|
US9217155B2
(en)
|
2008-05-28 |
2015-12-22 |
University Of Massachusetts |
Isolation of novel AAV'S and uses thereof
|
|
US8734809B2
(en)
|
2009-05-28 |
2014-05-27 |
University Of Massachusetts |
AAV's and uses thereof
|
|
WO2012145624A2
(en)
|
2011-04-21 |
2012-10-26 |
University Of Massachusetts |
Raav-based compositions and methods for treating alpha-1 anti-trypsin deficiencies
|
|
WO2013066438A2
(en)
|
2011-07-22 |
2013-05-10 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
GB201122458D0
(en)
*
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
US9737480B2
(en)
|
2012-02-06 |
2017-08-22 |
President And Fellows Of Harvard College |
ARRDC1-mediated microvesicles (ARMMs) and uses thereof
|
|
EP2841572B1
(en)
|
2012-04-27 |
2019-06-19 |
Duke University |
Genetic correction of mutated genes
|
|
CA2890110C
(en)
*
|
2012-11-01 |
2023-05-02 |
Factor Bioscience Inc. |
Methods and products for expressing proteins in cells
|
|
EP2931899A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
WO2014093709A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
SG10201707569YA
(en)
|
2012-12-12 |
2017-10-30 |
Broad Inst Inc |
Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications
|
|
HK1220154A1
(zh)
*
|
2013-03-15 |
2017-04-28 |
Sarepta Therapeutics, Inc. |
改进的用於治疗肌营养不良的组合物
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
WO2014197748A2
(en)
*
|
2013-06-05 |
2014-12-11 |
Duke University |
Rna-guided gene editing and gene regulation
|
|
EP3011033B1
(en)
|
2013-06-17 |
2020-02-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
KR20250012194A
(ko)
|
2013-06-17 |
2025-01-23 |
더 브로드 인스티튜트, 인코퍼레이티드 |
바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용
|
|
WO2014204725A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
|
|
ES2777217T3
(es)
|
2013-06-17 |
2020-08-04 |
Broad Inst Inc |
Suministro, modificación y optimización de sistemas de guía en tándem, métodos y composiciones para la manipulación de secuencias
|
|
JP6738728B2
(ja)
|
2013-06-17 |
2020-08-19 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
肝臓ターゲティングおよび治療のためのCRISPR−Cas系、ベクターおよび組成物の送達および使用
|
|
CN105517579B
(zh)
*
|
2013-07-10 |
2019-11-15 |
哈佛大学校长及研究员协会 |
用于RNA向导的基因调节和编辑的正交Cas9蛋白
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
ES2681622T3
(es)
|
2013-09-18 |
2018-09-14 |
Kymab Limited |
Métodos, células y organismos
|
|
CN111218447B
(zh)
|
2013-11-07 |
2024-10-11 |
爱迪塔斯医药有限公司 |
使用统治型gRNA的CRISPR相关方法和组合物
|
|
CN111206032B
(zh)
|
2013-12-12 |
2024-07-19 |
布罗德研究所有限公司 |
用于基因组编辑的crispr-cas系统和组合物的递送、用途和治疗应用
|
|
US20150166984A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting alpha-antitrypsin point mutations
|
|
WO2015089473A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
KR20160097338A
(ko)
|
2013-12-12 |
2016-08-17 |
더 브로드 인스티튜트, 인코퍼레이티드 |
뉴클레오티드 반복 장애에서의 crispr-cas 시스템의 조성물 및 방법 및 용도
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
JP6793547B2
(ja)
|
2013-12-12 |
2020-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
最適化機能CRISPR−Cas系による配列操作のための系、方法および組成物
|
|
CN105899658B
(zh)
|
2013-12-12 |
2020-02-18 |
布罗德研究所有限公司 |
针对hbv和病毒性疾病以及障碍的crispr-cas系统和组合物的递送、用途和治疗应用
|
|
WO2015127128A2
(en)
|
2014-02-19 |
2015-08-27 |
University Of Massachusetts |
Recombinant aavs having useful transcytosis properties
|
|
US11028388B2
(en)
|
2014-03-05 |
2021-06-08 |
Editas Medicine, Inc. |
CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa
|
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
US9938521B2
(en)
|
2014-03-10 |
2018-04-10 |
Editas Medicine, Inc. |
CRISPR/CAS-related methods and compositions for treating leber's congenital amaurosis 10 (LCA10)
|
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
AU2015229299A1
(en)
*
|
2014-03-12 |
2016-09-22 |
Precision Biosciences, Inc. |
Dystrophin gene exon deletion using engineered nucleases
|
|
JP6756700B2
(ja)
|
2014-03-18 |
2020-09-16 |
ユニバーシティ オブ マサチューセッツ |
筋萎縮性側索硬化症を処置するためのrAAVベースの組成物および方法
|
|
EP3981876A1
(en)
|
2014-03-26 |
2022-04-13 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
|
EP3540061A1
(en)
|
2014-04-02 |
2019-09-18 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
|
WO2015164786A1
(en)
|
2014-04-25 |
2015-10-29 |
University Of Massachusetts |
Recombinant aav vectors useful for reducing immunity against transgene products
|
|
BR122023023211A2
(pt)
|
2014-04-28 |
2024-01-23 |
Recombinetics, Inc. |
Método de fazer edições de genes multiplex em uma célula de vertebrado ou de embrião primário não-humano
|
|
AU2015298571B2
(en)
|
