DE3176448D1 - Mature human leukocyte interferon a, process for its microbial preparation, intermediates therefor and compositions containing it. - Google Patents

Mature human leukocyte interferon a, process for its microbial preparation, intermediates therefor and compositions containing it.

Info

Publication number
DE3176448D1
DE3176448D1 DE8181105067T DE3176448T DE3176448D1 DE 3176448 D1 DE3176448 D1 DE 3176448D1 DE 8181105067 T DE8181105067 T DE 8181105067T DE 3176448 T DE3176448 T DE 3176448T DE 3176448 D1 DE3176448 D1 DE 3176448D1
Authority
DE
Germany
Prior art keywords
compositions containing
mature human
human leukocyte
microbial preparation
leukocyte interferon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181105067T
Other languages
German (de)
English (en)
Inventor
David Van Norman Goeddel
Sidney Pestka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3176448(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/256,204 external-priority patent/US6610830B1/en
Application filed by F Hoffmann La Roche AG, Genentech Inc filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE3176448D1 publication Critical patent/DE3176448D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE8181105067T 1980-07-01 1981-06-30 Mature human leukocyte interferon a, process for its microbial preparation, intermediates therefor and compositions containing it. Expired DE3176448D1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16498680A 1980-07-01 1980-07-01
US18490980A 1980-09-08 1980-09-08
US20557880A 1980-11-10 1980-11-10
US06/256,204 US6610830B1 (en) 1980-07-01 1981-04-21 Microbial production of mature human leukocyte interferons

Publications (1)

Publication Number Publication Date
DE3176448D1 true DE3176448D1 (en) 1987-10-22

Family

ID=27496622

Family Applications (3)

Application Number Title Priority Date Filing Date
DE8181105067T Expired DE3176448D1 (en) 1980-07-01 1981-06-30 Mature human leukocyte interferon a, process for its microbial preparation, intermediates therefor and compositions containing it.
DE3125706A Expired - Lifetime DE3125706C2 (de) 1980-07-01 1981-06-30 Polypeptide mit der Aminosäuresequenz eines reifen Human-Leukozyten-Interferons ohne Präsequenz, deren Herstellung und Verwendung
DE3177288T Expired - Lifetime DE3177288T3 (de) 1980-07-01 1981-06-30 Reife menschliche Leukozyten-Interferone, Verfahren zu ihrer bacteriellen Herstellung, Zwischenprodukte hierfür und Zusammensetzungen diese enthaltend.

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE3125706A Expired - Lifetime DE3125706C2 (de) 1980-07-01 1981-06-30 Polypeptide mit der Aminosäuresequenz eines reifen Human-Leukozyten-Interferons ohne Präsequenz, deren Herstellung und Verwendung
DE3177288T Expired - Lifetime DE3177288T3 (de) 1980-07-01 1981-06-30 Reife menschliche Leukozyten-Interferone, Verfahren zu ihrer bacteriellen Herstellung, Zwischenprodukte hierfür und Zusammensetzungen diese enthaltend.

Country Status (36)

Country Link
EP (2) EP0043980B1 (enEXAMPLES)
AR (1) AR242833A1 (enEXAMPLES)
AT (3) AT380272B (enEXAMPLES)
AU (1) AU552004B2 (enEXAMPLES)
BG (1) BG42189A3 (enEXAMPLES)
BR (1) BR8104189A (enEXAMPLES)
CH (2) CH657141A5 (enEXAMPLES)
CS (1) CS273152B2 (enEXAMPLES)
DD (3) DD210304A5 (enEXAMPLES)
DE (3) DE3176448D1 (enEXAMPLES)
DK (1) DK173543B1 (enEXAMPLES)
DZ (1) DZ312A1 (enEXAMPLES)
ES (1) ES8207514A1 (enEXAMPLES)
FI (1) FI82712C (enEXAMPLES)
FR (1) FR2486098B1 (enEXAMPLES)
GB (1) GB2079291B (enEXAMPLES)
GE (1) GEP19960519B (enEXAMPLES)
GR (1) GR75714B (enEXAMPLES)
HK (1) HK49285A (enEXAMPLES)
HU (1) HU196457B (enEXAMPLES)
IE (1) IE49255B1 (enEXAMPLES)
IT (1) IT1137272B (enEXAMPLES)
KE (1) KE3534A (enEXAMPLES)
LU (1) LU83461A1 (enEXAMPLES)
MC (1) MC1396A1 (enEXAMPLES)
MY (1) MY8700711A (enEXAMPLES)
NL (1) NL8103151A (enEXAMPLES)
NO (1) NO159392C (enEXAMPLES)
NZ (1) NZ197572A (enEXAMPLES)
PH (1) PH18036A (enEXAMPLES)
PL (3) PL148276B1 (enEXAMPLES)
PT (1) PT73289B (enEXAMPLES)
RO (1) RO87590A (enEXAMPLES)
SE (2) SE465223C5 (enEXAMPLES)
SU (1) SU1414319A3 (enEXAMPLES)
YU (1) YU47700B (enEXAMPLES)

