CH651308A5 - Interferone und deren herstellung. - Google Patents
Interferone und deren herstellung. Download PDFInfo
- Publication number
- CH651308A5 CH651308A5 CH4244/81A CH424481A CH651308A5 CH 651308 A5 CH651308 A5 CH 651308A5 CH 4244/81 A CH4244/81 A CH 4244/81A CH 424481 A CH424481 A CH 424481A CH 651308 A5 CH651308 A5 CH 651308A5
- Authority
- CH
- Switzerland
- Prior art keywords
- fragment
- interferon
- leif
- plasmid
- human leukocyte
- Prior art date
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Life Sciences & Earth Sciences (AREA)
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- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/466,339 US4479833A (en) | 1981-06-26 | 1982-06-22 | Process for manufacturing a semi-finished product or a finished component from a metallic material by hot working |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16498680A | 1980-07-01 | 1980-07-01 | |
| US18490980A | 1980-09-08 | 1980-09-08 | |
| US20557880A | 1980-11-10 | 1980-11-10 | |
| US06/256,204 US6610830B1 (en) | 1980-07-01 | 1981-04-21 | Microbial production of mature human leukocyte interferons |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH651308A5 true CH651308A5 (de) | 1985-09-13 |
Family
ID=27496622
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1475/85A CH657141A5 (de) | 1980-07-01 | 1981-06-26 | Dns-sequenzen, rekombinante expressionsvektoren zur mikrobiellen herstellung von human-leukozyten-interferonen und transformierte mikroorganismen. |
| CH4244/81A CH651308A5 (de) | 1980-07-01 | 1981-06-26 | Interferone und deren herstellung. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1475/85A CH657141A5 (de) | 1980-07-01 | 1981-06-26 | Dns-sequenzen, rekombinante expressionsvektoren zur mikrobiellen herstellung von human-leukozyten-interferonen und transformierte mikroorganismen. |
Country Status (36)
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA811368B (en) * | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
| IE57069B1 (en) | 1980-04-03 | 1992-04-22 | Biogen Inc | Dna sequences,recombinant dna molecules and processes for producing human fibroblast interferon |
| DE3176011D1 (en) * | 1980-06-12 | 1987-04-23 | Japan Found Cancer | Plasmid |
| DK489481A (da) * | 1980-11-10 | 1982-05-11 | Searle & Co | Plasmidvektor og frmgangsmaade til fremstilling deraf |
| NZ199722A (en) * | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
| WO1983000693A1 (en) * | 1981-08-14 | 1983-03-03 | Berg, Kurt, Frimann | SUBJECTS RELATING TO HUMAN INTEFERON-'alpha' SUBTYPE PROTEINS AND CORRESPONDING ANTIBODIES |
| JPS58110548A (ja) * | 1981-12-24 | 1983-07-01 | Asahi Chem Ind Co Ltd | 新規な生理活性ペプチド |
| US4975276A (en) * | 1982-01-15 | 1990-12-04 | Cetus Corporation | Interferon-alpha 54 |
| US5098703A (en) * | 1982-01-15 | 1992-03-24 | Cetus Corporation | Interferon-alpha 76 |
| US4973479A (en) * | 1982-01-15 | 1990-11-27 | Cetus Corporation | Interferon-α61 |
| US5827694A (en) * | 1982-03-08 | 1998-10-27 | Genentech, Inc. | DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides |
| US4775622A (en) * | 1982-03-08 | 1988-10-04 | Genentech, Inc. | Expression, processing and secretion of heterologous protein by yeast |
| IE54592B1 (en) * | 1982-03-08 | 1989-12-06 | Genentech Inc | Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby |
| US6432677B1 (en) | 1982-03-08 | 2002-08-13 | Genentech, Inc. | Non-human animal interferons |
| ATE64618T1 (de) * | 1982-03-15 | 1991-07-15 | Schering Corp | Hybride dns, damit hergestellte bindungszusammensetzung und verfahren dafuer. |
| US4748233A (en) * | 1982-03-23 | 1988-05-31 | Bristol-Myers Company | Alpha-interferon Gx-1 |
| CA1210714A (en) * | 1982-03-23 | 1986-09-02 | Alan Sloma | .alpha.-INTERFERON GX-1 |
| US4695543A (en) * | 1982-03-23 | 1987-09-22 | Bristol-Myers Company | Alpha Interferon GX-1 |
| US6936694B1 (en) * | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| US5831023A (en) * | 1982-11-01 | 1998-11-03 | Genentech, Inc. | Recombinant animal interferon polypeptides |
| GB2150573B (en) * | 1983-02-24 | 1987-11-11 | Inst Organicheskogo Sinteza Ak | Leukocytic human interferon n and method to obtain it in bacterial cells |
