CH641670A5 - Preparations therapeutiques a liberation prolongee a base d'hydroxypropylmethylcellulose. - Google Patents
Preparations therapeutiques a liberation prolongee a base d'hydroxypropylmethylcellulose. Download PDFInfo
- Publication number
- CH641670A5 CH641670A5 CH730582A CH730582A CH641670A5 CH 641670 A5 CH641670 A5 CH 641670A5 CH 730582 A CH730582 A CH 730582A CH 730582 A CH730582 A CH 730582A CH 641670 A5 CH641670 A5 CH 641670A5
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- CH
- Switzerland
- Prior art keywords
- preparation according
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- active medicament
- active
- chosen
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims description 54
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 title claims description 43
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 title claims description 43
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 title claims description 34
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 title claims description 33
- 230000001225 therapeutic effect Effects 0.000 title claims description 6
- 238000013268 sustained release Methods 0.000 title description 5
- 239000012730 sustained-release form Substances 0.000 title description 5
- 239000003814 drug Substances 0.000 claims description 78
- -1 hydroxypropoxyl Chemical group 0.000 claims description 43
- 229940079593 drug Drugs 0.000 claims description 39
- 239000000203 mixture Substances 0.000 claims description 21
- 230000002035 prolonged effect Effects 0.000 claims description 17
- 239000000126 substance Substances 0.000 claims description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 8
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 8
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims description 7
- 239000001856 Ethyl cellulose Substances 0.000 claims description 6
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 6
- 229920001249 ethyl cellulose Polymers 0.000 claims description 6
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 6
- 229960000201 isosorbide dinitrate Drugs 0.000 claims description 6
- MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 claims description 6
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 claims description 6
- 229910052808 lithium carbonate Inorganic materials 0.000 claims description 6
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims description 6
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims description 5
- 210000004369 blood Anatomy 0.000 claims description 5
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- 229960002085 oxycodone Drugs 0.000 claims description 5
- RPTUSVTUFVMDQK-UHFFFAOYSA-N Hidralazin Chemical compound C1=CC=C2C(NN)=NN=CC2=C1 RPTUSVTUFVMDQK-UHFFFAOYSA-N 0.000 claims description 4
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 4
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- 239000011668 ascorbic acid Substances 0.000 claims description 4
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 4
- 230000002496 gastric effect Effects 0.000 claims description 4
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 claims description 4
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- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 claims description 4
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 4
- 239000000932 sedative agent Substances 0.000 claims description 4
- 229940124549 vasodilator Drugs 0.000 claims description 4
- 239000003071 vasodilator agent Substances 0.000 claims description 4
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 3
- KBAFPSLPKGSANY-UHFFFAOYSA-N Naftidrofuryl Chemical compound C=1C=CC2=CC=CC=C2C=1CC(C(=O)OCCN(CC)CC)CC1CCCO1 KBAFPSLPKGSANY-UHFFFAOYSA-N 0.000 claims description 3
- TZRXHJWUDPFEEY-UHFFFAOYSA-N Pentaerythritol Tetranitrate Chemical compound [O-][N+](=O)OCC(CO[N+]([O-])=O)(CO[N+]([O-])=O)CO[N+]([O-])=O TZRXHJWUDPFEEY-UHFFFAOYSA-N 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 3
- 229940069428 antacid Drugs 0.000 claims description 3
- 239000003159 antacid agent Substances 0.000 claims description 3
- 230000001142 anti-diarrhea Effects 0.000 claims description 3
- 230000002924 anti-infective effect Effects 0.000 claims description 3
- 230000001062 anti-nausea Effects 0.000 claims description 3
- 239000000924 antiasthmatic agent Substances 0.000 claims description 3
- 239000001961 anticonvulsive agent Substances 0.000 claims description 3
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- 229940124584 antitussives Drugs 0.000 claims description 3
- 230000002490 cerebral effect Effects 0.000 claims description 3
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims description 3
- 239000000850 decongestant Substances 0.000 claims description 3
- 229960004166 diltiazem Drugs 0.000 claims description 3
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 claims description 3
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- HYPPXZBJBPSRLK-UHFFFAOYSA-N diphenoxylate Chemical group C1CC(C(=O)OCC)(C=2C=CC=CC=2)CCN1CCC(C#N)(C=1C=CC=CC=1)C1=CC=CC=C1 HYPPXZBJBPSRLK-UHFFFAOYSA-N 0.000 claims description 3
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- DBGIVFWFUFKIQN-UHFFFAOYSA-N (+-)-Fenfluramine Chemical compound CCNC(C)CC1=CC=CC(C(F)(F)F)=C1 DBGIVFWFUFKIQN-UHFFFAOYSA-N 0.000 claims description 2
