AU552004B2 - Interferons and process for their preparation - Google Patents

Interferons and process for their preparation

Info

Publication number
AU552004B2
AU552004B2 AU72462/81A AU7246281A AU552004B2 AU 552004 B2 AU552004 B2 AU 552004B2 AU 72462/81 A AU72462/81 A AU 72462/81A AU 7246281 A AU7246281 A AU 7246281A AU 552004 B2 AU552004 B2 AU 552004B2
Authority
AU
Australia
Prior art keywords
interferons
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired, expires
Application number
AU72462/81A
Other languages
English (en)
Other versions
AU7246281A (en
Inventor
Sidney Pestka
David Van Norman Goeddel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Genentech Inc
Original Assignee
F Hoffmann La Roche AG
Genentech Inc
Hoffmann La Roche Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU552004(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/256,204 external-priority patent/US6610830B1/en
Application filed by F Hoffmann La Roche AG, Genentech Inc, Hoffmann La Roche Inc filed Critical F Hoffmann La Roche AG
Publication of AU7246281A publication Critical patent/AU7246281A/en
Application granted granted Critical
Publication of AU552004B2 publication Critical patent/AU552004B2/en
Adjusted expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU72462/81A 1980-07-01 1981-07-01 Interferons and process for their preparation Expired AU552004B2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US16498680A 1980-07-01 1980-07-01
US164986 1980-07-01
US18490980A 1980-09-08 1980-09-08
US184909 1980-09-08
US20557880A 1980-11-10 1980-11-10
US205578 1980-11-10
US06/256,204 US6610830B1 (en) 1980-07-01 1981-04-21 Microbial production of mature human leukocyte interferons
US256204 1981-04-21

Publications (2)

Publication Number Publication Date
AU7246281A AU7246281A (en) 1982-01-07
AU552004B2 true AU552004B2 (en) 1986-05-22

Family

ID=27496622

Family Applications (1)

Application Number Title Priority Date Filing Date
AU72462/81A Expired AU552004B2 (en) 1980-07-01 1981-07-01 Interferons and process for their preparation

Country Status (36)

Country Link
EP (2) EP0211148B2 (enEXAMPLES)
AR (1) AR242833A1 (enEXAMPLES)
AT (3) ATE29727T1 (enEXAMPLES)
AU (1) AU552004B2 (enEXAMPLES)
BG (1) BG42189A3 (enEXAMPLES)
BR (1) BR8104189A (enEXAMPLES)
CH (2) CH651308A5 (enEXAMPLES)
CS (1) CS273152B2 (enEXAMPLES)
DD (3) DD210305A5 (enEXAMPLES)
DE (3) DE3176448D1 (enEXAMPLES)
DK (1) DK173543B1 (enEXAMPLES)
DZ (1) DZ312A1 (enEXAMPLES)
ES (1) ES503528A0 (enEXAMPLES)
FI (1) FI82712C (enEXAMPLES)
FR (1) FR2486098B1 (enEXAMPLES)
GB (1) GB2079291B (enEXAMPLES)
GE (1) GEP19960519B (enEXAMPLES)
GR (1) GR75714B (enEXAMPLES)
HK (1) HK49285A (enEXAMPLES)
HU (1) HU196457B (enEXAMPLES)
IE (1) IE49255B1 (enEXAMPLES)
IT (1) IT1137272B (enEXAMPLES)
KE (1) KE3534A (enEXAMPLES)
LU (1) LU83461A1 (enEXAMPLES)
MC (1) MC1396A1 (enEXAMPLES)
MY (1) MY8700711A (enEXAMPLES)
NL (1) NL8103151A (enEXAMPLES)
NO (1) NO159392C (enEXAMPLES)
NZ (1) NZ197572A (enEXAMPLES)
PH (1) PH18036A (enEXAMPLES)
PL (3) PL148260B1 (enEXAMPLES)
PT (1) PT73289B (enEXAMPLES)
RO (1) RO87590A (enEXAMPLES)
SE (2) SE465223C5 (enEXAMPLES)
SU (1) SU1414319A3 (enEXAMPLES)
YU (1) YU47700B (enEXAMPLES)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU580959B2 (en) * 1980-03-24 1989-02-09 Genentech Inc. A method of cleving double stranded DNA

