|
US9217155B2
(en)
|
2008-05-28 |
2015-12-22 |
University Of Massachusetts |
Isolation of novel AAV'S and uses thereof
|
|
US8734809B2
(en)
|
2009-05-28 |
2014-05-27 |
University Of Massachusetts |
AAV's and uses thereof
|
|
WO2012145624A2
(en)
|
2011-04-21 |
2012-10-26 |
University Of Massachusetts |
Raav-based compositions and methods for treating alpha-1 anti-trypsin deficiencies
|
|
WO2013066438A2
(en)
|
2011-07-22 |
2013-05-10 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
GB201122458D0
(en)
*
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
WO2013119602A1
(en)
|
2012-02-06 |
2013-08-15 |
President And Fellows Of Harvard College |
Arrdc1-mediated microvesicles (armms) and uses thereof
|
|
WO2013163628A2
(en)
|
2012-04-27 |
2013-10-31 |
Duke University |
Genetic correction of mutated genes
|
|
BR122019025681B1
(pt)
*
|
2012-11-01 |
2023-04-18 |
Factor Bioscience Inc |
Método para inserir uma sequência de ácido nucleico em uma localização segura de um genoma de uma célula
|
|
EP3434776A1
(en)
|
2012-12-12 |
2019-01-30 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
EP2931899A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
KR20150105956A
(ko)
|
2012-12-12 |
2015-09-18 |
더 브로드 인스티튜트, 인코퍼레이티드 |
서열 조작 및 치료적 적용을 위한 시스템, 방법 및 조성물의 전달, 유전자 조작 및 최적화
|
|
NZ732507A
(en)
*
|
2013-03-15 |
2018-08-31 |
Sarepta Therapeutics Inc |
Improved compositions for treating muscular dystrophy
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
JP7085716B2
(ja)
*
|
2013-06-05 |
2022-06-17 |
デューク ユニバーシティ |
Rnaガイド遺伝子編集及び遺伝子調節
|
|
EP3674411A1
(en)
|
2013-06-17 |
2020-07-01 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
CA2915795C
(en)
|
2013-06-17 |
2021-07-13 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
|
|
EP3725885A1
(en)
|
2013-06-17 |
2020-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
CN107995927B
(zh)
|
2013-06-17 |
2021-07-30 |
布罗德研究所有限公司 |
用于肝靶向和治疗的crispr-cas系统、载体和组合物的递送与用途
|
|
CN105492611A
(zh)
|
2013-06-17 |
2016-04-13 |
布罗德研究所有限公司 |
用于序列操纵的优化的crispr-cas双切口酶系统、方法以及组合物
|
|
SG10201800213VA
(en)
*
|
2013-07-10 |
2018-02-27 |
Harvard College |
Orthogonal cas9 proteins for rna-guided gene regulation and editing
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
US9737604B2
(en)
|
2013-09-06 |
2017-08-22 |
President And Fellows Of Harvard College |
Use of cationic lipids to deliver CAS9
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
EP3988649B1
(en)
|
2013-09-18 |
2024-11-27 |
Kymab Limited |
Methods, cells and organisms
|
|
KR20230054509A
(ko)
|
2013-11-07 |
2023-04-24 |
에디타스 메디신, 인코포레이티드 |
지배적인 gRNA를 이용하는 CRISPR-관련 방법 및 조성물
|
|
SG10201804973TA
(en)
|
2013-12-12 |
2018-07-30 |
Broad Inst Inc |
Compositions and Methods of Use of Crispr-Cas Systems in Nucleotide Repeat Disorders
|
|
BR112016013201B1
(pt)
*
|
2013-12-12 |
2023-01-31 |
The Broad Institute, Inc. |
Uso de uma composição compreendendo um sistema crispr-cas no tratamento de uma doença genética ocular
|
|
EP3540051B1
(en)
|
2013-12-12 |
2022-08-17 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for hsv and viral diseases and disorders.
|
|
US11053481B2
(en)
|
2013-12-12 |
2021-07-06 |
President And Fellows Of Harvard College |
Fusions of Cas9 domains and nucleic acid-editing domains
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
EP3080259B1
(en)
|
2013-12-12 |
2023-02-01 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
EP3080271B1
(en)
|
2013-12-12 |
2020-02-12 |
The Broad Institute, Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
WO2015127128A2
(en)
|
2014-02-19 |
2015-08-27 |
University Of Massachusetts |
Recombinant aavs having useful transcytosis properties
|
|
WO2015134812A1
(en)
|
2014-03-05 |
2015-09-11 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
|
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
EP3553176A1
(en)
|
2014-03-10 |
2019-10-16 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
|
|
ES2821149T3
(es)
*
|
2014-03-12 |
2021-04-23 |
Prec Biosciences Inc |
Eliminación del exón del gen de la distrofina mediante nucleasas modificadas genéticamente
|
|
DK3119797T3
(da)
|
2014-03-18 |
2021-03-15 |
Univ Massachusetts |
Raav-baserede sammensætninger og fremgangsmåder til behandling af amyotrofisk lateralsklerose
|
|
EP3122880B1
(en)
|
2014-03-26 |
2021-05-05 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
|
EP3540061A1
(en)
|
2014-04-02 |
2019-09-18 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
|
US10975391B2
(en)
|
2014-04-25 |
2021-04-13 |
University Of Massachusetts |
Recombinant AAV vectors useful for reducing immunity against transgene products
|
|
MX2016014066A
(es)
|
2014-04-28 |
2017-05-03 |
Recombinetics Inc |
Edicion de genes multiples en cerdos.