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ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
IE57069B1 (en) 1980-04-03 1992-04-22 Biogen Inc Dna sequences,recombinant dna molecules and processes for producing human fibroblast interferon
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
WO1983000693A1 (en) * 1981-08-14 1983-03-03 Berg, Kurt, Frimann SUBJECTS RELATING TO HUMAN INTEFERON-'alpha' SUBTYPE PROTEINS AND CORRESPONDING ANTIBODIES
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
ATE64618T1 (de) * 1982-03-15 1991-07-15 Schering Corp Hybride dns, damit hergestellte bindungszusammensetzung und verfahren dafuer.
US4748233A (en) * 1982-03-23 1988-05-31 Bristol-Myers Company Alpha-interferon Gx-1
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
US4695543A (en) * 1982-03-23 1987-09-22 Bristol-Myers Company Alpha Interferon GX-1
US6936694B1 (en) * 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
GB2150573B (en) * 1983-02-24 1987-11-11 Inst Organicheskogo Sinteza Ak Leukocytic human interferon n and method to obtain it in bacterial cells
WO1985002862A1 (en) * 1983-12-23 1985-07-04 Monash University PRODUCTION OF HUMAN INTERFERON-alpha
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
WO1986002068A1 (en) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Mutual separation of proteins
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
CA1309044C (en) * 1987-11-09 1992-10-20 Toshiya Takano Method of producing foreign gene products
GB8813032D0 (en) * 1988-06-02 1988-07-06 Boehringer Ingelheim Int Antiviral pharmaceutical composition
WO1991003251A1 (en) * 1989-09-08 1991-03-21 California Institute Of Biological Research Cr2 ligand compositions and methods for modulating immune cell functions
DE3932311A1 (de) * 1989-09-28 1991-04-11 Boehringer Ingelheim Int Verfahren zur reinigung von beta-interferon
ATE227133T1 (de) * 1994-03-07 2002-11-15 Imperial College Verwendung von interferon-alpha 8 subtype zur herstellung von medikamenten zur behandlung von viralinfektionen der leber
EP1104809A1 (en) * 1994-04-09 2001-06-06 F. Hoffmann-La Roche Ag Process for producing alpha-interferon
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
CA2311681A1 (en) 1997-12-08 1999-06-17 Genentech, Inc. Human interferon-epsilon: a type i interferon
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
EP1588716B1 (en) 1998-08-06 2011-02-16 Mountain View Pharmaceuticals, Inc. Peg-urate oxidase conjugates and use thereof
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
JP2004537964A (ja) * 2000-11-03 2004-12-24 ペストカ バイオメディカル ラボラトリーズ インコーポレイテッド インターフェロン、それに関する使用及び組成物
FR2822845B1 (fr) 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr) 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
AU2006235495B2 (en) 2005-04-11 2012-04-12 Horizon Therapeutics Usa, Inc. Variant forms of urate oxidase and use thereof
CN107033233A (zh) * 2008-01-18 2017-08-11 弗·哈夫曼-拉罗切有限公司 非糖基化蛋白质的纯化
EP2446260B1 (en) 2009-06-25 2018-12-26 Horizon Pharma Rheumatology LLC Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
WO2018087345A1 (en) 2016-11-14 2018-05-17 F. Hoffmann-La Roche Ag COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
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IN150740B (enEXAMPLES) * 1978-11-24 1982-12-04 Hoffmann La Roche
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
FI86558C (fi) * 1980-01-08 1992-09-10 Biogen Inc Dna- sekvenser, rekombinant-dna- molekyler och foerfaranden foer framstaellning av humant interferon av -typ och val av dna-sekvensen.
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
ES506955A0 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
DE3280127D1 (de) * 1981-03-27 1990-04-12 Ici Plc Genetisch modifizierte mikroorganismen.

