CN102596260B - 锆放射性标记的、半胱氨酸改造的抗体缀合物 - Google Patents

锆放射性标记的、半胱氨酸改造的抗体缀合物 Download PDF

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CN102596260B
CN102596260B CN201080050134.4A CN201080050134A CN102596260B CN 102596260 B CN102596260 B CN 102596260B CN 201080050134 A CN201080050134 A CN 201080050134A CN 102596260 B CN102596260 B CN 102596260B
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antibody
cysteine
zirconium
antibodies
cysteine engineered
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CN102596260A (zh
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H·吉尔
J·R·尤努图拉
H·B·洛曼
J·马里克
J·提尼阿诺
S·威廉姆斯
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F Hoffmann La Roche AG
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    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
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    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
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    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
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    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201080050134.4A 2009-11-05 2010-11-04 锆放射性标记的、半胱氨酸改造的抗体缀合物 Active CN102596260B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/612,912 US20100111856A1 (en) 2004-09-23 2009-11-05 Zirconium-radiolabeled, cysteine engineered antibody conjugates
US12/612,912 2009-11-05
PCT/US2010/055465 WO2011056983A1 (en) 2009-11-05 2010-11-04 Zirconium-radiolabeled, cysteine engineered antibody conjugates

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CN102596260B true CN102596260B (zh) 2017-04-05

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US (2) US20100111856A1 (enExample)
EP (1) EP2496270B1 (enExample)
JP (1) JP5850843B2 (enExample)
KR (2) KR20170136652A (enExample)
CN (1) CN102596260B (enExample)
BR (1) BR112012007774A2 (enExample)
CA (1) CA2780216A1 (enExample)
MX (1) MX340674B (enExample)
RU (1) RU2562862C2 (enExample)
WO (1) WO2011056983A1 (enExample)

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