CA2996415A1 - Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders - Google Patents

Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders Download PDF

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Publication number
CA2996415A1
CA2996415A1 CA2996415A CA2996415A CA2996415A1 CA 2996415 A1 CA2996415 A1 CA 2996415A1 CA 2996415 A CA2996415 A CA 2996415A CA 2996415 A CA2996415 A CA 2996415A CA 2996415 A1 CA2996415 A1 CA 2996415A1
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CA
Canada
Prior art keywords
moiety
compound
bond
pharmaceutically acceptable
disorder
Prior art date
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Application number
CA2996415A
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English (en)
French (fr)
Inventor
Jason Allan Wiles
Avinash S. Phadke
Milind Deshpande
Atul Agarwal
Dawei Chen
Venkat Rao GADHACHANDA
Akihiro Hashimoto
Godwin Pais
Qiuping Wang
Xiangzhu Wang
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Achillion Pharmaceuticals Inc
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Achillion Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Achillion Pharmaceuticals Inc filed Critical Achillion Pharmaceuticals Inc
Publication of CA2996415A1 publication Critical patent/CA2996415A1/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/4965—Non-condensed pyrazines
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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  • Chemical & Material Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
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  • Neurology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
CA2996415A 2015-08-26 2016-08-25 Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders Pending CA2996415A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562209972P 2015-08-26 2015-08-26
US62/209,972 2015-08-26
PCT/US2016/048696 WO2017035353A1 (en) 2015-08-26 2016-08-25 Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders

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EP (2) EP3340981B1 (enExample)
JP (3) JP6877406B2 (enExample)
KR (1) KR102668548B1 (enExample)
CN (2) CN114044800A (enExample)
AR (1) AR106018A1 (enExample)
AU (2) AU2016311425B2 (enExample)
CA (1) CA2996415A1 (enExample)
DK (1) DK3340981T3 (enExample)
EA (2) EA201992884A3 (enExample)
ES (1) ES2935633T3 (enExample)
FI (1) FI3340981T3 (enExample)
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IL (2) IL295844B2 (enExample)
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PT (1) PT3340981T (enExample)
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SI (1) SI3340981T1 (enExample)
TW (1) TW201722932A (enExample)
WO (1) WO2017035353A1 (enExample)
ZA (1) ZA201800641B (enExample)

Families Citing this family (47)

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Publication number Priority date Publication date Assignee Title
EA201691727A1 (ru) 2014-02-25 2017-01-30 Ачиллион Фармасьютикалс, Инк. Фосфонатные соединения для лечения опосредованных комплементом нарушений
AR105809A1 (es) 2015-08-26 2017-11-08 Achillion Pharmaceuticals Inc Compuestos para el tratamiento de trastornos médicos
WO2017035401A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Amide compounds for treatment of immune and inflammatory disorders
WO2017035351A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Amino compounds for treatment of medical disorders
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