CN101518653B - 使用抗ErbB抗体-类美坦素偶联物的治疗方法 - Google Patents
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- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Oncology (AREA)
- Genetics & Genomics (AREA)
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- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Applications Claiming Priority (5)
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| US14131699P | 1999-06-25 | 1999-06-25 | |
| US60/141,316 | 1999-06-25 | ||
| US18984400P | 2000-03-16 | 2000-03-16 | |
| US60/189,844 | 2000-03-16 | ||
| CNB008117829A CN100482281C (zh) | 1999-06-25 | 2000-06-23 | 抗ErbB抗体-类美坦素偶联物在制备药物中的应用 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB008117829A Division CN100482281C (zh) | 1999-06-25 | 2000-06-23 | 抗ErbB抗体-类美坦素偶联物在制备药物中的应用 |
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| CN101518653A CN101518653A (zh) | 2009-09-02 |
| CN101518653B true CN101518653B (zh) | 2015-08-19 |
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| CNB008118981A Expired - Lifetime CN100340575C (zh) | 1999-06-25 | 2000-06-23 | 人源化抗ErbB2抗体及其在制备药物中的应用 |
| CN200910126199.1A Expired - Lifetime CN101518653B (zh) | 1999-06-25 | 2000-06-23 | 使用抗ErbB抗体-类美坦素偶联物的治疗方法 |
| CN2007101411129A Expired - Lifetime CN101121021B (zh) | 1999-06-25 | 2000-06-23 | 人源化抗ErbB2抗体及用抗ErbB2抗体进行的治疗 |
| CNA2007101411114A Pending CN101121750A (zh) | 1999-06-25 | 2000-06-23 | 人源化抗ErbB2抗体及用抗ErbB2抗体进行的治疗 |
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| CNB008118981A Expired - Lifetime CN100340575C (zh) | 1999-06-25 | 2000-06-23 | 人源化抗ErbB2抗体及其在制备药物中的应用 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2007101411129A Expired - Lifetime CN101121021B (zh) | 1999-06-25 | 2000-06-23 | 人源化抗ErbB2抗体及用抗ErbB2抗体进行的治疗 |
| CNA2007101411114A Pending CN101121750A (zh) | 1999-06-25 | 2000-06-23 | 人源化抗ErbB2抗体及用抗ErbB2抗体进行的治疗 |
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