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- YKFCISHFRZHKHY-NGQGLHOPSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;trihydrate Chemical compound O.O.O.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 YKFCISHFRZHKHY-NGQGLHOPSA-N 0.000 claims description 2
- DKSZLDSPXIWGFO-BLOJGBSASA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;phosphoric acid;hydrate Chemical compound O.OP(O)(O)=O.OP(O)(O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC DKSZLDSPXIWGFO-BLOJGBSASA-N 0.000 claims description 2
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- SEVKYLYIYIKRSW-UHFFFAOYSA-N 1-phenylpropan-2-ylazanium;chloride Chemical compound Cl.CC(N)CC1=CC=CC=C1 SEVKYLYIYIKRSW-UHFFFAOYSA-N 0.000 claims description 2
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- 230000000506 psychotropic effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 229940098466 sublingual tablet Drugs 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- KFVSLSTULZVNPG-UHFFFAOYSA-N terbutaline sulfate Chemical compound [O-]S([O-])(=O)=O.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1 KFVSLSTULZVNPG-UHFFFAOYSA-N 0.000 description 1
- 229960005105 terbutaline sulfate Drugs 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 230000006016 thyroid dysfunction Effects 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 229960002726 vincamine Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/332,348 US4369172A (en) | 1981-12-18 | 1981-12-18 | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH641670A5 true CH641670A5 (fr) | 1984-03-15 |
Family
ID=23297834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH730582A CH641670A5 (fr) | 1981-12-18 | 1982-12-15 | Preparations therapeutiques a liberation prolongee a base d'hydroxypropylmethylcellulose. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4369172A (enExample) |
| JP (1) | JPS58110513A (enExample) |
| AR (1) | AR228699A1 (enExample) |
| BE (1) | BE895391A (enExample) |
| CA (1) | CA1195929A (enExample) |
| CH (1) | CH641670A5 (enExample) |
| DE (1) | DE3246492C2 (enExample) |
| DK (1) | DK160076C (enExample) |
| ES (1) | ES518321A0 (enExample) |
| FR (1) | FR2518409B1 (enExample) |
| GB (1) | GB2111386A (enExample) |
| IL (1) | IL67497A (enExample) |
| IT (1) | IT1164472B (enExample) |
| MX (1) | MX160316A (enExample) |
| NL (1) | NL190472C (enExample) |
| SE (1) | SE453796B (enExample) |
| ZA (1) | ZA829267B (enExample) |
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| FR2556965B1 (fr) * | 1983-12-21 | 1986-08-22 | Rhone Poulenc Sante | Nouvelle forme galenique du ketoprofene a liberation controlee |
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| US2887440A (en) * | 1957-08-12 | 1959-05-19 | Dow Chemical Co | Enteric coating |
| BE587330A (enExample) * | 1959-04-13 | 1900-01-01 | ||
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| US3870790A (en) * | 1970-01-22 | 1975-03-11 | Forest Laboratories | Solid pharmaceutical formulations containing hydroxypropyl methyl cellulose |
| US3852421A (en) * | 1970-03-23 | 1974-12-03 | Shinetsu Chemical Co | Excipient and shaped medicaments prepared therewith |
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| US4259314A (en) * | 1979-12-10 | 1981-03-31 | Hans Lowey | Method and composition for the preparation of controlled long-acting pharmaceuticals |
-
1981
- 1981-12-18 US US06/332,348 patent/US4369172A/en not_active Expired - Lifetime
-
1982
- 1982-12-03 AR AR291504A patent/AR228699A1/es active
- 1982-12-14 MX MX195610A patent/MX160316A/es unknown
- 1982-12-15 CH CH730582A patent/CH641670A5/fr not_active IP Right Cessation
- 1982-12-15 SE SE8207167A patent/SE453796B/sv not_active IP Right Cessation
- 1982-12-16 IL IL67497A patent/IL67497A/xx not_active IP Right Cessation
- 1982-12-16 IT IT12690/82A patent/IT1164472B/it active
- 1982-12-16 FR FR8221109A patent/FR2518409B1/fr not_active Expired
- 1982-12-16 JP JP57221055A patent/JPS58110513A/ja active Granted
- 1982-12-16 GB GB08235858A patent/GB2111386A/en not_active Expired - Lifetime
- 1982-12-16 DE DE3246492A patent/DE3246492C2/de not_active Expired
- 1982-12-17 DK DK560782A patent/DK160076C/da not_active IP Right Cessation
- 1982-12-17 ZA ZA829267A patent/ZA829267B/xx unknown
- 1982-12-17 CA CA000417978A patent/CA1195929A/en not_active Expired
- 1982-12-17 ES ES518321A patent/ES518321A0/es active Granted
- 1982-12-17 NL NLAANVRAGE8204893,A patent/NL190472C/xx not_active IP Right Cessation
- 1982-12-17 BE BE0/209760A patent/BE895391A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NL190472B (nl) | 1993-10-18 |
| ES8402155A1 (es) | 1984-01-16 |
| BE895391A (fr) | 1983-04-15 |
| AR228699A1 (es) | 1983-03-30 |
| FR2518409B1 (fr) | 1986-02-21 |
| IT1164472B (it) | 1987-04-08 |
| IT8212690A0 (it) | 1982-12-16 |
| GB2111386A (en) | 1983-07-06 |
| NL190472C (nl) | 1994-03-16 |
| DK560782A (da) | 1983-06-19 |
| SE8207167L (sv) | 1983-06-19 |
| ES518321A0 (es) | 1984-01-16 |
| US4369172A (en) | 1983-01-18 |
| JPH059413B2 (enExample) | 1993-02-04 |
| DK160076B (da) | 1991-01-28 |
| IL67497A0 (en) | 1983-05-15 |
| MX160316A (es) | 1990-02-01 |
| GB2111386B (enExample) | |
| DK160076C (da) | 1991-06-24 |
| FR2518409A1 (fr) | 1983-06-24 |
| ZA829267B (en) | 1983-08-31 |
| SE8207167D0 (sv) | 1982-12-15 |
| NL8204893A (nl) | 1983-07-18 |
| SE453796B (sv) | 1988-03-07 |
| DE3246492A1 (de) | 1983-06-30 |
| IL67497A (en) | 1986-02-28 |
| CA1195929A (en) | 1985-10-29 |
| DE3246492C2 (de) | 1985-12-19 |
| JPS58110513A (ja) | 1983-07-01 |
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| PL | Patent ceased |