|
|
AU2015298571B2
(en)
|
2014-07-30 |
2020-09-03 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
EP3180034B1
(en)
*
|
2014-08-11 |
2022-04-20 |
The Board of Regents of The University of Texas System |
Prevention of muscular dystrophy by crispr/cas9-mediated gene editing
|
|
WO2016049024A2
(en)
*
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo
|
|
US10370432B2
(en)
|
2014-10-03 |
2019-08-06 |
University Of Massachusetts |
Heterologous targeting peptide grafted AAVS
|
|
US10711270B2
(en)
|
2014-10-03 |
2020-07-14 |
University Of Massachusetts |
High efficiency library-identified AAV vectors
|
|
EP3204496A1
(en)
|
2014-10-10 |
2017-08-16 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
RU2020140209A
(ru)
|
2014-10-21 |
2021-01-25 |
Юниверсити Оф Массачусетс |
Варианты рекомбинантных aav и их применения
|
|
GB201418965D0
(enExample)
|
2014-10-24 |
2014-12-10 |
Ospedale San Raffaele And Fond Telethon |
|
|
US9816080B2
(en)
*
|
2014-10-31 |
2017-11-14 |
President And Fellows Of Harvard College |
Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
|
|
AU2015342749B2
(en)
|
2014-11-07 |
2022-01-27 |
Editas Medicine, Inc. |
Methods for improving CRISPR/Cas-mediated genome-editing
|
|
WO2016089866A1
(en)
*
|
2014-12-01 |
2016-06-09 |
President And Fellows Of Harvard College |
Rna-guided systems for in vivo gene editing
|
|
JP6529110B2
(ja)
*
|
2014-12-01 |
2019-06-12 |
国立大学法人 東京大学 |
複数のユニットが多重に連結したdnaカセットおよび該カセットを含むベクターの製造方法
|
|
EP3889260A1
(en)
|
2014-12-12 |
2021-10-06 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
EP3237615B2
(en)
|
2014-12-24 |
2023-07-26 |
The Broad Institute, Inc. |
Crispr having or associated with destabilization domains
|
|
EP3239298A4
(en)
*
|
2014-12-26 |
2018-06-13 |
Riken |
Gene knockout method
|
|
CA2972454C
(en)
*
|
2014-12-31 |
2024-09-10 |
Synthetic Genomics Inc |
Compositions and methods for high efficiency in vivo genome editing
|
|
EP3256487A4
(en)
*
|
2015-02-09 |
2018-07-18 |
Duke University |
Compositions and methods for epigenome editing
|
|
EP3256170B1
(en)
|
2015-02-13 |
2020-09-23 |
University of Massachusetts |
Compositions and methods for transient delivery of nucleases
|
|
AU2016225178B2
(en)
*
|
2015-02-23 |
2022-05-05 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
|
US12129471B2
(en)
|
2015-02-23 |
2024-10-29 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of human genetic diseases including hemoglobinopathies
|
|
DK3064587T3
(da)
|
2015-03-06 |
2019-09-30 |
Leibniz Inst Fuer Pflanzenbiochemie Ipb |
Bibliotek af syntetiske promotere til koordineret genekspression i eukaryotiske celler eller organismer
|
|
EP3748004A1
(en)
*
|
2015-04-01 |
2020-12-09 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating duchenne muscular dystrophy and becker muscular dystrophy
|
|
US11674144B2
(en)
*
|
2015-04-16 |
2023-06-13 |
California Institute Of Technology |
Fractional regulation of transcription
|
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
|
WO2016172008A1
(en)
|
2015-04-24 |
2016-10-27 |
University Of Massachusetts |
Modified aav constructions and uses thereof
|
|
JP2018522249A
(ja)
|
2015-04-24 |
2018-08-09 |
エディタス・メディシン、インコーポレイテッド |
Cas9分子/ガイドrna分子複合体の評価
|
|
EP3294896A1
(en)
|
2015-05-11 |
2018-03-21 |
Editas Medicine, Inc. |
Optimized crispr/cas9 systems and methods for gene editing in stem cells
|
|
WO2016201047A1
(en)
|
2015-06-09 |
2016-12-15 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for improving transplantation
|
|
US9790490B2
(en)
*
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
CN109536474A
(zh)
|
2015-06-18 |
2019-03-29 |
布罗德研究所有限公司 |
降低脱靶效应的crispr酶突变
|
|
US10648020B2
(en)
|
2015-06-18 |
2020-05-12 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
US10954513B2
(en)
*
|
2015-06-18 |
2021-03-23 |
University Of Utah Research Foundation |
RNA-guided transcriptional regulation and methods of using the same for the treatment of back pain
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
CN105255886B
(zh)
*
|
2015-07-09 |
2018-09-14 |
青岛市畜牧兽医研究所 |
一对靶向猪RelA基因的sgRNA
|
|
WO2017015637A1
(en)
*
|
2015-07-22 |
2017-01-26 |
Duke University |
High-throughput screening of regulatory element function with epigenome editing technologies
|
|
JP6905755B2
(ja)
|
2015-08-25 |
2021-07-21 |
デューク ユニバーシティ |
Rnaガイド型エンドヌクレアーゼを使用してゲノム工学における特異性を改善する組成物および方法
|
|
WO2017035342A2
(en)
|
2015-08-27 |
2017-03-02 |
University Of Washington |
Drug discovery platform for duchenne cardiomyopathy
