CN109890339A - 多层伤口敷料及制造方法 - Google Patents
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Abstract
一种多层伤口敷料，其包括用于从伤口部位吸收流出物的纤维吸收层。所述伤口敷料还包括支撑层，所述支撑层构造成减少伤口敷料的至少一部分的收缩。
Description
本发明涉及多层伤口敷料和制造这种伤口敷料的方法。具体而言，但并非排他性地，本发明的实施例涉及具有纤维吸收层的多层伤口敷料，所述纤维吸收层甚至在极端灭菌方法和储存条件下能够抵抗收缩，本发明的实施例具有改善的美观性和机械强度，从而提高产品在其保质期内的一致性。
伤口敷料可以用液体不可渗透的顶层(离伤口最远的外层)形成，这防止伤口流出物刺穿敷料并从敷料渗漏。顶层通常也是透气的和液体蒸气可渗透的，以有助于最小化对伤口的浸渍。
在一些已知的伤口敷料中，液体不可渗透的顶层可易于受起皱影响(起皱包括但不限于不一致的外观、皱纹、折痕纹理化表面)。当伤口敷料被包装于无菌包装时，可能发生起皱，并且起皱可能是由于一个或多个伤口敷料层随时间推移而收缩造成的。这可能是由于选择的包装和灭菌方法的类型造成的。医务人员可能会觉得如果出现起皱，则产品已经被损坏。因此，可能无法确定伤口敷料是否仍适合使用。当使用伤口敷料时，顶层的起皱还可能发生。起皱的伤口敷料还在视觉上对患者无吸引力。
伤口敷料通常需要使产品保质期尽可能长，通常为5年，因此需要生产这样的伤口敷料，其中液体不可渗透的顶层不太可能起皱，随时间的推移外观不太可能变得不一致或美感不太可能改变。
EP 1,314,410公开了一种具有顶部膜层的多层伤口敷料，但没有公开任何减少或防止敷料的收缩或起皱的方式。
根据本发明的第一方面，提供了一种多层伤口敷料，其包括：
纤维吸收层，所述纤维吸收层用于从伤口部位吸收流出物；和
支撑层，所述支撑层构造成减少所述伤口敷料的至少一部分的收缩。
根据本发明的第二方面，提供了一种制造多层伤口敷料的方法，所述方法包括：
形成支撑层；
形成用于从伤口部位吸收流出物的纤维吸收层；以及
将所述支撑层和所述吸收层层压在一起以形成所述伤口敷料；
其中所述支撑层构造成减少所述伤口敷料的至少一部分的收缩。
根据本发明的第三方面，提供了一种治疗伤口的方法，所述方法包括在伤口上放置根据本文公开的任何实施例所述的多层伤口敷料。
根据本发明的第四方面，提供了一种向伤口提供负压伤口治疗的方法，所述方法包括：
在伤口上放置根据本文公开的任何实施例所述的多层伤口敷料；
在所述伤口敷料和负压源之间形成流体流动路径；和
操作所述负压源以向伤口提供负压。
根据本发明的第五方面，提供了一种操作负压伤口系统的方法，所述方法包括：
操作流体连接至根据本文公开的任何实施例的多层伤口敷料的负压源，所述伤口敷料构造成定位在伤口上。
根据本发明的第六方面，提供了一种负压伤口治疗套件，所述负压伤口治疗套件包括根据本文公开的任何实施例所述的多层伤口敷料和构造成流体连接至所述伤口敷料的负压源。
根据另一个方面，提供了一种多层伤口敷料，其包括：
纤维吸收层，所述纤维吸收层用于从伤口部位吸收流出物；和
支撑层，所述支撑层构造成减少所述伤口敷料的至少一部分的收缩，
其中，所述支撑层包括网，所述网包括几何结构，所述几何结构具有延伸穿过其中的多个大致几何孔隙；和
所述几何结构包括多个凸台，所述多个凸台基本均匀地间隔开并通过聚合物股线接合以在所述聚合物股线之间形成大致几何孔隙。
根据另一个方面，提供了一种多层伤口敷料，其包括：