| WO1985002862A1 (en) * | 1983-12-23 | 1985-07-04 | Monash University | PRODUCTION OF HUMAN INTERFERON-alpha |
| SU1364343A1 (ru) * | 1984-07-13 | 1988-01-07 | Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов | Способ получени человеческого лейкоцитарного интерферона альфа-2 |
| IL76360A0 (en) | 1984-09-26 | 1986-01-31 | Takeda Chemical Industries Ltd | Mutual separation of proteins |
| WO1986002068A1 (en) * | 1984-09-26 | 1986-04-10 | Takeda Chemical Industries, Ltd. | Mutual separation of proteins |
| US5196323A (en) * | 1985-04-27 | 1993-03-23 | Boehringer Ingelheim International Gmbh | Process for preparing and purifying alpha-interferon |
| DE3515336C2 (de) * | 1985-04-27 | 1994-01-20 | Boehringer Ingelheim Int | Verfahren zur Herstellung und Reinigung von â-Interferon |
| JP2514950B2 (ja) * | 1986-03-10 | 1996-07-10 | エフ・ホフマン―ラ ロシユ アーゲー | 化学修飾蛋白質，その製造法および中間体 |
| JPS6463395A (en) * | 1987-05-04 | 1989-03-09 | Oncogen | Oncostatin m and novel composition having antitumor activity |
| CA1309044C (en) * | 1987-11-09 | 1992-10-20 | Toshiya Takano | Method of producing foreign gene products |
| GB8813032D0 (en) * | 1988-06-02 | 1988-07-06 | Boehringer Ingelheim Int | Antiviral pharmaceutical composition |
| WO1991003251A1 (en) * | 1989-09-08 | 1991-03-21 | California Institute Of Biological Research | Cr2 ligand compositions and methods for modulating immune cell functions |
| DE3932311A1 (de) * | 1989-09-28 | 1991-04-11 | Boehringer Ingelheim Int | Verfahren zur reinigung von beta-interferon |
| ATE227133T1 (de) * | 1994-03-07 | 2002-11-15 | Imperial College | Verwendung von interferon-alpha 8 subtype zur herstellung von medikamenten zur behandlung von viralinfektionen der leber |
| EP1104809A1 (en) * | 1994-04-09 | 2001-06-06 | F. Hoffmann-La Roche Ag | Process for producing alpha-interferon |
| GB9609932D0 (en) * | 1996-05-13 | 1996-07-17 | Hoffmann La Roche | Use of IL-12 and IFN alpha for the treatment of infectious diseases |
| US20030190307A1 (en) | 1996-12-24 | 2003-10-09 | Biogen, Inc. | Stable liquid interferon formulations |
| CA2311681A1 (en) | 1997-12-08 | 1999-06-17 | Genentech, Inc. | Human interferon-epsilon: a type i interferon |
| ZA9811070B (en) | 1997-12-08 | 2000-07-03 | Genentech Inc | Type I interferons. |
| US6783965B1 (en) | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| EP1588716B1 (en) | 1998-08-06 | 2011-02-16 | Mountain View Pharmaceuticals, Inc. | Peg-urate oxidase conjugates and use thereof |
| US6268178B1 (en) | 1999-05-25 | 2001-07-31 | Phage Biotechnology Corp. | Phage-dependent super-production of biologically active protein and peptides |
| JP2004537964A (ja) * | 2000-11-03 | 2004-12-24 | ペストカ バイオメディカル ラボラトリーズ インコーポレイテッド | インターフェロン、それに関する使用及び組成物 |
| FR2822845B1 (fr) | 2001-03-30 | 2003-12-12 | Genodyssee | Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques |
| FR2823220B1 (fr) | 2001-04-04 | 2003-12-12 | Genodyssee | Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo) |
| FR2825716B1 (fr) | 2001-06-11 | 2004-09-24 | Genodyssee | Nouveaux polynucleotides et polypeptides de l'ifn alpha 7 |
| AU2006235495B2 (en) | 2005-04-11 | 2012-04-12 | Horizon Therapeutics Usa, Inc. | Variant forms of urate oxidase and use thereof |
| CN107033233A (zh) * | 2008-01-18 | 2017-08-11 | 弗·哈夫曼-拉罗切有限公司 | 非糖基化蛋白质的纯化 |
| EP2446260B1 (en) | 2009-06-25 | 2018-12-26 | Horizon Pharma Rheumatology LLC | Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy |
| WO2018087345A1 (en) | 2016-11-14 | 2018-05-17 | F. Hoffmann-La Roche Ag | COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON |
| US12269875B2 (en) | 2023-08-03 | 2025-04-08 | Jeff R. Peterson | Gout flare prevention methods using IL-1BETA blockers |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN150740B (enEXAMPLES) * | 1978-11-24 | 1982-12-04 | Hoffmann La Roche | |
| FI77877C (fi) * | 1979-04-20 | 1989-05-10 | Technobiotic Ltd | Foerfarande foer framstaellning och rening av human le-formig interferonprotein. |