|
|
JP6937513B2
(ja)
*
|
2015-09-11 |
2021-09-22 |
国立研究開発法人理化学研究所 |
転写因子結合部位特異的なdna脱メチル化方法
|
|
WO2017049407A1
(en)
*
|
2015-09-23 |
2017-03-30 |
UNIVERSITé LAVAL |
Modification of the dystrophin gene and uses thereof
|
|
CA2999500A1
(en)
|
2015-09-24 |
2017-03-30 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
|
WO2017053729A1
(en)
|
2015-09-25 |
2017-03-30 |
The Board Of Trustees Of The Leland Stanford Junior University |
Nuclease-mediated genome editing of primary cells and enrichment thereof
|
|
IL297017A
(en)
|
2015-10-08 |
2022-12-01 |
Harvard College |
Multiplexed genome editing
|
|
EP4089175A1
(en)
*
|
2015-10-13 |
2022-11-16 |
Duke University |
Genome engineering with type i crispr systems in eukaryotic cells
|
|
US11426469B2
(en)
|
2015-10-22 |
2022-08-30 |
University Of Massachusetts |
Prostate-targeting adeno-associated virus serotype vectors
|
|
CA3002982A1
(en)
|
2015-10-22 |
2017-04-27 |
University Of Massachusetts |
Methods and compositions for treating metabolic imbalance in neurodegenerative disease
|
|
US12043852B2
(en)
|
2015-10-23 |
2024-07-23 |
President And Fellows Of Harvard College |
Evolved Cas9 proteins for gene editing
|
|
EP3368054A4
(en)
|
2015-10-28 |
2019-07-03 |
Voyager Therapeutics, Inc. |
REGULATORY EXPRESSION USING THE ADENO-ASSOCIATED VIRUS (AAV)
|
|
ES3040945T3
(en)
*
|
2015-10-28 |
2025-11-06 |
Vertex Pharma |
Materials and methods for treatment of duchenne muscular dystrophy
|
|
WO2017077394A2
(en)
|
2015-11-04 |
2017-05-11 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
|
MX2018005377A
(es)
*
|
2015-11-30 |
2018-11-09 |
Univ Duke |
Dianas terapeuticas para la correccion del gen de la distrofina humana por edicion genica y metodos de uso.
|
|
US12110490B2
(en)
|
2015-12-18 |
2024-10-08 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
NZ743983A
(en)
|
2016-01-11 |
2025-08-29 |
Univ Leland Stanford Junior |
Chimeric proteins and methods of regulating gene expression
|
|
SG10202112024PA
(en)
|
2016-01-11 |
2021-12-30 |
Univ Leland Stanford Junior |
Chimeric proteins and methods of immunotherapy
|
|
CA3011458A1
(en)
*
|
2016-01-14 |
2017-07-20 |
The Brigham And Women's Hospital, Inc. |
Genome editing for treating glioblastoma
|
|
US11826433B2
(en)
|
2016-02-02 |
2023-11-28 |
University Of Massachusetts |
Method to enhance the efficiency of systemic AAV gene delivery to the central nervous system
|
|
JP6998313B2
(ja)
*
|
2016-02-11 |
2022-02-04 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
細胞のゲノムにおける変異ジストロフィン遺伝子を修飾する方法及び組成物
|
|
CA3012344A1
(en)
|
2016-02-12 |
2017-08-17 |
University Of Massachusetts |
Anti-angiogenic mirna therapeutics for inhibiting corneal neovascularization
|
|
IL313038A
(en)
*
|
2016-03-14 |
2024-07-01 |
Editas Medicine Inc |
Methods and preparations related to CRISPR/CAS - for the treatment of diseases in the hemoglobin cell
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
EP3433363A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
EP3433364A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
LT3436077T
(lt)
*
|
2016-03-30 |
2025-06-25 |
Intellia Therapeutics, Inc. |
Lipidų nanodalelių vaisto formos, skirtos crispr/cas komponentams
|
|
MA45328A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Compositions acide nucléique-polypeptide et utilisations de celles-ci
|
|
WO2017176929A1
(en)
|
2016-04-05 |
2017-10-12 |
University Of Massachusetts |
Compositions and methods for selective inhibition of grainyhead-like protein expression
|
|
EP4047092B1
(en)
|
2016-04-13 |
2025-07-30 |
Editas Medicine, Inc. |
Cas9 fusion molecules, gene editing systems, and methods of use thereof
|
|
WO2017180915A2
(en)
|
2016-04-13 |
2017-10-19 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
US11413356B2
(en)
|
2016-04-15 |
2022-08-16 |
University Of Massachusetts |
Methods and compositions for treating metabolic imbalance
|
|
KR102424476B1
(ko)
|
2016-04-19 |
2022-07-25 |
더 브로드 인스티튜트, 인코퍼레이티드 |
신규한 crispr 효소 및 시스템
|
|
US11286478B2
(en)
|
2016-04-19 |
2022-03-29 |
The Broad Institute, Inc. |
Cpf1 complexes with reduced indel activity
|
|
ES2957660T3
(es)
|
2016-05-05 |
2024-01-23 |
Univ Duke |
Composiciones relacionadas con crispr/cas para tratar la distrofia muscular de duchenne
|
|
CA3026321C
(en)
*
|
2016-06-02 |
2023-10-03 |
Sigma-Aldrich Co. Llc |
Using programmable dna binding proteins to enhance targeted genome modification
|
|
US11882815B2
(en)
|
2016-06-15 |