纤维吸收层，所述纤维吸收层用于从伤口部位吸收流出物；和
支撑层，所述支撑层构造成减少所述伤口敷料的至少一部分的收缩，
其中，所述网由高密度聚乙烯形成。
根据另一个方面，提供了一种多层伤口敷料，其包括：
纤维吸收层，所述纤维吸收层用于从伤口部位吸收流出物；和
支撑层，所述支撑层构造成减少所述伤口敷料的至少一部分的收缩，
其中，所述支撑层具有0.05Nm至0.06Nm的拉伸强度。
根据另一个方面，提供了一种多层伤口敷料，其包括：
纤维吸收层，所述纤维吸收层用于从伤口部位吸收流出物；和
支撑层，所述支撑层构造成减少所述伤口敷料的至少一部分的收缩，
其中，所述支撑层粘结到所述吸收层的顶表面中的纤维，
所述支撑层还包括粘结层，其中，所述支撑层通过所述粘结层热层压到所述吸收层中的纤维；和
其中，所述粘结层包含低熔点乙烯-乙酸乙烯酯粘合剂。
与已知伤口敷料相比，本发明的某些实施例提供了至少部分伤口敷料随时间的推移不太可能收缩的优点。
本发明的某些方面提供一种伤口敷料，其中防止或减少伤口敷料的一层或几层(例如液体不可渗透的膜层)的起皱。
在下文参考附图进一步描述了本发明的实施例，在附图中：
图1是伤口敷料的一个实例的截面的示意图；
图2是支撑层的一个实例的示意图；
图3A是伤口敷料的另一实例的截面的示意图；
图3B是图3A的伤口敷料的透视图；
图4是制造图3A的伤口敷料的方法的一个实例的流程图；
图5是伤口敷料的又一个实例的示意图；和
图6是伤口敷料的再一个实例的示意图。
图7是负压伤口治疗系统的一个实例的示意图。
在附图中，相同的附图标记指代相同的部分。
图1显示了多层伤口敷料100的一个实例。伤口敷料100包括位于伤口敷料100顶部的液体不可渗透的膜层102。使用中，膜层102是伤口敷料100的顶层，在离伤口部位的最远端。
膜层102也是气体和蒸气可渗透的，从而允许流体或伤口流出物从伤口敷料100蒸发，并有助于防止伤口的浸渍。在该实例中，膜层102由聚氨酯共混物形成，但其他合适的材料可包括其他聚合材料，例如聚乙烯或聚丙烯。
吸收层108位于膜层102下面。吸收层108具有用于从伤口部位吸收流出物的纤维结构。在该实例中，吸收层108包括超级吸收性纤维。吸收层108还包括其他纤维。在该实例中，吸收层包括超级吸收性纤维、粘胶纤维和聚酯纤维。
在该实例中，吸收层108包括40％左右的超级吸收性纤维、40％的粘胶纤维和20％的聚酯纤维。在其他实例中，吸收层可包括0-50％左右的超级吸收性纤维、0-100％的粘胶纤维和0-50％的聚酯纤维。合适的超级吸收性纤维包括部分中和成钠盐的交联丙烯酸酯共聚物纤维，不过其他超级吸收性纤维也可用。吸收层108可以使用针刺工艺制造，在针刺工艺中纤维以机械方式缠结在一起。
在其他实例中，吸收层可包括其他比率的超级吸收性纤维、粘胶纤维和聚酯纤维。例如，吸收层可包括50％左右的超级吸收性纤维、35％的粘胶纤维和20％的聚酯纤维。或者，吸收层可包括40％的超级吸收性纤维和60％的粘胶纤维。
膜层102位于吸收层108上方，使得收集在吸收层108中的伤口流出物可以通过膜层102从伤口敷料100蒸发。
支撑层106位于膜层102与吸收层108之间。支撑层106有助于增强吸收层108的结构并且由此减少伤口敷料100的收缩。支撑层102还有助于向膜层102提供额外的机械强度，以减少或防止膜层102随时间推移而起皱。机械强度还降低了敷料变形或卷起导致压力点的可能性。
