CN101302515B - 结合人TNFα的人抗体 - Google Patents
结合人TNFα的人抗体 Download PDFInfo
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- CN101302515B CN101302515B CN2008101088480A CN200810108848A CN101302515B CN 101302515 B CN101302515 B CN 101302515B CN 2008101088480 A CN2008101088480 A CN 2008101088480A CN 200810108848 A CN200810108848 A CN 200810108848A CN 101302515 B CN101302515 B CN 101302515B
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Abstract
Description
抗体 | Koffsec-1 | KonM-1sec-1 | KdM | 化学计量 |
D2E7 IgG1 | 8.81×10-5 | 1.91×105 | 6.09×10-10 | 1.2 |
2SD4 IgG4 | 8.4×10-3 | 4.20×105 | 2.00×10-8 | 0.8 |
MAK195F(ab’)2 | 8.70×10-5 | 1.90×105 | 4.60×10-10 | 1.4 |
抗体 | [Ab],nM | 结合的rhTNFα,RUs | 结合的Ab,RUs | rhTNFα/Ab | Koff,sec-1,(Avg) |
D2E7 | 267 | 373 | 1215 | 1.14 | 8.45×10-5 |
133 | 420 | 1569 | 1.30 | 5.42×10-5 | |
67 | 434 | 1633 | 1.31 | 4.75×10-5 | |
33 | 450 | 1532 | 1.19 | 4.46×10-5 | |
17 | 460 | 1296 | 0.98 | 3.47×10-5 | |
8 | 486 | 936 | 0.67 | 2.63×10-5 | |
4 | 489 | 536 | 0.38 | 2.17×10-5 | |
2 | 470 | 244 | 0.18 | 3.68×10-5 | |
(4.38×10-5) | |||||
MAK 195 | 400 | 375 | 881 | 1.20 | 5.38×10-5 |
200 | 400 | 1080 | 1.38 | 4.54×10-5 | |
100 | 419 | 1141 | 1.39 | 3.54×10-5 | |
50 | 427 | 1106 | 1.32 | 3.67×10-5 | |
25 | 446 | 957 | 1.09 | 4.41×10-5 | |
13 | 464 | 708 | 0.78 | 3.66×10-5 | |
6 | 474 | 433 | 0.47 | 7.37×10-5 | |
3 | 451 | 231 | 0.26 | 6.95×10-5 | |
(4.94×10-5) |
实验 | Kd(s-1) |
1 | 9.58×10-5 |
2 | 9.26×10-5 |
3 | 7.60×10-5 |
平均 | 8.81±1.06×10-5 |
实验 | Ka(M-1,s-1) |
1 | 1.33×105 |
2 | 1.05×105 |
3 | 3.36×105 |
平均 | 1.91±1.26×105 |
实验 | Ka(M-1,s-1) | Kd(s-1) | Ka(M) |
1 | 1.33×105 | 9.58×10-5 | 7.20×10-10 |
2 | 1.05×105 | 9.26×10-5 | 8.82×10-10 |
3 | 3.36×105 | 7.60×10-5 | 2.26×10-10 |
平均 | 1.91±1.26×105 | 8.81±1.06×10-5 | 6.09±3.42×10-10 |
VH | VL | K off (sec -1) |
D2E7 VH | D2E7 VL | 9.65×10-5 |
HD2E7*.A1 | D2E7 VL | 1.4×10-4 |
HD2E7*.A2 | D2E7 VL | 4.6×10-4 |
HD2E7*.A3 | D2E7 VL | 8.15×10-4 |
HD2E7*.A4 | D2E7 VL | 1.8×10-4 |
HD2E7*.A5 | D2E7 VL | 2.35×10-4 |
HD2E7*.A6 | D2E7 VL | 2.9×10-4 |
HD2E7*.A7 | D2E7 VL | 1.0×10-4 |
HD2E7*.A8 | D2E7 VL | 3.1×10-4 |
HD2E7*.A9 | D2E7 VL | 8.1×10-4 |
D2E7 VH | LD2E7*.A1 | 6.6×10-5 |
D2E7 VH | LD2E7*.A3 | NOT DETECTABLE |
D2E7 VH | LD2E7*.A4 | 1.75×10-4 |
D2E7 VH | LD2E7*.A5 | 1.8×10-4 |
D2E7 VH | LD2E7*.A7 | 1.4×10-4 |
D2E7 VH | LD2E7*.A8 | 3.65×10-4 |
HD2E7*.A9 | LD2E7*.A1 | 1.05×10-4 |
VH | VL | 形式 | K off (sec -1) |
D2E7 VH | D2E7 VL | IgG1/IgG4 | 9.65×10-5 |
VH1-D2 | LOE7 | IgG1/IgG4 | 7.7×10-5 |
VH1-D2 | LOE7 | scFv | 4.6×10-4 |
VH1-D2.N | LOE7.T | IgG4 | 2.1×10-5 |
VH1-D2.Y | LOE7.A | IgG4 | 2.7×10-5 |
VH1-D2.N | LOE7.A | IgG4 | 3.2×10-5 |
VH1-D2 | EP B12 | scFv | 8.0×10-4 |
VH1-D2 | 2SD4 VL | scFv | 1.94×10-3 |
3C-H2 | LOE7 | scFv | 1.5×10-3 |
2SD4 VH | LOE7 | scFv | 6.07×10-3 |
2SD4 VH | 2SD4 VL | scFv | 1.37×10-2 |
VH1A11 | 2SD4 VL | scFv | 1.34×10-2 |
VH1B12 | 2SD4 VL | scFv | 1.01×10-2 |
VH1B11 | 2SD4 VL | scFv | 9.8×10-3 |
VH1E4 | 2SD4 VL | scFv | 1.59×10-2 |
VH1F6 | 2SD4 VL | scFv | 2.29×10-2 |
VH1D8 | 2SD4 VL | scFv | 9.5×10-3 |
VH1G1 | 2SD4 VL | scFv | 2.14×10-2 |
2SD4 VH | EP B12 | scFv | 6.7×10-3 |
2SD4 VH | VL10E4 | scFv | 9.6×10-3 |
2SD4 VH | VL100A9 | scFv | 1.33×10-2 |
2SD4 VH | VL100D2 | scFv | 1.41×10-2 |
2SD4 VH | VL10F4 | scFv | 1.11×10-2 |
2SD4 VH | VLLOE5 | scFv | 1.16×10-2 |
2SD4 VH | VLL0F9 | scFv | 6.09×10-3 |
2SD4 VH | VLL0F10 | scFv | 1.34×10-2 |
2SD4 VH | VLLOG7 | scFv | 1.56×10-2 |
2SD4 VH | VLLOG9 | scFv | 1.46×10-2 |
2SD4 VH | VLLOH1 | scFv | 1.17×10-2 |
2SD4 VH | VLLOH10 | scFv | 1.12×10-2 |
2SD4 VH | VL1B7 | scFv | 1.3×10-2 |
2SD4 VH | VL1C1 | scFv | 1.36×10-2 |
2SD4 VH | VL1C7 | scFv | 2.0×10-2 |
2SD4 VH | VL0.1F4 | scFv | 1.76×10-2 |
2SD4 VH | VL0.1H8 | scFv | 1.14×10-2 |
VH | VL | 结构 | IC 50 ,M |
D2E7 | D2E7 | scFv | 1.1×10-10 |
D2E7 | D2E7 | IgG4 | 4.7×10-11 |
2SD4 | 2SD4 | scFv/IgG1/IgG4 | 3.0×10-7 |
2SD4 | LOE7 | scFv | 4.3×10-8 |
VH1-D2 | 2SD4 | scFv | 1.0×10-8 |
VH1-D2 | LOE7 | scFv/IgG1/IgG4 | 3.4×10-10 |
VH1.D2.Y | LOE7.T | IgG4 | 8.1×10-11 |
VH1-D2.N | LOE7.T | IgG4 | 1.3×10-10 |
VH1-D2.Y | LOE7.A | IgG4 | 2.8×10-11 |
VH1-D2.N | LOE7.A | IgG4 | 6.2×10-11 |
MAK 195 | MAK 195 | scFv | 1.9×10-8 |
MAK 195 | MAK195 | F(ab′)2 | 6.2×10-11 |
实验 | IC50[M] |
1 | 1.26×10-10 |
2 | 1.33×10-10 |
3 | 1.15×10-10 |
平均 | 1.25±0.01×10-10 |
实验 | IC50[M] |
1 | 1.70×10-10 |
2 | 1.49×10-10 |
3 | 1.50×10-10 |
平均 | 1.56±0.12×10-10 |
实验 | IC50[M] |
1 | 1.95×10-10 |
2 | 1.69×10-10 |
3 | 1.90×10-10 |
平均 | 1.85±0.14×10-10 |
组 | 存活率(生存/总数) | 存活率(%) |
1(无抗体) | 0/7 | 0 |
2(1μg) | 1/7 | 14 |
3(2.6μg) | 5/7 | 71 |
4(5.2μg) | 6/7 | 86 |
5(26μg) | 6/7 | 86 |
6(26μg;无rhTNF) | 7/7 | 100 |
7(25μg Hu IgG1) | 1/7 | 14 |
组别 | 治疗 | 组织病理学计分 | 关节炎计分 |
1 | 无 | 3(7/70 | +++(7/7) |
2 | 盐水 | 3(8/8) | +++(8/8) |
6 | IgG1对照 | 3(9/9) | +++(7/9) |
3 | 1.5μg/g的D2E7 | 0(6/8) | 0(8/8) |
4 | 15μg/g的D2E7 | 0(7/8) | 0(8/8) |
5 | 30μg/g的D2E7 | 0(8/8) | 0(8/8) |
TNFα * | 来源 | D2E7中和的IC 50 (M) ** |
人 | 重组 | 7.8×10-11 |
黑猩猩 | LPS刺激的PBMC | 5.5×10-11 |
狒狒 | 重组 | 6.0×10-11 |
狨 | LPS刺激的PBMC | 4.0×10-10 |
猕猴 | LPS刺激的PBMC | 8.0×10-11 |
恒河猴 | LPS刺激的PBMC | 3.0×10-11 |
犬 | LPS刺激的WBC | 2.2×10-10 |
猪 | 重组 | 1.0×10-7 |
鼠 | 重组 | >1.0×10-7 |
SEQ ID NO: | 抗体链 | 区 | 序列类型 |
1 | D2E7 | VL | 氨基酸 |
2 | D2E7 | VH | 氨基酸 |
3 | D2E7 | VL CDR3 | 氨基酸 |
4 | D2E7 | VH CDR3 | 氨基酸 |
5 | D2E7 | VL CDR2 | 氨基酸 |
6 | D2E7 | VH CDR2 | 氨基酸 |
7 | D2E7 | VL CDR1 | 氨基酸 |
8 | D2E7 | VH CDR1 | 氨基酸 |
9 | 2SD4 | VL | 氨基酸 |
10 | 2SD4 | VH | 氨基酸 |
11 | 2SD4 | VL CDR3 | 氨基酸 |
12 | EP B12 | VL CDR3 | 氨基酸 |
13 | VL10E4 | VL CDR3 | 氨基酸 |
14 | VL100A9 | VL CDR3 | 氨基酸 |
15 | VLL100D2 | VL CDR3 | 氨基酸 |
16 | VLL0F4 | VL CDR3 | 氨基酸 |
17 | LOE5 | VL CDR3 | 氨基酸 |
18 | VLLOG7 | VL CDR3 | 氨基酸 |
19 | VLLOG9 | VL CDR3 | 氨基酸 |
20 | VLLOH1 | VL CDR3 | 氨基酸 |
21 | VLLOH10 | VL CDR3 | 氨基酸 |
22 | VL187 | VL CDR3 | 氨基酸 |
23 | VL1C1 | VL CDR3 | 氨基酸 |
24 | VL0.1F4 | VL CDR3 | 氨基酸 |
25 | VL0.1H8 | VL CDR3 | 氨基酸 |
26 | LOE7.A | VL CDR3 | 氨基酸 |
27 | 2SD4 | VH CDR3 | 氨基酸 |
28 | VH1B11 | VH CDR3 | 氨基酸 |
29 | VH1D8 | VH CDR3 | 氨基酸 |
30 | VH1A11 | VH CDR3 | 氨基酸 |
31 | VH1B12 | VH CDR3 | 氨基酸 |
32 | VH1E4 | VH CDR3 | 氨基酸 |
33 | VH1F6 | VH CDR3 | 氨基酸 |
34 | 3C-H2 | VH CDR3 | 氨基酸 |
35 | VH1-D2.N | VH CDR3 | 氨基酸 |
36 | D2E7 | VL | 核酸 |
37 | D2E7 | VH | 核酸 |
Claims (11)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US08/599,226 | 1996-02-09 | ||
US08/599,226 US6090382A (en) | 1996-02-09 | 1996-02-09 | Human antibodies that bind human TNFα |
US3147696P | 1996-11-25 | 1996-11-25 | |
US60/031,476 | 1996-11-25 |
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CN2006101018258A Expired - Lifetime CN1935260B (zh) | 1996-02-09 | 1997-02-10 | 结合人TNFα的人抗体 |
CN200810212687.XA Expired - Lifetime CN101343324B (zh) | 1996-02-09 | 1997-02-10 | 体外抑制人TNFα活性的方法 |
CN200610156666.1A Expired - Lifetime CN101003573B (zh) | 1996-02-09 | 1997-02-10 | 结合人TNFα的人抗体 |
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CN200810212687.XA Expired - Lifetime CN101343324B (zh) | 1996-02-09 | 1997-02-10 | 体外抑制人TNFα活性的方法 |
CN200610156666.1A Expired - Lifetime CN101003573B (zh) | 1996-02-09 | 1997-02-10 | 结合人TNFα的人抗体 |
CNA200610058091XA Pending CN1876683A (zh) | 1996-02-09 | 1997-02-10 | 结合人TNFα的人抗体 |
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US (8) | US6090382A (zh) |
EP (9) | EP2305712A1 (zh) |
CN (5) | CN101302515B (zh) |
BR (1) | BRPI9715219C8 (zh) |
CA (2) | CA2389943C (zh) |
NZ (4) | NZ614727A (zh) |
RO (1) | RO128628A2 (zh) |
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Families Citing this family (363)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030225254A1 (en) | 1989-08-07 | 2003-12-04 | Rathjen Deborah Ann | Tumour necrosis factor binding ligands |
CA2064915C (en) | 1989-08-07 | 2001-05-29 | Deborah A. Rathjen | Tumour necrosis factor binding ligands |
US5959087A (en) * | 1989-08-07 | 1999-09-28 | Peptide Technology, Ltd. | Tumour necrosis factor binding ligands |
US6713610B1 (en) * | 1990-01-12 | 2004-03-30 | Raju Kucherlapati | Human antibodies derived from immunized xenomice |
US7192584B2 (en) * | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