2024-01-30 |
University Of Massachusetts |
Recombinant adeno-associated viruses for delivering gene editing molecules to embryonic cells
|
|
CN106119269B
(zh)
*
|
2016-06-23 |
2019-12-06 |
百奥迈科生物技术有限公司 |
一种在大肠杆菌中制备线性单链dna的方法
|
|
EP3481956A4
(en)
|
2016-07-05 |
2020-07-08 |
The Johns Hopkins University |
COMPOSITIONS AND METHODS COMPRISING CRISPR-GUIDED RNA ENHANCEMENTS USING THE H1 PROMOTER
|
|
EP3487523B1
(en)
|
2016-07-19 |
2023-09-06 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
|
WO2018026976A1
(en)
|
2016-08-02 |
2018-02-08 |
Editas Medicine, Inc. |
Compositions and methods for treating cep290 associated disease
|
|
KR20250103795A
(ko)
|
2016-08-03 |
2025-07-07 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
아데노신 핵염기 편집제 및 그의 용도
|
|
CN109804066A
(zh)
|
2016-08-09 |
2019-05-24 |
哈佛大学的校长及成员们 |
可编程cas9-重组酶融合蛋白及其用途
|
|
WO2018031762A1
(en)
*
|
2016-08-10 |
2018-02-15 |
Duke University |
Compositions, systems and methods for programming immune cell function through targeted gene regulation
|
|
IL264872B2
(en)
*
|
2016-08-18 |
2025-02-01 |
Univ California |
CRISPR-CAS genome engineering using a modular AAV delivery system
|
|
AU2017313616B2
(en)
*
|
2016-08-19 |
2022-12-08 |
Institute For Basic Science |
Artificially engineered angiogenesis regulatory system
|
|
US11542509B2
(en)
|
2016-08-24 |
2023-01-03 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
US10457940B2
(en)
|
2016-09-22 |
2019-10-29 |
University Of Massachusetts |
AAV treatment of Huntington's disease
|
|
CN107880132B
(zh)
*
|
2016-09-30 |
2022-06-17 |
北京大学 |
一种融合蛋白及使用其进行同源重组的方法
|
|
EP3518981A4
(en)
|
2016-10-03 |
2020-06-10 |
President and Fellows of Harvard College |
THERAPEUTIC RNA DELIVERY THROUGH ARRDC1 MICROVESICLES
|
|
AU2017341849B2
(en)
|
2016-10-13 |
2024-03-21 |
University Of Massachusetts |
AAV capsid designs
|
|
AU2017342543B2
(en)
|
2016-10-14 |
2024-06-27 |
President And Fellows Of Harvard College |
AAV delivery of nucleobase editors
|
|
CN106318947A
(zh)
*
|
2016-10-17 |
2017-01-11 |
北京大北农科技集团股份有限公司 |
基因组编辑系统及其用途
|
|
FR3058160A1
(fr)
*
|
2016-10-28 |
2018-05-04 |
Universite Pierre Et Marie Curie - Paris 6 (Upmc) |
Procede de differenciation de cellules souches pluripotentes en cardiomyocytes
|
|
CN109689693B
(zh)
*
|
2016-11-03 |
2022-06-28 |
深圳华大生命科学研究院 |
提高基因编辑效率的方法和系统
|
|
CA3044531A1
(en)
*
|
2016-11-28 |
2018-05-31 |
The Board Of Regents Of The University Of Texas System |
Prevention of muscular dystrophy by crispr/cpf1-mediated gene editing
|
|
MX2019006426A
(es)
|
2016-12-01 |
2019-08-14 |
Sangamo Therapeutics Inc |
Reguladores de tau, y composiciones y metodos para su administracion.
|
|
JP7026906B2
(ja)
*
|
2016-12-12 |
2022-03-01 |
アステラス製薬株式会社 |
転写調節融合ポリペプチド
|
|
US12286727B2
(en)
|
2016-12-19 |
2025-04-29 |
Editas Medicine, Inc. |
Assessing nuclease cleavage
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
JOP20190166A1
(ar)
*
|
2017-01-05 |
2019-07-02 |
Univ Texas |
استراتيجية مثلى من أجل تعديلات تخطي إكسون باستخدام crispr/cas9 مع متواليات توجيه ثلاثي
|
|
WO2018129384A1
(en)
|
2017-01-06 |
2018-07-12 |
Avidity Biosciences Llc |
Nucleic acid-polypeptide compositions and methods of inducing exon skipping
|
|
US20220283144A1
(en)
*
|
2017-01-06 |
2022-09-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods identifying and using stem cell differentiation markers
|
|
EP3565907B1
(en)
|
2017-01-06 |
2022-05-04 |
Editas Medicine, Inc. |
Methods of assessing nuclease cleavage
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
WO2018147343A1
(en)
*
|
2017-02-07 |
2018-08-16 |
Edigene Corporation |
Method of treating diseases associated with elevated kras expression using crispr-gndm system
|
|
CN110312797A
(zh)
|
2017-02-10 |
2019-10-08 |
齐默尔根公司 |
组装和编辑用于多个宿主的多个dna构建体的模块化通用质粒设计策略
|
|
US20190380314A1
(en)
*
|
2017-02-23 |
2019-12-19 |
President And Fellows Of Harvard College |
Methods of Genetic Modification of a Cell
|
|
WO2018160695A1
(en)
*
|
2017-02-28 |
2018-09-07 |
Trustees Of Boston University |
Opto-genetic modulator
|
|
US10687520B2
(en)
|
2017-03-07 |
2020-06-23 |
The Board Of Regents Of The University Of Texas System |
Generation and correction of a humanized mouse model with a deletion of dystrophin exon 44
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
EP3592381A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Cancer vaccine
|
|
KR20190127797A
(ko)
|
2017-03-10 |
2019-11-13 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