2014-07-30 |
2020-09-03 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
US20160058889A1
(en)
*
|
2014-08-11 |
2016-03-03 |
The Board Of Regents Of The University Of Texas System |
Prevention of muscular dystrophy by crispr/cas9-mediated gene editing
|
|
WO2016049024A2
(en)
*
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo
|
|
WO2016054557A1
(en)
|
2014-10-03 |
2016-04-07 |
University Of Massachusetts |
Novel high efficiency library-identified aav vectors
|
|
US10370432B2
(en)
|
2014-10-03 |
2019-08-06 |
University Of Massachusetts |
Heterologous targeting peptide grafted AAVS
|
|
EP3204496A1
(en)
|
2014-10-10 |
2017-08-16 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
WO2016065001A1
(en)
|
2014-10-21 |
2016-04-28 |
University Of Massachusetts |
Recombinant aav variants and uses thereof
|
|
GB201418965D0
(enExample)
|
2014-10-24 |
2014-12-10 |
Ospedale San Raffaele And Fond Telethon |
|
|
US9816080B2
(en)
|
2014-10-31 |
2017-11-14 |
President And Fellows Of Harvard College |
Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
|
|
WO2016073990A2
(en)
|
2014-11-07 |
2016-05-12 |
Editas Medicine, Inc. |
Methods for improving crispr/cas-mediated genome-editing
|
|
WO2016089866A1
(en)
*
|
2014-12-01 |
2016-06-09 |
President And Fellows Of Harvard College |
Rna-guided systems for in vivo gene editing
|
|
JP6529110B2
(ja)
*
|
2014-12-01 |
2019-06-12 |
国立大学法人 東京大学 |
複数のユニットが多重に連結したdnaカセットおよび該カセットを含むベクターの製造方法
|
|
EP3985115A1
(en)
|
2014-12-12 |
2022-04-20 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
WO2016106244A1
(en)
|
2014-12-24 |
2016-06-30 |
The Broad Institute Inc. |
Crispr having or associated with destabilization domains
|
|
EP3239298A4
(en)
*
|
2014-12-26 |
2018-06-13 |
Riken |
Gene knockout method
|
|
JP2018500037A
(ja)
*
|
2014-12-31 |
2018-01-11 |
シンセティック ジェノミクス インコーポレーテッド |
高効率なインビボゲノム編集のための組成物及び方法
|
|
US10676726B2
(en)
*
|
2015-02-09 |
2020-06-09 |
Duke University |
Compositions and methods for epigenome editing
|
|
EP3256170B1
(en)
|
2015-02-13 |
2020-09-23 |
University of Massachusetts |
Compositions and methods for transient delivery of nucleases
|
|
WO2016135558A2
(en)
*
|
2015-02-23 |
2016-09-01 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
|
US12129471B2
(en)
|
2015-02-23 |
2024-10-29 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of human genetic diseases including hemoglobinopathies
|
|
DK3064587T3
(da)
|
2015-03-06 |
2019-09-30 |
Leibniz Inst Fuer Pflanzenbiochemie Ipb |
Bibliotek af syntetiske promotere til koordineret genekspression i eukaryotiske celler eller organismer
|
|
CA2981508A1
(en)
*
|
2015-04-01 |
2016-10-06 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating duchenne muscular dystrophy and becker muscular dystrophy
|
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
|
US11674144B2
(en)
*
|
2015-04-16 |
2023-06-13 |
California Institute Of Technology |
Fractional regulation of transcription
|
|
EP4019975A1
(en)
|
2015-04-24 |
2022-06-29 |
Editas Medicine, Inc. |
Evaluation of cas9 molecule/guide rna molecule complexes
|
|
US11046955B2
(en)
|
2015-04-24 |
2021-06-29 |
University Of Massachusetts |
Modified AAV constructs and uses thereof
|
|
CA2986310A1
(en)
|
2015-05-11 |
2016-11-17 |
Editas Medicine, Inc. |
Optimized crispr/cas9 systems and methods for gene editing in stem cells
|
|
US11911415B2
(en)
|
2015-06-09 |
2024-02-27 |
Editas Medicine, Inc. |
CRISPR/Cas-related methods and compositions for improving transplantation
|
|
US9790490B2
(en)
*
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
EP3929287A3
(en)
|
2015-06-18 |
2022-04-13 |
The Broad Institute, Inc. |
Crispr enzyme mutations reducing off-target effects
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
US10648020B2
(en)
|
2015-06-18 |
2020-05-12 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
US10954513B2
(en)
*
|
2015-06-18 |
2021-03-23 |
University Of Utah Research Foundation |
RNA-guided transcriptional regulation and methods of using the same for the treatment of back pain
|
|
CN105255886B
(zh)
*
|
2015-07-09 |
2018-09-14 |
青岛市畜牧兽医研究所 |
一对靶向猪RelA基因的sgRNA
|
|
ES3009026T3
(en)
*
|
2015-07-22 |
2025-03-25 |
Univ Duke |
High-throughput screening of regulatory element function with epigenome editing technologies
|
|
KR20240132120A
(ko)
*
|
2015-08-25 |
2024-09-02 |
듀크 유니버시티 |
Rna-가이드된 엔도뉴클레아제를 이용하는 게놈 조작에서 특이성을 개선하는 조성물 및 방법
|
|
US11661583B2
(en)
|
2015-08-27 |
2023-05-30 |
University Of Washington |
Drug discovery platform for Duchenne cardiomyopathy
