CN105693645B - 作为离子通道调节剂的稠合杂环化合物 - Google Patents
作为离子通道调节剂的稠合杂环化合物 Download PDFInfo
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- CN105693645B CN105693645B CN201610186640.5A CN201610186640A CN105693645B CN 105693645 B CN105693645 B CN 105693645B CN 201610186640 A CN201610186640 A CN 201610186640A CN 105693645 B CN105693645 B CN 105693645B
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- heteroaryl
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- phenyl
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- 0 **1C#CC=C(*c2ccc(CCN(*)*3)c3c2)*=C1 Chemical compound **1C#CC=C(*c2ccc(CCN(*)*3)c3c2)*=C1 0.000 description 8
- ZHQCEGDPANFHBB-UHFFFAOYSA-N CC(C)(C)CC(N(CC1)CCN1c1ncccn1)=O Chemical compound CC(C)(C)CC(N(CC1)CCN1c1ncccn1)=O ZHQCEGDPANFHBB-UHFFFAOYSA-N 0.000 description 1
- NAWUDZUUXXEXBD-PLNGDYQASA-N CC(C1)(CN1C(N(CC1)CC(C)=C1/C=C\C(c1ccc(C(F)(F)F)cc1)=C)=O)O Chemical compound CC(C1)(CN1C(N(CC1)CC(C)=C1/C=C\C(c1ccc(C(F)(F)F)cc1)=C)=O)O NAWUDZUUXXEXBD-PLNGDYQASA-N 0.000 description 1
- GRPPPTRYJSSDRJ-UHFFFAOYSA-N CC(CC1)CCN1c1ncccn1 Chemical compound CC(CC1)CCN1c1ncccn1 GRPPPTRYJSSDRJ-UHFFFAOYSA-N 0.000 description 1
- CFSVVKYPZDGOKQ-UHFFFAOYSA-N CC(NC(c1c2)=O)Oc1ccc2-c(cc1)ccc1OC(F)(F)F Chemical compound CC(NC(c1c2)=O)Oc1ccc2-c(cc1)ccc1OC(F)(F)F CFSVVKYPZDGOKQ-UHFFFAOYSA-N 0.000 description 1
- XQDNOJORTIHTNK-UHFFFAOYSA-N CCOC(C[n]1nnc(C(N(CC2)Cc3c2ccc(-c2ccc(C(F)(F)F)cc2)c3)=O)c1)=O Chemical compound CCOC(C[n]1nnc(C(N(CC2)Cc3c2ccc(-c2ccc(C(F)(F)F)cc2)c3)=O)c1)=O XQDNOJORTIHTNK-UHFFFAOYSA-N 0.000 description 1
- BEJSXTRJVMOIMR-UHFFFAOYSA-N Cc1n[o]c(CN(C(c2c3)=O)N=Nc2ccc3-c(cc2)ccc2Oc2ccccc2)n1 Chemical compound Cc1n[o]c(CN(C(c2c3)=O)N=Nc2ccc3-c(cc2)ccc2Oc2ccccc2)n1 BEJSXTRJVMOIMR-UHFFFAOYSA-N 0.000 description 1
- NBRJCGZMFHTYQN-UHFFFAOYSA-N Cc1nc(CN(C(c2c3)=O)N=Nc2ccc3-c(cc2)ccc2OC(F)(F)F)c[o]1 Chemical compound Cc1nc(CN(C(c2c3)=O)N=Nc2ccc3-c(cc2)ccc2OC(F)(F)F)c[o]1 NBRJCGZMFHTYQN-UHFFFAOYSA-N 0.000 description 1
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- FBPYNRKZMQEMHM-UHFFFAOYSA-N O=C(CN1N=Nc(ccc(-c(cc2)ccc2Oc(cc2)ccc2Cl)c2)c2C1=O)N(CC1)CCN1c1ncccn1 Chemical compound O=C(CN1N=Nc(ccc(-c(cc2)ccc2Oc(cc2)ccc2Cl)c2)c2C1=O)N(CC1)CCN1c1ncccn1 FBPYNRKZMQEMHM-UHFFFAOYSA-N 0.000 description 1
- YQACCKXKBZZMLX-UHFFFAOYSA-N O=C(Cc1ncccc1)N1Cc2cc(-c3ccc(C(F)(F)F)cc3)ccc2CC1 Chemical compound O=C(Cc1ncccc1)N1Cc2cc(-c3ccc(C(F)(F)F)cc3)ccc2CC1 YQACCKXKBZZMLX-UHFFFAOYSA-N 0.000 description 1
- FPKUCEXGARYZEA-UHFFFAOYSA-N O=C(N(CC1)CC1F)N1Cc2cc(-c3ccc(C(F)(F)F)cc3)ccc2CC1 Chemical compound O=C(N(CC1)CC1F)N1Cc2cc(-c3ccc(C(F)(F)F)cc3)ccc2CC1 FPKUCEXGARYZEA-UHFFFAOYSA-N 0.000 description 1