Also Published As

Publication number Publication date
PL148260B1 (en) 1989-09-30
DK291081A (da) 1982-01-02
BG42189A3 (en) 1987-10-15
GB2079291B (en) 1984-06-13
FI82712C (fi) 1991-04-10
ES503528A0 (es) 1982-10-01
FI812067L (fi) 1982-01-02
DE3177288T3 (de) 2000-03-16
GEP19960519B (en) 1996-07-02
ATE29727T1 (de) 1987-10-15
IE811463L (en) 1982-01-01
DD202307A5 (de) 1983-09-07
HK49285A (en) 1985-07-05
EP0211148B1 (en) 1992-08-26
PL148261B1 (en) 1989-09-30
PT73289A (en) 1981-07-01
DE3125706C2 (de) 1995-05-24
MY8700711A (en) 1987-12-31
ATE79901T1 (de) 1992-09-15
NL8103151A (nl) 1982-02-01
NO159392B (no) 1988-09-12
DD210304A5 (de) 1984-06-06
ATA290981A (de) 1985-09-15
AT380272B (de) 1986-05-12
FR2486098A1 (fr) 1982-01-08
EP0043980A3 (en) 1982-09-15
YU47700B (sh) 1996-01-08
EP0043980B1 (en) 1987-09-16
SU1414319A3 (ru) 1988-07-30
IT8122682A0 (it) 1981-07-01
IE49255B1 (en) 1985-09-04
DE3125706A1 (de) 1982-04-15
NO812247L (no) 1982-01-04
SE8104093L (sv) 1982-01-02
AU7246281A (en) 1982-01-07
PL231940A1 (en) 1983-07-18
AU552004B2 (en) 1986-05-22
EP0211148A1 (en) 1987-02-25
PL148276B1 (en) 1989-09-30
NO159392C (no) 1988-12-21
KE3534A (en) 1985-06-07
ES8207514A1 (es) 1982-10-01
BR8104189A (pt) 1982-03-16
LU83461A1 (de) 1983-04-06
GB2079291A (en) 1982-01-20
AR242833A1 (es) 1993-05-31
FI82712B (fi) 1990-12-31
IT1137272B (it) 1986-09-03
SE465223B (sv) 1991-08-12
CH651308A5 (de) 1985-09-13
EP0211148B2 (en) 1999-11-24
DE3177288D1 (de) 1992-10-01
RO87590A (ro) 1986-07-30
YU162281A (en) 1984-02-29
NZ197572A (en) 1985-07-31
MC1396A1 (fr) 1982-04-27
DK173543B1 (da) 2001-02-05
HU196457B (en) 1988-11-28
DD210305A5 (de) 1984-06-06
PT73289B (en) 1983-05-11
EP0043980A2 (en) 1982-01-20
CS503781A2 (en) 1990-07-12
CH657141A5 (de) 1986-08-15
CS273152B2 (en) 1991-03-12
GR75714B (enEXAMPLES) 1984-08-02
SE465223C5 (sv) 1998-02-10
PH18036A (en) 1985-03-06
DZ312A1 (fr) 2004-09-13
FR2486098B1 (fr) 1985-12-27
DE3177288T2 (de) 1992-12-10

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Legal Events

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8327 Change in the person/name/address of the patent owner

Owner name: F. HOFFMANN-LA ROCHE AG, BASEL, CH GENENTECH, INC.