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR74498B (enEXAMPLES) 1980-04-03 1984-06-28 Biogen Inc
EP0042246B1 (en) * 1980-06-12 1987-03-18 The Cancer Institute Of Japanese Foundation For Cancer Research Plasmid
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
WO1983000693A1 (en) * 1981-08-14 1983-03-03 Berg, Kurt, Frimann SUBJECTS RELATING TO HUMAN INTEFERON-'alpha' SUBTYPE PROTEINS AND CORRESPONDING ANTIBODIES
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
EP0088994B1 (en) * 1982-03-15 1991-06-19 Schering Corporation Hybrid dna, binding composition prepared thereby and processes therefor
US4695543A (en) * 1982-03-23 1987-09-22 Bristol-Myers Company Alpha Interferon GX-1
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
US4748233A (en) * 1982-03-23 1988-05-31 Bristol-Myers Company Alpha-interferon Gx-1
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
FR2541579B1 (fr) * 1983-02-24 1987-12-18 Inst Organicheskogo Sinteza Ak Interferon n leucocytaire humain et procede d'obtention de celui-ci dans les cellules bacteriennes
EP0165942A1 (en) * 1983-12-23 1986-01-02 Monash University PRODUCTION OF HUMAN INTERFERON-$g(a)
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
WO1986002068A1 (en) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Mutual separation of proteins
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
CA1309044C (en) * 1987-11-09 1992-10-20 Toshiya Takano Method of producing foreign gene products
GB8813032D0 (en) * 1988-06-02 1988-07-06 Boehringer Ingelheim Int Antiviral pharmaceutical composition
WO1991003251A1 (en) * 1989-09-08 1991-03-21 California Institute Of Biological Research Cr2 ligand compositions and methods for modulating immune cell functions
DE3932311A1 (de) * 1989-09-28 1991-04-11 Boehringer Ingelheim Int Verfahren zur reinigung von beta-interferon
EP0741577B1 (en) * 1994-03-07 2002-11-06 IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE The use of interferon subtype alpha 8 in the preparation of medicaments to treat viral infections of the liver
ES2161793T3 (es) * 1994-04-09 2001-12-16 Hoffmann La Roche Proceso para la produccion de alfa-interferona.
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
US6299869B1 (en) 1997-12-08 2001-10-09 Genentech, Inc. Human interferon-epsilon: a type I interferon
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
CN1896231B (zh) 1998-08-06 2012-09-05 山景药品公司 分离四聚体尿酸氧化酶的方法
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
IL155741A0 (en) * 2000-11-03 2003-12-23 Pbl Biomedical Lab Interferons, uses and compositions related thereto
FR2822845B1 (fr) 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr) 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
CA2604399A1 (en) 2005-04-11 2006-10-19 Savient Pharmaceuticals, Inc. Variant forms of urate oxidase and use thereof
CN107033233A (zh) * 2008-01-18 2017-08-11 弗·哈夫曼-拉罗切有限公司 非糖基化蛋白质的纯化
SG10201408480RA (en) 2009-06-25 2015-02-27 Crealta Pharmaceuticals Llc Methods for preventing or predicting infusion reactions or antibody-mediated loss of response, by monitoring serum uric acid levels during pegylated uricase therapy
WO2018087345A1 (en) 2016-11-14 2018-05-17 F. Hoffmann-La Roche Ag COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (enEXAMPLES) * 1978-11-24 1982-12-04 Hoffmann La Roche
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
NZ195980A (en) * 1980-01-08 1984-10-19 Biogen Nv Dna sequences,recombinant dna molecules and processes for producing leukocyte interferon-like polypeptides;pharmaceutical and veterinary compositions
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
EP0042246B1 (en) * 1980-06-12 1987-03-18 The Cancer Institute Of Japanese Foundation For Cancer Research Plasmid
ES8302778A1 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
DE3280127D1 (de) * 1981-03-27 1990-04-12 Ici Plc Genetisch modifizierte mikroorganismen.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU580959B2 (en) * 1980-03-24 1989-02-09 Genentech Inc. A method of cleving double stranded DNA