- DPQBBWZRDOXZFQ-UHFFFAOYSA-N O=C(N1CCCC1)N(CC1)Cc2c1ccc(-c(cc1)ccc1OC(F)(F)F)c2 Chemical compound O=C(N1CCCC1)N(CC1)Cc2c1ccc(-c(cc1)ccc1OC(F)(F)F)c2 DPQBBWZRDOXZFQ-UHFFFAOYSA-N 0.000 description 1
- LTVIHCINJDCRMN-UHFFFAOYSA-N O=C(c([nH]cn1)c1F)N1Cc2cc(-c3ccc(C(F)(F)F)cc3)ccc2CC1 Chemical compound O=C(c([nH]cn1)c1F)N1Cc2cc(-c3ccc(C(F)(F)F)cc3)ccc2CC1 LTVIHCINJDCRMN-UHFFFAOYSA-N 0.000 description 1
- RMHUZTFIZINNOW-UHFFFAOYSA-N O=C(c1c2)N(Cc3ncccn3)N=Nc1ccc2-c(cc1)ccc1OC(F)(F)F Chemical compound O=C(c1c2)N(Cc3ncccn3)N=Nc1ccc2-c(cc1)ccc1OC(F)(F)F RMHUZTFIZINNOW-UHFFFAOYSA-N 0.000 description 1
- CSUKHRGDGHLWNB-UHFFFAOYSA-N O=C(c1c2)NC3(COC3)Oc1ccc2-c(cc1)ccc1OC(F)(F)F Chemical compound O=C(c1c2)NC3(COC3)Oc1ccc2-c(cc1)ccc1OC(F)(F)F CSUKHRGDGHLWNB-UHFFFAOYSA-N 0.000 description 1
- DTBWRSXRFICCIP-UHFFFAOYSA-N O=C(c1c2)NN=Nc1ccc2-c(cc1)ccc1OC(F)(F)F Chemical compound O=C(c1c2)NN=Nc1ccc2-c(cc1)ccc1OC(F)(F)F DTBWRSXRFICCIP-UHFFFAOYSA-N 0.000 description 1
- JYWCWBAVDUJSAG-UHFFFAOYSA-N O=C(c1ncccn1)N1Cc2cc(-c(cc3)cc(F)c3Cl)ccc2CC1 Chemical compound O=C(c1ncccn1)N1Cc2cc(-c(cc3)cc(F)c3Cl)ccc2CC1 JYWCWBAVDUJSAG-UHFFFAOYSA-N 0.000 description 1
- OEOOFQZIUGTPKU-UHFFFAOYSA-N O=C1N(Cc2n[o]c(-c3cccc(C(F)(F)F)c3)n2)N=Cc(cc2)c1cc2-c(cc1)ccc1OC(F)(F)F Chemical compound O=C1N(Cc2n[o]c(-c3cccc(C(F)(F)F)c3)n2)N=Cc(cc2)c1cc2-c(cc1)ccc1OC(F)(F)F OEOOFQZIUGTPKU-UHFFFAOYSA-N 0.000 description 1
- XHEPANNURIQWRM-UHFFFAOYSA-N OC(CCl)c(ccc(Cl)c1)c1Cl Chemical compound OC(CCl)c(ccc(Cl)c1)c1Cl XHEPANNURIQWRM-UHFFFAOYSA-N 0.000 description 1
- VLUFTRQTDQIXBT-UHFFFAOYSA-N OC(CN(C(c1c2)=O)N=Nc1ccc2-c(cc1)ccc1OC(F)(F)F)c(ccc(Cl)c1)c1Cl Chemical compound OC(CN(C(c1c2)=O)N=Nc1ccc2-c(cc1)ccc1OC(F)(F)F)c(ccc(Cl)c1)c1Cl VLUFTRQTDQIXBT-UHFFFAOYSA-N 0.000 description 1
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
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- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
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Correction item: Inventor Correct: CORKEY BRITTON KENNETH|ELZEIN ELFATIH|JIANG ROBERT H.|KALLA RAO V.|Jeremy Lin|KOLTUN DMITRY|Li Xiaofen|MARTINEZ RUBEN|Notte Gregory|PARKHILL ERIC Q.|PERRY THAO|ZABLOCKI JEFF|VENKATARAMANI CHANDRASEKAR|Graupe Michael|GUERRERO JUAN False: CORKEY BRITTON KENNETH|ELZEIN ELFATIH|JIANG ROBERT H.|KALLA RAO V.|Jeremy Lin|KOLTUN DMITRY|Li Xiaofen|MARTINEZ RUBEN|Notte Gregory|PARKHILL ERIC Q.|PERRY THAO|ZABLOCKI JEFF|VENKATARAMANI CHANDRASEKAR|GUERRERO JUAN Number: 25 Volume: 32 |
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