DK256977A - Fremgangsmaade til fremstilling af flerdobbelt halogenerede steroider - Google Patents

Fremgangsmaade til fremstilling af flerdobbelt halogenerede steroider

Info

Publication number
DK256977A
DK256977A DK256977A DK256977A DK256977A DK 256977 A DK256977 A DK 256977A DK 256977 A DK256977 A DK 256977A DK 256977 A DK256977 A DK 256977A DK 256977 A DK256977 A DK 256977A
Authority
DK
Denmark
Prior art keywords
procedure
production
double halogenated
halogenated steroids
steroids
Prior art date
Application number
DK256977A
Other languages
English (en)
Other versions
DK146017B (da
DK146017C (da
Inventor
J Kalvoda
G Anner
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of DK256977A publication Critical patent/DK256977A/da
Publication of DK146017B publication Critical patent/DK146017B/da
Application granted granted Critical
Publication of DK146017C publication Critical patent/DK146017C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J21/00Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J31/00Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/001Oxiranes
    • C07J71/0015Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK256977A 1976-09-29 1977-06-09 Analogifremgangsmaade til fremstilling af 17alfa-acyloxy-9alfa,21-dihalogen-11beta-hydroxy-6alfa-fluor-16beta-methyl-pregna-1,4-dien-3,20-dion-forbindelser DK146017C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU75903 1976-09-29
LU75903A LU75903A1 (da) 1976-09-29 1976-09-29

Publications (3)

Publication Number Publication Date
DK256977A true DK256977A (da) 1978-03-30
DK146017B DK146017B (da) 1983-05-24
DK146017C DK146017C (da) 1983-10-24

Family

ID=19728370

Family Applications (1)

Application Number Title Priority Date Filing Date
DK256977A DK146017C (da) 1976-09-29 1977-06-09 Analogifremgangsmaade til fremstilling af 17alfa-acyloxy-9alfa,21-dihalogen-11beta-hydroxy-6alfa-fluor-16beta-methyl-pregna-1,4-dien-3,20-dion-forbindelser

Country Status (24)

Country Link
JP (1) JPS5356652A (da)
AT (3) AT363197B (da)
AU (1) AU514200B2 (da)
BE (1) BE859120A (da)
CA (1) CA1101410A (da)
CH (9) CH624967A5 (da)
CY (1) CY1178A (da)
DD (1) DD133150A5 (da)
DE (1) DE2743069A1 (da)
DK (1) DK146017C (da)
ES (1) ES462763A1 (da)
FR (1) FR2366311A1 (da)
GB (1) GB1563638A (da)
HK (1) HK16683A (da)
HU (1) HU175218B (da)
IE (1) IE46047B1 (da)
IL (1) IL53012A (da)
KE (1) KE3258A (da)
LU (1) LU75903A1 (da)
MY (1) MY8400092A (da)
NL (1) NL7710089A (da)
SE (1) SE436751B (da)
SG (1) SG3383G (da)
ZA (1) ZA775800B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
DE3227312A1 (de) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
EP0523132A1 (en) * 1990-03-27 1993-01-20 Schering Corporation PROCESS FOR 9$g(a)-HYDROXY STEROID DEHYDRATION
US5972922A (en) * 1990-06-11 1999-10-26 Alcon Laboratories, Inc. Steroids which inhibit angiogenesis
MXPA04005188A (es) 2001-11-29 2004-08-11 Taro Pharma Ind Metodo para la produccion de 6-alfa-fluorocorticosteroides.
US11957753B2 (en) 2010-11-22 2024-04-16 Bausch Health Ireland Limited Pharmaceutical formulations containing corticosteroids for topical administration
US8809307B2 (en) 2010-11-22 2014-08-19 Dow Pharmaceutical Sciences, Inc. Pharmaceutical formulations containing corticosteroids for topical administration
JP6997624B2 (ja) 2015-06-18 2022-01-17 ボシュ ヘルス ユーエス,エルエルシー. 乾癬を治療するためのコルチコステロイドおよびレチノイドを含む局所用組成物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB898292A (en) * 1959-03-18 1962-06-06 Upjohn Co Improvements in or relating to steroids and the manufacture thereof
US3644340A (en) * 1970-03-19 1972-02-22 Syntex Corp Preparation of 21-chloro steroids
US3992422A (en) * 1975-08-14 1976-11-16 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes

Also Published As

Publication number Publication date
HK16683A (en) 1983-05-27
DK146017B (da) 1983-05-24
SG3383G (en) 1983-09-09
JPS6214557B2 (da) 1987-04-02
AT363202B (de) 1981-07-27
CH625810A5 (en) 1981-10-15
ATA151279A (de) 1980-12-15
BE859120A (fr) 1978-03-28
ATA151379A (de) 1980-12-15
CH631999A5 (en) 1982-09-15
CA1101410A (en) 1981-05-19
IE46047L (en) 1978-03-29
DE2743069C2 (da) 1987-03-05
NL7710089A (nl) 1978-03-31
KE3258A (en) 1983-03-04
SE436751B (sv) 1985-01-21
DE2743069A1 (de) 1978-03-30
FR2366311A1 (fr) 1978-04-28
JPS5356652A (en) 1978-05-23
IL53012A0 (en) 1977-11-30
AT363203B (de) 1981-07-27
FR2366311B1 (da) 1982-12-03
DK146017C (da) 1983-10-24
ATA691077A (de) 1980-12-15
CY1178A (en) 1983-06-10
CH625809A5 (en) 1981-10-15
HU175218B (hu) 1980-06-28
AT363197B (de) 1981-07-10
SE7706673L (sv) 1978-03-30
ES462763A1 (es) 1978-05-16
AU514200B2 (en) 1981-01-29
IE46047B1 (en) 1983-02-09
CH624967A5 (en) 1981-08-31
CH631998A5 (en) 1982-09-15
DD133150A5 (de) 1978-12-13
IL53012A (en) 1982-05-31
ZA775800B (en) 1978-08-30
CH632521A5 (en) 1982-10-15
LU75903A1 (da) 1978-05-16
GB1563638A (en) 1980-03-26
MY8400092A (en) 1984-12-31
CH632000A5 (en) 1982-09-15
CH632279A5 (en) 1982-09-30
CH625808A5 (en) 1981-10-15
AU2914877A (en) 1979-04-05

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