US6270766B1 (en) * | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
MX336813B (es) * | 1996-02-09 | 2016-02-02 | Abbvie Biotechnology Ltd | Anticuerpos humanos que ligan el tnfa humano. |
US7608262B2 (en) * | 1996-02-16 | 2009-10-27 | The Kennedy Institute Of Rheumatology | Methods of preventing or treating thrombosis with tumor necrosis factor antagonists |
KR100942002B1 (ko) * | 1996-12-03 | 2010-02-12 | 암젠 프레몬트 인코포레이티드 | 복수의 vh 및 vk 부위를 함유하는 사람 면역글로불린 유전자좌를 갖는 형질전환된 포유류 및 이로부터 생성된 항체 |
US20040009166A1 (en) * | 1997-04-30 | 2004-01-15 | Filpula David R. | Single chain antigen-binding polypeptides for polymer conjugation |
WO1998048837A1 (en) * | 1997-04-30 | 1998-11-05 | Enzon, Inc. | Polyalkylene oxide-modified single chain polypeptides |
GB9722131D0 (en) * | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
US20020114802A1 (en) * | 1998-02-10 | 2002-08-22 | Tjellstrom Bo Arthur Einar | Oral immunoglobulin treatment for inflammatory bowel disease |
US7067144B2 (en) * | 1998-10-20 | 2006-06-27 | Omeros Corporation | Compositions and methods for systemic inhibition of cartilage degradation |
EP1022027A1 (en) * | 1999-01-22 | 2000-07-26 | Applied Research Systems ARS Holding N.V. | Tumor necrosis factor antagonists and their use in endometriosis |
US6914128B1 (en) | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
US7883704B2 (en) * | 1999-03-25 | 2011-02-08 | Abbott Gmbh & Co. Kg | Methods for inhibiting the activity of the P40 subunit of human IL-12 |
US20070111259A1 (en) * | 1999-10-02 | 2007-05-17 | Medarex, Inc. | Human antibodies |
US7135287B1 (en) | 1999-10-02 | 2006-11-14 | Biosite, Inc. | Human antibodies |
US6680209B1 (en) * | 1999-12-06 | 2004-01-20 | Biosite, Incorporated | Human antibodies as diagnostic reagents |
CA2408408C (en) | 2000-05-12 | 2013-07-09 | Genzyme Corporation | Modulators of tnf- alpha signaling |
US20110195063A1 (en) * | 2000-08-07 | 2011-08-11 | Centocor, Inc. | Methods of Treating Ankylosing Spondylitis Using Anti-TNF Antibodies and Peptides of Human Tumor Necrosis Factor |
UA81743C2 (uk) * | 2000-08-07 | 2008-02-11 | Центокор, Инк. | МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ |
US7087726B2 (en) | 2001-02-22 | 2006-08-08 | Genentech, Inc. | Anti-interferon-α antibodies |
AU2013204357B2 (en) * | 2001-06-08 | 2017-03-30 | Abbvie Biotechnology Ltd | Methods of administering anti-TNFalpha antibodies |
CA2385745C (en) | 2001-06-08 | 2015-02-17 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
AU2011218743B2 (en) * | 2001-06-08 | 2012-09-06 | Abbvie Biotechnology Ltd | Methods of administering anti-TNFalpha antibodies |
AU2008202001B2 (en) * | 2001-06-08 | 2011-09-22 | Abbvie Biotechnology Ltd | Methods of administering anti-TNFalpha antibodies |
WO2003002187A2 (en) * | 2001-06-26 | 2003-01-09 | Photomed Technologies, Inc. | Multiple wavelength illuminator |
BRPI0210579B8 (pt) | 2001-06-26 | 2021-05-25 | Amgen Fremont Inc | anticorpo e composição farmacêutica |
US20050271663A1 (en) * | 2001-06-28 | 2005-12-08 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
WO2004081026A2 (en) * | 2003-06-30 | 2004-09-23 | Domantis Limited | Polypeptides |
US20060073141A1 (en) * | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
WO2003054018A2 (en) * | 2001-12-21 | 2003-07-03 | Genpat77 Pharmacogenetics Ag | Anti-tirc7 antibodies in therapy of inflammatory diseases |
US20040009172A1 (en) * | 2002-04-26 | 2004-01-15 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
US20030206898A1 (en) * | 2002-04-26 | 2003-11-06 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
TWI426919B (zh) * | 2002-06-07 | 2014-02-21 | Abbvie Biotechnology Ltd | 投予抗-TNFα抗體之方法 |
AU2012203853B2 (en) * | 2002-07-19 | 2015-09-03 | Abbvie Biotechnology Ltd | Treatment of TNFalpha related disorders |
AU2013204153A1 (en) * | 2002-07-19 | 2013-05-02 | Abbvie Biotechnology Ltd | Treatment of TNFalpha related disorders |
US20090280065A1 (en) * | 2006-04-10 | 2009-11-12 | Willian Mary K | Uses and Compositions for Treatment of Psoriasis |
NZ598346A (en) * | 2002-07-19 | 2013-10-25 | Abbvie Biotechnology Ltd | Treatment of tnf alpha related disorders |
US20040033228A1 (en) * | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
US20040105858A1 (en) * | 2002-08-29 | 2004-06-03 | Kim Joanne Young Hee Kwak | Diagnosis and treatment of infertility |
MY150740A (en) | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
WO2004039841A2 (en) | 2002-10-29 | 2004-05-13 | Borean Pharma A/S | Trimeric binding proteins for trimeric cytokines |
DE60335652D1 (de) * | 2002-11-21 | 2011-02-17 | Genzyme Corp | Verwendung eines diamidderivats zur verhinderung der chronischen transplantatabstossung |
ATE520400T1 (de) * | 2002-11-21 | 2011-09-15 | Genzyme Corp | Kombination von einem diamidderivat und immunsuppressiva zur unterdrückung der transplantatabstossung |
US20040162414A1 (en) * | 2002-11-22 | 2004-08-19 | Santora Ling C. | Method for reducing or preventing modification of a polypeptide in solution |
US20040101939A1 (en) * | 2002-11-22 | 2004-05-27 | Santora Ling C. | Method for reducing or preventing modification of a polypeptide in solution |
ATE472556T1 (de) * | 2002-12-02 | 2010-07-15 | Amgen Fremont Inc | Gegen den tumor nekrose faktor gerichtete antikörper und deren verwendungen |
CA2511823A1 (en) * | 2002-12-30 | 2004-07-22 | Amgen Inc. | Combination therapy with co-stimulatory factors |
US7101978B2 (en) * | 2003-01-08 | 2006-09-05 | Applied Molecular Evolution | TNF-α binding molecules |
US20040208876A1 (en) | 2003-04-18 | 2004-10-21 | Kim Kyung Jin | Monoclonal antibodies to hepatocyte growth factor |
US20070027075A1 (en) * | 2003-06-09 | 2007-02-01 | Smithrud David B | Compositions and methods for targeted drug delivery |
PL1648998T3 (pl) * | 2003-07-18 | 2015-03-31 | Amgen Inc | Specyficzne czynniki wiążące czynnik wzrostu hepatocytów |
SG148877A1 (en) | 2003-07-22 | 2009-01-29 | Micron Technology Inc | Semiconductor substrates including input/output redistribution using wire bonds and anisotropically conductive film, methods of fabrication and assemblies including same |
US7871610B2 (en) * | 2003-08-12 | 2011-01-18 | Dyax Corp. | Antibodies to Tie1 ectodomain |
US7485297B2 (en) * | 2003-08-12 | 2009-02-03 | Dyax Corp. | Method of inhibition of vascular development using an antibody |
WO2005019267A2 (en) * | 2003-08-12 | 2005-03-03 | Dyax Corp. | Tie1-binding ligands |
FR2859725B1 (fr) | 2003-09-16 | 2006-03-10 | Neovacs | Procede a haut rendement pour l'obtention d'anticorps humains neutralisant l'activite biologique d'une cytokine humaine |
US7435799B2 (en) * | 2004-01-08 | 2008-10-14 | Applied Molecular Evolution | TNF-α binding molecules |
TWI439284B (zh) * | 2004-04-09 | 2014-06-01 | Abbvie Biotechnology Ltd | 用於治療TNFα相關失調症之多重可變劑量療法 |
GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
EP2322554A1 (en) | 2004-06-30 | 2011-05-18 | Domantis Limited | Composition comprising an anti-TNF-alpha domain antibody for the treatment of rheumatoid arthritis |
US20060024308A1 (en) * | 2004-07-06 | 2006-02-02 | Roberto Crea | High affinity anti-TNF-alpha antibodies and method |
WO2006041970A2 (en) * | 2004-10-08 | 2006-04-20 | Abbott Biotechnology Ltd. | Treatment of respiratory syncytial virus (rsv) infection |
CN100460508C (zh) * | 2004-11-03 | 2009-02-11 | 马延高 | 人胰岛素基因在甲醇酵母中的分泌表达方法 |
EP1831257B9 (en) * | 2004-12-29 | 2011-05-04 | Yuhan Corporation | Humanized antibody specific for tumor necrosis factor-alpha |
US7731965B2 (en) * | 2005-02-17 | 2010-06-08 | Abbott Lab | Human ring specific BNP antibodies |
KR101465456B1 (ko) | 2005-05-16 | 2014-11-27 | 애브비 바이오테크놀로지 리미티드 | 미란성 다발관절염의 치료를 위한 tnf 억제제의 용도 |
CA2609999C (en) * | 2005-06-07 | 2017-05-30 | Esbatech Ag | Stable and soluble antibodies inhibiting tnf.alpha. |
CA2610839C (en) | 2005-06-14 | 2019-06-25 | Amgen Inc. | Self-buffering protein formulations |
WO2006138690A2 (en) * | 2005-06-17 | 2006-12-28 | Abbott Laboratories | Improved method of treating degenerative spinal disorders |
EP2484774A3 (en) * | 2005-07-21 | 2012-11-14 | Abbott Laboratories | Multiple gene expression including sorf contructs and methods with polyproteins, pro-proteins, and proteolysis |