支撑层106被适当地构造成具有0.05Nm至0.06Nm的拉伸强度，以向周围层(例如，膜层102和吸收层108)提供机械强度，而不会损坏伤口敷料100的柔韧性。支撑层106可具有50μm至150μm的厚度。支撑层106可适当地具有100μm左右至110μm的厚度。
参考图2，支撑层106包括网200，所述网200构造成减少伤口敷料100的收缩。网200被适当地构造成减少吸收层108和/或膜层102的收缩，以有助于减少膜层102的起皱。
在此实例中，网200具有大致六边形(或蜂窝)结构204，该结构包括延伸穿过其中的多个大致三角形形状的孔隙202。
六边形结构204由聚合物股线208接合的多个点(或凸台)206形成。点206相对于彼此基本上均匀地间隔开。每个点在结构204中形成六边形图案的顶点。每个点206通过聚合物股线208接合到六个周围的点206。也就是说，六个聚合物股线208从每个点206延伸，并且每一个股线连接到相应的周围点206，以在聚合物股线208之间形成具有三角形形状的孔隙202的六边形结构204。
每个三角形形状的孔隙202可具有0.005至0.32mm2的面积A。这允许来自伤口的液体蒸气自由通过孔隙，同时仍向支撑层106提供足够的强度。
还可以认为结构204是这样一种结构，其包括接合形成多个三角形的多个股线或支柱。在此实例中，三角形成排地镶嵌成花纹。应了解，可以其它形式布置股线或支柱，例如具有不同几何形状且因此具有不同开口面积的方形、菱形或矩形。
在此实例中，支撑层106位于紧邻吸收层108处。因而，支撑层106可有效地为吸收层108的顶表面中的纤维提供另外的机械强度。这可有助于防止纤维移动并减少吸收层108的收缩。
支撑层106适当地粘结到吸收层108的顶表面中的纤维。这可以有助于将纤维锁定在适当位置，并防止或减少任何移动。在此实例中，支撑层106还包括用于将网200热层压到吸收层108的粘结层。支撑层106因此通过粘结层热层压到吸收层108中的纤维。
包含在网内的粘结层具有比网200低的熔融温度，使得支撑层106可以热层压到吸收层108，同时保持网200的结构。粘结层可由低熔点聚合物(例如低熔点乙烯-乙酸乙烯酯)形成，而网200可由高密度聚乙烯形成，所述高密度聚乙烯在比粘结层更高的温度下熔化。熔点比网200低的其它聚合物也是适合的。例如，粘结层可以是单独的层，或者替代性地包括乙烯-丙烯酸酯型粘合剂或热塑性聚亚安酯型粘合剂。
网200和粘结层可被共挤压以形成支撑层106。适当地，以与网200相似的结构形状挤压粘结层，使得网200中的孔隙202不受粘结层阻挡。这有助于确保流出物能够从吸收层108通过支撑层，并且通过膜层102从伤口敷料100蒸发。
图3图示了多层伤口敷料300的另一实例。伤口敷料300包括膜层302、支撑层306和吸收层308，他们与关于图1描述的膜层102、支撑层106和吸收层108相同。
伤口敷料300还包括位于膜层302与支撑层306之间的第一粘合剂层304，以用于将膜层302附接到支撑层306。第一粘合剂层304是施加到膜层302的面向伤口侧(下侧)的热熔粘合剂。适当地，第一粘合剂层304以图案涂布到膜层302上以包括孔，使得气体和液体蒸气可以通过第一粘合剂层304中的孔。在其他实例中，膜层302可以直接层压(例如，热层压)到支撑层306上，其间不需要有粘合剂层304。
在此实例中，伤口敷料300还包括泡沫层312，泡沫层312是流体传输层。泡沫层312位于吸收层306下方。泡沫层312用于将流体吸离伤口部位并将流体输送到吸收层308。本领域技术人员将认识到泡沫层可以由开孔聚氨酯泡沫形成，其他选项也可用。
