SE7706673L - Forfarande for framstellning av flerfaldigt halogenerade steroider - Google Patents

Forfarande for framstellning av flerfaldigt halogenerade steroider

Info

Publication number
SE7706673L
SE7706673L SE7706673A SE7706673A SE7706673L SE 7706673 L SE7706673 L SE 7706673L SE 7706673 A SE7706673 A SE 7706673A SE 7706673 A SE7706673 A SE 7706673A SE 7706673 L SE7706673 L SE 7706673L
Authority
SE
Sweden
Prior art keywords
alpha
halogenerated
steroids
procedure
chlorine
Prior art date
Application number
SE7706673A
Other languages
Unknown language ( )
English (en)
Other versions
SE436751B (sv
Inventor
J Kalvoda
G Anner
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of SE7706673L publication Critical patent/SE7706673L/sv
Publication of SE436751B publication Critical patent/SE436751B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SE7706673A 1976-09-29 1977-06-08 Forfarande enligt krav 1 i patentet 7613920-3 (publ.nr 423903) for framstellning av 17alfa-acyloxi-9alfa, 21-dihalogen-11beta-hydroxi-6alfa-fluor-16beta-metyl-pregna-1,4-dien-3,20-dion-foreningar SE436751B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU75903A LU75903A1 (sv) 1976-09-29 1976-09-29

Publications (2)

Publication Number Publication Date
SE7706673L true SE7706673L (sv) 1978-03-30
SE436751B SE436751B (sv) 1985-01-21

Family

ID=19728370

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7706673A SE436751B (sv) 1976-09-29 1977-06-08 Forfarande enligt krav 1 i patentet 7613920-3 (publ.nr 423903) for framstellning av 17alfa-acyloxi-9alfa, 21-dihalogen-11beta-hydroxi-6alfa-fluor-16beta-metyl-pregna-1,4-dien-3,20-dion-foreningar

Country Status (24)

Country Link
JP (1) JPS5356652A (sv)
AT (3) AT363197B (sv)
AU (1) AU514200B2 (sv)
BE (1) BE859120A (sv)
CA (1) CA1101410A (sv)
CH (9) CH624967A5 (sv)
CY (1) CY1178A (sv)
DD (1) DD133150A5 (sv)
DE (1) DE2743069C2 (sv)
DK (1) DK146017C (sv)
ES (1) ES462763A1 (sv)
FR (1) FR2366311A1 (sv)
GB (1) GB1563638A (sv)
HK (1) HK16683A (sv)
HU (1) HU175218B (sv)
IE (1) IE46047B1 (sv)
IL (1) IL53012A (sv)
KE (1) KE3258A (sv)
LU (1) LU75903A1 (sv)
MY (1) MY8400092A (sv)
NL (1) NL7710089A (sv)
SE (1) SE436751B (sv)
SG (1) SG3383G (sv)
ZA (1) ZA775800B (sv)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
DE3227312A1 (de) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
AU7556291A (en) * 1990-03-27 1991-10-21 Schering Corporation Process for 9alpha-hydroxy steroid dehydration
US5972922A (en) * 1990-06-11 1999-10-26 Alcon Laboratories, Inc. Steroids which inhibit angiogenesis
BR0214520A (pt) 2001-11-29 2006-05-30 Taro Pharmaceuticals Usa Inc método para a preparação de corticosteróides de 6alfa-fluoro
US8809307B2 (en) 2010-11-22 2014-08-19 Dow Pharmaceutical Sciences, Inc. Pharmaceutical formulations containing corticosteroids for topical administration
US11957753B2 (en) 2010-11-22 2024-04-16 Bausch Health Ireland Limited Pharmaceutical formulations containing corticosteroids for topical administration
LT3310389T (lt) 2015-06-18 2020-11-10 Bausch Health Ireland Limited Vietinio vartojimo kompozicijos, apimančios kortikosteroidą ir retinoidą, skirtos psoriazės gydymui

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB898292A (en) * 1959-03-18 1962-06-06 Upjohn Co Improvements in or relating to steroids and the manufacture thereof
US3644340A (en) * 1970-03-19 1972-02-22 Syntex Corp Preparation of 21-chloro steroids
US3992422A (en) * 1975-08-14 1976-11-16 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes

Also Published As

Publication number Publication date
SE436751B (sv) 1985-01-21
FR2366311A1 (fr) 1978-04-28
CA1101410A (en) 1981-05-19
ATA151379A (de) 1980-12-15
ATA691077A (de) 1980-12-15
FR2366311B1 (sv) 1982-12-03
CH632279A5 (en) 1982-09-30
AT363203B (de) 1981-07-27
ES462763A1 (es) 1978-05-16
JPS6214557B2 (sv) 1987-04-02
ATA151279A (de) 1980-12-15
IL53012A0 (en) 1977-11-30
AU2914877A (en) 1979-04-05
CH632000A5 (en) 1982-09-15
LU75903A1 (sv) 1978-05-16
AT363202B (de) 1981-07-27
HK16683A (en) 1983-05-27
DK146017C (da) 1983-10-24
IE46047L (en) 1978-03-29
CH632521A5 (en) 1982-10-15
CH625810A5 (en) 1981-10-15
CH624967A5 (en) 1981-08-31
CH625808A5 (en) 1981-10-15
CH631999A5 (en) 1982-09-15
DK256977A (da) 1978-03-30
SG3383G (en) 1983-09-09
HU175218B (hu) 1980-06-28
ZA775800B (en) 1978-08-30
JPS5356652A (en) 1978-05-23
IL53012A (en) 1982-05-31
AT363197B (de) 1981-07-10
KE3258A (en) 1983-03-04
GB1563638A (en) 1980-03-26
DD133150A5 (de) 1978-12-13
DE2743069C2 (de) 1987-03-05
MY8400092A (en) 1984-12-31
DE2743069A1 (de) 1978-03-30
CH631998A5 (en) 1982-09-15
DK146017B (da) 1983-05-24
BE859120A (fr) 1978-03-28
IE46047B1 (en) 1983-02-09
AU514200B2 (en) 1981-01-29
CY1178A (en) 1983-06-10
CH625809A5 (en) 1981-10-15
NL7710089A (nl) 1978-03-31

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