ATE364595T1 - Pyridoxin- und pyridoxalanaloga als cardiovasculäre therapeutika - Google Patents
Pyridoxin- und pyridoxalanaloga als cardiovasculäre therapeutikaInfo
- Publication number
- ATE364595T1 ATE364595T1 AT01951279T AT01951279T ATE364595T1 AT E364595 T1 ATE364595 T1 AT E364595T1 AT 01951279 T AT01951279 T AT 01951279T AT 01951279 T AT01951279 T AT 01951279T AT E364595 T1 ATE364595 T1 AT E364595T1
- Authority
- AT
- Austria
- Prior art keywords
- pyridoxal
- pyridoxine
- analogs
- analogues
- cardiovascular therapeutics
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/48—Aldehydo radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21690700P | 2000-07-07 | 2000-07-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE364595T1 true ATE364595T1 (de) | 2007-07-15 |
Family
ID=22808954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01951279T ATE364595T1 (de) | 2000-07-07 | 2001-07-06 | Pyridoxin- und pyridoxalanaloga als cardiovasculäre therapeutika |
Country Status (9)
Country | Link |
---|---|
US (1) | US6417204B1 (de) |
EP (1) | EP1299358B1 (de) |
JP (1) | JP2004502757A (de) |
AT (1) | ATE364595T1 (de) |
AU (2) | AU2001272263B2 (de) |
CA (1) | CA2414188A1 (de) |
DE (1) | DE60128912T9 (de) |
NZ (1) | NZ523815A (de) |
WO (1) | WO2002004421A2 (de) |
Families Citing this family (25)
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US6489345B1 (en) * | 1999-07-13 | 2002-12-03 | Medicure, Inc. | Treatment of diabetes and related pathologies |
EP1872797A3 (de) * | 1999-08-24 | 2008-04-02 | Medicure International Inc. | Behandlung kardiovaskulärer und verwandter Leiden |
US7442689B2 (en) * | 2000-02-29 | 2008-10-28 | Medicure International Inc. | Cardioprotective phosphonates and malonates |
US6897228B2 (en) * | 2000-07-07 | 2005-05-24 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: new uses |
US20040121988A1 (en) * | 2001-03-28 | 2004-06-24 | Medicure International Inc. | Treatment of cerebrovascular disease |
US20040186077A1 (en) * | 2003-03-17 | 2004-09-23 | Medicure International Inc. | Novel heteroaryl phosphonates as cardioprotective agents |
CA2520422A1 (en) * | 2003-03-27 | 2004-10-07 | Medicure Inc. | Compositions for treating angina |
WO2004084895A2 (en) * | 2003-03-27 | 2004-10-07 | Medicure, Inc. | Modulation of cell death |
PL1750862T3 (pl) | 2004-06-04 | 2011-06-30 | Teva Pharma | Kompozycja farmaceutyczna zawierająca irbesartan |
EP1773370A1 (de) * | 2004-07-07 | 2007-04-18 | Medicure International Inc. | Kombinationstherapien mit thrombozytenaggregations-arzneimitteln |
US20070060549A1 (en) * | 2004-08-10 | 2007-03-15 | Friesen Albert D | Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders |
US20060094749A1 (en) * | 2004-10-28 | 2006-05-04 | Medicure International Inc. | Substituted pyridoxines as anti-platelet agents |
CA2585165A1 (en) * | 2004-10-28 | 2006-05-18 | Medicure International Inc. | Dual antiplatelet/anticoagulant pyridoxine analogs |
US7459468B2 (en) * | 2004-10-28 | 2008-12-02 | Medicure International, Inc. | Aryl sulfonic pyridoxines as antiplatelet agents |
WO2006056079A1 (en) * | 2004-11-26 | 2006-06-01 | Medicure International Inc. | Formulations of pyridoxal -5'-phosphate and methods of preparation |
EP1827455A1 (de) * | 2004-11-26 | 2007-09-05 | Medicure International Inc. | Neue formulierung von pyridoxal 5'-phosphat und herstellungsverfahren |
US7375112B2 (en) * | 2005-01-05 | 2008-05-20 | Medicure International Inc. | Compounds and methods for regulating triglyceride levels |
CA2503087A1 (en) * | 2005-03-30 | 2006-09-30 | Medicure International Inc. | Intravenous formulations of pyridoxal 5'-phosphate and method of preparation |
AU2006317440A1 (en) * | 2005-11-28 | 2007-05-31 | Medicure International Inc. | Selected dosage for the treatment of cardiovascular and related pathologies |
US20070249562A1 (en) * | 2006-04-25 | 2007-10-25 | Friesen Albert D | Treatment of atrial fibrillation |
WO2010080871A1 (en) | 2009-01-08 | 2010-07-15 | Univation Technologies, Llc | Additive for gas phase polymerization processes |
EP3632899A1 (de) * | 2009-05-29 | 2020-04-08 | RaQualia Pharma Inc. | Arylsubstituierte carboxamidderivate als calcium- oder natriumkanalblocker |
EP2630136A1 (de) * | 2010-10-21 | 2013-08-28 | Universität des Saarlandes | Selektive cyp11b1-inhibitoren zur behandlung von cortisolbedingten erkrankungen |
CN102617455B (zh) * | 2011-12-26 | 2014-06-04 | 浙江工业大学 | 一种吡哆醛或盐酸吡哆醛的制备方法 |
WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
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-
2001
- 2001-07-06 WO PCT/CA2001/000994 patent/WO2002004421A2/en active IP Right Grant
- 2001-07-06 AU AU2001272263A patent/AU2001272263B2/en not_active Ceased
- 2001-07-06 US US09/900,718 patent/US6417204B1/en not_active Expired - Fee Related
- 2001-07-06 EP EP01951279A patent/EP1299358B1/de not_active Expired - Lifetime
- 2001-07-06 CA CA002414188A patent/CA2414188A1/en not_active Abandoned
- 2001-07-06 DE DE60128912T patent/DE60128912T9/de active Active
- 2001-07-06 NZ NZ523815A patent/NZ523815A/en unknown
- 2001-07-06 AU AU7226301A patent/AU7226301A/xx active Pending
- 2001-07-06 JP JP2002509088A patent/JP2004502757A/ja active Pending
- 2001-07-06 AT AT01951279T patent/ATE364595T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1299358A2 (de) | 2003-04-09 |
WO2002004421A3 (en) | 2002-04-04 |
US6417204B1 (en) | 2002-07-09 |
DE60128912T9 (de) | 2008-06-26 |
JP2004502757A (ja) | 2004-01-29 |
AU7226301A (en) | 2002-01-21 |
AU2001272263B2 (en) | 2005-12-15 |
NZ523815A (en) | 2004-07-30 |
CA2414188A1 (en) | 2002-01-17 |
WO2002004421A2 (en) | 2002-01-17 |
DE60128912D1 (en) | 2007-07-26 |
DE60128912T2 (de) | 2008-02-14 |
EP1299358B1 (de) | 2007-06-13 |
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