Also Published As

Publication number Publication date
CH657141A5 (de) 1986-08-15
PT73289B (en) 1983-05-11
DE3176448D1 (en) 1987-10-22
BG42189A3 (en) 1987-10-15
BR8104189A (pt) 1982-03-16
FR2486098B1 (fr) 1985-12-27
IE49255B1 (en) 1985-09-04
YU47700B (sh) 1996-01-08
DE3177288T3 (de) 2000-03-16
CS503781A2 (en) 1990-07-12
CS273152B2 (en) 1991-03-12
FI82712B (fi) 1990-12-31
ES8207514A1 (es) 1982-10-01
GR75714B (enEXAMPLES) 1984-08-02
GB2079291B (en) 1984-06-13
YU162281A (en) 1984-02-29
DD210305A5 (de) 1984-06-06
EP0043980A3 (en) 1982-09-15
EP0211148A1 (en) 1987-02-25
DE3177288D1 (de) 1992-10-01
NL8103151A (nl) 1982-02-01
NZ197572A (en) 1985-07-31
CH651308A5 (de) 1985-09-13
LU83461A1 (de) 1983-04-06
ATE29727T1 (de) 1987-10-15
HK49285A (en) 1985-07-05
DE3177288T2 (de) 1992-12-10
EP0043980A2 (en) 1982-01-20
SE465223B (sv) 1991-08-12
ATE79901T1 (de) 1992-09-15
SE8104093L (sv) 1982-01-02
ATA290981A (de) 1985-09-15
EP0043980B1 (en) 1987-09-16
DE3125706C2 (de) 1995-05-24
DD210304A5 (de) 1984-06-06
NO159392C (no) 1988-12-21
AU7246281A (en) 1982-01-07
FR2486098A1 (fr) 1982-01-08
MY8700711A (en) 1987-12-31
PL231940A1 (en) 1983-07-18
HU196457B (en) 1988-11-28
PT73289A (en) 1981-07-01
IE811463L (en) 1982-01-01
AR242833A1 (es) 1993-05-31
KE3534A (en) 1985-06-07
DK291081A (da) 1982-01-02
PL148276B1 (en) 1989-09-30
AT380272B (de) 1986-05-12
PL148261B1 (en) 1989-09-30
DE3125706A1 (de) 1982-04-15
MC1396A1 (fr) 1982-04-27
PL148260B1 (en) 1989-09-30
GB2079291A (en) 1982-01-20
FI82712C (fi) 1991-04-10
IT1137272B (it) 1986-09-03
GEP19960519B (en) 1996-07-02
DZ312A1 (fr) 2004-09-13
EP0211148B1 (en) 1992-08-26
NO159392B (no) 1988-09-12
SU1414319A3 (ru) 1988-07-30
IT8122682A0 (it) 1981-07-01
DD202307A5 (de) 1983-09-07
EP0211148B2 (en) 1999-11-24
DK173543B1 (da) 2001-02-05
RO87590A (ro) 1986-07-30
NO812247L (no) 1982-01-04
SE465223C5 (sv) 1998-02-10
PH18036A (en) 1985-03-06
ES503528A0 (es) 1982-10-01
FI812067L (fi) 1982-01-02

Similar Documents

Publication Publication Date Title
AU552004B2 (en) Interferons and process for their preparation
ZW14781A1 (en) Interferons and process for their preparation
DE3067058D1 (en) Dipyridamol retard-forms and process for their preparation
IL67022A (en) 2-halo-3-chloro-5-haloalkylpyridines and process for their preparation
AU6670581A (en) Powder forms and articles
AU7803281A (en) Pharmaceutical compound and method
ZA814375B (en) Interferons and process for their preparation
EP0034741A3 (en) Substituted bromofluorobenzene and process for its preparation
GB2068957B (en) Thioloesters and process for their preparation
DE3166969D1 (en) 6-quinazolinesulfonyl derivatives and process for preparation thereof
AU524882B2 (en) Carbapenams and carbapen-2-ems
GB2083477B (en) Endoproteinase-lys-c and process for the preparation thereof
GB2071655B (en) N-amidazolyl derivatives of1-chroman and process for their preparation
AU1898983A (en) Perfluoroalkylmaleinamides and perfluoroalkylfumaramides
AU557398B2 (en) 7-oxoprostacyclin derivatives and process for the preparation thereof
DE3166862D1 (en) Bromopolyfluoralkylthioethers and process for their preparation
DE3071273D1 (en) Disoxidant and process for preparing same
DE3169906D1 (en) 17-beta-ethynylsteroids and process for preparing same
DE3160397D1 (en) Phenoxyalkane derivative and processes for preparing same
AU524033B2 (en) Process
MTP892B (en) Interferons and process for their preparation
AU539462B2 (en) Disoxidant and process for preparing same
AU6038180A (en) Depalletisers and palletisers
AU8881682A (en) Biphenylmethanols and derivatives thereof
AU521934B2 (en) Process

Legal Events

Date Code Title Description
NDB Extension of term for standard patent granted (sect.76)

Free format text: PRODUCT NAME: INTERFERON ALFA-2A (PRODUCED BY RECOMBINANT DNA TECHNOLOGY)

Extension date: 20020731

MK14 Patent ceased section 143(a) (annual fees not paid) or expired