TW200726776A (en) * | 2005-07-29 | 2007-07-16 | Friedrich Alexander University Of Erlangen Nuremberg | CD33-specific single-chain immunotoxin and methods of use |
DE602006014691D1 (de) * | 2005-08-02 | 2010-07-15 | Xbiotech Inc | DIAGNOSE, BEHANDLUNG UND PRÄVENTION VON GEFÄSSERKRANKUNGEN MITTELS IL-1alpha-AUTOANTIKÖRPERN |
US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
US20070041905A1 (en) * | 2005-08-19 | 2007-02-22 | Hoffman Rebecca S | Method of treating depression using a TNF-alpha antibody |
GB2430880A (en) * | 2005-10-04 | 2007-04-11 | Cambridge Biostability Ltd | Pharmaceutical compositions stabilized in glassy particles |
TW201337266A (zh) | 2005-11-01 | 2013-09-16 | Abbott Biotech Ltd | 利用生物標記診斷關節黏連脊椎炎之方法及組合物 |
US20070207152A1 (en) * | 2005-11-09 | 2007-09-06 | Brophy Susan E | Human BNP immunospecific antibodies |
US7939069B2 (en) | 2005-11-09 | 2011-05-10 | Abbott Laboratories | Human BNP immunospecific antibodies |
AR056806A1 (es) | 2005-11-14 | 2007-10-24 | Amgen Inc | Moleculas quimericas de anticuerpo rankl- pth/ pthrp |
WO2007087673A1 (en) * | 2006-02-01 | 2007-08-09 | Arana Therapeutics Limited | Domain antibody construct |
CA2637707A1 (en) * | 2006-02-02 | 2007-08-09 | Rinat Neuroscience Corporation | Methods for treating obesity by administering a trkb antagonist |
EP1988923A1 (en) * | 2006-02-02 | 2008-11-12 | Rinat Neuroscience Corp. | Methods for treating unwanted weight loss or eating disorders by administering a trkb agonist |
SG170837A1 (en) * | 2006-04-05 | 2011-05-30 | Abbott Biotech Ltd | Antibody purification |
US20080118496A1 (en) * | 2006-04-10 | 2008-05-22 | Medich John R | Uses and compositions for treatment of juvenile rheumatoid arthritis |
EP2012586A4 (en) | 2006-04-10 | 2010-08-18 | Abbott Biotech Ltd | USES AND COMPOSITIONS FOR THE TREATMENT OF ANKYLOSANTE SPONDYLARTHRITIS |
EP2666472A3 (en) | 2006-04-10 | 2014-04-02 | Abbott Biotechnology Ltd | Uses and compositions for treatment of psoriatic arthritis |
EP2010214A4 (en) * | 2006-04-10 | 2010-06-16 | Abbott Biotech Ltd | USES AND COMPOSITIONS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS |
CA2564435A1 (en) | 2006-04-10 | 2007-10-10 | Abbott Biotechnology Ltd. | Methods for monitoring and treating intestinal disorders |
US9605064B2 (en) * | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
EP2666479A3 (en) | 2006-04-10 | 2014-03-26 | Abbott Biotechnology Ltd | Uses and compositions for treatment of juvenile rheumatoid arthritis |
US20090317399A1 (en) * | 2006-04-10 | 2009-12-24 | Pollack Paul F | Uses and compositions for treatment of CROHN'S disease |
US20080131374A1 (en) * | 2006-04-19 | 2008-06-05 | Medich John R | Uses and compositions for treatment of rheumatoid arthritis |
US8022188B2 (en) * | 2006-04-24 | 2011-09-20 | Abbott Laboratories | Immunosuppressant binding antibodies and methods of obtaining and using same |
US20110008282A1 (en) * | 2006-05-15 | 2011-01-13 | Xbiotech, Inc. | IL-1alpha immunization induces autoantibodies protective against atherosclerosis |
US20100040574A1 (en) * | 2006-05-22 | 2010-02-18 | Xbiotech Inc. | TREATMENT OF CANCER WITH ANTI-IL-1alpha ANTIBODIES |
BRPI0712224B8 (pt) * | 2006-06-02 | 2021-05-25 | Regeneron Pharma | anticorpos de alta afinidade para o receptor de il-6 humano e composições farmacêuticas |
US20100021451A1 (en) | 2006-06-08 | 2010-01-28 | Wong Robert L | Uses and compositions for treatment of ankylosing spondylitis |
US20080311043A1 (en) * | 2006-06-08 | 2008-12-18 | Hoffman Rebecca S | Uses and compositions for treatment of psoriatic arthritis |
TWI498137B (zh) | 2006-06-30 | 2015-09-01 | Abbvie Biotechnology Ltd | 自動注射裝置 |
JP5385135B2 (ja) | 2006-07-03 | 2014-01-08 | チャールズ デイビッド アデア, | 細胞接着分子の発現を調節するための組成物 |
US20080064045A1 (en) * | 2006-09-07 | 2008-03-13 | Huaiqin Wu | Biomarker fragments for the detection of human BNP |
US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
MY185872A (en) | 2006-09-13 | 2021-06-14 | Abbvie Inc | Cell culture improvements |
EP2500416A1 (en) | 2006-09-13 | 2012-09-19 | Abbott Laboratories | Cell culture improvements |
KR20150065959A (ko) | 2006-10-02 | 2015-06-15 | 메다렉스, 엘.엘.시. | Cxcr4에 결합하는 인간 항체 및 이의 용도 |
CN101616932A (zh) | 2006-10-27 | 2009-12-30 | 艾博特生物技术有限公司 | 结晶型抗-hTNFα抗体 |
US8754107B2 (en) * | 2006-11-17 | 2014-06-17 | Abbvie Inc. | Aminopyrrolidines as chemokine receptor antagonists |
MX2009005776A (es) | 2006-12-01 | 2009-06-10 | Medarex Inc | Anticuerpos humanos que se enlazan al cd 22 y sus usos. |
CL2007003622A1 (es) | 2006-12-13 | 2009-08-07 | Medarex Inc | Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales. |
JP2010513306A (ja) | 2006-12-14 | 2010-04-30 | メダレックス インコーポレーティッド | Cd70に結合するヒト抗体およびその使用 |
KR20090091181A (ko) * | 2006-12-20 | 2009-08-26 | 리나트 뉴로사이언스 코퍼레이션 | 자가면역 장애의 치료를 위한 티로신 수용체 키나아제 b 작용제 |
US20080213253A1 (en) * | 2007-01-12 | 2008-09-04 | Dyax Corp. | Combination therapy for the treatment of cancer |
KR20090100461A (ko) * | 2007-01-16 | 2009-09-23 | 아보트 러보러터리즈 | 건선의 치료방법 |
CN101679507A (zh) | 2007-03-29 | 2010-03-24 | 艾博特公司 | 结晶抗人类il-12抗体 |
US20100255513A1 (en) | 2007-03-30 | 2010-10-07 | Denson Lee A | Serological markers of inflammatory bowel disease phenotype and disease progression |
US7807168B2 (en) * | 2007-04-10 | 2010-10-05 | Vaccinex, Inc. | Selection of human TNFα specific antibodies |
US8092998B2 (en) * | 2007-05-31 | 2012-01-10 | Abbott Laboratories | Biomarkers predictive of the responsiveness to TNFα inhibitors in autoimmune disorders |
MX2009012968A (es) * | 2007-06-06 | 2010-04-01 | Domantis Ltd | Polipeptidos, dominios variables de anticuerpo y antagonistas. |
EP2171451A4 (en) | 2007-06-11 | 2011-12-07 | Abbott Biotech Ltd | METHOD FOR TREATING JUVENILIAN IDIOPATHIC ARTHRITIS |
CN101848733A (zh) * | 2007-07-13 | 2010-09-29 | 艾博特生物技术有限公司 | 用于肺部给予TNFα抑制剂的方法和组合物 |
RU2010107994A (ru) | 2007-08-08 | 2011-09-20 | Эбботт Лэборетриз (Us) | Композиции и способы кристаллизации антител |
KR20100087291A (ko) * | 2007-09-25 | 2010-08-04 | 아보트 러보러터리즈 | 케모카인 수용체 길항제로서의 옥타하이드로펜탈렌 화합물 |
US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
KR20150080038A (ko) | 2007-11-30 | 2015-07-08 | 애브비 바이오테크놀로지 리미티드 | 단백질 제형 및 이의 제조방법 |
WO2009073805A2 (en) * | 2007-12-04 | 2009-06-11 | Verdezyne, Inc. | Aglycosylated therapeutic antibodies and therapeutic antibody-encoding nucleotide sequences |
EP2799450A1 (en) | 2007-12-31 | 2014-11-05 | Bayer Intellectual Property GmbH | Antibodies to TNFalpha |
CA2710333A1 (en) * | 2008-01-03 | 2009-07-09 | Abbott Biotechnology Ltd. | Predicting long-term efficacy of a compound in the treatment of psoriasis |
BRPI0906490A2 (pt) | 2008-01-15 | 2015-07-14 | Abbott Lab | Vetores de expressão de mamífero melhorados e uso dos mesmos |
CA2711984A1 (en) | 2008-01-15 | 2009-07-23 | Abbott Gmbh & Co. Kg | Powdered protein compositions and methods of making same |
US8178092B2 (en) | 2008-03-18 | 2012-05-15 | Abbott Laboratories | Methods of treating psoriasis by administration of antibodies to the p40 subunit of IL-12 and/or IL-23 |
EP2899209A1 (en) * | 2008-04-29 | 2015-07-29 | Abbvie Inc. | Dual Variable Domain Immunoglobulins and uses thereof |
JPWO2009142186A1 (ja) * | 2008-05-20 | 2011-09-29 | 株式会社カネカ | 細胞障害性組成物 |
RU2640249C2 (ru) | 2008-05-23 | 2017-12-27 | Сива Корпорейшн | Способы, композиции и приборы для облегчения регенерации |
MX2010012963A (es) * | 2008-05-30 | 2011-04-05 | Xbiotech Inc | Anticuerpos de interleucina-1 alfa y metodos de uso. |
JP5723769B2 (ja) | 2008-06-03 | 2015-05-27 | アッヴィ・インコーポレイテッド | 二重可変ドメイン免疫グロブリン及びその使用 |
BRPI0913406A2 (pt) | 2008-06-03 | 2018-01-09 | Abbott Lab | imunoglobulinas de domínio variável duplo e usos das mesmas |
TWI527819B (zh) | 2008-06-10 | 2016-04-01 | 艾伯維有限公司 | 新穎三環化合物 |
PT2307457T (pt) * | 2008-06-25 | 2018-10-16 | Esbatech Alcon Biomed Res Unit | Anticorpos estáveis e solúveis que inibem o tnf |
CA2729949A1 (en) * | 2008-07-08 | 2010-01-14 | Abbott Laboratories | Prostaglandin e2 dual variable domain immunoglobulins and uses thereof |
AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