시토신에서 구아닌으로의 염기 편집제
|
|
WO2018169983A1
(en)
*
|
2017-03-13 |
2018-09-20 |
President And Fellows Of Harvard College |
Methods of modulating expression of target nucleic acid sequences in a cell
|
|
WO2018170184A1
(en)
*
|
2017-03-14 |
2018-09-20 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
US11771703B2
(en)
|
2017-03-17 |
2023-10-03 |
The Johns Hopkins University |
Targeted epigenetic therapy against distal regulatory element of TGFβ2 expression
|
|
CA3057192A1
(en)
|
2017-03-23 |
2018-09-27 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
|
CN107012158B
(zh)
*
|
2017-03-28 |
2020-09-11 |
东南大学 |
一种端粒酶启动基因表达方法及其应用
|
|
KR102758434B1
(ko)
*
|
2017-03-30 |
2025-01-21 |
고쿠리츠 다이가쿠 호진 교토 다이가쿠 |
게놈 편집에 의한 엑손 스키핑 유도 방법
|
|
CN107058358B
(zh)
*
|
2017-04-01 |
2020-06-09 |
中国科学院微生物研究所 |
一种双spacer序列识别切割CRISPR-Cas9载体构建及其在疣孢菌中的应用
|
|
EP3385373A1
(en)
|
2017-04-05 |
2018-10-10 |
Centro de Neurociências e Biologia Celular |
Compositions for reprogramming cells into dendritic cells or antigen presenting cells, methods and uses thereof
|
|
JP7303743B2
(ja)
|
2017-04-05 |
2023-07-05 |
アスガード セラピューティクス エービー |
細胞を樹状細胞または抗原提示細胞にリプログラムするための組成物、その方法および使用
|
|
US12058986B2
(en)
|
2017-04-20 |
2024-08-13 |
Egenesis, Inc. |
Method for generating a genetically modified pig with inactivated porcine endogenous retrovirus (PERV) elements
|
|
EP3615672A1
(en)
|
2017-04-28 |
2020-03-04 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide rna molecules
|
|
JP7327803B2
(ja)
|
2017-05-09 |
2023-08-16 |
ユニバーシティ オブ マサチューセッツ |
筋萎縮性側索硬化症(als)を処置する方法
|
|
WO2018209158A2
(en)
|
2017-05-10 |
2018-11-15 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
WO2018209320A1
(en)
|
2017-05-12 |
2018-11-15 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
|
|
US12139720B2
(en)
*
|
2017-06-02 |
2024-11-12 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Recombinant lentiviral vector for stem cell- based gene therapy of sickle cell disorder
|
|
CN110997908A
(zh)
|
2017-06-09 |
2020-04-10 |
爱迪塔斯医药公司 |
工程化的cas9核酸酶
|
|
AU2018283372B2
(en)
|
2017-06-16 |
2024-06-13 |
Avery Therapeutics, Inc. |
Three dimensional tissue compositions and methods of use
|
|
US20200140896A1
(en)
*
|
2017-06-30 |
2020-05-07 |
Novartis Ag |
Methods for the treatment of disease with gene editing systems
|
|
EP3652312A1
(en)
|
2017-07-14 |
2020-05-20 |
Editas Medicine, Inc. |
Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
|
|
US20200158716A1
(en)
*
|
2017-07-17 |
2020-05-21 |
Massachusetts Institute Of Technology |
Cell atlas of healthy and diseased barrier tissues
|
|
GB201711809D0
(en)
|
2017-07-21 |
2017-09-06 |
Governors Of The Univ Of Alberta |
Antisense oligonucleotide
|
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
|
CN107488649A
(zh)
*
|
2017-08-25 |
2017-12-19 |
南方医科大学 |
一种Cpf1和p300核心结构域的融合蛋白、相应的DNA靶向激活系统和应用
|
|
WO2019139645A2
(en)
|
2017-08-30 |
2019-07-18 |
President And Fellows Of Harvard College |
High efficiency base editors comprising gam
|
|
WO2019055536A1
(en)
*
|
2017-09-14 |
2019-03-21 |
The Children's Medical Center Corporation |
COMPOSITIONS AND METHODS FOR ENHANCING THE EFFICACY OF CELL TRANSPLANTATION
|
|
CN107513531B
(zh)
*
|
2017-09-21 |
2020-02-21 |
无锡市妇幼保健院 |
用于内源性过表达lncRNA-XIST的gRNA靶点序列及其应用
|
|
CN111448321A
(zh)
|
2017-09-22 |
2020-07-24 |
马萨诸塞大学 |
Sod1双表达载体及其用途
|
|
US11572574B2
(en)
|
2017-09-28 |
2023-02-07 |
Toolgen Incorporated |
Artificial genome manipulation for gene expression regulation
|
|
CN107722125B
(zh)
*
|
2017-09-28 |
2021-05-07 |
中山大学 |
一种人工转录激活因子dCas9-TV及其编码基因与应用
|
|
CA3082251A1
(en)
|
2017-10-16 |
2019-04-25 |
The Broad Institute, Inc. |
Uses of adenosine base editors
|
|
WO2019089623A1
(en)
*
|
2017-10-30 |
2019-05-09 |
Children's Hospital Medical Center |
Fusion proteins for use in improving gene correction via homologous recombination
|
|
BR112020008654A2
(pt)
*
|
2017-11-01 |
2020-11-10 |
The Regents Of The University Of California |
composições casz e métodos de uso
|
|
WO2019090160A2
(en)
*
|
2017-11-03 |
2019-05-09 |
Hunterian Medicine Llc |
Compositions and methods of use thereof for the treatment of duchenne muscular dystrophy
|
|
KR102132198B1
(ko)
*
|
2017-12-14 |
2020-07-09 |
단국대학교 산학협력단 |
Tert 프로모터 돌연변이에 특이적인 crispr 시스템 및 그의 이용
|
|
EP3724214A4
(en)
|
2017-12-15 |
2021-09-01 |
The Broad Institute Inc. |
SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING
|
|
MX2020006800A
(es)
|
2017-12-28 |
2020-09-03 |
Takeda Pharmaceuticals Co |
Lipidos cationicos.