粘合剂网层310位于泡沫层312和吸收层108之间，以将泡沫层312粘附到吸收层308。粘合剂网层可以由双组分聚丙烯/聚乙烯纤维形成。此类双组分纤维是本领域已知的，因此为简洁起见，将不会详细讨论。粘合剂网层310包括多个延伸穿过其中的孔隙，以允许流出物从泡沫层312传递至吸收层108。
伤口敷料300还包括伤口接触层320，该伤口接触层包括穿孔膜316。穿孔膜316位于泡沫层312下方，有助于防止在伤口愈合时伤口敷料100附着到伤口。例如，在伤口敷料300包括泡沫层112时，穿孔膜316可防止新组织生长到泡沫层312的单元中。在其他实例中，泡沫层312可以不存在，并且穿孔膜316可有助于防止吸收层308的纤维嵌入伤口中。穿孔膜316中的穿孔适当地大体上均匀分布并具有合适的尺寸，以允许流出物传递到伤口敷料300中，例如具有直径为1mm-2.5mm的孔。穿孔膜316适当地由聚氨酯形成。
伤口接触层320还可以包括位于穿孔膜316下方(即在穿孔膜316的面向伤口的一侧上)的粘合剂318，以用于将伤口敷料300粘附到皮肤。在这种情况下，粘合剂是硅酮318，并且以涂层重量30-200克/米2左右适当地散布到穿孔膜的下侧上。在一些其他实例中，附加的附接元件(例如绷带、胶带条或压缩绷带)可用于将伤口敷料300固定到患者。
穿孔膜316的顶侧(即远离伤口的这侧)可以用另一粘合剂层314涂布。另一粘合剂层314将伤口接触层320粘附到泡沫层312。适当地，另一粘合剂层314可以是丙烯酸粘合剂，但也可以使用其他合适的粘合剂。在其他实例中，伤口接触层320可以直接层压(例如热层压)至泡沫层312，其间不需要另一粘合剂层314。
图4图示了制造伤口敷料300的方法的一个实例。所述方法不限于所示步骤，且如上文所描述，可包括额外步骤。所述方法也不限于图4中所展示的顺序。本领域技术人员将了解，可以不同顺序执行所展示的方法步骤中的几个步骤。在一些实施例中，伤口敷料300通过以下步骤制造：形成每个层并且以正确顺序组装这些层，然后将它们热层压在一起。
膜层302可通过挤压形成。在步骤401，将第一粘合剂层304施加到膜层。适当地，第一粘合剂层304以图案涂布到挤出的膜层302的下侧上。
在步骤402，将支撑层306和吸收层308热层压在一起以形成单件。在步骤403，将膜层302和第一粘合剂层304热层压到单件的顶侧上的支撑层306，并且将粘合剂网层310和泡沫层312热层压到吸收层308。虽然将这些层描述为以特定顺序热层压在一起，但是这些层可以被分开地层压在一起或同时层压在一起。
在步骤404，通过用硅酮粘合剂层314涂布膜层的一面，并且用另一粘合剂层314涂布膜层的另一面，形成伤口接触层320。然后在步骤405(例如，通过针刺)对膜层打孔以形成包括穿孔膜316、用于接触伤口的硅酮粘合剂层314以及另一粘合剂层314的伤口接触层320。或者，在增加另一粘合剂层314之前，膜层可被打孔。
如步骤406所示，接着可以将伤口接触层层压(例如，用热、超声和/或射频焊接)至泡沫层312的下侧以形成伤口敷料300。
在步骤407，可将可移除盖施加到硅酮粘合剂层318的下侧。在伤口敷料300施加到患者之前，此盖可被移除。
在步骤408，伤口敷料300可以被切割成分开的伤口敷料段，每个敷料段大小适用于预期应用。