WO2010030979A2 (en) * | 2008-09-12 | 2010-03-18 | Xbiotech, Inc. | Targeting pathogenic monocytes |
AU2009314311B2 (en) * | 2008-10-29 | 2013-01-10 | Ablynx N.V. | Methods for purification of single domain antigen binding molecules |
CA2742791A1 (en) * | 2008-11-28 | 2010-06-03 | Abbott Laboratories | Stable antibody compositions and methods for stabilizing same |
AU2009333489A1 (en) | 2008-12-30 | 2010-07-08 | Centocor Ortho Biotech Inc. | Serum markers predicting clinical response to anti-TNF antibodies in patients with ankylosing spondylitis |
WO2010081787A1 (en) * | 2009-01-14 | 2010-07-22 | Domantis Limited | IMPROVED TNFα ANTAGONISM, PROPHYLAXIS & THERAPY WITH REDUCED ORGAN NECROSIS |
IT1394281B1 (it) | 2009-01-19 | 2012-06-06 | Zardi | Processo per la produzione di proteine di fusione polivalenti e polispecifiche utilizzando come struttura portante l'uteroglobina e prodotti cosi' ottenuti. |
EP2810652A3 (en) | 2009-03-05 | 2015-03-11 | AbbVie Inc. | IL-17 binding proteins |
WO2010105446A1 (zh) * | 2009-03-20 | 2010-09-23 | 上海宏源生物技术有限公司 | 抗人肿瘤坏死因子受体α单抗及其应用 |
AU2010236256C1 (en) * | 2009-04-16 | 2015-10-22 | Abbvie Biotherapeutics Inc. | Anti-TNF-alpha antibodies and their uses |
RU2524487C2 (ru) | 2009-04-29 | 2014-07-27 | Эббви Байотекнолоджи Лтд | Автоматическое инъекционное устройство |
EP2424566A4 (en) * | 2009-05-01 | 2013-07-31 | Abbvie Inc | IMMUNOGLOBULINE WITH DOUBLE VARIABLE DOMAIN AND ITS USE |
CN104490767A (zh) * | 2009-05-04 | 2015-04-08 | 艾伯维生物技术有限公司 | 人抗TNF-α抗体的稳定高蛋白质浓度制剂 |
TW201109438A (en) * | 2009-07-29 | 2011-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
CN102630168A (zh) * | 2009-09-14 | 2012-08-08 | 雅培制药有限公司 | 用于治疗银屑病的方法 |
US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
CA2775959A1 (en) * | 2009-10-15 | 2011-04-21 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
SG10201406713XA (en) | 2009-10-20 | 2014-11-27 | Abbvie Inc | Isolation and purification of anti-il-13 antibodies using protein a affinity chromatography |
UY32979A (es) * | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
US20110150861A1 (en) * | 2009-10-30 | 2011-06-23 | Abbott Laboratories | Sorf constructs and multiple gene expression |
SI2506716T1 (sl) | 2009-12-01 | 2017-10-30 | Abb Vie Inc. | Nove triciklične spojine |
JP2013512282A (ja) * | 2009-12-01 | 2013-04-11 | アボット・ラボラトリーズ | 新規三環式化合物 |
US8871208B2 (en) * | 2009-12-04 | 2014-10-28 | Abbvie Inc. | 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof |
US8758301B2 (en) | 2009-12-15 | 2014-06-24 | Abbvie Biotechnology Ltd | Firing button for automatic injection device |
WO2011075578A1 (en) | 2009-12-16 | 2011-06-23 | Philip Bosch | Methods of treating interstitial cystitis |
WO2011079308A2 (en) | 2009-12-23 | 2011-06-30 | Emergent Product Development Seattle, Llc | Compositions comprising tnf-alpha and il-6 antagonists and methods of use thereof |
CA2789168A1 (en) | 2010-02-02 | 2011-08-11 | Abbott Biotechnology Ltd. | Methods and compositions for predicting responsiveness to treatment with tnf-.alpha. inhibitor |
WO2011095174A1 (en) | 2010-02-08 | 2011-08-11 | Aarhus Universitet | Human herpes virus 6 and 7 u20 polypeptide and polynucleotides for use as a medicament or diagnosticum |
CN102958537B (zh) * | 2010-04-07 | 2015-09-16 | Abbvie公司 | TNF-α结合蛋白 |
RU2573042C2 (ru) | 2010-04-21 | 2016-01-20 | Эббви Байотекнолоджи Лтд. | Носимое устройство для автоматической инъекции для управляемой подачи терапевтических агентов |
WO2011146727A1 (en) | 2010-05-19 | 2011-11-24 | Philip Bosch | Methods of treating interstitial cystitis |
HUE039740T2 (hu) | 2010-06-03 | 2019-01-28 | Abbvie Biotechnology Ltd | Alkalmazások és készítmények hidradenitis suppurativa (HS) kezelésére |
CA2825986C (en) | 2010-06-18 | 2019-10-29 | Xbiotech Inc. | Arthritis treatment |
WO2012018790A2 (en) | 2010-08-03 | 2012-02-09 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
KR102314003B1 (ko) | 2010-08-23 | 2021-10-19 | 얀센 바이오테크 인코포레이티드 | 종양성 질병들에 대한 치료 |
JP2013539364A (ja) | 2010-08-26 | 2013-10-24 | アッヴィ・インコーポレイテッド | 二重可変ドメイン免疫グロブリンおよびその使用 |
EP3511017A1 (en) | 2010-09-27 | 2019-07-17 | Siwa Corporation | Selective removal of age-modified cells for treatment of atherosclerosis |
EP3431485B1 (en) | 2010-10-01 | 2020-12-30 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
UY33679A (es) | 2010-10-22 | 2012-03-30 | Esbatech | Anticuerpos estables y solubles |
EP2632446B1 (en) * | 2010-10-30 | 2018-12-12 | Oxford University Innovation Limited | Treatment for dupuytren's disease |
AU2011325974B2 (en) | 2010-11-11 | 2016-10-27 | Abbvie Biotechnology Ltd. | Improved high concentration anti-TNFalpha antibody liquid formulations |
US8721571B2 (en) | 2010-11-22 | 2014-05-13 | Siwa Corporation | Selective removal of cells having accumulated agents |
EP2490024A1 (en) | 2010-12-22 | 2012-08-22 | Proteomika, S.L. | Method to optimize the treatment of patients with biological drugs |
AU2012210170B2 (en) | 2011-01-24 | 2016-09-29 | Elcam Medical Agricultural Cooperative Association Ltd. | Injector |
BR112013018905B1 (pt) | 2011-01-24 | 2021-07-13 | Abbvie Biotechnology Ltd | Dispositivos de injeção automática que têm superfícies de pega sobremoldadas. |
BR112013018773A2 (pt) | 2011-01-24 | 2016-10-25 | Abbvie Biotechnology Ltd | remoção de proteções de agulha de seringas e dispositivos de injeção automática |
JP2014508715A (ja) * | 2011-03-07 | 2014-04-10 | 国立大学法人徳島大学 | 筋萎縮性側索硬化症の治療方法 |
CN103608053B (zh) | 2011-03-18 | 2016-06-22 | 艾伯维公司 | 用于组装自动注射装置及其子组件的系统、装置和方法 |
TWI622597B (zh) | 2011-03-28 | 2018-05-01 | 賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
CA2831563A1 (en) | 2011-03-29 | 2012-10-04 | Abbvie Inc. | Improved shroud deployment in automatic injection devices |
WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
WO2012145752A2 (en) | 2011-04-21 | 2012-10-26 | Abbott Laboratories | Wearable automatic injection device for controlled administration of therapeutic agents |
EP2702077A2 (en) * | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
AR086113A1 (es) | 2011-04-30 | 2013-11-20 | Abbott Lab | Isoxazolinas como agentes terapeuticos |
CA2835094C (en) | 2011-05-06 | 2020-12-22 | David Gearing | Anti-nerve growth factor antibodies and methods of preparing and using the same |
GB201112429D0 (en) | 2011-07-19 | 2011-08-31 | Glaxo Group Ltd | Antigen-binding proteins with increased FcRn binding |
EP2751139A1 (en) | 2011-08-30 | 2014-07-09 | NVIP Pty Ltd | Caninised tumour necrosis factor antibodies and methods of using the same |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
WO2013043826A1 (en) | 2011-09-21 | 2013-03-28 | Abbvie Inc. | Tricyclic compounds useful as protein kinase inhibitors |
EP2750709B1 (en) | 2011-09-23 | 2018-08-15 | XBiotech, Inc | Cachexia treatment |
AU2012318752B2 (en) | 2011-10-03 | 2017-08-31 | Modernatx, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
WO2013066707A1 (en) | 2011-10-31 | 2013-05-10 | Merck Sharp & Dohme Corp. | Chromatography process for resolving heterogeneous antibody aggregates |
WO2013080050A2 (en) | 2011-11-30 | 2013-06-06 | Universitaetsklinikum Erlangen | Methods and compositions for determining responsiveness to treatment with a tnf-alpha inhibitor |
EP2791171A1 (en) | 2011-12-16 | 2014-10-22 | Synthon Biopharmaceuticals B.V. | EXPRESSION OF SECRETORY IgA ANTIBODIES IN DUCKWEED |
CN104114572A (zh) | 2011-12-16 | 2014-10-22 | 现代治疗公司 | 经修饰的核苷、核苷酸和核酸组合物 |
BR112014015851A2 (pt) | 2011-12-30 | 2019-09-24 | Abbvie Inc | proteínas de ligação específicas duplas direcionadas contra il-13 e/ou il-17 |
EA201491644A1 (ru) | 2012-03-07 | 2014-12-30 | Кадила Хелзкэр Лимитед | Фармацевтические композиции |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
WO2013149376A1 (en) | 2012-04-02 | 2013-10-10 | Abbott Laboratories | Chemokine receptor antagonists |
US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
EP2833923A4 (en) | 2012-04-02 | 2016-02-24 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS |
RU2499000C1 (ru) * | 2012-04-06 | 2013-11-20 | Открытое акционерное общество "Всероссийский научный центр молекулярной диагностики и лечения" (ОАО "ВНЦМДЛ") | ВАРИАБЕЛЬНЫЕ ДОМЕНЫ ЛЕГКОЙ И ТЯЖЕЛОЙ ЦЕПИ МЫШИНОГО МОНОКЛОНАЛЬНОГО АНТИТЕЛА ПРОТИВ ФАКТОРА НЕКРОЗА ОПУХОЛИ АЛЬФА (ФНО-α) ЧЕЛОВЕКА (ВАРИАНТЫ), АНТИГЕНСВЯЗЫВАЮЩИЙ ФРАГМЕНТ (Fab) ПРОТИВ ФНО-α ЧЕЛОВЕКА, СОДЕРЖАЩИЙ УКАЗАННЫЕ ДОМЕНЫ (ВАРИАНТЫ) |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
PT2692865E (pt) | 2012-07-30 | 2015-02-06 | Nbe Therapeutics Llc | Identificação mediada por transposição de proteínas funcionais ou de ligação específicas |
SG11201504249XA (en) * | 2012-09-02 | 2015-07-30 | Abbvie Inc | Methods to control protein heterogeneity |
US9512214B2 (en) * | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
TW201422590A (zh) | 2012-09-07 | 2014-06-16 | Abbvie Inc | 雜環核激素受體調節劑 |
WO2014039903A2 (en) | 2012-09-07 | 2014-03-13 | Coherus Biosciences, Inc. | Stable aqueous formulations of adalimumab |
US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
US9279016B2 (en) | 2012-09-19 | 2016-03-08 | Abbvie Biotherapeutics Inc. | Methods for identifying antibodies with reduced immunogenicity |
TW202210507A (zh) | 2012-11-01 | 2022-03-16 | 美商艾伯維有限公司 | 抗-vegf/dll4雙重可變區域免疫球蛋白及其用途 |
US9597380B2 (en) | 2012-11-26 | 2017-03-21 | Modernatx, Inc. | Terminally modified RNA |
CA2894225A1 (fr) | 2012-12-17 | 2014-06-26 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation d'anticorps monoclonaux pour le traitement de l'inflammation et d'infections bacteriennes |
CN105190314A (zh) | 2013-01-21 | 2015-12-23 | 阿布维公司 | 用于炎性疾病的抗-tnf和抗-il17联合疗法生物标志物 |
CN105051064A (zh) | 2013-01-24 | 2015-11-11 | 葛兰素史克知识产权开发有限公司 | 抗TNF-α抗原结合蛋白 |
KR101759687B1 (ko) | 2013-01-25 | 2017-07-19 | 타이몬, 엘엘씨 | 순환하는 생물활성 가용성 tnf의 선택적 감소를 위한 조성물 및 tnf-매개 질환의 치료 방법 |
AR094780A1 (es) * | 2013-02-13 | 2015-08-26 | Laboratoire Français Du Fractionnement Et Des Biotechnologies | ANTICUERPOS ANTI-TNF-a ALTAMENTE GALACTOSILADOS Y SUS USOS |
TW201444867A (zh) | 2013-03-08 | 2014-12-01 | Lilly Co Eli | 抗tnf-抗il-17雙特異性抗體 |
EP2830651A4 (en) | 2013-03-12 | 2015-09-02 | Abbvie Inc | HUMAN ANTIBODIES THAT BIND TNF-ALPHA AND PREPARATION METHODS |
US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
AU2014240431A1 (en) | 2013-03-14 | 2015-08-27 | Abbvie Inc. | Low acidic species compositions and methods for producing the same using displacement chromatography |
US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
AU2013384204B2 (en) | 2013-03-14 | 2017-03-16 | Abbvie Inc. | Low acidic species compositions and methods for producing and using the same |
WO2014149750A1 (en) | 2013-03-15 | 2014-09-25 | Donaldson Company, Inc. | Filter media and elements |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
CA2904448A1 (en) | 2013-03-15 | 2014-09-18 | Tariq Ghayur | Dual specific binding proteins directed against il-1.beta. and/or il-17 |
US9416181B2 (en) | 2013-05-06 | 2016-08-16 | Abbvie Inc. | Compositions for cell culture and methods of using the same |
AU2014302365B2 (en) | 2013-06-26 | 2018-11-15 | Abbvie Inc. | Primary carboxamides as BTK inhibitors |
WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
EP3052640A2 (en) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
WO2015057910A1 (en) | 2013-10-16 | 2015-04-23 | Oncobiologics, Inc. | Buffer formulations for enhanced antibody stability |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
CN104726393A (zh) * | 2013-12-24 | 2015-06-24 | 江苏省农业科学院 | TNF-α诱导的人脐静脉内皮细胞HUVEC炎症反应模型的制备方法 |
CN103965357B (zh) | 2013-12-31 | 2016-08-17 | 嘉和生物药业有限公司 | 一种抗人rankl抗体 |
JP6797458B2 (ja) | 2014-01-29 | 2020-12-09 | エルジー・ケム・リミテッド | 培養培地の最適化により組換えタンパク質のガラクトシル化を調節する方法 |
WO2015138337A1 (en) | 2014-03-09 | 2015-09-17 | Abbvie, Inc. | Compositions and methods for treating rheumatoid arthritis |
SG11201607746QA (en) | 2014-03-21 | 2016-10-28 | Abbvie Inc | Anti-egfr antibodies and antibody drug conjugates |
ES2572919T3 (es) | 2014-05-23 | 2016-06-03 | Ares Trading S.A. | Composición farmacéutica líquida |
PT2946765T (pt) | 2014-05-23 | 2016-11-10 | Ares Trading Sa | Composição farmacêutica líquida |
WO2015191783A2 (en) | 2014-06-10 | 2015-12-17 | Abbvie Inc. | Biomarkers for inflammatory disease and methods of using same |
WO2015198320A1 (en) | 2014-06-24 | 2015-12-30 | Insight Biopharmaceuticals Ltd. | Methods of purifying antibodies |
US20170226552A1 (en) | 2014-07-03 | 2017-08-10 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using cobalt |
WO2016007764A1 (en) | 2014-07-09 | 2016-01-14 | Abbvie Inc. | Methods for modulating the glycosylation profile of recombinant proteins using non-commonly used sugars |
SG10201912591RA (en) | 2014-09-03 | 2020-02-27 | Boehringer Ingelheim Int | Compound targeting il-23a and tnf-alpha and uses thereof |
US10435464B1 (en) | 2014-09-05 | 2019-10-08 | Coherus Biosciences, Inc. | Methods for making recombinant proteins |
ES2908203T3 (es) | 2014-09-19 | 2022-04-28 | Siwa Corp | Anticuerpos anti-age para el tratamiento de inflamación y trastornos autoinmunes |
HUP1400510A1 (hu) | 2014-10-28 | 2016-05-30 | Richter Gedeon Nyrt | Gyógyászati TNFalfa ellenes antitest készítmény |
AR102417A1 (es) * | 2014-11-05 | 2017-03-01 | Lilly Co Eli | Anticuerpos biespecíficos anti-tnf- / anti-il-23 |
US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
US10358502B2 (en) | 2014-12-18 | 2019-07-23 | Siwa Corporation | Product and method for treating sarcopenia |
US9993535B2 (en) | 2014-12-18 | 2018-06-12 | Siwa Corporation | Method and composition for treating sarcopenia |
WO2016103093A1 (en) | 2014-12-23 | 2016-06-30 | Pfizer Inc. | Stable aqueous antibody formulation for anti tnf alpha antibodies |
EP3085709B1 (en) | 2014-12-28 | 2019-08-21 | Genor Biopharma Co., Ltd | Humanized anti-human rankl antibody, pharmaceutical composition and use thereof |
EP3247718B1 (en) | 2015-01-21 | 2021-09-01 | Outlook Therapeutics, Inc. | Modulation of charge variants in a monoclonal antibody composition |
WO2016162819A1 (en) | 2015-04-07 | 2016-10-13 | Lupin Limited | Stable aqueous pharmaceutical composition of anti-tnf alpha antibody |
EP3078675A1 (en) | 2015-04-10 | 2016-10-12 | Ares Trading S.A. | Induction dosing regimen for the treatment of tnf alpha mediated disorders |
TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
EP3362455A1 (en) | 2015-10-16 | 2018-08-22 | AbbVie Inc. | PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF |
US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US11524964B2 (en) | 2015-10-16 | 2022-12-13 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US11773106B2 (en) | 2015-10-16 | 2023-10-03 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US11512092B2 (en) | 2015-10-16 | 2022-11-29 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US11229702B1 (en) | 2015-10-28 | 2022-01-25 | Coherus Biosciences, Inc. | High concentration formulations of adalimumab |
US11583584B1 (en) | 2015-10-28 | 2023-02-21 | Coherus Biosciences, Inc. | Stable protein compositions and methods of their use |
EP3400241B1 (en) | 2016-01-06 | 2020-07-22 | Outlook Therapeutics, Inc. | Modulation of afucosylated species in a monoclonal antibody composition |
WO2017120359A1 (en) | 2016-01-06 | 2017-07-13 | Oncobiologics, Inc. | Reduction of high molecular weight species, acidic charge species, and fragments in a monoclonal antibody composition |
MX2018009341A (es) | 2016-02-03 | 2019-05-15 | Oncobiologics Inc | Formulaciones tamponadas para una mayor estabilidad de anticuerpos. |
ES2770787T3 (es) | 2016-02-19 | 2020-07-03 | Siwa Corp | Método y composición para tratar el cáncer, destruir las células cancerosas metastásicas y evitar la metástasis del cáncer usando anticuerpo para productos finales de glicación avanzada (AGE) |
US11919924B1 (en) * | 2016-03-15 | 2024-03-05 | Fresenius Kabi Deutschland Gmbh | Methods of purifying and producing an adalimumab antibody |
JP2019513737A (ja) | 2016-04-08 | 2019-05-30 | ギリアード サイエンシーズ, インコーポレイテッド | がん、炎症性疾患および自己免疫疾患を処置するための組成物および方法 |
WO2017181116A1 (en) | 2016-04-15 | 2017-10-19 | Siwa Corporation | Anti-age antibodies for treating neurodegenerative disorders |
WO2017184880A1 (en) | 2016-04-20 | 2017-10-26 | Coherus Biosciences, Inc. | A method of filling a container with no headspace |