|
|
CN111527204B
(zh)
|
2017-12-28 |
2023-09-01 |
国立大学法人京都大学 |
靶基因改造用组合物
|
|
CN108559731A
(zh)
*
|
2018-01-15 |
2018-09-21 |
南方医科大学 |
一种可调控基因表达的人类胚胎干细胞系及其应用
|
|
US11268077B2
(en)
|
2018-02-05 |
2022-03-08 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of hemoglobinopathies
|
|
SG11202007382TA
(en)
*
|
2018-02-15 |
2020-08-28 |
Sigma Aldrich Co Llc |
Engineered cas9 systems for eukaryotic genome modification
|
|
CN110229814B
(zh)
*
|
2018-03-06 |
2025-11-14 |
中国科学院动物研究所 |
改进的向导rna
|
|
SG11202008956XA
(en)
|
2018-03-14 |
2020-10-29 |
Editas Medicine Inc |
Systems and methods for the treatment of hemoglobinopathies
|
|
CN112334577B
(zh)
|
2018-04-19 |
2023-10-17 |
加利福尼亚大学董事会 |
用于基因编辑的组合物和方法
|
|
US12152242B2
(en)
|
2018-04-23 |
2024-11-26 |
The Curators Of The University Of Missouri |
CRISPR therapy
|
|
CN112166194A
(zh)
*
|
2018-04-23 |
2021-01-01 |
杜克大学 |
通过dna甲基化的靶向编辑下调snca的表达
|
|
WO2019210279A1
(en)
*
|
2018-04-27 |
2019-10-31 |
The Regents Of The University Of California |
De novo formation of the biliary system by hepatocyte transdifferentiation
|
|
US12133884B2
(en)
|
2018-05-11 |
2024-11-05 |
Beam Therapeutics Inc. |
Methods of substituting pathogenic amino acids using programmable base editor systems
|
|
KR20210045360A
(ko)
|
2018-05-16 |
2021-04-26 |
신테고 코포레이션 |
가이드 rna 설계 및 사용을 위한 방법 및 시스템
|
|
WO2019226953A1
(en)
|
2018-05-23 |
2019-11-28 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
CA3104856A1
(en)
|
2018-06-29 |
2020-01-02 |
Editas Medicine, Inc. |
Synthetic guide molecules, compositions and methods relating thereto
|
|
US12297241B2
(en)
|
2018-07-06 |
2025-05-13 |
The Regents Of The University Of California |
Method to engineer transplantable human tissues
|
|
CN109055375B
(zh)
*
|
2018-07-26 |
2021-11-12 |
东南大学 |
一种crispr辅助反式增强子激活基因表达的方法及其应用
|
|
CN110760511B
(zh)
*
|
2018-07-27 |
2021-09-07 |
广东赤萌医疗科技有限公司 |
一种用于治疗杜氏肌营养不良症的gRNA、表达载体、CRISPR-Cas9系统
|
|
US20210308273A1
(en)
|
2018-08-02 |
2021-10-07 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating dystrophinopathies
|
|
JP2021533200A
(ja)
|
2018-08-02 |
2021-12-02 |
ダイン セラピューティクス, インコーポレーテッドDyne Therapeutics, Inc. |
顔面・肩甲・上腕筋ジストロフィーを処置するための筋標的化複合体およびそれらの使用
|
|
US12018087B2
(en)
|
2018-08-02 |
2024-06-25 |
Dyne Therapeutics, Inc. |
Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
|
|
US11168141B2
(en)
|
2018-08-02 |
2021-11-09 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating dystrophinopathies
|
|
GB201813011D0
(en)
|
2018-08-10 |
2018-09-26 |
Vib Vzw |
Means and methods for drought tolerance in crops
|
|
CN112703250A
(zh)
*
|
2018-08-15 |
2021-04-23 |
齐默尔根公司 |
CRISPRi在高通量代谢工程中的应用
|
|
EP3836974A4
(en)
|
2018-08-18 |
2022-06-15 |
President and Fellows of Harvard College |
IN SITU GENE EDIT
|
|
WO2020051562A2
(en)
|
2018-09-07 |
2020-03-12 |
Beam Therapeutics Inc. |
Compositions and methods for improving base editing
|
|
JP7250031B2
(ja)
*
|
2018-09-25 |
2023-03-31 |
公益財団法人微生物化学研究会 |
新規ウイルスベクターおよびその製造方法と使用方法
|
|
CN113226333A
(zh)
|
2018-10-02 |
2021-08-06 |
桑格摩生物治疗股份有限公司 |
用于调控Tau蛋白的方法和组合物
|
|
CA3113817A1
(en)
*
|
2018-10-09 |
2020-04-16 |
The University Of North Carolina At Chapel Hill |
Regulated gene editing system
|
|
WO2020081604A2
(en)
*
|
2018-10-15 |
2020-04-23 |
Avery Therapeutics, Inc. |
Cell-free compositions and methods for restoration or enhancement of tissue function
|
|
WO2020081922A1
(en)
|
2018-10-18 |
2020-04-23 |
University Of Utah Research Foundation |
Rna-guided transcriptional regulation and methods of using the same for the treatment of back pain
|
|
US12281338B2
(en)
|
2018-10-29 |
2025-04-22 |
The Broad Institute, Inc. |
Nucleobase editors comprising GeoCas9 and uses thereof
|
|
WO2020092725A1
(en)
*
|
2018-11-01 |
2020-05-07 |
Montana State University |
Gene modulation with crispr system type i
|
|
WO2020097083A1
(en)
*
|
2018-11-06 |
2020-05-14 |
Cellino Biotech, Inc. |
Systems for cell control
|
|
BR112021009481A2
(pt)
*
|
2018-11-16 |
2021-08-17 |
Astellas Pharma Inc. |
método para tratamento da distrofia muscular direcionando gene de utrofina.
