CN108024992A - 用于治疗医学障碍的芳基、杂芳基和杂环化合物 - Google Patents
用于治疗医学障碍的芳基、杂芳基和杂环化合物 Download PDFInfo
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- CN108024992A CN108024992A CN201680049237.6A CN201680049237A CN108024992A CN 108024992 A CN108024992 A CN 108024992A CN 201680049237 A CN201680049237 A CN 201680049237A CN 108024992 A CN108024992 A CN 108024992A
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- 0 CC*C=CC(C=CC=NC)=C Chemical compound CC*C=CC(C=CC=NC)=C 0.000 description 64
- RSNKNQDGNBSTLQ-UHFFFAOYSA-N CC(C(CC(O)=O)N=C(C(C)=O)c1c2)c1ccc2-c1cnc(C)nc1 Chemical compound CC(C(CC(O)=O)N=C(C(C)=O)c1c2)c1ccc2-c1cnc(C)nc1 RSNKNQDGNBSTLQ-UHFFFAOYSA-N 0.000 description 1
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- RGLYPHRWYWIBNL-UHFFFAOYSA-N CCC(CC1)=C(N)N=C1Br Chemical compound CCC(CC1)=C(N)N=C1Br RGLYPHRWYWIBNL-UHFFFAOYSA-N 0.000 description 1
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- FHJHIPVEROBSEU-ZCFIWIBFSA-N C[C@H](C=C1)C=C(CO)C(F)=C1Cl Chemical compound C[C@H](C=C1)C=C(CO)C(F)=C1Cl FHJHIPVEROBSEU-ZCFIWIBFSA-N 0.000 description 1
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- QLQCNQZEGBVEPT-UHFFFAOYSA-N Nc(cnc(Cl)c1)c1C(I)=N Chemical compound Nc(cnc(Cl)c1)c1C(I)=N QLQCNQZEGBVEPT-UHFFFAOYSA-N 0.000 description 1
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- BDTTZPYKBYXKSN-RQJHMYQMSA-N O=C([C@H](C1)NC[C@@H]1F)Nc1nc(C(F)(F)F)ccc1 Chemical compound O=C([C@H](C1)NC[C@@H]1F)Nc1nc(C(F)(F)F)ccc1 BDTTZPYKBYXKSN-RQJHMYQMSA-N 0.000 description 1
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- WHDIUBHAKZDSJL-UHFFFAOYSA-N OB(c(cc1)ccc1N1CCOCC1)O Chemical compound OB(c(cc1)ccc1N1CCOCC1)O WHDIUBHAKZDSJL-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
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- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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| US201562209972P | 2015-08-26 | 2015-08-26 | |
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| PCT/US2016/048696 WO2017035353A1 (en) | 2015-08-26 | 2016-08-25 | Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders |
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| CN202111364018.6A Pending CN114044800A (zh) | 2015-08-26 | 2016-08-25 | 用于治疗医学障碍的芳基、杂芳基和杂环化合物 |
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| CN112375027A (zh) * | 2020-12-07 | 2021-02-19 | 中国药科大学 | 吲哚磺酰胺类衍生物及其医药用途 |
| CN112375027B (zh) * | 2020-12-07 | 2023-03-31 | 中国药科大学 | 吲哚磺酰胺类衍生物及其医药用途 |
| CN114437043A (zh) * | 2022-02-02 | 2022-05-06 | 浙江乐普药业股份有限公司 | 一种抗新冠药物Nirmatrelvir的制备方法 |
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