CN101883774A - 噻吩并嘧啶和吡唑并嘧啶化合物及其用作mtor激酶和pi3激酶抑制剂的用途 - Google Patents

噻吩并嘧啶和吡唑并嘧啶化合物及其用作mtor激酶和pi3激酶抑制剂的用途 Download PDF

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Publication number
CN101883774A
CN101883774A CN2008801190434A CN200880119043A CN101883774A CN 101883774 A CN101883774 A CN 101883774A CN 2008801190434 A CN2008801190434 A CN 2008801190434A CN 200880119043 A CN200880119043 A CN 200880119043A CN 101883774 A CN101883774 A CN 101883774A
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phenyl
oxa
pyrimidine
azabicyclo
pyrazolo
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A·扎斯克
J·A·卡普兰
J·C·维海珍
K·J·柯伦
D·J·理查德
S·艾罗尔-卡劳斯申
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Wyeth LLC
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    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2008801190434A 2007-10-16 2008-10-15 噻吩并嘧啶和吡唑并嘧啶化合物及其用作mtor激酶和pi3激酶抑制剂的用途 Pending CN101883774A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US98033207P 2007-10-16 2007-10-16
US60/980,332 2007-10-16
US2759508P 2008-02-11 2008-02-11
US61/027,595 2008-02-11
PCT/US2008/079940 WO2009052145A1 (en) 2007-10-16 2008-10-15 Thienopyrimidine and pyrazolopyrimidine compounds and their use as mtor kinase and pi3 kinase inhibitors

Publications (1)

Publication Number Publication Date
CN101883774A true CN101883774A (zh) 2010-11-10

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CN2008801190434A Pending CN101883774A (zh) 2007-10-16 2008-10-15 噻吩并嘧啶和吡唑并嘧啶化合物及其用作mtor激酶和pi3激酶抑制剂的用途

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Country Link
US (1) US8129371B2 (https=)
EP (1) EP2212333A1 (https=)
JP (1) JP2011500702A (https=)
KR (1) KR20100083170A (https=)
CN (1) CN101883774A (https=)
AP (1) AP2010005234A0 (https=)
AR (1) AR068898A1 (https=)
AU (1) AU2008312631A1 (https=)
BR (1) BRPI0817681A2 (https=)
CA (1) CA2702838A1 (https=)
CL (1) CL2008003061A1 (https=)
CO (1) CO6321257A2 (https=)
CR (1) CR11373A (https=)
DO (1) DOP2010000118A (https=)
EA (1) EA201000484A1 (https=)
EC (1) ECSP10010112A (https=)
IL (1) IL205109A0 (https=)
MA (1) MA31884B1 (https=)
MX (1) MX2010004260A (https=)
NI (1) NI201000060A (https=)
PA (1) PA8799101A1 (https=)
PE (1) PE20091384A1 (https=)
TN (1) TN2010000171A1 (https=)
TW (1) TW200922593A (https=)
WO (1) WO2009052145A1 (https=)
ZA (1) ZA201003430B (https=)

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WO2013152717A1 (zh) * 2012-04-10 2013-10-17 上海昀怡健康管理咨询有限公司 稠合嘧啶类化合物，其制备方法，中间体，组合物和应用
CN104080789A (zh) * 2012-01-31 2014-10-01 南京奥昭生物科技有限公司 作为布鲁顿酪氨酸激酶抑制剂的环状分子
CN108358949A (zh) * 2018-03-01 2018-08-03 南京法恩化学有限公司 一种2，4-二氯噻吩并[3，2-d]嘧啶的制备方法
CN109824701A (zh) * 2019-03-26 2019-05-31 武汉工程大学 一种吡啶并噻唑类化合物及其制备方法和应用
CN110850012A (zh) * 2018-08-21 2020-02-28 成都弘达药业有限公司 一种1-（2,3-二氯苯基）哌嗪盐酸盐及其有关物质的检测方法
CN111646995A (zh) * 2019-03-04 2020-09-11 四川大学 4-氨基-嘧啶并氮杂环-苯基脲类衍生物及其制备方法和用途
CN113278015A (zh) * 2021-05-31 2021-08-20 云南大学 一种荧光探针及其制备方法和应用
WO2025201469A1 (zh) * 2024-03-28 2025-10-02 励缔(杭州)医药科技有限公司 具有mTOR抑制活性的有机化合物及其用途

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