CH624967A5 - Process for the preparation of polyhalogenated steroids - Google Patents

Process for the preparation of polyhalogenated steroids Download PDF

Info

Publication number
CH624967A5
CH624967A5 CH1549976A CH1549976A CH624967A5 CH 624967 A5 CH624967 A5 CH 624967A5 CH 1549976 A CH1549976 A CH 1549976A CH 1549976 A CH1549976 A CH 1549976A CH 624967 A5 CH624967 A5 CH 624967A5
Authority
CH
Switzerland
Prior art keywords
dione
diene
chlorine
methyl
pregna
Prior art date
Application number
CH1549976A
Other languages
German (de)
English (en)
Inventor
Jaroslav Dr Kalvoda
Georg Dr Anner
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of CH624967A5 publication Critical patent/CH624967A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CH1549976A 1976-09-29 1976-12-09 Process for the preparation of polyhalogenated steroids CH624967A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU75903A LU75903A1 (no) 1976-09-29 1976-09-29

Publications (1)

Publication Number Publication Date
CH624967A5 true CH624967A5 (en) 1981-08-31

Family

ID=19728370

Family Applications (9)

Application Number Title Priority Date Filing Date
CH1549976A CH624967A5 (en) 1976-09-29 1976-12-09 Process for the preparation of polyhalogenated steroids
CH1172177A CH632279A5 (en) 1976-09-29 1977-09-26 Process for the preparation of polyhalogenated steroids
CH853780A CH625808A5 (en) 1976-09-29 1980-11-18 Process for the preparation of polyhalogenated steroids
CH853880A CH625809A5 (en) 1976-09-29 1980-11-18 Process for the preparation of polyhalogenated steroids
CH853980A CH625810A5 (en) 1976-09-29 1980-11-18 Process for the preparation of polyhalogenated steroids
CH683281A CH632000A5 (en) 1976-09-29 1981-10-26 Process for the preparation of polyhalogenated steroids
CH683081A CH631998A5 (en) 1976-09-29 1981-10-26 Process for the preparation of polyhalogenated steroids
CH683181A CH631999A5 (en) 1976-09-29 1981-10-26 Process for the preparation of polyhalogenated steroids
CH4682A CH632521A5 (en) 1976-09-29 1982-01-06 Process for the preparation of polyhalogenated steroids

Family Applications After (8)

Application Number Title Priority Date Filing Date
CH1172177A CH632279A5 (en) 1976-09-29 1977-09-26 Process for the preparation of polyhalogenated steroids
CH853780A CH625808A5 (en) 1976-09-29 1980-11-18 Process for the preparation of polyhalogenated steroids
CH853880A CH625809A5 (en) 1976-09-29 1980-11-18 Process for the preparation of polyhalogenated steroids
CH853980A CH625810A5 (en) 1976-09-29 1980-11-18 Process for the preparation of polyhalogenated steroids
CH683281A CH632000A5 (en) 1976-09-29 1981-10-26 Process for the preparation of polyhalogenated steroids
CH683081A CH631998A5 (en) 1976-09-29 1981-10-26 Process for the preparation of polyhalogenated steroids
CH683181A CH631999A5 (en) 1976-09-29 1981-10-26 Process for the preparation of polyhalogenated steroids
CH4682A CH632521A5 (en) 1976-09-29 1982-01-06 Process for the preparation of polyhalogenated steroids

Country Status (24)

Country Link
JP (1) JPS5356652A (no)
AT (3) AT363197B (no)
AU (1) AU514200B2 (no)
BE (1) BE859120A (no)
CA (1) CA1101410A (no)
CH (9) CH624967A5 (no)
CY (1) CY1178A (no)
DD (1) DD133150A5 (no)
DE (1) DE2743069C2 (no)
DK (1) DK146017C (no)
ES (1) ES462763A1 (no)
FR (1) FR2366311A1 (no)
GB (1) GB1563638A (no)
HK (1) HK16683A (no)
HU (1) HU175218B (no)
IE (1) IE46047B1 (no)
IL (1) IL53012A (no)
KE (1) KE3258A (no)
LU (1) LU75903A1 (no)
MY (1) MY8400092A (no)
NL (1) NL7710089A (no)
SE (1) SE436751B (no)
SG (1) SG3383G (no)
ZA (1) ZA775800B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
DE3227312A1 (de) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
WO1991014700A2 (en) * 1990-03-27 1991-10-03 Schering Corporation PROCESS FOR 9α-HYDROXY STEROID DEHYDRATION
US5972922A (en) * 1990-06-11 1999-10-26 Alcon Laboratories, Inc. Steroids which inhibit angiogenesis
US7098328B2 (en) 2001-11-29 2006-08-29 Taro Pharmaceutical Industries Limited Method for the preparation of 6α-fluoro corticosteroids
US11957753B2 (en) 2010-11-22 2024-04-16 Bausch Health Ireland Limited Pharmaceutical formulations containing corticosteroids for topical administration
US8809307B2 (en) 2010-11-22 2014-08-19 Dow Pharmaceutical Sciences, Inc. Pharmaceutical formulations containing corticosteroids for topical administration
WO2016205001A1 (en) 2015-06-18 2016-12-22 Valeant Pharmaceuticals North America Topical compositions comprising a corticosteroid and a retinoid for treating psoriasis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB898292A (en) * 1959-03-18 1962-06-06 Upjohn Co Improvements in or relating to steroids and the manufacture thereof
US3644340A (en) * 1970-03-19 1972-02-22 Syntex Corp Preparation of 21-chloro steroids
US3992422A (en) * 1975-08-14 1976-11-16 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes

Also Published As

Publication number Publication date
ATA691077A (de) 1980-12-15
JPS6214557B2 (no) 1987-04-02
CA1101410A (en) 1981-05-19
ATA151379A (de) 1980-12-15
DK146017B (da) 1983-05-24
CH625810A5 (en) 1981-10-15
ATA151279A (de) 1980-12-15
DE2743069A1 (de) 1978-03-30
CH631999A5 (en) 1982-09-15
HK16683A (en) 1983-05-27
BE859120A (fr) 1978-03-28
IL53012A (en) 1982-05-31
DK256977A (da) 1978-03-30
SE7706673L (sv) 1978-03-30
GB1563638A (en) 1980-03-26
CH625809A5 (en) 1981-10-15
CH632521A5 (en) 1982-10-15
KE3258A (en) 1983-03-04
SE436751B (sv) 1985-01-21
CH632279A5 (en) 1982-09-30
HU175218B (hu) 1980-06-28
AU514200B2 (en) 1981-01-29
AT363203B (de) 1981-07-27
SG3383G (en) 1983-09-09
CH625808A5 (en) 1981-10-15
DE2743069C2 (de) 1987-03-05
CH631998A5 (en) 1982-09-15
IL53012A0 (en) 1977-11-30
AT363197B (de) 1981-07-10
NL7710089A (nl) 1978-03-31
CY1178A (en) 1983-06-10
MY8400092A (en) 1984-12-31
ZA775800B (en) 1978-08-30
JPS5356652A (en) 1978-05-23
FR2366311A1 (fr) 1978-04-28
IE46047B1 (en) 1983-02-09
LU75903A1 (no) 1978-05-16
AT363202B (de) 1981-07-27
DD133150A5 (de) 1978-12-13
DK146017C (da) 1983-10-24
IE46047L (en) 1978-03-29
CH632000A5 (en) 1982-09-15
AU2914877A (en) 1979-04-05
ES462763A1 (es) 1978-05-16
FR2366311B1 (no) 1982-12-03

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PL Patent ceased