|
|
WO2017043647A1
(ja)
*
|
2015-09-11 |
2017-03-16 |
国立研究開発法人理化学研究所 |
転写因子結合部位特異的なdna脱メチル化方法
|
|
EP3332008A4
(en)
*
|
2015-09-23 |
2019-01-16 |
Université Laval |
CHANGE OF THE DYSTROPHINE GENE AND USES THEREOF
|
|
CA2999500A1
(en)
|
2015-09-24 |
2017-03-30 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
|
WO2017053729A1
(en)
|
2015-09-25 |
2017-03-30 |
The Board Of Trustees Of The Leland Stanford Junior University |
Nuclease-mediated genome editing of primary cells and enrichment thereof
|
|
AU2016335698B2
(en)
|
2015-10-08 |
2022-12-01 |
President And Fellows Of Harvard College |
Multiplexed genome editing
|
|
WO2017066497A2
(en)
|
2015-10-13 |
2017-04-20 |
Duke University |
Genome engineering with type i crispr systems in eukaryotic cells
|
|
WO2017070516A1
(en)
|
2015-10-22 |
2017-04-27 |
University Of Massachusetts |
Prostate-targeting adeno-associated virus serotype vectors
|
|
EP3364997B1
(en)
|
2015-10-22 |
2024-01-17 |
University of Massachusetts |
Aspartoacylase gene therapy in the treatment of canavan disease
|
|
WO2017070632A2
(en)
|
2015-10-23 |
2017-04-27 |
President And Fellows Of Harvard College |
Nucleobase editors and uses thereof
|
|
EP4279084B1
(en)
*
|
2015-10-28 |
2025-06-11 |
Vertex Pharmaceuticals Inc. |
Materials and methods for treatment of duchenne muscular dystrophy
|
|
US20180230489A1
(en)
|
2015-10-28 |
2018-08-16 |
Voyager Therapeutics, Inc. |
Regulatable expression using adeno-associated virus (aav)
|
|
EP3371306B8
(en)
|
2015-11-04 |
2023-02-22 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of hemoglobinopathies
|
|
US12214054B2
(en)
*
|
2015-11-30 |
2025-02-04 |
Duke University |
Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use
|
|
WO2017106657A1
(en)
|
2015-12-18 |
2017-06-22 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
JP7012645B2
(ja)
|
2016-01-11 |
2022-01-28 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
キメラタンパク質および免疫治療の方法
|
|
WO2017123559A2
(en)
|
2016-01-11 |
2017-07-20 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric proteins and methods of regulating gene expression
|
|
US12049625B2
(en)
|
2016-01-14 |
2024-07-30 |
The Brigham And Women's Hospital, Inc. |
Genome editing for treating glioblastoma
|
|
CA3011939A1
(en)
|
2016-02-02 |
2017-08-10 |
University Of Massachusetts |
Method to enhance the efficiency of systemic aav gene delivery to the central nervous system
|
|
JP6998313B2
(ja)
*
|
2016-02-11 |
2022-02-04 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
細胞のゲノムにおける変異ジストロフィン遺伝子を修飾する方法及び組成物
|
|
CA3012344A1
(en)
|
2016-02-12 |
2017-08-17 |
University Of Massachusetts |
Anti-angiogenic mirna therapeutics for inhibiting corneal neovascularization
|
|
IL313038A
(en)
*
|
2016-03-14 |
2024-07-01 |
Editas Medicine Inc |
Crispr/cas-related methods and compositions for treating beta hemoglobinopathies
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
EP3433364A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
WO2017165826A1
(en)
|
2016-03-25 |
2017-09-28 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
ES3030658T3
(en)
*
|
2016-03-30 |
2025-07-01 |
Intellia Therapeutics Inc |
Lipid nanoparticle formulations for crispr/cas components
|
|
KR102775461B1
(ko)
|
2016-04-01 |
2025-02-28 |
어비디티 바이오사이언시스 인크. |
핵산-폴리펩타이드 조성물 및 이의 용도
|
|
EP3440210A4
(en)
|
2016-04-05 |
2019-11-27 |
University of Massachusetts |
COMPOSITIONS AND METHOD FOR SELECTIVELY INHIBITING THE EXPRESSION OF GRAINYHEAD LIKE PROTEIN
|
|
US11236313B2
(en)
|
2016-04-13 |
2022-02-01 |
Editas Medicine, Inc. |
Cas9 fusion molecules, gene editing systems, and methods of use thereof
|
|
EP3443081A4
(en)
|
2016-04-13 |
2019-10-30 |
Duke University |
CRISPR / CAS9-BASED REPRESSORS FOR IN VIVO SHUT-OFF OF GEN-TARGETS AND METHOD OF USE
|
|
US11413356B2
(en)
|
2016-04-15 |
2022-08-16 |
University Of Massachusetts |
Methods and compositions for treating metabolic imbalance
|
|
EP3445853A1
(en)
|
2016-04-19 |
2019-02-27 |
The Broad Institute, Inc. |
Cpf1 complexes with reduced indel activity
|
|
KR20260004568A
(ko)
|
2016-04-19 |
2026-01-08 |
더 브로드 인스티튜트, 인코퍼레이티드 |
신규한 crispr 효소 및 시스템
|
|
WO2017193029A2
(en)
|
2016-05-05 |
2017-11-09 |
Duke University |
Crispr/cas-related methods and compositions for treating duchenne muscular dystrophy
|
|
DK3604527T3
(da)
|
2016-06-02 |
2021-05-31 |
Sigma Aldrich Co Llc |
Anvendelse af programmerbare dna-bindingsproteiner til at forbedre målrettet genommodifikation
|
|
US11882815B2
(en)
|