| FI86558C (fi) * | 1980-01-08 | 1992-09-10 | Biogen Inc | Dna- sekvenser, rekombinant-dna- molekyler och foerfaranden foer framstaellning av humant interferon av -typ och val av dna-sekvensen. |
| DE3005897A1 (de) * | 1980-02-16 | 1981-09-03 | Hoechst Ag, 6000 Frankfurt | Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus |
| DE3176011D1 (en) * | 1980-06-12 | 1987-04-23 | Japan Found Cancer | Plasmid |
| ES506955A0 (es) * | 1980-11-10 | 1983-02-01 | Genentech Inc | Un procedimiento para producir un polipeptido antiviral. |
| FI64813C (fi) * | 1980-12-31 | 1984-01-10 | Ilkka Antero Palva | Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer |
| DE3280127D1 (de) * | 1981-03-27 | 1990-04-12 | Ici Plc | Genetisch modifizierte mikroorganismen. |
-
1981
- 1981-06-26 CH CH1475/85A patent/CH657141A5/de not_active IP Right Cessation
- 1981-06-26 CH CH4244/81A patent/CH651308A5/de not_active IP Right Cessation
- 1981-06-29 FR FR8112724A patent/FR2486098B1/fr not_active Expired
- 1981-06-29 MC MC811525A patent/MC1396A1/xx unknown
- 1981-06-29 DZ DZ816241A patent/DZ312A1/fr active
- 1981-06-29 HU HU811882A patent/HU196457B/hu unknown
- 1981-06-29 BG BG052673A patent/BG42189A3/xx unknown
- 1981-06-30 AT AT0290981A patent/AT380272B/de not_active IP Right Cessation
- 1981-06-30 AR AR81285934A patent/AR242833A1/es active
- 1981-06-30 AT AT81105067T patent/ATE29727T1/de not_active IP Right Cessation
- 1981-06-30 GR GR65379A patent/GR75714B/el unknown
- 1981-06-30 DE DE8181105067T patent/DE3176448D1/de not_active Expired
- 1981-06-30 IE IE1463/81A patent/IE49255B1/en not_active IP Right Cessation
- 1981-06-30 NL NL8103151A patent/NL8103151A/nl not_active Application Discontinuation
- 1981-06-30 SU SU813302642A patent/SU1414319A3/ru active
- 1981-06-30 NO NO812247A patent/NO159392C/no not_active IP Right Cessation
- 1981-06-30 RO RO81104732A patent/RO87590A/ro unknown
- 1981-06-30 AT AT86105365T patent/ATE79901T1/de not_active IP Right Cessation
- 1981-06-30 SE SE8104093A patent/SE465223C5/xx not_active IP Right Cessation
- 1981-06-30 YU YU162281A patent/YU47700B/sh unknown
- 1981-06-30 LU LU83461A patent/LU83461A1/de unknown
- 1981-06-30 DE DE3125706A patent/DE3125706C2/de not_active Expired - Lifetime
- 1981-06-30 CS CS503781A patent/CS273152B2/cs unknown
- 1981-06-30 ES ES503528A patent/ES8207514A1/es not_active Expired
- 1981-06-30 PL PL1981255774A patent/PL148276B1/pl unknown
- 1981-06-30 DE DE3177288T patent/DE3177288T3/de not_active Expired - Lifetime
- 1981-06-30 DK DK198102910A patent/DK173543B1/da not_active IP Right Cessation
- 1981-06-30 EP EP81105067A patent/EP0043980B1/en not_active Expired
- 1981-06-30 SE SE8104093D patent/SE8104093L/xx not_active Application Discontinuation
- 1981-06-30 PL PL1981255773A patent/PL148261B1/pl unknown
- 1981-06-30 PL PL1981231940A patent/PL148260B1/pl unknown
- 1981-06-30 NZ NZ197572A patent/NZ197572A/en unknown
- 1981-06-30 EP EP86105365A patent/EP0211148B2/en not_active Expired - Lifetime
- 1981-06-30 PT PT73289A patent/PT73289B/pt unknown
- 1981-07-01 PH PH25843A patent/PH18036A/en unknown
- 1981-07-01 FI FI812067A patent/FI82712C/fi not_active IP Right Cessation
- 1981-07-01 DD DD81255299A patent/DD210304A5/de not_active IP Right Cessation
- 1981-07-01 IT IT22682/81A patent/IT1137272B/it active Protection Beyond IP Right Term
- 1981-07-01 GB GB8120279A patent/GB2079291B/en not_active Expired
- 1981-07-01 AU AU72462/81A patent/AU552004B2/en not_active Expired
- 1981-07-01 DD DD81231371A patent/DD202307A5/de not_active IP Right Cessation
- 1981-07-01 BR BR8104189A patent/BR8104189A/pt unknown
- 1981-07-01 DD DD81255300A patent/DD210305A5/de not_active IP Right Cessation
-
1985
- 1985-05-21 KE KE3534A patent/KE3534A/xx unknown
- 1985-06-27 HK HK492/85A patent/HK49285A/xx not_active IP Right Cessation
-
1987
- 1987-12-30 MY MY711/87A patent/MY8700711A/xx unknown
-
1993
- 1993-07-12 GE GEAP1993999A patent/GEP19960519B/en unknown
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Legal Events
| Date | Code | Title | Description |
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| PUE | Assignment |
Owner name: F. HOFFMANN-LA ROCHE AG |
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| PL | Patent ceased |