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
US20220079972A1
(en)
*
|
2019-01-28 |
2022-03-17 |
The Administrators Of The Tulane Educational Fund |
Crispr-based methods and novel compositions for treating vascular disorders
|
|
AU2020223060B2
(en)
|
2019-02-13 |
2023-04-13 |
Beam Therapeutics Inc. |
Compositions and methods for treating hemoglobinopathies
|
|
CN109929865B
(zh)
*
|
2019-03-11 |
2022-03-08 |
东南大学 |
基于gal4-uas系统的crispr辅助反式增强子激活基因表达的方法及其应用
|
|
DE112020001306T5
(de)
*
|
2019-03-19 |
2022-01-27 |
Massachusetts Institute Of Technology |
Verfahren und zusammensetzungen zur editierung von nukleotidsequenzen
|
|
US20220145249A1
(en)
*
|
2019-04-11 |
2022-05-12 |
Agency For Science, Technology And Research |
A Method of Altering a Differentiation Status of a Cell
|
|
JP2022526669A
(ja)
*
|
2019-04-12 |
2022-05-25 |
デューク ユニバーシティ |
ジストロフィン機能を修復するためのCRISPR/Casをベースにした塩基編集組成物
|
|
EP3952925A4
(en)
*
|
2019-04-12 |
2024-01-24 |
The Regents of the University of California |
COMPOSITIONS AND METHODS FOR MODIFYING DYSTROPHIN GENES
|
|
US20220184229A1
(en)
*
|
2019-04-14 |
2022-06-16 |
Duke University |
Aav vector-mediated deletion of large mutational hotspot for treatment of duchenne muscular dystrophy
|
|
EP3930766A4
(en)
*
|
2019-04-14 |
2023-02-22 |
Duke University |
CRISPR/CAS-BASED GENE EDITING COMPOSITION TO RESTORE DYSTROPHIN FUNCTION
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
WO2020232373A1
(en)
*
|
2019-05-15 |
2020-11-19 |
Board Of Regents, The University Of Texas System |
Crispr methods for treating cancers
|
|
AU2020280107A1
(en)
*
|
2019-05-23 |
2021-12-23 |
American Molecular Laboratories, Inc. |
Methods for detecting a level of H. pylori in a fecal sample
|
|
CN112266418A
(zh)
*
|
2019-07-08 |
2021-01-26 |
中国科学院微生物研究所 |
改进的基因组编辑系统及其应用
|
|
JP7708737B2
(ja)
|
2019-07-18 |
2025-07-15 |
ユニバーシティー オブ ロチェスター |
細胞の細胞型選択的免疫保護
|
|
WO2021051054A1
(en)
*
|
2019-09-13 |
2021-03-18 |
The Regents Of The University Of Colorado, A Body Corporate |
Methods and compositions for cell and tissue rejuvenation
|
|
US20220409744A1
(en)
*
|
2019-09-23 |
2022-12-29 |
Vigeneron Gmbh |
Method of transactivating a homologous gene of a gene of interest and an in vitro method of diagnosing a disease
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
WO2021075555A1
(ja)
*
|
2019-10-18 |
2021-04-22 |
株式会社Epigeneron |
標的核酸の検出方法、核酸結合分子の検出方法、及び核酸結合能の評価方法
|
|
AU2020378619A1
(en)
|
2019-11-06 |
2022-06-09 |
Association Institut De Myologie |
Combined therapy for muscular diseases
|
|
WO2021113536A1
(en)
*
|
2019-12-03 |
2021-06-10 |
Duke University |
Systems and methods for lipid nanoparticle delivery of gene editing machinery
|
|
WO2021127057A1
(en)
*
|
2019-12-16 |
2021-06-24 |
President And Fellows Of Harvard College |
Methods and compositions for correction of dmd mutations
|
|
EP4126224A4
(en)
*
|
2020-04-27 |
2024-07-03 |
Duke University |
HIGH-THROUGHPUT SCREENING METHODS TO DISCOVER OPTIMAL GRNA PAIRS FOR CRISPR-MEDIATED EXON DELETION
|
|
EP4125349A4
(en)
*
|
2020-04-27 |
2024-07-10 |
Duke University |
GENE EDITING OF SATELLITE CELLS IN VIVO USING AAV VECTORS ENCODING MUSCLE-SPECIFIC PROMOTERS
|
|
JP2023525304A
(ja)
|
2020-05-08 |
2023-06-15 |
ザ ブロード インスティテュート,インコーポレーテッド |
標的二本鎖ヌクレオチド配列の両鎖同時編集のための方法および組成物
|
|
WO2021231575A1
(en)
*
|
2020-05-12 |
2021-11-18 |
Myogene Bio Llc |
Immunosuppressive agents and viral delivery re-dosing methods for gene therapy
|
|
WO2022008557A2
(en)
|
2020-07-08 |
2022-01-13 |
UCB Biopharma SRL |
Modulation of cftr expression
|
|
US20230313186A1
(en)
*
|
2020-07-24 |
2023-10-05 |
The Trustees Of The University Of Pennsylvania |
Trophin genome editing for treating duchenne muscular dystrophy (dmd)
|
|
CN115011598A
(zh)
*
|
2020-09-02 |
2022-09-06 |
西湖大学 |
杜氏肌营养不良症相关的外显子剪接增强子、sgRNA、基因编辑工具及应用
|
|
AU2021345112A1
(en)
|
2020-09-15 |
2023-04-27 |
Research Institute At Nationwide Children's Hospital |
Aav-mediated homology-independent targeted integration gene editing for correction of diverse dmd mutations in patients with muscular dystrophy
|
|
US20240043818A1
(en)
*
|
2020-10-15 |
2024-02-08 |
Northeastern University |
Engineered Cells for Increased Collagen Production
|
|
EP4232152A4
(en)
*
|
2020-10-21 |
2025-04-23 |
Duke University |
Dual AAV vector-mediated deletion of a large mutation hotspot for the treatment of Duchenne muscular dystrophy
|
|
CN112662674B
