PL3548033T3 - Związki i sposoby ich stosowania - Google Patents
Związki i sposoby ich stosowaniaInfo
- Publication number
- PL3548033T3 PL3548033T3 PL17874657.4T PL17874657T PL3548033T3 PL 3548033 T3 PL3548033 T3 PL 3548033T3 PL 17874657 T PL17874657 T PL 17874657T PL 3548033 T3 PL3548033 T3 PL 3548033T3
- Authority
- PL
- Poland
- Prior art keywords
- compounds
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662427044P | 2016-11-28 | 2016-11-28 | |
| US201762458306P | 2017-02-13 | 2017-02-13 | |
| US201762552073P | 2017-08-30 | 2017-08-30 | |
| PCT/US2017/063533 WO2018098499A1 (en) | 2016-11-28 | 2017-11-28 | Compounds and their methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3548033T3 true PL3548033T3 (pl) | 2025-06-02 |
Family
ID=62195384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17874657.4T PL3548033T3 (pl) | 2016-11-28 | 2017-11-28 | Związki i sposoby ich stosowania |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11629146B2 (pl) |
| EP (2) | EP4397308A3 (pl) |
| JP (4) | JP7105797B2 (pl) |
| CN (2) | CN110337295B (pl) |
| AU (3) | AU2017364901A1 (pl) |
| BR (1) | BR112019010880A2 (pl) |
| CA (2) | CA3281817A1 (pl) |
| DK (1) | DK3548033T3 (pl) |
| ES (1) | ES2992063T3 (pl) |
| FI (1) | FI3548033T3 (pl) |
| HU (1) | HUE068842T2 (pl) |
| PL (1) | PL3548033T3 (pl) |
| PT (1) | PT3548033T (pl) |
| WO (1) | WO2018098499A1 (pl) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3281817A1 (en) | 2016-11-28 | 2026-03-02 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018098491A1 (en) | 2016-11-28 | 2018-05-31 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11492345B2 (en) | 2017-02-13 | 2022-11-08 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018187480A1 (en) | 2017-04-04 | 2018-10-11 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11278535B2 (en) | 2017-08-15 | 2022-03-22 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| IL309843B2 (en) * | 2018-05-30 | 2026-05-01 | Praxis Prec Medicines Inc | History of [4,2,1]triazolo[3,4-a]pyridines and their use as sodium ion channel modulators |
| CA3110211A1 (en) | 2018-08-20 | 2020-02-27 | Rogcon, Inc. | Antisense oligonucleotides targeting scn2a for the treatment of scn1a encephalopathies |
| EA202092908A1 (ru) | 2018-09-28 | 2021-05-14 | Праксис Пресижн Медсинз, Инк. | Модуляторы ионных каналов |
| US11773099B2 (en) | 2019-05-28 | 2023-10-03 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11279700B2 (en) | 2019-05-31 | 2022-03-22 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| US11505554B2 (en) | 2019-05-31 | 2022-11-22 | Praxis Precision Medicines, Inc. | Substituted pyridines as ion channel modulators |
| WO2021039961A1 (ja) * | 2019-08-30 | 2021-03-04 | 大日本住友製薬株式会社 | 縮環ピラゾール誘導体 |
| JP2023503343A (ja) | 2019-11-26 | 2023-01-27 | プラクシス プレシジョン メディシンズ， インコーポレイテッド | イオンチャネルモジュレーター |
| US11767325B2 (en) | 2019-11-26 | 2023-09-26 | Praxis Precision Medicines, Inc. | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators |
| PE20221280A1 (es) * | 2019-11-27 | 2022-09-05 | Praxis Prec Medicines Inc | Formulaciones de moduladores de canales ionicos y metodos de preparacion y uso de moduladores de canales ionicos |
| JP7880201B2 (ja) * | 2020-06-10 | 2026-06-25 | アムジエン・インコーポレーテツド | シクロプロピルジヒドロキノリンスルホンアミド化合物 |
| WO2023036934A1 (en) * | 2021-09-13 | 2023-03-16 | Boehringer Ingelheim Vetmedica Gmbh | Cyclopropyl-(hetero)aryl-substituted ethylsulphonylpyridine derivatives |
| KR20250005348A (ko) | 2022-04-26 | 2025-01-09 | 프락시스 프리시젼 메디신즈, 인크. | 신경 장애의 치료 |
| WO2024077273A2 (en) * | 2022-10-07 | 2024-04-11 | Denali Therapeutics Inc. | Compounds, compositions, and methods |
| WO2026082004A1 (zh) * | 2024-10-14 | 2026-04-23 | 上海京新生物医药有限公司 | 稠合杂芳基衍生物及其制备方法与应用 |
| CN119613413B (zh) * | 2024-12-26 | 2026-02-06 | 上海皓元医药股份有限公司 | 一种非唑奈坦的制备方法 |
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| US4112095A (en) * | 1976-10-07 | 1978-09-05 | American Cyanamid Company | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents |
| US4242515A (en) | 1979-03-28 | 1980-12-30 | American Cyanamid Company | Substituted 3-alkyl-6-phenyl-1,2,4-triazolo-[4,3-a]pyridines |