EP3464318B1 (en) | 2016-06-02 | 2021-04-21 | AbbVie Inc. | Glucocorticoid receptor agonist and immunoconjugates thereof |
JP2019524651A (ja) | 2016-06-08 | 2019-09-05 | アッヴィ・インコーポレイテッド | 抗cd98抗体及び抗体薬物コンジュゲート |
JP2019521973A (ja) | 2016-06-08 | 2019-08-08 | アッヴィ・インコーポレイテッド | 抗bh7−h3抗体及び抗体薬物コンジュゲート |
BR112018075626A2 (pt) | 2016-06-08 | 2019-03-19 | Abbvie Inc. | anticorpos anti-b7-h3 e conjugados de fármaco anticorpo |
JP2019521975A (ja) | 2016-06-08 | 2019-08-08 | アッヴィ・インコーポレイテッド | 抗egfr抗体薬物コンジュゲート |
BR112018075653A2 (pt) | 2016-06-08 | 2019-08-27 | Abbvie Inc | anticorpos anti-b7-h3 e conjugados anticorpo fármaco |
AU2017277422A1 (en) | 2016-06-08 | 2019-01-03 | Abbvie Inc. | Anti-EGFR antibody drug conjugates |
EP3257866A1 (en) | 2016-06-17 | 2017-12-20 | Academisch Medisch Centrum | Modified anti-tnf antibody and use thereof in the treatment of ibd |
JP2019518763A (ja) | 2016-06-23 | 2019-07-04 | シワ コーポレーション | 様々な疾患及び障害の治療において使用するためのワクチン |
WO2018075408A1 (en) | 2016-10-17 | 2018-04-26 | Alexion Pharmaceuticals, Inc. | Methods of treating acute myeloid leukemia (aml) with combinations of anti-cd200 antibodies, cytarabine, and daunorubicin |
MX2019004580A (es) | 2016-10-21 | 2019-08-12 | Amgen Inc | Formulaciones farmaceuticas y metodos para prepararlas. |
WO2018102594A1 (en) | 2016-12-01 | 2018-06-07 | Alexion Pharmaceuticals, Inc. | Methods of treating solid tumors with anti-cd200 antibodies |
AU2017370942A1 (en) | 2016-12-07 | 2019-06-13 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
MX2019006864A (es) | 2016-12-14 | 2019-10-15 | Progenity Inc | Tratamiento de una enfermedad del tracto gastrointestinal con un inhibidor de factor de necrosis tumoral (tnf). |
GB2557655A (en) | 2016-12-14 | 2018-06-27 | Teva Pharma | Medical injection device packaging |
EP3339444A1 (en) | 2016-12-20 | 2018-06-27 | Mabxience Research, S.L. | Method for obtaining a glycoprotein with an increased percentage of afucosylated glycans |
MA47106A (fr) | 2016-12-21 | 2019-10-30 | Amgen Inc | Formulations d'anticorps anti-tnf alpha |
JOP20190162A1 (ar) | 2016-12-30 | 2019-06-27 | Biocad Joint Stock Co | تركيبة صيدلانية مائية من جسم مضاد لـ tnf? أحادي النسيلة معاود الارتباط الجيني |
US10858449B1 (en) | 2017-01-06 | 2020-12-08 | Siwa Corporation | Methods and compositions for treating osteoarthritis |
US10995151B1 (en) | 2017-01-06 | 2021-05-04 | Siwa Corporation | Methods and compositions for treating disease-related cachexia |
US10961321B1 (en) | 2017-01-06 | 2021-03-30 | Siwa Corporation | Methods and compositions for treating pain associated with inflammation |
US10925937B1 (en) | 2017-01-06 | 2021-02-23 | Siwa Corporation | Vaccines for use in treating juvenile disorders associated with inflammation |
CN110167531A (zh) | 2017-01-11 | 2019-08-23 | 赛特瑞恩股份有限公司 | 稳定的液体调配物 |
MX2019009798A (es) | 2017-02-16 | 2020-01-30 | Xbiotech Inc | Tratamiento de la hidradenitis supurativa. |
BR112019021471A2 (pt) | 2017-04-13 | 2020-05-12 | Siwa Corporation | Anticorpo monoclonal humanizado de produto final da glicação avançada |
AR112341A1 (es) | 2017-08-02 | 2019-10-16 | Lilly Co Eli | ANTICUERPOS BIESPECÍFICOS ANTI-TNF- / ANTI-IL-23 DE IgG |
WO2019057631A1 (en) | 2017-09-20 | 2019-03-28 | Alvotech Hf | PHARMACEUTICAL FORMULATIONS FOR ADALIMUMAB |
US11761963B2 (en) | 2017-09-27 | 2023-09-19 | Alexion Pharmaceuticals, Inc. | Biomarker signature for predicting tumor response to anti-CD200 therapy |
AU2018374634A1 (en) | 2017-12-01 | 2020-05-28 | Abbvie Inc. | Glucocorticoid receptor agonist and immunoconjugates thereof |
WO2019126536A1 (en) | 2017-12-20 | 2019-06-27 | Alexion Pharmaceuticals Inc. | Humanized anti-cd200 antibodies and uses thereof |
WO2019126133A1 (en) | 2017-12-20 | 2019-06-27 | Alexion Pharmaceuticals, Inc. | Liquid formulations of anti-cd200 antibodies |
US11518801B1 (en) | 2017-12-22 | 2022-12-06 | Siwa Corporation | Methods and compositions for treating diabetes and diabetic complications |
EP3514541A1 (de) * | 2018-01-17 | 2019-07-24 | Siemens Healthcare Diagnostics Products GmbH | Verfahren zur quantitativen bestimmung eines therapeutischen tnf-alpha inhibitors |
US11913951B2 (en) | 2018-03-26 | 2024-02-27 | Alexion Pharmaceuticals, Inc. | High throughput method for measuring the protease activity of complement C3 convertase |
EP3581203A1 (en) | 2018-06-11 | 2019-12-18 | Laboratoire Français du Fractionnement et des Biotechnologies | Antibodies with increased activity in the digestive tract |
US20230312700A1 (en) | 2018-06-20 | 2023-10-05 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a tnf inhibitor |
JP2021529780A (ja) | 2018-07-03 | 2021-11-04 | ノバルティス アーゲー | Nlrp3アンタゴニストを使用するtnf阻害剤に対して抵抗性の対象のための治療の方法又は治療を選択する方法 |
KR20210040827A (ko) | 2018-07-25 | 2021-04-14 | 이노벤트 바이오로직스 (쑤저우) 컴퍼니, 리미티드 | 항 tigit 항체 및 그 용도 |
WO2020053661A1 (en) | 2018-09-13 | 2020-03-19 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Methods of purifying antibodies from the milk of transgenic non-human mammals comprising the use of chitosan |
EP3870168A1 (en) | 2018-10-24 | 2021-09-01 | Novartis AG | Compounds and compositions for treating conditions associated with nlrp activity |
ES2957692T3 (es) | 2018-11-13 | 2024-01-24 | Novartis Ag | Compuestos y composiciones para el tratamiento de afecciones asociadas a la actividad de NLRP |
CN113015730A (zh) | 2018-11-13 | 2021-06-22 | 诺华股份有限公司 | 用于治疗与nlrp活性相关的病症的化合物和组合物 |
US20220249814A1 (en) | 2018-11-19 | 2022-08-11 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
WO2020118011A1 (en) | 2018-12-06 | 2020-06-11 | Alexion Pharmaceuticals, Inc. | Anti-alk2 antibodies and uses thereof |
CN109762067B (zh) | 2019-01-17 | 2020-02-28 | 北京天广实生物技术股份有限公司 | 结合人Claudin 18.2的抗体及其用途 |
WO2020154321A1 (en) | 2019-01-22 | 2020-07-30 | Novartis Inflammasome Research, Inc. | Compounds and compositions for treating conditions associated with nlrp activity |
WO2020157305A1 (en) | 2019-01-31 | 2020-08-06 | Numab Therapeutics AG | Multispecific antibodies having specificity for tnfa and il-17a, antibodies targeting il-17a, and methods of use thereof |
WO2020187760A1 (en) | 2019-03-18 | 2020-09-24 | Alvotech Hf | Aqueous formulations of tnf-alpha antibodies in high concentrations |
WO2021002887A1 (en) | 2019-07-02 | 2021-01-07 | Novartis Inflammasome Research, Inc. | Gut-targeted nlrp3 antagonists and their use in therapy |
EP4309722A2 (en) | 2019-12-13 | 2024-01-24 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
US20230105029A1 (en) | 2020-02-27 | 2023-04-06 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Antibodies binding il4r and uses thereof |
AU2021233503A1 (en) | 2020-03-13 | 2022-09-22 | Samsung Bioepis Co., Ltd. | Liquid pharmaceutical composition having improved stability |
CN115461370A (zh) | 2020-05-12 | 2022-12-09 | 正大天晴药业集团股份有限公司 | St2抗原结合蛋白 |
US11672929B2 (en) | 2020-12-02 | 2023-06-13 | Breathe Restore, Inc. | Product delivery devices and methods |
WO2022133191A2 (en) | 2020-12-18 | 2022-06-23 | Kiniksa Pharmaceuticals, Ltd. | Protein compositions and methods for producing and using the same |
AR124681A1 (es) | 2021-01-20 | 2023-04-26 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
CN117881786A (zh) | 2021-04-27 | 2024-04-12 | 世代生物公司 | 表达治疗性抗体的非病毒dna载体及其用途 |
EP4329884A1 (en) | 2021-04-27 | 2024-03-06 | Generation Bio Co. | Non-viral dna vectors expressing anti-coronavirus antibodies and uses thereof |
CA3226744A1 (en) | 2021-07-27 | 2023-02-02 | Astrazeneca Ab | Treatment of lupus |
KR20240073051A (ko) | 2021-09-16 | 2024-05-24 | 주식회사 에이프로젠 | 항-TNFα 항체를 포함하는 약제학적 조성물 |
WO2023154799A1 (en) | 2022-02-14 | 2023-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Combination immunotherapy for treating cancer |
WO2024054934A1 (en) | 2022-09-07 | 2024-03-14 | Mdx Management Llc | Shp-1 inhibitors for treating cancer |
WO2024097804A1 (en) | 2022-11-02 | 2024-05-10 | Mdx Management Llc | Combination of a tyrosine kinase inhibitor and a pro-inflammatory agent for treating cancer |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1300173C (zh) * | 1996-02-09 | 2007-02-14 | 艾博特生物技术有限公司 | 结合人TNFα的人抗体 |
CN100426232C (zh) * | 2005-10-28 | 2008-10-15 | 纬创资通股份有限公司 | 可开机通用序列总线存储装置的制作方法 |