2016-06-15 |
2024-01-30 |
University Of Massachusetts |
Recombinant adeno-associated viruses for delivering gene editing molecules to embryonic cells
|
|
CN106119269B
(zh)
*
|
2016-06-23 |
2019-12-06 |
百奥迈科生物技术有限公司 |
一种在大肠杆菌中制备线性单链dna的方法
|
|
SG11201900038QA
(en)
*
|
2016-07-05 |
2019-02-27 |
Univ Johns Hopkins |
Compositions and methods comprising improvements of crispr guide rnas using the h1 promoter
|
|
JP7490211B2
(ja)
|
2016-07-19 |
2024-05-27 |
デューク ユニバーシティ |
Cpf1に基づくゲノム編集の治療適用
|
|
US11566263B2
(en)
|
2016-08-02 |
2023-01-31 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290 associated disease
|
|
WO2018027078A1
(en)
|
2016-08-03 |
2018-02-08 |
President And Fellows Of Harard College |
Adenosine nucleobase editors and uses thereof
|
|
AU2017308889B2
(en)
|
2016-08-09 |
2023-11-09 |
President And Fellows Of Harvard College |
Programmable Cas9-recombinase fusion proteins and uses thereof
|
|
EP3497221A4
(en)
*
|
2016-08-10 |
2020-02-05 |
Duke University |
COMPOSITIONS, SYSTEMS AND METHODS FOR PROGRAMMING IMMUNE CELL FUNCTION BY TARGETED GENE REGULATION
|
|
CA3034089A1
(en)
*
|
2016-08-18 |
2018-02-22 |
The Regents Of The University Of California |
Crispr-cas genome engineering via a modular aav delivery system
|
|
JP7050215B2
(ja)
*
|
2016-08-19 |
2022-04-08 |
ツールゲン インコーポレイテッド |
人工的に操作された血管新生調節系
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
US10457940B2
(en)
|
2016-09-22 |
2019-10-29 |
University Of Massachusetts |
AAV treatment of Huntington's disease
|
|
CN107880132B
(zh)
*
|
2016-09-30 |
2022-06-17 |
北京大学 |
一种融合蛋白及使用其进行同源重组的方法
|
|
EP3518981A4
(en)
|
2016-10-03 |
2020-06-10 |
President and Fellows of Harvard College |
THERAPEUTIC RNA DELIVERY THROUGH ARRDC1 MICROVESICLES
|
|
KR20190075964A
(ko)
|
2016-10-13 |
2019-07-01 |
유니버시티 오브 매사추세츠 |
Aav 캡시드 설계
|
|
KR20240007715A
(ko)
|
2016-10-14 |
2024-01-16 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵염기 에디터의 aav 전달
|
|
CN106318947A
(zh)
*
|
2016-10-17 |
2017-01-11 |
北京大北农科技集团股份有限公司 |
基因组编辑系统及其用途
|
|
FR3058160A1
(fr)
*
|
2016-10-28 |
2018-05-04 |
Universite Pierre Et Marie Curie - Paris 6 (Upmc) |
Procede de differenciation de cellules souches pluripotentes en cardiomyocytes
|
|
WO2018081978A1
(zh)
*
|
2016-11-03 |
2018-05-11 |
深圳华大基因研究院 |
提高基因编辑效率的方法和系统
|
|
AU2017364106A1
(en)
*
|
2016-11-28 |
2019-06-20 |
The Board Of Regents Of The University Of Texas System |
Prevention of muscular dystrophy by CRISPR/Cpfl-mediated gene editing
|
|
CN110214184B
(zh)
|
2016-12-01 |
2024-07-02 |
桑格摩生物治疗股份有限公司 |
τ蛋白调节剂以及用于其递送的方法和组合物
|
|
WO2018110471A1
(ja)
*
|
2016-12-12 |
2018-06-21 |
アステラス製薬株式会社 |
転写調節融合ポリペプチド
|
|
EP3555297A1
(en)
|
2016-12-19 |
2019-10-23 |
Editas Medicine, Inc. |
Assessing nuclease cleavage
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
JOP20190166A1
(ar)
*
|
2017-01-05 |
2019-07-02 |
Univ Texas |
استراتيجية مثلى من أجل تعديلات تخطي إكسون باستخدام crispr/cas9 مع متواليات توجيه ثلاثي
|
|
US20220283144A1
(en)
*
|
2017-01-06 |
2022-09-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods identifying and using stem cell differentiation markers
|
|
KR20240172236A
(ko)
|
2017-01-06 |
2024-12-09 |
어비디티 바이오사이언시스 인크. |
핵산-폴리펩티드 조성물 및 엑손 스키핑을 유도하는 방법
|
|
WO2018129368A2
(en)
|
2017-01-06 |
2018-07-12 |
Editas Medicine, Inc. |
Methods of assessing nuclease cleavage
|
|
TW201839136A
(zh)
*
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
WO2018147343A1
(en)
*
|
2017-02-07 |
2018-08-16 |
Edigene Corporation |
Method of treating diseases associated with elevated kras expression using crispr-gndm system
|
|
CN110312797A
(zh)
|
2017-02-10 |
2019-10-08 |
齐默尔根公司 |
组装和编辑用于多个宿主的多个dna构建体的模块化通用质粒设计策略
|
|
WO2018156824A1
(en)
*
|
2017-02-23 |
2018-08-30 |
President And Fellows Of Harvard College |
Methods of genetic modification of a cell
|
|
WO2018160695A1
(en)
*
|
2017-02-28 |
2018-09-07 |
Trustees Of Boston University |
Opto-genetic modulator
|
|
US10687520B2
(en)
|
2017-03-07 |
2020-06-23 |
The Board Of Regents Of The University Of Texas System |
Generation and correction of a humanized mouse model with a deletion of dystrophin exon 44
|
|
WO2018165504A1
(en)
|
2017-03-09 |
2018-09-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
KR20190123328A
(ko)
|
2017-03-09 |
2019-10-31 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
암 백신
|
|
CN110914310A
(zh)
|
2017-03-10 |
2020-03-24 |
哈佛大学的校长及成员们 |
胞嘧啶至鸟嘌呤碱基编辑器
|
|
US11674138B2
(en)
|
2017-03-13 |
2023-06-13 |
President And Fellows Of Harvard College |