(zh)
*
|
2021-01-12 |
2023-04-11 |
广州瑞风生物科技有限公司 |
靶向编辑VEGFA基因外显子区域的gRNA及其应用
|
|
CN114854791A
(zh)
*
|
2021-02-04 |
2022-08-05 |
北京中因科技有限公司 |
一种新型CRISPR-Cas9系统载体及其应用
|
|
WO2022170059A1
(en)
|
2021-02-05 |
2022-08-11 |
Christiana Care Health Services, Inc. |
Methods of and compositions for reducing gene expression and/or activity
|
|
CN112779259B
(zh)
*
|
2021-03-18 |
2023-05-26 |
新疆畜牧科学院生物技术研究所(新疆畜牧科学院中国-澳大利亚绵羊育种研究中心) |
一种用于精准编辑绵羊OCT4基因的sgRNA、扩增用引物和应用
|
|
US11969475B2
(en)
|
2021-07-09 |
2024-04-30 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
|
|
EP4366784A1
(en)
|
2021-07-09 |
2024-05-15 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and formulations for treating dystrophinopathies
|
|
US11771776B2
(en)
|
2021-07-09 |
2023-10-03 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating dystrophinopathies
|
|
US11638761B2
(en)
|
2021-07-09 |
2023-05-02 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
|
|
CA3227105A1
(en)
|
2021-07-30 |
2023-02-02 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating expression of methyl-cpg binding protein 2 (mecp2)
|
|
US20240254483A1
(en)
|
2021-07-30 |
2024-08-01 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating expression of frataxin (fxn)
|
|
CN113637658A
(zh)
*
|
2021-08-19 |
2021-11-12 |
中国农业科学院棉花研究所 |
基于dCas9-oToV的基因转录系统及其应用
|
|
EP4377465A4
(en)
*
|
2021-09-10 |
2025-05-21 |
The Regents of the University of California |
TEMPERATURE-REGULATED CRISPR-CAS SYSTEMS AND METHODS OF USE THEREOF
|
|
WO2023050158A1
(zh)
*
|
2021-09-29 |
2023-04-06 |
深圳先进技术研究院 |
一种实现多碱基编辑的方法
|
|
EP4463548A1
(en)
|
2022-01-14 |
2024-11-20 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for programming t cell phenotypes through targeted gene activation
|
|
EP4463549A2
(en)
|
2022-01-14 |
2024-11-20 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for programming t cell phenotypes through targeted gene repression
|
|
EP4215614A1
(en)
|
2022-01-24 |
2023-07-26 |
Dynacure |
Combination therapy for dystrophin-related diseases
|
|
US20250290100A1
(en)
*
|
2022-04-26 |
2025-09-18 |
University of Massaachusetts |
SINGLE pegRNA-MEDIATED LARGE INSERTIONS
|
|
CN114941032B
(zh)
*
|
2022-06-13 |
2025-05-06 |
大连医科大学 |
Rnf122在制备抗肿瘤药物中的应用
|
|
WO2023250511A2
(en)
|
2022-06-24 |
2023-12-28 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for reducing low-density lipoprotein through targeted gene repression
|
|
CN119487186A
(zh)
|
2022-06-24 |
2025-02-18 |
欧洲分子生物学实验室 |
用于在目标基因座特异性引入表观遗传性修饰的基于crispr的模块化工具
|
|
CA3261865A1
(en)
|
2022-07-12 |
2024-01-18 |
Tune Therapeutics Inc |
TARGETED TRANSCRIPTIONAL ACTIVATION COMPOSITIONS, SYSTEMS AND METHODS
|
|
CA3264214A1
(en)
|
2022-08-19 |
2024-02-22 |
Tune Therapeutics Inc |
Compositions, systems and methods of regulating the hepatitis B virus by targeted gene suppression
|
|
CN120239746A
(zh)
|
2022-09-19 |
2025-07-01 |
图恩疗法股份有限公司 |
用于调节t细胞功能的组合物、系统和方法
|
|
WO2024081937A2
(en)
*
|
2022-10-13 |
2024-04-18 |
Duke University |
Cas12a fusion proteins and methods of using same
|
|
WO2024163678A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Fusion proteins and systems for targeted activation of frataxin (fxn) and related methods
|
|
WO2024163683A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Systems, compositions, and methods for modulating expression of methyl-cpg binding protein 2 (mecp2) and x-inactive specific transcript (xist)
|
|
EP4662319A2
(en)
*
|
2023-02-10 |
2025-12-17 |
Integrate Bioscience LLC |
Personalized crispr profiling for cancer
|
|
WO2024206714A1
(en)
*
|
2023-03-31 |
2024-10-03 |
Mammoth Biosciences, Inc. |
Engineered effector proteins, compositions, systems and methods of use thereof
|
|
WO2025029840A1
(en)
|
2023-07-31 |
2025-02-06 |
Tune Therapeutics, Inc. |
Compositions and methods for multiplexed activation and repression of t cell gene expression
|
|
WO2025029835A1
(en)
|
2023-07-31 |
2025-02-06 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating il-2 gene expression
|
|
WO2025038494A1
(en)
|
2023-08-11 |
2025-02-20 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for lymphoid cell differentiation using targeted gene activation
|
|
WO2025059073A1
(en)
|
2023-09-11 |
2025-03-20 |
Tune Therapeutics, Inc. |
Epigenetic editing methods and systems for differentiating stem cells
|
|
CN118291415B
(zh)
*
|
2024-03-14 |
2024-11-19 |
内蒙古大学 |
一种CRISPR::Cr-P300M巴豆酰化修饰编辑工具及其应用
|