Family Cites Families (128)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
EP0101681B1 (en) * | 1981-09-08 | 1994-12-14 | The Rockefeller University | Antibody to a mediator activity composition and its use in a pharmaceutical composition |
US4510245A (en) | 1982-11-18 | 1985-04-09 | Chiron Corporation | Adenovirus promoter system |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US5672347A (en) * | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
IL73883A (en) * | 1984-12-20 | 1990-12-23 | Yeda Res & Dev | Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha |
US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
ATE114673T1 (de) * | 1985-08-16 | 1994-12-15 | Univ Rockefeller | Modulator der anabolischen aktivität und seine verwendungen. |
US4870163A (en) | 1985-08-29 | 1989-09-26 | New York Blood Center, Inc. | Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor |
US4968615A (en) | 1985-12-18 | 1990-11-06 | Ciba-Geigy Corporation | Deoxyribonucleic acid segment from a virus |
EP0230574A3 (en) | 1986-01-31 | 1989-03-22 | Yale University | Pharmaceutical compositions against infections caused by lav/htlv iii virus and the use thereof |
US5013249A (en) * | 1986-06-19 | 1991-05-07 | Labinal Components And Systems, Inc. | Electrical connectors |
DE3631229A1 (de) | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
NZ229922A (en) * | 1988-07-18 | 1992-04-28 | Chiron Corp | Monoclonal antibodies specifically binding cachectin (tumor necrosis factor) and compositions |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
EP0366043B1 (en) * | 1988-10-24 | 1994-03-30 | Otsuka Pharmaceutical Co., Ltd. | Monoclonal antibody |
DE68927671T2 (de) | 1988-12-19 | 1997-05-07 | American Cyanamid Co | Produkte zur Behandlung des Endotoxin -Schocks bei einem Säugetier |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
IE63847B1 (en) * | 1989-05-05 | 1995-06-14 | Res Dev Foundation | A novel antibody delivery system for biological response modifiers |
US6498237B2 (en) * | 1989-08-07 | 2002-12-24 | Peptech Limited | Tumor necrosis factor antibodies |
US5959087A (en) * | 1989-08-07 | 1999-09-28 | Peptide Technology, Ltd. | Tumour necrosis factor binding ligands |
CA2064915C (en) | 1989-08-07 | 2001-05-29 | Deborah A. Rathjen | Tumour necrosis factor binding ligands |
FR2651130B1 (fr) * | 1989-08-23 | 1991-12-13 | Roussel Uclaf | Sequence d'oligonucleotides anti-sens, anti-arn message du tnf alpha, procede de preparation, application a titre de medicaments et compositions pharmaceutiques. |
GB8921123D0 (en) | 1989-09-19 | 1989-11-08 | Millar Ann B | Treatment of ards |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
DE4037604A1 (de) | 1990-04-25 | 1991-10-31 | Bayer Ag | Verwendung von anti-tnf-antikoerpern als arzneimittel bei der behandlung von ischaemien und deren folgen |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
ES2139598T3 (es) | 1990-07-10 | 2000-02-16 | Medical Res Council | Procedimientos para la produccion de miembros de parejas de union especifica. |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
WO1992003145A1 (en) | 1990-08-27 | 1992-03-05 | Peptide Technology Ltd. | Method of treating viral infection |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US7084260B1 (en) | 1996-10-10 | 2006-08-01 | Genpharm International, Inc. | High affinity human antibodies and human antibodies against human antigens |
KR100272077B1 (ko) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
GB9022547D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Purified immunoglobulin |
ATE164395T1 (de) | 1990-12-03 | 1998-04-15 | Genentech Inc | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
GB2279077B (en) * | 1990-12-21 | 1995-06-14 | Celltech Ltd | Therapeutic compositions comprising recombinant antibodies specific for the TNFalpha |
US5994510A (en) | 1990-12-21 | 1999-11-30 | Celltech Therapeutics Limited | Recombinant antibodies specific for TNFα |
GB9109645D0 (en) * | 1991-05-03 | 1991-06-26 | Celltech Ltd | Recombinant antibodies |
GB9028123D0 (en) * | 1990-12-28 | 1991-02-13 | Erba Carlo Spa | Monoclonal antibodies against human tumor necrosis factor alpha |
DK1820858T3 (da) | 1991-03-01 | 2009-11-02 | Dyax Corp | Kimært protein omfatende mikroprotein med to eller flere disulfidbindinger og udförelsesformer deraf |
DK0575545T3 (da) | 1991-03-15 | 2003-09-15 | Amgen Inc | Pegylering af polypeptider |
US7192584B2 (en) * | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
US20060246073A1 (en) * | 1991-03-18 | 2006-11-02 | Knight David M | Anti-TNF antibodies and peptides of human tumor necrosis factor |
US20040120952A1 (en) * | 2000-08-07 | 2004-06-24 | Centocor, Inc | Anti-TNF antibodies and peptides of human tumor necrosis factor |
US6277969B1 (en) * | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
US20070298040A1 (en) * | 1991-03-18 | 2007-12-27 | Centocor, Inc. | Methods of treating seronegative arthropathy with anti-TNF antibodies |
US5698195A (en) | 1991-03-18 | 1997-12-16 | New York University Medical Center | Methods of treating rheumatoid arthritis using chimeric anti-TNF antibodies |
US5656272A (en) * | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
ES2156859T5 (es) * | 1991-03-18 | 2008-03-16 | New York University | Anticuerpos monoclonales y quimericos especificos para el factor de necrosis tumoral humano. |
DK0604418T3 (da) | 1991-03-29 | 1999-06-14 | Immunex Corp | Isolerede viralproteincytokinantagonister |
CA2108147C (en) | 1991-04-10 | 2009-01-06 | Angray Kang | Heterodimeric receptor libraries using phagemids |
DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
US5328985A (en) * | 1991-07-12 | 1994-07-12 | The Regents Of The University Of California | Recombinant streptavidin-protein chimeras useful for conjugation of molecules in the immune system |
DE4124758A1 (de) * | 1991-07-25 | 1993-01-28 | Max Planck Gesellschaft | Antitumorwirksame substanz aus humanen makrophagen |
DE69229477T2 (de) * | 1991-09-23 | 1999-12-09 | Cambridge Antibody Tech | Methoden zur Herstellung humanisierter Antikörper |
WO1993011793A1 (en) | 1991-12-17 | 1993-06-24 | Schering Corporation | Use of the combination of anti-tumor necrosis factor plus interleukin-6 to treat septic shock |
WO1993019751A1 (en) | 1992-04-02 | 1993-10-14 | Smithkline Beecham Corporation | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor |
DE69321909T2 (de) | 1992-08-28 | 1999-04-01 | Bayer Ag | Verwendung von monoklonalen Anti-TNF-Antikörpern für die Behandlung von bakteriellen Meningitiden |
AU670125B2 (en) | 1992-09-15 | 1996-07-04 | Immunex Corporation | Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists |
US6270766B1 (en) | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
WO1994008609A1 (en) | 1992-10-15 | 1994-04-28 | Dana-Farber Cancer Institute, Inc. | TREATMENT OF INSULIN RESISTANCE IN OBESITY LINKED TYPE II DIABETES USING ANTAGONISTS TO TNF-α FUNCTION |
ATE204299T1 (de) * | 1993-03-05 | 2001-09-15 | Bayer Ag | Humane monoklonale anti-tnf alpha antikörper |
DE4307508A1 (de) | 1993-03-10 | 1994-09-15 | Knoll Ag | Verwendung von anti-TNF-Antikörpern als Arzneimittel bei der Behandlung von Herzinsuffizienz (Herzmuskelschwäche) |
ES2108460T3 (es) * | 1993-06-03 | 1997-12-16 | Therapeutic Antibodies Inc | Fragmentos de anticuerpos en terapeutica. |
AU8083594A (en) * | 1993-10-19 | 1995-05-08 | Scripps Research Institute, The | Synthetic human neutralizing monoclonal antibodies to human immunodeficiency virus |
EP0659766A1 (en) * | 1993-11-23 | 1995-06-28 | Schering-Plough | Human monoclonal antibodies against human cytokines and methods of making and using such antibodies |
NZ278607A (en) | 1994-02-07 | 1999-05-28 | Knoll Ag | Use of tnf antagonists for treating disorders involving elevated serum levels of il-6 wherein the serum levels are 500pg/ml or above |
JPH09509835A (ja) * | 1994-03-04 | 1997-10-07 | メルク エンド カンパニー インコーポレーテッド | アラニン走査型突然変異誘発によるin vitro抗体アフィニティー成熟 |
US5561053A (en) * | 1994-08-05 | 1996-10-01 | Genentech, Inc. | Method for selecting high-expressing host cells |
US6113898A (en) * | 1995-06-07 | 2000-09-05 | Idec Pharmaceuticals Corporation | Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies |
US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
US20060018907A1 (en) * | 2000-08-07 | 2006-01-26 | Centocor, Inc. | Anti-TNF antibodies and peptides of human tumor necrosis factor |
UA81743C2 (uk) * | 2000-08-07 | 2008-02-11 | Центокор, Инк. | МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ |
US20050249735A1 (en) * | 2000-08-07 | 2005-11-10 | Centocor, Inc. | Methods of treating ankylosing spondylitis using anti-TNF antibodies and peptides of human tumor necrosis factor |
WO2002096461A1 (en) * | 2001-05-25 | 2002-12-05 | Abbott Gmbh & Co. Kg | Use of anti-tnf antibodies as drugs in treating septic disorders of anemic patients |
CA2385745C (en) * | 2001-06-08 | 2015-02-17 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
US20030161828A1 (en) * | 2002-02-19 | 2003-08-28 | Abbott Gmbh & Co. Kg | Use of TNF antagonists as drugs for the treatment of patients with an inflammatory reaction and without suffering from total organ failure |
US20030206898A1 (en) | 2002-04-26 | 2003-11-06 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
US20040009172A1 (en) * | 2002-04-26 | 2004-01-15 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
NZ598346A (en) | 2002-07-19 | 2013-10-25 | Abbvie Biotechnology Ltd | Treatment of tnf alpha related disorders |
US20090280065A1 (en) * | 2006-04-10 | 2009-11-12 | Willian Mary K | Uses and Compositions for Treatment of Psoriasis |
US20040033228A1 (en) * | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
MY150740A (en) * | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
TWI439284B (zh) * | 2004-04-09 | 2014-06-01 | Abbvie Biotechnology Ltd | 用於治療TNFα相關失調症之多重可變劑量療法 |
WO2006041970A2 (en) * | 2004-10-08 | 2006-04-20 | Abbott Biotechnology Ltd. | Treatment of respiratory syncytial virus (rsv) infection |
KR101465456B1 (ko) * | 2005-05-16 | 2014-11-27 | 애브비 바이오테크놀로지 리미티드 | 미란성 다발관절염의 치료를 위한 tnf 억제제의 용도 |
US20070041905A1 (en) * | 2005-08-19 | 2007-02-22 | Hoffman Rebecca S | Method of treating depression using a TNF-alpha antibody |
TW201337266A (zh) | 2005-11-01 | 2013-09-16 | Abbott Biotech Ltd | 利用生物標記診斷關節黏連脊椎炎之方法及組合物 |
SG170837A1 (en) * | 2006-04-05 | 2011-05-30 | Abbott Biotech Ltd | Antibody purification |
EP2010214A4 (en) * | 2006-04-10 | 2010-06-16 | Abbott Biotech Ltd | USES AND COMPOSITIONS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS |
US20090317399A1 (en) * | 2006-04-10 | 2009-12-24 | Pollack Paul F | Uses and compositions for treatment of CROHN'S disease |
US9605064B2 (en) | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
EP2012586A4 (en) * | 2006-04-10 | 2010-08-18 | Abbott Biotech Ltd | USES AND COMPOSITIONS FOR THE TREATMENT OF ANKYLOSANTE SPONDYLARTHRITIS |
EP2666472A3 (en) * | 2006-04-10 | 2014-04-02 | Abbott Biotechnology Ltd | Uses and compositions for treatment of psoriatic arthritis |
US20080118496A1 (en) | 2006-04-10 | 2008-05-22 | Medich John R | Uses and compositions for treatment of juvenile rheumatoid arthritis |
US20080131374A1 (en) | 2006-04-19 | 2008-06-05 | Medich John R | Uses and compositions for treatment of rheumatoid arthritis |
US20100021451A1 (en) * | 2006-06-08 | 2010-01-28 | Wong Robert L | Uses and compositions for treatment of ankylosing spondylitis |
US20080311043A1 (en) | 2006-06-08 | 2008-12-18 | Hoffman Rebecca S | Uses and compositions for treatment of psoriatic arthritis |
TWI498137B (zh) * | 2006-06-30 | 2015-09-01 | Abbvie Biotechnology Ltd | 自動注射裝置 |
MY185872A (en) | 2006-09-13 | 2021-06-14 | Abbvie Inc | Cell culture improvements |
CN101616932A (zh) * | 2006-10-27 | 2009-12-30 | 艾博特生物技术有限公司 | 结晶型抗-hTNFα抗体 |
US8092998B2 (en) | 2007-05-31 | 2012-01-10 | Abbott Laboratories | Biomarkers predictive of the responsiveness to TNFα inhibitors in autoimmune disorders |
EP2152318A4 (en) * | 2007-06-01 | 2011-12-07 | Abbott Biotech Ltd | COMPOSITIONS AND USES FOR THE TREATMENT OF PSORIASIS AND CROHN'S DISEASE |
EP2171451A4 (en) * | 2007-06-11 | 2011-12-07 | Abbott Biotech Ltd | METHOD FOR TREATING JUVENILIAN IDIOPATHIC ARTHRITIS |
CN101848733A (zh) * | 2007-07-13 | 2010-09-29 | 艾博特生物技术有限公司 | 用于肺部给予TNFα抑制剂的方法和组合物 |
RU2010107994A (ru) * | 2007-08-08 | 2011-09-20 | Эбботт Лэборетриз (Us) | Композиции и способы кристаллизации антител |
KR20150080038A (ko) * | 2007-11-30 | 2015-07-08 | 애브비 바이오테크놀로지 리미티드 | 단백질 제형 및 이의 제조방법 |
CA2710333A1 (en) * | 2008-01-03 | 2009-07-09 | Abbott Biotechnology Ltd. | Predicting long-term efficacy of a compound in the treatment of psoriasis |
BRPI0906490A2 (pt) * | 2008-01-15 | 2015-07-14 | Abbott Lab | Vetores de expressão de mamífero melhorados e uso dos mesmos |
CA2711984A1 (en) * | 2008-01-15 | 2009-07-23 | Abbott Gmbh & Co. Kg | Powdered protein compositions and methods of making same |
MX2010010503A (es) * | 2008-03-24 | 2010-11-09 | Abbott Biotech Ltd | Metodos y composiciones para tratar perdida osea. |
RU2524487C2 (ru) * | 2009-04-29 | 2014-07-27 | Эббви Байотекнолоджи Лтд | Автоматическое инъекционное устройство |
CN104490767A (zh) * | 2009-05-04 | 2015-04-08 | 艾伯维生物技术有限公司 | 人抗TNF-α抗体的稳定高蛋白质浓度制剂 |
HUE039740T2 (hu) | 2010-06-03 | 2019-01-28 | Abbvie Biotechnology Ltd | Alkalmazások és készítmények hidradenitis suppurativa (HS) kezelésére |
-
1996
- 1996-02-09 US US08/599,226 patent/US6090382A/en not_active Expired - Lifetime
-
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- 1997-02-10 CN CN2008101088480A patent/CN101302515B/zh not_active Expired - Lifetime
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- 1997-02-10 EP EP10184662A patent/EP2305712A1/en not_active Withdrawn
- 1997-02-10 EP EP10184643.4A patent/EP2357200B1/en not_active Expired - Lifetime
- 1997-02-10 EP EP02022788A patent/EP1285930A3/en not_active Withdrawn
- 1997-02-10 BR BRPI9715219A patent/BRPI9715219C8/pt unknown
- 1997-02-10 CN CN200810212687.XA patent/CN101343324B/zh not_active Expired - Lifetime
- 1997-02-10 EP EP10184680A patent/EP2305713A1/en not_active Withdrawn
- 1997-02-10 EP EP15165128.8A patent/EP2930185A1/en not_active Withdrawn
- 1997-02-10 CN CN200610156666.1A patent/CN101003573B/zh not_active Expired - Lifetime
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- 1997-02-10 EP EP15165138.7A patent/EP2930187A1/en not_active Withdrawn
- 1997-02-10 EP EP15165134.6A patent/EP2930186A1/en not_active Withdrawn
- 1997-02-10 UA UAA200805824A patent/UA102988C2/ru unknown
- 1997-02-10 EP EP15165123.9A patent/EP2933267A1/en not_active Withdrawn
- 1997-02-10 EP EP10184622.8A patent/EP2397494B1/en not_active Expired - Lifetime
- 1997-02-10 NZ NZ598487A patent/NZ598487A/en not_active IP Right Cessation
- 1997-02-10 NZ NZ587678A patent/NZ587678A/en not_active IP Right Cessation
- 1997-02-10 CA CA002596476A patent/CA2596476A1/en not_active Abandoned
- 1997-02-10 CN CNA200610058091XA patent/CN1876683A/zh active Pending
- 1997-02-10 NZ NZ546790A patent/NZ546790A/en not_active IP Right Cessation
- 1997-02-10 RU RU98117079/13A patent/RU2268266C2/ru active
-
2000
- 2000-03-31 US US09/540,018 patent/US6509015B1/en not_active Expired - Lifetime
-
2002
- 2002-11-22 US US10/302,356 patent/US20030219438A1/en not_active Abandoned
-
2005
- 2005-09-21 US US11/233,252 patent/US7588761B2/en not_active Expired - Fee Related
-
2009
- 2009-03-10 US US12/401,469 patent/US8197813B2/en not_active Expired - Fee Related
-
2011
- 2011-12-30 US US13/340,805 patent/US8414894B2/en not_active Expired - Fee Related
-
2012
- 2012-05-08 US US13/466,892 patent/US8372401B2/en not_active Expired - Fee Related
-
2013
- 2013-01-10 US US13/738,432 patent/US20130122018A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1300173C (zh) * | 1996-02-09 | 2007-02-14 | 艾博特生物技术有限公司 | 结合人TNFα的人抗体 |
CN100426232C (zh) * | 2005-10-28 | 2008-10-15 | 纬创资通股份有限公司 | 可开机通用序列总线存储装置的制作方法 |
Non-Patent Citations (2)
Title |
---|
Andrew D.Griffiths.Human anti-self antibodies with high specificity from phage display libraries.The EMBO Journal.1993,12(2),摘要. |
Human anti-self antibodies with high specificity from phage display libraries;Andrew D.Griffiths;The EMBO Journal;19930228;12(2);摘要 * |
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