e.g. regulating, parameters of gas supply
    • F26B21/10—Temperature; Pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B11/00—Machines or apparatus for drying solid materials or objects with movement which is non-progressive
    • F26B11/02—Machines or apparatus for drying solid materials or objects with movement which is non-progressive in moving drums or other mainly-closed receptacles
    • F26B11/04—Machines or apparatus for drying solid materials or objects with movement which is non-progressive in moving drums or other mainly-closed receptacles rotating about a horizontal or slightly-inclined axis
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/004—Nozzle assemblies; Air knives; Air distributors; Blow boxes
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/02—Circulating air or gases in closed cycles, e.g. wholly within the drying enclosure
    • F26B21/04—Circulating air or gases in closed cycles, e.g. wholly within the drying enclosure partly outside the drying enclosure
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/06—Controlling, e.g. regulating, parameters of gas supply
    • F26B21/08—Humidity
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/06—Controlling, e.g. regulating, parameters of gas supply
    • F26B21/12—Velocity of flow; Quantity of flow, e.g. by varying fan speed, by modifying cross flow area
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • F26B3/06—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour flowing through the materials or objects to be dried
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S53/00—Package making
    • Y10S53/90—Capsules

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Drying Of Solid Materials (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Disintegrating Or Milling (AREA)
JP2019531045A 2016-12-08 2017-12-08 カプセルシェル応力を軽減してひび割れや損傷の可能性を減少させる方法 Active JP7129977B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662431569P 2016-12-08 2016-12-08
US62/431,569 2016-12-08
PCT/US2017/065398 WO2018107080A1 (en) 2016-12-08 2017-12-08 A method to relieve stress in capsule shells to reduce propensity to break

Publications (4)

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JP2020500643A JP2020500643A (ja) 2020-01-16
JP2020500643A5 JP2020500643A5 (enExample) 2020-12-24
JPWO2018107080A5 JPWO2018107080A5 (enExample) 2022-07-15
JP7129977B2 true JP7129977B2 (ja) 2022-09-02

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JP2019530494A Active JP7013465B2 (ja) 2016-12-08 2017-12-08 制御された環境におけるソフトカプセルの加速乾燥

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US (3) US11026865B2 (enExample)
EP (2) EP3551158B1 (enExample)
JP (2) JP7129977B2 (enExample)
KR (2) KR102475555B1 (enExample)
CN (2) CN109923360B (enExample)
AU (2) AU2017374037B2 (enExample)
BR (1) BR112019010069A2 (enExample)
CA (2) CA3045127A1 (enExample)
CO (2) CO2019005095A2 (enExample)
ES (1) ES2927068T3 (enExample)
IL (2) IL266694B2 (enExample)
MX (2) MX2019005930A (enExample)
RU (2) RU2765074C2 (enExample)
WO (2) WO2018107019A1 (enExample)

Families Citing this family (5)

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CN114787512B (zh) * 2019-12-11 2024-07-05 W.L.戈尔及同仁股份有限公司 用于评估蒸气泵性能的方法
CN115792141B (zh) * 2023-01-06 2023-05-02 广州兰泰仪器有限公司 一种提高水活度仪平衡检测效率的方法及系统

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RU2019112049A (ru) 2021-01-12
MX2019005930A (es) 2019-07-08
CO2019005238A2 (es) 2019-05-31
IL266694A (en) 2019-07-31
IL266694B (en) 2022-11-01
US12161605B2 (en) 2024-12-10
EP3551158B1 (en) 2024-07-10
AU2017371180B2 (en) 2023-05-11
NZ752946A (en) 2025-03-28
AU2017371180A1 (en) 2019-05-23
BR112019010644A2 (pt) 2019-10-01
US20200069524A1 (en) 2020-03-05
KR102328603B1 (ko) 2021-11-18
CN109923360B (zh) 2022-02-11
CN110167510B (zh) 2021-12-14
IL266695A (en) 2019-07-31
ES2927068T3 (es) 2022-11-02
EP3551158A1 (en) 2019-10-16
US11026865B2 (en) 2021-06-08
IL266695B (en) 2022-09-01
EP3551950A1 (en) 2019-10-16
US20200069525A1 (en) 2020-03-05
KR20190084990A (ko) 2019-07-17
WO2018107080A1 (en) 2018-06-14
IL266694B2 (en) 2023-03-01
CN110167510A (zh) 2019-08-23
RU2765074C2 (ru) 2022-01-25
JP7013465B2 (ja) 2022-01-31
WO2018107019A1 (en) 2018-06-14
MX2019005956A (es) 2019-07-10
US20250025377A1 (en) 2025-01-23
EP3551158A4 (en) 2020-06-03
EP3551950B1 (en) 2022-06-22
RU2019113369A3 (enExample) 2021-03-18
CA3045127A1 (en) 2018-06-14
JP2020500643A (ja) 2020-01-16
CO2019005095A2 (es) 2019-05-31
CA3041560A1 (en) 2018-06-14
CN109923360A (zh) 2019-06-21
RU2019112049A3 (enExample) 2021-01-21
BR112019010069A2 (pt) 2019-08-20
RU2745334C2 (ru) 2021-03-24
RU2745334C9 (ru) 2021-05-24
AU2017374037B2 (en) 2023-02-23
AU2017374037A1 (en) 2019-05-16
KR102475555B1 (ko) 2022-12-07
JP2020501101A (ja) 2020-01-16
RU2019113369A (ru) 2021-01-13
EP3551158C0 (en) 2024-07-10
EP3551950A4 (en) 2020-06-03
KR20190069576A (ko) 2019-06-19

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Melocchi et al. The chronotopic™ system for pulsatile and colonic delivery of active molecules in the era of precision medicine: feasibility by 3D printing via fused deposition modeling (FDM). Pharmaceutics 2021; 13 (5): 759
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