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| CA3281817A1 (en) | 2016-11-28 | 2026-03-02 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018098491A1 (en) | 2016-11-28 | 2018-05-31 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018098500A1 (en) | 2016-11-28 | 2018-05-31 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11492345B2 (en) | 2017-02-13 | 2022-11-08 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018187480A1 (en) | 2017-04-04 | 2018-10-11 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11278535B2 (en) | 2017-08-15 | 2022-03-22 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| IL309843B2 (en) | 2018-05-30 | 2026-05-01 | Praxis Prec Medicines Inc | History of [4,2,1]triazolo[3,4-a]pyridines and their use as sodium ion channel modulators |
| EA202092908A1 (ru) | 2018-09-28 | 2021-05-14 | Праксис Пресижн Медсинз, Инк. | Модуляторы ионных каналов |
| US11773099B2 (en) | 2019-05-28 | 2023-10-03 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11505554B2 (en) | 2019-05-31 | 2022-11-22 | Praxis Precision Medicines, Inc. | Substituted pyridines as ion channel modulators |
| US11279700B2 (en) | 2019-05-31 | 2022-03-22 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| US11767325B2 (en) | 2019-11-26 | 2023-09-26 | Praxis Precision Medicines, Inc. | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators |
| JP2023503343A (ja) | 2019-11-26 | 2023-01-27 | プラクシス プレシジョン メディシンズ， インコーポレイテッド | イオンチャネルモジュレーター |
| PE20221280A1 (es) | 2019-11-27 | 2022-09-05 | Praxis Prec Medicines Inc | Formulaciones de moduladores de canales ionicos y metodos de preparacion y uso de moduladores de canales ionicos |
-
2017
- 2017-11-28 CA CA3281817A patent/CA3281817A1/en active Pending
- 2017-11-28 CA CA3045121A patent/CA3045121C/en active Active
- 2017-11-28 US US16/464,468 patent/US11629146B2/en active Active
- 2017-11-28 EP EP24160394.3A patent/EP4397308A3/en active Pending
- 2017-11-28 DK DK17874657.4T patent/DK3548033T3/da active
- 2017-11-28 PL PL17874657.4T patent/PL3548033T3/pl unknown
- 2017-11-28 JP JP2019548536A patent/JP7105797B2/ja active Active
- 2017-11-28 CN CN201780084790.8A patent/CN110337295B/zh active Active
- 2017-11-28 PT PT178746574T patent/PT3548033T/pt unknown
- 2017-11-28 CN CN202310582446.9A patent/CN116763791A/zh active Pending
- 2017-11-28 WO PCT/US2017/063533 patent/WO2018098499A1/en not_active Ceased
- 2017-11-28 AU AU2017364901A patent/AU2017364901A1/en not_active Abandoned
- 2017-11-28 HU HUE17874657A patent/HUE068842T2/hu unknown
- 2017-11-28 BR BR112019010880-7A patent/BR112019010880A2/pt not_active Application Discontinuation
- 2017-11-28 EP EP17874657.4A patent/EP3548033B1/en active Active
- 2017-11-28 FI FIEP17874657.4T patent/FI3548033T3/fi active
- 2017-11-28 ES ES17874657T patent/ES2992063T3/es active Active
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2022
- 2022-07-12 JP JP2022111844A patent/JP7495962B2/ja active Active
-
2023
- 2023-03-10 US US18/119,963 patent/US20230322790A1/en not_active Abandoned
- 2023-12-14 AU AU2023282271A patent/AU2023282271A1/en not_active Abandoned
-
2024
- 2024-05-24 JP JP2024084718A patent/JP7801794B2/ja active Active
- 2024-12-06 US US18/971,281 patent/US20250163068A1/en active Pending
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2025
- 2025-09-23 AU AU2025237912A patent/AU2025237912A1/en active Pending
- 2025-12-23 JP JP2025279047A patent/JP2026062794A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3045121A1 (en) | 2018-05-31 |
| CN110337295A (zh) | 2019-10-15 |
| CA3281817A1 (en) | 2026-03-02 |
| US20230322790A1 (en) | 2023-10-12 |
| US20250163068A1 (en) | 2025-05-22 |
| CN116763791A (zh) | 2023-09-19 |
| AU2023282271A1 (en) | 2024-01-18 |
| US20210188852A1 (en) | 2021-06-24 |
| WO2018098499A1 (en) | 2018-05-31 |
| AU2025237912A1 (en) | 2025-10-16 |
| HUE068842T2 (hu) | 2025-01-28 |
| JP7801794B2 (ja) | 2026-01-19 |
| CA3045121C (en) | 2025-12-16 |
| JP7495962B2 (ja) | 2024-06-05 |
| EP4397308A2 (en) | 2024-07-10 |
| DK3548033T3 (da) | 2024-07-15 |
| JP2024100974A (ja) | 2024-07-26 |
| EP3548033A1 (en) | 2019-10-09 |
| AU2017364901A1 (en) | 2019-06-13 |
| EP3548033A4 (en) | 2020-09-09 |
| BR112019010880A2 (pt) | 2019-10-01 |
| EP3548033B1 (en) | 2024-04-10 |
| ES2992063T3 (es) | 2024-12-09 |
| EP4397308A3 (en) | 2024-08-21 |
| FI3548033T3 (fi) | 2024-07-10 |
| JP2022141773A (ja) | 2022-09-29 |
| US11629146B2 (en) | 2023-04-18 |
| JP2019535838A (ja) | 2019-12-12 |
| JP7105797B2 (ja) | 2022-07-25 |
| CN110337295B (zh) | 2023-06-09 |
| JP2026062794A (ja) | 2026-04-10 |
| PT3548033T (pt) | 2024-08-09 |
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