Methods of modulating expression of target nucleic acid sequences in a cell
|
|
EP3596217A1
(en)
|
2017-03-14 |
2020-01-22 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
EP3596117A4
(en)
*
|
2017-03-17 |
2021-01-13 |
The Johns Hopkins University |
TARGETED EPIGENETIC THERAPY AGAINST THE DISTAL EXPRESSION REGULATORY ELEMENT OF TGFB2
|
|
IL306092A
(en)
|
2017-03-23 |
2023-11-01 |
Harvard College |
Nucleic base editors that include nucleic acid programmable DNA binding proteins
|
|
CN107012158B
(zh)
*
|
2017-03-28 |
2020-09-11 |
东南大学 |
一种端粒酶启动基因表达方法及其应用
|
|
CN110892069B
(zh)
*
|
2017-03-30 |
2024-02-09 |
国立大学法人京都大学 |
基于基因组编辑的外显子跳跃诱导方法
|
|
CN107058358B
(zh)
*
|
2017-04-01 |
2020-06-09 |
中国科学院微生物研究所 |
一种双spacer序列识别切割CRISPR-Cas9载体构建及其在疣孢菌中的应用
|
|
US11345891B2
(en)
|
2017-04-05 |
2022-05-31 |
Asgard Therapeutics Ab |
Compositions for reprogramming cells into dendritic cells or antigen presenting cells, methods and uses thereof
|
|
EP3385373A1
(en)
|
2017-04-05 |
2018-10-10 |
Centro de Neurociências e Biologia Celular |
Compositions for reprogramming cells into dendritic cells or antigen presenting cells, methods and uses thereof
|
|
CN116732106A
(zh)
|
2017-04-20 |
2023-09-12 |
E开创生物技术股份有限公司 |
产生基因修改的动物的方法
|
|
US11499151B2
(en)
|
2017-04-28 |
2022-11-15 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide RNA molecules
|
|
AU2018264996A1
(en)
|
2017-05-09 |
2019-12-05 |
University Of Massachusetts |
Methods of treating Amyotrophic Lateral Sclerosis (ALS)
|
|
EP3622070A2
(en)
*
|
2017-05-10 |
2020-03-18 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
EP3635120A1
(en)
*
|
2017-06-02 |
2020-04-15 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Recombinant lentiviral vector for stem cell-based gene therapy of sickle cell disorder
|
|
CN110997908A
(zh)
|
2017-06-09 |
2020-04-10 |
爱迪塔斯医药公司 |
工程化的cas9核酸酶
|
|
WO2018232323A1
(en)
|
2017-06-16 |
2018-12-20 |
Avery Therapeutics, Inc. |
Three dimensional tissue compositions and methods of use
|
|
US20200140896A1
(en)
*
|
2017-06-30 |
2020-05-07 |
Novartis Ag |
Methods for the treatment of disease with gene editing systems
|
|
EP3652312A1
(en)
|
2017-07-14 |
2020-05-20 |
Editas Medicine, Inc. |
Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
|
|
EP3655961A4
(en)
*
|
2017-07-17 |
2021-09-01 |
Massachusetts Institute of Technology |
HEALTHY AND SICK BARRIER TISSUE CELL ATLAS
|
|
GB201711809D0
(en)
|
2017-07-21 |
2017-09-06 |
Governors Of The Univ Of Alberta |
Antisense oligonucleotide
|
|
EP3658573A1
(en)
|
2017-07-28 |
2020-06-03 |
President and Fellows of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
|
|
CN107488649A
(zh)
*
|
2017-08-25 |
2017-12-19 |
南方医科大学 |
一种Cpf1和p300核心结构域的融合蛋白、相应的DNA靶向激活系统和应用
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
WO2019055536A1
(en)
*
|
2017-09-14 |
2019-03-21 |
The Children's Medical Center Corporation |
COMPOSITIONS AND METHODS FOR ENHANCING THE EFFICACY OF CELL TRANSPLANTATION
|
|
CN107513531B
(zh)
*
|
2017-09-21 |
2020-02-21 |
无锡市妇幼保健院 |
用于内源性过表达lncRNA-XIST的gRNA靶点序列及其应用
|
|
CN118006607A
(zh)
|
2017-09-22 |
2024-05-10 |
马萨诸塞大学 |
Sod1双表达载体及其用途
|
|
US11572574B2
(en)
|
2017-09-28 |
2023-02-07 |
Toolgen Incorporated |
Artificial genome manipulation for gene expression regulation
|
|
CN107722125B
(zh)
*
|
2017-09-28 |
2021-05-07 |
中山大学 |
一种人工转录激活因子dCas9-TV及其编码基因与应用
|
|
CA3082251A1
(en)
|
2017-10-16 |
2019-04-25 |
The Broad Institute, Inc. |
Uses of adenosine base editors
|
|
MA50849A
(fr)
|
2017-10-26 |
2020-09-02 |
Vertex Pharma |
Substances et procédés pour le traitement d'hémoglobinopathies
|
|
WO2019089623A1
(en)
*
|
2017-10-30 |
2019-05-09 |
Children's Hospital Medical Center |
Fusion proteins for use in improving gene correction via homologous recombination
|
|
CN117487776A
(zh)
*
|
2017-11-01 |
2024-02-02 |
加利福尼亚大学董事会 |
Casz组合物和使用方法
|
|
US20200354419A1
(en)
*
|
2017-11-03 |
2020-11-12 |
Hunterian Medicine Llc |
Compositions and methods of use thereof for the treatment of duchenne muscular dystrophy
|
|
KR102132198B1
(ko)
*
|
2017-12-14 |
2020-07-09 |
단국대학교 산학협력단 |
Tert 프로모터 돌연변이에 특이적인 crispr 시스템 및 그의 이용
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
CA3086885A1
(en)
|
2017-12-28 |
2019-07-04 |
Kyoto University |
Composition for modifying target gene
|
|
TWI802627B
(zh)
|
2017-12-28 |
2023-05-21 |
日商武田藥品工業股份有限公司 |
陽離子性脂質
|
|
CN108559731A
(zh)
*
|
2018-01-15 |
2018-09-21 |
南方医科大学 |
一种可调控基因表达的人类胚胎干细胞系及其应用
|
|
US12509492B2
(en)
|
2018-01-19 |
2025-12-30 |
Duke University |
