CN105307672B - 用于医学用途的稳定、延长的glp-1/胰高血糖素受体共激动剂 - Google Patents

用于医学用途的稳定、延长的glp-1/胰高血糖素受体共激动剂 Download PDF

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CN105307672B
CN105307672B CN201480034914.8A CN201480034914A CN105307672B CN 105307672 B CN105307672 B CN 105307672B CN 201480034914 A CN201480034914 A CN 201480034914A CN 105307672 B CN105307672 B CN 105307672B
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amino
carboxy
butyryl
ethoxy
glucagon
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CN105307672A (zh
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U.森斯富斯
T.克鲁塞
J.F.劳
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Novo Nordisk AS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201480034914.8A 2013-04-18 2014-04-22 用于医学用途的稳定、延长的glp-1/胰高血糖素受体共激动剂 Active CN105307672B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP13164272.0 2013-04-18
EP13164272 2013-04-18
US201361814969P 2013-04-23 2013-04-23
US61/814969 2013-04-23
EP13196656.6 2013-12-11
EP13196656 2013-12-11
PCT/EP2014/058084 WO2014170496A1 (en) 2013-04-18 2014-04-22 Stable, protracted glp-1/glucagon receptor co-agonists for medical use

Publications (2)

Publication Number Publication Date
CN105307672A CN105307672A (zh) 2016-02-03
CN105307672B true CN105307672B (zh) 2021-01-05

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CN201480034914.8A Active CN105307672B (zh) 2013-04-18 2014-04-22 用于医学用途的稳定、延长的glp-1/胰高血糖素受体共激动剂

Country Status (16)

Country Link
US (3) US9474790B2 (https=)
EP (1) EP2986313B1 (https=)
JP (1) JP6594856B2 (https=)
KR (1) KR20160021758A (https=)
CN (1) CN105307672B (https=)
AU (1) AU2014255608B2 (https=)
BR (1) BR112015025464A2 (https=)
CA (1) CA2909581A1 (https=)
MX (1) MX362275B (https=)
MY (1) MY174727A (https=)
PL (1) PL2986313T3 (https=)
RS (1) RS59124B1 (https=)
RU (1) RU2683039C2 (https=)
SI (1) SI2986313T1 (https=)
WO (1) WO2014170496A1 (https=)
ZA (1) ZA201507010B (https=)

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WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
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TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
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