在另一实例中，如图5所示，膜层502可具有比伤口敷料500的其余部分更大的表面积，使得其向外延伸得比伤口敷料的其他层更远。膜层的面向伤口(下侧)面可以用压敏粘合剂504(或其他合适的粘合剂)涂布，以用于将敷料粘贴在患者的伤口周边周围。压敏粘合剂504还可将膜层502粘附到伤口敷料500的支撑层506。伤口敷料还可以包括吸收层508、粘合剂网层510、泡沫层512、另一粘合剂层514和伤口接触层520。此实例中的每一层可与上文关于图3A和图3B所描述的对应层类似，因此为了简洁起见，将不再对其进行详细描述。
在该实例中，伤口敷料可以在上述步骤401至407之后制造。然而，代替将敷料切割成适当尺寸(步骤408)，每个伤口敷料可被单独地制作，在将所有层层压在一起之前每层被切割或形成为期望的尺寸，使得最终伤口敷料具有比其他层大的膜层。
在另一个实例中，如图6中所示，伤口接触层620和膜层602都可以延伸到伤口敷料600的剩余层之外。伤口接触层620和膜层可围绕周边粘附在一起(例如，通过粘合剂层604)，使得伤口敷料的剩余层夹在伤口接触层620与膜层602之间。换句话说，支撑层606、吸收层608、粘合剂网层610和泡沫层612可密封在膜层602与伤口接触层620之间的腔体622内。在此实例中，另一粘合剂层614将泡沫层612粘附到伤口接触层620，但是在其他实例中，可能不需要另一粘合剂层614。此实例中的每一层可与上文关于图3A和图3B所描述的对应层类似，因此为了简洁起见，将不再对其进行详细描述。
本实例中的伤口敷料600可以类似于如上所述的伤口敷料300制造，但膜层602和伤口接触层620围绕周边层压在一起(例如，通过粘合剂层604)以将其余层夹在膜层602与伤口接触层620之间。或者，膜层602可以在不需要附加的粘合剂层604的情况下直接在周边周围层压(例如，热层压)到伤口接触层620。
虽然已描述了具有几个粘合剂层的伤口敷料300、500、600，但是这些层中的一个或多个层可以不存在。例如，穿孔膜自身可由热熔粘合剂材料形成，使得其可直接热层压到泡沫层上，在这种情况下，可能不需要另一粘合剂层。在另一实例中，如果泡沫层和吸收层以另一种方式粘附，则粘合剂网层可以不存在。例如，泡沫层和吸收层可以直接化学键合在一起。类似地，可以不需要第一粘合剂层。例如，如果支撑层包括粘合剂材料，或者如果膜层自身由热熔粘合剂形成，则膜层和支撑层可以直接粘附在一起。
在另一实例中，可以提供没有泡沫层的伤口敷料。泡沫层有助于从伤口向外输送流出物。然而，在一些情况下，取决于伤口的严重性，吸收层可以在不需要泡沫层的情况下充分地从伤口吸取流出物。
尽管在上述实例中，支撑层通过粘结层热层压到吸收层，但其他层压技术可以适用。举例来说，粘结层可包含压敏粘合剂。在这种情况下，可以不需要热来将支撑层和粘合剂层层压在一起。
尽管在上述实例中，将网层描述为具有大致六边形形状的结构，但其它几何结构也可以适用。使用其他几何结构，孔隙也可以具有不同的几何形状。
在另一实例中，伤口敷料可包括一个以上的支撑层，以对伤口敷料中的其他层提供支撑。例如，第一支撑层可位于液体不可渗透的膜层与吸收层之间，并且另一支撑层可位于吸收层与流体传输层(泡沫层)之间。这可有助于从两侧支撑吸收层以进一步减少吸收层的收缩。
本文中所描述的实例中的任一个可适于与负压系统(有时称为减压系统)一起使用，所述负压系统包括负压源，例如负压泵。举例来说，膜层可包括负压接口，例如端口，负压供应管可连接到所述负压接口。供应管可连接到负压源，使得使用中负压源将负压施加到膜层与伤口之间的伤口敷料，以帮助将伤口流出物从伤口抽吸到敷料的吸收层中。