Genome engineering with CRISPR-Cas systems in eukaryotes
|
|
EP3749768A1
(en)
|
2018-02-05 |
2020-12-16 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of hemoglobinopathies
|
|
WO2019161290A1
(en)
*
|
2018-02-15 |
2019-08-22 |
Sigma-Aldrich Co. Llc |
Engineered cas9 systems for eukaryotic genome modification
|
|
CN110229814B
(zh)
*
|
2018-03-06 |
2025-11-14 |
中国科学院动物研究所 |
改进的向导rna
|
|
IL277234B2
(en)
|
2018-03-14 |
2026-03-01 |
Editas Medicine Inc |
Systems and methods for treating hemoglobin diseases
|
|
AU2019255789B2
(en)
|
2018-04-19 |
2025-11-20 |
The Regents Of The University Of California |
Compositions and methods for gene editing
|
|
WO2019209777A1
(en)
|
2018-04-23 |
2019-10-31 |
The Curators Of The University Of Missouri |
Improved crispr therapy
|
|
JP2021523696A
(ja)
*
|
2018-04-23 |
2021-09-09 |
デューク ユニバーシティ |
Dnaメチル化の標的化された編集によるsnca発現の下方調節
|
|
WO2019210279A1
(en)
*
|
2018-04-27 |
2019-10-31 |
The Regents Of The University Of California |
De novo formation of the biliary system by hepatocyte transdifferentiation
|
|
WO2019217942A1
(en)
|
2018-05-11 |
2019-11-14 |
Beam Therapeutics Inc. |
Methods of substituting pathogenic amino acids using programmable base editor systems
|
|
CN112654710A
(zh)
|
2018-05-16 |
2021-04-13 |
辛瑟高公司 |
用于指导rna设计和使用的方法和系统
|
|
WO2019226953A1
(en)
|
2018-05-23 |
2019-11-28 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
AU2019291918B2
(en)
|
2018-06-29 |
2025-06-12 |
Editas Medicine, Inc. |
Synthetic guide molecules, compositions and methods relating thereto
|
|
US12297241B2
(en)
|
2018-07-06 |
2025-05-13 |
The Regents Of The University Of California |
Method to engineer transplantable human tissues
|
|
EP3820495A4
(en)
|
2018-07-09 |
2022-07-20 |
The Broad Institute Inc. |
RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES
|
|
WO2020018918A1
(en)
|
2018-07-19 |
2020-01-23 |
The Board Of Trustees Of The University Of Illinois |
Methods for exon skipping and gene knockout using base editors
|
|
CN109055375B
(zh)
*
|
2018-07-26 |
2021-11-12 |
东南大学 |
一种crispr辅助反式增强子激活基因表达的方法及其应用
|
|
CN110760511B
(zh)
*
|
2018-07-27 |
2021-09-07 |
广东赤萌医疗科技有限公司 |
一种用于治疗杜氏肌营养不良症的gRNA、表达载体、CRISPR-Cas9系统
|
|
US11168141B2
(en)
|
2018-08-02 |
2021-11-09 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating dystrophinopathies
|
|
WO2020028832A1
(en)
|
2018-08-02 |
2020-02-06 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating dystrophinopathies
|
|
EP3830259A4
(en)
|
2018-08-02 |
2022-05-04 |
Dyne Therapeutics, Inc. |
MUSCLE TARGETED COMPLEXES AND THEIR USES IN THE TREATMENT OF FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY
|
|
US12018087B2
(en)
|
2018-08-02 |
2024-06-25 |
Dyne Therapeutics, Inc. |
Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
|
|
GB201813011D0
(en)
|
2018-08-10 |
2018-09-26 |
Vib Vzw |
Means and methods for drought tolerance in crops
|
|
KR20210044795A
(ko)
*
|
2018-08-15 |
2021-04-23 |
지머젠 인코포레이티드 |
고 처리량 대사 공학에서 CRISPRi의 응용
|
|
MX2021001850A
(es)
*
|
2018-08-18 |
2021-07-15 |
Harvard College |
Edicion genica in situ.
|
|
KR20210055733A
(ko)
|
2018-09-07 |
2021-05-17 |
빔 테라퓨틱스, 인크. |
핵염기 편집 시스템을 전달하기 위한 조성물 및 방법
|
|
EP3850088A4
(en)
|
2018-09-07 |
2023-07-19 |
Beam Therapeutics, Inc. |
Compositions and methods for improving base editing
|
|
JP7250031B2
(ja)
*
|
2018-09-25 |
2023-03-31 |
公益財団法人微生物化学研究会 |
新規ウイルスベクターおよびその製造方法と使用方法
|
|
IL326834A
(en)
|
2018-10-02 |
2026-04-01 |
Sangamo Therapeutics Inc |
Artificial zinc finger protein transcription factors repressing mapt expression for the prevention and/or treatment of tauopathies
|
|
AU2019359276A1
(en)
*
|
2018-10-09 |
2021-04-29 |
The University Of North Carolina At Chapel Hill |
Regulated gene editing system
|
|
WO2020081604A2
(en)
*
|
2018-10-15 |
2020-04-23 |
Avery Therapeutics, Inc. |
Cell-free compositions and methods for restoration or enhancement of tissue function
|
|
WO2020081922A1
(en)
|
2018-10-18 |
2020-04-23 |
University Of Utah Research Foundation |
Rna-guided transcriptional regulation and methods of using the same for the treatment of back pain
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
WO2020092725A1
(en)
*
|
2018-11-01 |
2020-05-07 |
Montana State University |
Gene modulation with crispr system type i
|
|
EP3877748A4
(en)
*
|
2018-11-06 |
2022-11-09 |
Cellino Biotech, Inc. |
Systems for cell control
|
|
MX2021005720A
(es)
*
|
2018-11-16 |
2021-07-21 |
Astellas Pharma Inc |
Metodo para tratar la distrofia muscular mediante el direccionamiento del gen de utrofina.
