JP7085716B2 - Ｒｎａガイド遺伝子編集及び遺伝子調節 - Google Patents

Ｒｎａガイド遺伝子編集及び遺伝子調節 Download PDF

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JP7085716B2
JP7085716B2 JP2016518017A JP2016518017A JP7085716B2 JP 7085716 B2 JP7085716 B2 JP 7085716B2 JP 2016518017 A JP2016518017 A JP 2016518017A JP 2016518017 A JP2016518017 A JP 2016518017A JP 7085716 B2 JP7085716 B2 JP 7085716B2
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gene
cas9
target
cells
expression
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JP2016521555A (ja
JP2016521555A5 (enExample
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シャルル エイ ジェールバッハ
アイザック ビー ヒルトン
パブロ ペレズピネラ
アミ エム カバディ
プラティクシャ アイ サコラ
デイヴィッド ジー オースターオート
ジョシュア ビー ブラック
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Duke University
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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JP2016518017A 2013-06-05 2014-06-05 Ｒｎａガイド遺伝子編集及び遺伝子調節 Active JP7085716B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2019200973A JP7313055B2 (ja) 2013-06-05 2019-11-05 Ｒｎａガイド遺伝子編集及び遺伝子調節
JP2022052186A JP7649046B2 (ja) 2013-06-05 2022-03-28 Ｒｎａガイド遺伝子編集及び遺伝子調節
JP2023131956A JP2023164823A (ja) 2013-06-05 2023-08-14 Ｒｎａガイド遺伝子編集及び遺伝子調節
JP2024196641A JP2025062594A (ja) 2013-06-05 2024-11-11 Ｒｎａガイド遺伝子編集及び遺伝子調節

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201361831481P 2013-06-05 2013-06-05
US61/831,481 2013-06-05
US201361839127P 2013-06-25 2013-06-25
US61/839,127 2013-06-25
US201361904911P 2013-11-15 2013-11-15
US61/904,911 2013-11-15
US201461967466P 2014-03-19 2014-03-19
US61/967,466 2014-03-19
US201461981575P 2014-04-18 2014-04-18
US61/981,575 2014-04-18
PCT/US2014/041190 WO2014197748A2 (en) 2013-06-05 2014-06-05 Rna-guided gene editing and gene regulation

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JP2019200973A Division JP7313055B2 (ja) 2013-06-05 2019-11-05 Ｒｎａガイド遺伝子編集及び遺伝子調節
JP2022052186A Division JP7649046B2 (ja) 2013-06-05 2022-03-28 Ｒｎａガイド遺伝子編集及び遺伝子調節

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JP2016521555A JP2016521555A (ja) 2016-07-25
JP2016521555A5 JP2016521555A5 (enExample) 2017-07-20
JP7085716B2 true JP7085716B2 (ja) 2022-06-17

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JP2019200973A Active JP7313055B2 (ja) 2013-06-05 2019-11-05 Ｒｎａガイド遺伝子編集及び遺伝子調節
JP2022052186A Active JP7649046B2 (ja) 2013-06-05 2022-03-28 Ｒｎａガイド遺伝子編集及び遺伝子調節
JP2023131956A Pending JP2023164823A (ja) 2013-06-05 2023-08-14 Ｒｎａガイド遺伝子編集及び遺伝子調節
JP2024196641A Pending JP2025062594A (ja) 2013-06-05 2024-11-11 Ｒｎａガイド遺伝子編集及び遺伝子調節

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JP2019200973A Active JP7313055B2 (ja) 2013-06-05 2019-11-05 Ｒｎａガイド遺伝子編集及び遺伝子調節
JP2022052186A Active JP7649046B2 (ja) 2013-06-05 2022-03-28 Ｒｎａガイド遺伝子編集及び遺伝子調節
JP2023131956A Pending JP2023164823A (ja) 2013-06-05 2023-08-14 Ｒｎａガイド遺伝子編集及び遺伝子調節
JP2024196641A Pending JP2025062594A (ja) 2013-06-05 2024-11-11 Ｒｎａガイド遺伝子編集及び遺伝子調節

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US (4) US10704060B2 (enExample)
EP (5) EP3004370B1 (enExample)
JP (5) JP7085716B2 (enExample)
KR (4) KR102307280B1 (enExample)
CN (3) CN105658805B (enExample)
AU (5) AU2014274840B2 (enExample)
CA (1) CA2914519A1 (enExample)
ES (3) ES2987399T3 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020058349A (ja) * 2013-06-05 2020-04-16 デューク ユニバーシティ Ｒｎａガイド遺伝子編集及び遺伝子調節

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WO2012145624A2 (en) 2011-04-21 2012-10-26 University Of Massachusetts Raav-based compositions and methods for treating alpha-1 anti-trypsin deficiencies
WO2013066438A2 (en) 2011-07-22 2013-05-10 President And Fellows Of Harvard College Evaluation and improvement of nuclease cleavage specificity
GB201122458D0 (en) * 2011-12-30 2012-02-08 Univ Wageningen Modified cascade ribonucleoproteins and uses thereof
WO2013119602A1 (en) 2012-02-06 2013-08-15 President And Fellows Of Harvard College Arrdc1-mediated microvesicles (armms) and uses thereof
WO2013163628A2 (en) 2012-04-27 2013-10-31 Duke University Genetic correction of mutated genes
BR122019025681B1 (pt) * 2012-11-01 2023-04-18 Factor Bioscience Inc Método para inserir uma sequência de ácido nucleico em uma localização segura de um genoma de uma célula
EP3434776A1 (en) 2012-12-12 2019-01-30 The Broad Institute, Inc. Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
EP2931899A1 (en) 2012-12-12 2015-10-21 The Broad Institute, Inc. Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
KR20150105956A (ko) 2012-12-12 2015-09-18 더 브로드 인스티튜트, 인코퍼레이티드 서열 조작 및 치료적 적용을 위한 시스템, 방법 및 조성물의 전달, 유전자 조작 및 최적화
NZ732507A (en) * 2013-03-15 2018-08-31 Sarepta Therapeutics Inc Improved compositions for treating muscular dystrophy
US9828582B2 (en) 2013-03-19 2017-11-28 Duke University Compositions and methods for the induction and tuning of gene expression
EP3674411A1 (en) 2013-06-17 2020-07-01 The Broad Institute, Inc. Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
CA2915795C (en) 2013-06-17 2021-07-13 The Broad Institute, Inc. Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
EP3725885A1 (en) 2013-06-17 2020-10-21 The Broad Institute, Inc. Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
CN107995927B (zh) 2013-06-17 2021-07-30 布罗德研究所有限公司 用于肝靶向和治疗的crispr-cas系统、载体和组合物的递送与用途
CN105492611A (zh) 2013-06-17 2016-04-13 布罗德研究所有限公司 用于序列操纵的优化的crispr-cas双切口酶系统、方法以及组合物
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EP4389903A3 (en) 2024-10-16
JP2023164823A (ja) 2023-11-14
JP2016521555A (ja) 2016-07-25
JP7313055B2 (ja) 2023-07-24
AU2014274840B2 (en) 2020-03-12
EP4389903A2 (en) 2024-06-26
JP2025062594A (ja) 2025-04-14
JP2020058349A (ja) 2020-04-16
AU2022250450B2 (en) 2025-05-22
EP3539573B1 (en) 2024-02-14
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AU2014274840A2 (en) 2016-01-21
EP3539573A1 (en) 2019-09-18
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