图7图示了负压伤口治疗系统700的一个实例。该系统包括由伤口敷料720覆盖的伤口腔710，该伤口敷料可以是根据本文所述的任何实例的敷料。敷料720可以定位在伤口腔710内部，进一步密封伤口腔，使得在伤口腔中可以保持负压。例如，伤口敷料720的膜层可以在伤口腔710上方提供流体基本上不可渗透的密封。单腔管或多腔管或导管740将伤口敷料720与负压装置750连接，负压装置构造成供应减小的压力。负压装置750包括负压源。负压装置750可以是无罐装置(意味着流出物收集在伤口敷料中和/或通过管740传递以在另一个位置收集)。在一些实施例中，负压装置750可以构造成包括或支持罐。另外，在本文公开的实施例的任一个中，负压装置750可完全或部分嵌入到伤口敷料720中、安装到所述伤口敷料或由所述伤口敷料支撑。
导管740可以是构造成在负压装置750与伤口腔710之间提供至少基本上密封的流体流动路径或通路的任何合适的制品，以便将减小的压力供应到伤口腔。导管740可以由聚氨酯、PVC、尼龙、聚乙烯、硅酮或任何其它适合的刚性或柔性材料形成。在一些实施例中，伤口敷料720可以具有构造成接收导管740的端部的端口。例如，端口可包括膜层中的孔。在一些实施例中，导管740可以以其它方式穿过伤口敷料720的膜层和/或在所述膜层下方穿过，以将减小的压力供应到伤口腔710，以便在伤口腔中维持所期望的减压水平。在一些实施例中，导管740的至少一部分与伤口敷料720成一体或附接到所述伤口敷料。
使用中，伤口敷料，如伤口敷料100、300、500或600被施加到伤口部位，伤口接触层320接触伤口。来自伤口的流出物可穿过穿孔膜116并进入泡沫层312，这用以将伤口流出物远离伤口输送到吸收层308中。收集在吸收层308中的伤口流出物可以通过蒸气可渗透膜层302从伤口敷料300蒸发。
支撑层有助于向吸收层提供机械强度，吸收层在湿润时可能膨胀，并且在其干燥时可能收缩。支撑层可有助最小化吸收层中的纤维在伤口远端的至少一侧移动，并且因此有助于防止伤口敷料收缩，特别是在该区域中。以此方式最小化伤口敷料的收缩又可以有助于防止膜层起皱。它还降低了敷料在二次保留时卷起/折叠的可能性。
当伤口敷料变成暴露于湿气(来自伤口或周围大气)时，它可能会膨胀或扩张，导致膜层的起皱增大。使支撑层附接到膜层可有助于为膜层提供支撑并通过向膜层提供额外的机械强度来抵抗膜层的起皱。
与先前已知的伤口敷料相比，上述伤口敷料在无菌包装中存放时不太可能表现出收缩。因此，可防止或减少在伤口敷料外部上的膜层起皱。因此，纯粹由于膜层的可视外观，医务人员不太可能忽略仍在其推荐保质期内、无菌且适于使用的伤口敷料。
支撑层的网结构的六边形和/或三角形形状有助于提供机械强度，并且在抵抗周围伤口敷料层收缩时尤其有效。
在本说明书的描述和权利要求中，词语“包括”和“包含”及其变体表示“包括但不限于”，并且它们不意指(且并不)排除其它基团、添加剂、组分、整数或步骤。在本说明书的描述和权利要求书中，除非上下文另外需要，否则单数涵盖复数。具体而言，在使用不定冠词的情况下，除非上下文另外需要，否则本说明书应理解为涵盖复数以及单数。
连同本发明的特定方面、实施例或实例描述的特征、整数、特性、化合物、化学基团或化学族要理解为适用于本文所述的任何其它方面、实施例或实例，除非与其不相容。本说明书(包括任何所附权利要求、摘要和附图)中公开的所有特征，和/或如此公开的任何方法或工艺的所有步骤，可以以任何组合来组合，但是此类特征和/或步骤中的至少一些相互排斥的组合除外。本发明不限于任何前述实施例的细节。本发明扩展到本说明书(包括任何所附权利要求、摘要和附图)中公开的特征的任何新颖特征或特征的任何新颖组合，或扩展到如此公开的任何方法或过程的步骤的任何新颖步骤或步骤的任何新颖组合。