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
WO2020159880A1
(en)
*
|
2019-01-28 |
2020-08-06 |
The Administrators Of The Tulane Educational Fund |
Crispr-based methods and novel compositions for treating vascular disorders
|
|
US12600971B2
(en)
|
2019-02-13 |
2026-04-14 |
Beam Therapeutics Inc. |
Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence
|
|
WO2020168135A1
(en)
|
2019-02-13 |
2020-08-20 |
Beam Therapeutics Inc. |
Compositions and methods for treating alpha-1 antitrypsin deficiency
|
|
CN114096666B
(zh)
|
2019-02-13 |
2025-03-18 |
比姆医疗股份有限公司 |
治疗血红素病变的组合物和方法
|
|
CN109929865B
(zh)
*
|
2019-03-11 |
2022-03-08 |
东南大学 |
基于gal4-uas系统的crispr辅助反式增强子激活基因表达的方法及其应用
|
|
WO2020191241A1
(en)
|
2019-03-19 |
2020-09-24 |
The Broad Institute, Inc. |
Methods and compositions for editing nucleotide sequences
|
|
US20220145249A1
(en)
*
|
2019-04-11 |
2022-05-12 |
Agency For Science, Technology And Research |
A Method of Altering a Differentiation Status of a Cell
|
|
JP7881154B2
(ja)
*
|
2019-04-12 |
2026-06-29 |
デューク ユニバーシティ |
ジストロフィン機能を修復するためのCRISPR/Casをベースにした塩基編集組成物
|
|
WO2020210214A1
(en)
*
|
2019-04-12 |
2020-10-15 |
The Regents Of The University Of California |
Compositions and methods for modifying dystrophin genes
|
|
TWI887234B
(zh)
*
|
2019-04-14 |
2025-06-21 |
美國公爵大學 |
治療杜興氏(duchenne)肌肉失養症之大型突變熱點之aav載體介導之刪除
|
|
TW202100748A
(zh)
*
|
2019-04-14 |
2021-01-01 |
美國公爵大學 |
恢復肌縮蛋白功能之基於crispr/cas之基因組編輯組合物
|
|
WO2020214842A1
(en)
|
2019-04-17 |
2020-10-22 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
WO2020219820A1
(en)
|
2019-04-25 |
2020-10-29 |
Avidity Biosciences, Inc. |
Nucleic acid compositions and methods of multi-exon skipping
|
|
WO2020232373A1
(en)
*
|
2019-05-15 |
2020-11-19 |
Board Of Regents, The University Of Texas System |
Crispr methods for treating cancers
|
|
CN114041188A
(zh)
*
|
2019-05-23 |
2022-02-11 |
美国分子实验室公司 |
用于检测粪便样品中的幽门螺杆菌水平的方法
|
|
CN112266418A
(zh)
*
|
2019-07-08 |
2021-01-26 |
中国科学院微生物研究所 |
改进的基因组编辑系统及其应用
|
|
WO2021011936A2
(en)
|
2019-07-18 |
2021-01-21 |
University Of Rochester |
Cell-type selective immunoprotection of cells
|
|
US12618053B2
(en)
|
2019-09-13 |
2026-05-05 |
The Regents Of The University Of Colorado, A Body Corporate |
Methods and compositions for cell and tissue rejuvenation
|
|
EP4034655A1
(en)
*
|
2019-09-23 |
2022-08-03 |
Vigeneron GmbH |
Method of transactivating a homologous gene of a gene of interest and an in vitro method of diagnosing a disease
|
|
EP4034088A4
(en)
|
2019-09-26 |
2023-10-11 |
President and Fellows of Harvard College |
Minimal arrestin domain containing protein 1 (arrdc1) constructs
|
|
US12594301B2
(en)
|
2019-09-27 |
2026-04-07 |
Beam Therapeutics Inc. |
Compositions and methods for treatment of liquid cancers
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
KR20220083700A
(ko)
*
|
2019-10-18 |
2022-06-20 |
에피제네론, 인크. |
표적 핵산의 검출 방법, 핵산 결합 분자의 검출 방법 및 핵산 결합능의 평가 방법
|
|
WO2021089736A1
(en)
|
2019-11-06 |
2021-05-14 |
Association Institut De Myologie |
Combined therapy for muscular diseases
|
|
EP4069314A4
(en)
*
|
2019-12-03 |
2024-06-26 |
Duke University |
SYSTEMS AND METHODS FOR LIPID NANOPARTICLE DELIVERY OF GENE EDITING MACHINERY
|
|
JP2023507174A
(ja)
*
|
2019-12-16 |
2023-02-21 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
Dmd変異の修正のための方法及び組成物
|
|
WO2021222327A1
(en)
*
|
2020-04-27 |
2021-11-04 |
Duke University |
A high-throughput screening method to discover optimal grna pairs for crispr-mediated exon deletion
|
|
EP4125349A4
(en)
*
|
2020-04-27 |
2024-07-10 |
Duke University |
GENE EDITING OF SATELLITE CELLS IN VIVO USING AAV VECTORS ENCODING MUSCLE-SPECIFIC PROMOTERS
|
|
CA3177481A1
(en)
|
2020-05-08 |
2021-11-11 |
David R. Liu |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
|
|
EP4149622A4
(en)
*
|
2020-05-12 |
2024-12-18 |
Myogene Bio LLC |
IMMUNOSUPPRESSIVE AGENTS AND METHODS OF RE-DOSING VIRAL ADMINISTRATION FOR GENE THERAPY
|
|
WO2022008557A2
(en)
|
2020-07-08 |
2022-01-13 |
UCB Biopharma SRL |
Modulation of cftr expression
|
|
US11638761B2
(en)
|
2021-07-09 |
2023-05-02 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
|
|
US11969475B2
(en)
|
2021-07-09 |
2024-04-30 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
|
|
US11771776B2
(en)
|
2021-07-09 |
2023-10-03 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating dystrophinopathies
|
|
WO2022020806A2
(en)
*
|
2020-07-24 |
2022-01-27 |
The Trustees Of The University Of Pennsylvania |
Utrophin genome editing for treating duchenne muscular dystrophy (dmd)
|
|
CN115011598A
(zh)
|
2020-09-02 |
2022-09-06 |
西湖大学 |
杜氏肌营养不良症相关的外显子剪接增强子、sgRNA、基因编辑工具及应用
|
|
JP2023541444A
(ja)
|
2020-09-15 |
2023-10-02 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
筋ジストロフィー患者における多様なdmd変異の補正のためのaav媒介性の相同性非依存的標的化組み込み遺伝子編集
|
|
AU2021347359A1
(en)
|
2020-09-25 |
2023-05-18 |
Beam Therapeutics Inc. |
Fratricide resistant modified immune cells and methods of using the same
|
|
CN116802289A
(zh)
*
|
2020-10-15 |
2023-09-22 |
东北大学 |
用于增加胶原蛋白产量的工程化细胞
|
|
WO2022087321A1
(en)
*
|
2020-10-21 |
2022-04-28 |
Duke University |
Dual aav vector-mediated deletion of large mutational hotspot for treatment of duchenne muscular dystrophy
|
|
IL302830A
(en)
|
2020-11-13 |
2023-07-01 |
Egenesis Inc |
Cells, tissues, organs and animals with one or more genes that have been modified for improved survival and tolerance of a different-sex transplant