读者的注意力针对与本申请有关的与本说明书同时提交或之前提交并开放公众对本说明书查阅的所有论文和文档，所有这些论文和文档的内容通过引用被并入本文中。
Claims (18)
1.一种多层伤口敷料，其包括：
纤维吸收层，所述纤维吸收层用于从伤口部位吸收流出物；和
支撑层，所述支撑层构造成减少所述伤口敷料的至少一部分的收缩。
2.根据权利要求1所述的多层伤口敷料，其还包括液体不可渗透的膜层，其中，所述支撑层位于所述吸收层与所述膜层之间。
3.根据权利要求1或2所述的多层伤口敷料，其中所述支撑层包括网。
4.根据权利要求3所述的多层伤口敷料，其中所述网包括几何结构，所述几何结构具有延伸穿过其中的多个大致几何孔隙。
5.根据权利要求4所述的多层伤口敷料，其中所述几何结构包括多个凸台，所述多个凸台基本上均匀地间隔开并且通过聚合物股线接合以在所述聚合物股线之间形成大致几何孔隙。
6.根据权利要求4或5所述的多层伤口敷料，其中所述孔隙具有0.005至0.32mm2的面积。
7.根据任一前述权利要求所述的多层伤口敷料，其中所述支撑层具有0.05Nm至0.06Nm的拉伸强度。
8.根据任一前述权利要求所述的多层伤口敷料，其中所述支撑层具有50μm至150μm的厚度。
9.根据任一前述权利要求所述的多层伤口敷料，其中所述支撑层位于紧邻所述吸收层处。
10.根据任一前述权利要求所述的多层伤口敷料，其中所述支撑层粘结到所述吸收层的顶表面中的纤维。
11.根据权利要求10所述的多层伤口敷料，其中所述支撑层还包括粘结层，其中所述支撑层通过所述粘结层热层压到所述吸收层中的纤维。
12.根据权利要求11所述的多层伤口敷料，其中所述粘结层包括低熔点乙烯-乙酸乙烯酯粘合剂。
13.根据任一前述权利要求所述的多层伤口敷料，其中所述网由高密度聚乙烯形成。
14.根据权利要求2至权利要求13中任一项所述的多层伤口敷料，其还包括将所述膜层附接到所述支撑层的粘合剂层。
15.根据任一前述权利要求所述的多层伤口敷料，其还包括邻近所述吸收层定位以邻近伤口定位的伤口接触层。
16.根据权利要求15所述的多层伤口敷料，其还包括在所述伤口接触层与所述吸收层之间的流体传输层，以用于将流出物远离伤口输送到所述吸收层中。
17.一种治疗伤口的方法，所述方法包括在伤口上放置根据任一前述权利要求所述的多层伤口敷料。
18.一种制造多层伤口敷料的方法，所述方法包括：
形成支撑层；
形成用于从伤口部位吸收流出物的纤维吸收层；以及
将所述支撑层和所述吸收层层压在一起以形成所述伤口敷料；
其中所述支撑层构造成减少所述伤口敷料的至少一部分的收缩。
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3531997B1 (en) | 2023-08-02 |
| GB2555584B (en) | 2020-05-27 |
| GB201618298D0 (en) | 2016-12-14 |
| GB2555584A (en) | 2018-05-09 |
| US20190274889A1 (en) | 2019-09-12 |
| US11559437B2 (en) | 2023-01-24 |
| EP3531997A1 (en) | 2019-09-04 |
| WO2018077872A1 (en) | 2018-05-03 |
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