|
|
CN112662674B
(zh)
*
|
2021-01-12 |
2023-04-11 |
广州瑞风生物科技有限公司 |
靶向编辑VEGFA基因外显子区域的gRNA及其应用
|
|
CN114854791A
(zh)
*
|
2021-02-04 |
2022-08-05 |
北京中因科技有限公司 |
一种新型CRISPR-Cas9系统载体及其应用
|
|
AU2022216614B2
(en)
|
2021-02-05 |
2026-03-05 |
Christiana Care Gene Editing Institute, Inc. |
Methods of and compositions for reducing gene expression and/or activity
|
|
CN112779259B
(zh)
*
|
2021-03-18 |
2023-05-26 |
新疆畜牧科学院生物技术研究所(新疆畜牧科学院中国-澳大利亚绵羊育种研究中心) |
一种用于精准编辑绵羊OCT4基因的sgRNA、扩增用引物和应用
|
|
WO2023283623A1
(en)
|
2021-07-09 |
2023-01-12 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and formulations for treating dystrophinopathies
|
|
AU2022318664A1
(en)
|
2021-07-30 |
2024-02-29 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating expression of methyl-cpg binding protein 2 (mecp2)
|
|
US20240254483A1
(en)
|
2021-07-30 |
2024-08-01 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating expression of frataxin (fxn)
|
|
CN113637658A
(zh)
*
|
2021-08-19 |
2021-11-12 |
中国农业科学院棉花研究所 |
基于dCas9-oToV的基因转录系统及其应用
|
|
US20250129388A1
(en)
*
|
2021-09-10 |
2025-04-24 |
The Regents Of The University Of California |
Temperature regulated crispr-cas systems and methods of use thereof
|
|
IL311610A
(en)
|
2021-09-21 |
2024-05-01 |
Scribe Therapeutics Inc |
Engineered CASX suppressor systems
|
|
WO2023050158A1
(zh)
*
|
2021-09-29 |
2023-04-06 |
深圳先进技术研究院 |
一种实现多碱基编辑的方法
|
|
US20250134999A1
(en)
|
2022-01-14 |
2025-05-01 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for programming t cell phenotypes through targeted gene activation
|
|
EP4463549A2
(en)
|
2022-01-14 |
2024-11-20 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for programming t cell phenotypes through targeted gene repression
|
|
EP4215614A1
(en)
|
2022-01-24 |
2023-07-26 |
Dynacure |
Combination therapy for dystrophin-related diseases
|
|
EP4514973A2
(en)
*
|
2022-04-26 |
2025-03-05 |
University of Massachusetts |
Single pegrna-mediated large insertions
|
|
CN114941032B
(zh)
*
|
2022-06-13 |
2025-05-06 |
大连医科大学 |
Rnf122在制备抗肿瘤药物中的应用
|
|
CA3260237A1
(en)
|
2022-06-24 |
2023-12-28 |
Tune Therapeutics, Inc. |
Compositions, systems and methods for reducing low-density lipoprotein by targeted gene repression
|
|
CA3260110A1
(en)
|
2022-06-24 |
2023-12-28 |
European Molecular Biology Laboratory |
MODULAR TOOL BASED ON CRISPR FOR THE SPECIFIC INTRODUCTION OF EPIGENETIC MODIFICATIONS ON TARGET LOCI
|
|
EP4554967A2
(en)
|
2022-07-12 |
2025-05-21 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for targeted transcriptional activation
|
|
WO2024040254A2
(en)
|
2022-08-19 |
2024-02-22 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for regulation of hepatitis b virus through targeted gene repression
|
|
JP2025531268A
(ja)
|
2022-09-19 |
2025-09-19 |
チューン セラピューティクス インコーポレイテッド |
T細胞機能を調節するための組成物、システム、および方法
|
|
WO2024081937A2
(en)
*
|
2022-10-13 |
2024-04-18 |
Duke University |
Cas12a fusion proteins and methods of using same
|
|
WO2024163678A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Fusion proteins and systems for targeted activation of frataxin (fxn) and related methods
|
|
WO2024163683A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Systems, compositions, and methods for modulating expression of methyl-cpg binding protein 2 (mecp2) and x-inactive specific transcript (xist)
|
|
US20260234583A1
(en)
*
|
2023-02-10 |
2026-08-13 |
Integrate Bioscience Llc |
Personalized crispr profiling for cancer
|
|
EP4689092A1
(en)
*
|
2023-03-31 |
2026-02-11 |
Mammoth Biosciences, Inc. |
Engineered effector proteins, compositions, systems and methods of use thereof
|
|
US20240386995A1
(en)
*
|
2023-05-19 |
2024-11-21 |
Mitre Corporation |
Systems and Methods for Detecting CRISPR-Mediated Residues Within Methylated Patterns of Genome Using Automated Statistical Methods and Long Short-Term Memory Autoencoders
|
|
EP4754248A1
(en)
|
2023-07-31 |
2026-06-10 |
Tune Therapeutics, Inc. |
Compositions and methods for multiplexed activation and repression of t cell gene expression
|
|
CN121909284A
(zh)
|
2023-07-31 |
2026-04-21 |
图恩疗法股份有限公司 |
用于调节il-2基因表达的组合物和方法
|
|
WO2025038494A1
(en)
|
2023-08-11 |
2025-02-20 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for lymphoid cell differentiation using targeted gene activation
|
|
WO2025059073A1
(en)
|
2023-09-11 |
2025-03-20 |
Tune Therapeutics, Inc. |
Epigenetic editing methods and systems for differentiating stem cells
|
|
CN118291415B
(zh)
*
|
2024-03-14 |
2024-11-19 |
内蒙古大学 |
一种CRISPR::Cr-P300M巴豆酰化修饰编辑工具及其应用
|
|
WO2025260068A1
(en)
|
2024-06-14 |
2025-12-18 |
Tune Therapeutics, Inc. |
Lipid nanoparticle formulation for delivery of nucleic acids to cells
|
|
WO2026015647A1
(en)
|
2024-07-09 |
2026-01-15 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for cell differentiation using targeted gene activation of dll4 and/or vcam1
|
|
WO2026064753A1
(en)
|
2024-09-23 |
2026-03-26 |
Tune Therapeutics, Inc. |
Dna methyltransferase-like protein (dnmt3l) or dna methyltransferase 3a (dnmt3a) repressor systems for epigenetic editing
|
|
WO2026102058A1
(en)
|
2024-11-06 |
2026-05-15 |
Tune Therapeutics, Inc. |
Methods for treating chronic hepatitis b infection and related formulations
|
|
WO2026161895A1
(en)
|
2025-01-27 |
2026-07-30 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for epigenetic regulation of lipoprotein a (lpa) gene expression
|