AT363197B - Verfahren zur herstellung von neuen 9alpha,21-dihalogen-11beta, 17alpha-dihydroxy-6alpha-fluor-16beta-methyl-pregna-1,4-dien-3,20-dion-verbindungen - Google Patents

Verfahren zur herstellung von neuen 9alpha,21-dihalogen-11beta, 17alpha-dihydroxy-6alpha-fluor-16beta-methyl-pregna-1,4-dien-3,20-dion-verbindungen

Info

Publication number
AT363197B
AT363197B AT0691077A AT691077A AT363197B AT 363197 B AT363197 B AT 363197B AT 0691077 A AT0691077 A AT 0691077A AT 691077 A AT691077 A AT 691077A AT 363197 B AT363197 B AT 363197B
Authority
AT
Austria
Prior art keywords
16beta
9alpha
6alpha
11beta
17alpha
Prior art date
Application number
AT0691077A
Other languages
German (de)
English (en)
Other versions
ATA691077A (de
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Priority to AT0151379A priority Critical patent/AT363203B/de
Priority to AT151479A priority patent/AT363204B/de
Priority to AT0151279A priority patent/AT363202B/de
Publication of ATA691077A publication Critical patent/ATA691077A/de
Application granted granted Critical
Publication of AT363197B publication Critical patent/AT363197B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT0691077A 1976-09-29 1977-09-28 Verfahren zur herstellung von neuen 9alpha,21-dihalogen-11beta, 17alpha-dihydroxy-6alpha-fluor-16beta-methyl-pregna-1,4-dien-3,20-dion-verbindungen AT363197B (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AT0151379A AT363203B (de) 1976-09-29 1979-02-28 Verfahren zur herstellung von neuen 9alpha,21-
AT151479A AT363204B (de) 1976-09-29 1979-02-28 Verfahren zur herstellung von mehrfach halogenierten steroiden
AT0151279A AT363202B (de) 1976-09-29 1979-02-28 Verfahren zur herstellung von neuen mehrfach halogenierten steroiden

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU75903A LU75903A1 (da) 1976-09-29 1976-09-29

Publications (2)

Publication Number Publication Date
ATA691077A ATA691077A (de) 1980-12-15
AT363197B true AT363197B (de) 1981-07-10

Family

ID=19728370

Family Applications (3)

Application Number Title Priority Date Filing Date
AT0691077A AT363197B (de) 1976-09-29 1977-09-28 Verfahren zur herstellung von neuen 9alpha,21-dihalogen-11beta, 17alpha-dihydroxy-6alpha-fluor-16beta-methyl-pregna-1,4-dien-3,20-dion-verbindungen
AT0151379A AT363203B (de) 1976-09-29 1979-02-28 Verfahren zur herstellung von neuen 9alpha,21-
AT0151279A AT363202B (de) 1976-09-29 1979-02-28 Verfahren zur herstellung von neuen mehrfach halogenierten steroiden

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT0151379A AT363203B (de) 1976-09-29 1979-02-28 Verfahren zur herstellung von neuen 9alpha,21-
AT0151279A AT363202B (de) 1976-09-29 1979-02-28 Verfahren zur herstellung von neuen mehrfach halogenierten steroiden

Country Status (24)

Country Link
JP (1) JPS5356652A (da)
AT (3) AT363197B (da)
AU (1) AU514200B2 (da)
BE (1) BE859120A (da)
CA (1) CA1101410A (da)
CH (9) CH624967A5 (da)
CY (1) CY1178A (da)
DD (1) DD133150A5 (da)
DE (1) DE2743069C2 (da)
DK (1) DK146017C (da)
ES (1) ES462763A1 (da)
FR (1) FR2366311A1 (da)
GB (1) GB1563638A (da)
HK (1) HK16683A (da)
HU (1) HU175218B (da)
IE (1) IE46047B1 (da)
IL (1) IL53012A (da)
KE (1) KE3258A (da)
LU (1) LU75903A1 (da)
MY (1) MY8400092A (da)
NL (1) NL7710089A (da)
SE (1) SE436751B (da)
SG (1) SG3383G (da)
ZA (1) ZA775800B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
DE3227312A1 (de) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
EP0523132A1 (en) * 1990-03-27 1993-01-20 Schering Corporation PROCESS FOR 9$g(a)-HYDROXY STEROID DEHYDRATION
US5972922A (en) * 1990-06-11 1999-10-26 Alcon Laboratories, Inc. Steroids which inhibit angiogenesis
CA2473471A1 (en) 2001-11-29 2003-06-12 Taro Pharmaceuticals U.S.A., Inc. Method for the preparation of 6-alpha-fluoro corticosteroids
US8809307B2 (en) 2010-11-22 2014-08-19 Dow Pharmaceutical Sciences, Inc. Pharmaceutical formulations containing corticosteroids for topical administration
US11957753B2 (en) 2010-11-22 2024-04-16 Bausch Health Ireland Limited Pharmaceutical formulations containing corticosteroids for topical administration
AU2016279801B2 (en) 2015-06-18 2021-09-09 Valeant Pharmaceuticals North America Topical compositions comprising a corticosteroid and a retinoid for treating psoriasis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB898292A (en) * 1959-03-18 1962-06-06 Upjohn Co Improvements in or relating to steroids and the manufacture thereof
US3644340A (en) * 1970-03-19 1972-02-22 Syntex Corp Preparation of 21-chloro steroids
US3992422A (en) * 1975-08-14 1976-11-16 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes

Also Published As

Publication number Publication date
BE859120A (fr) 1978-03-28
CH632521A5 (en) 1982-10-15
ZA775800B (en) 1978-08-30
IE46047L (en) 1978-03-29
FR2366311A1 (fr) 1978-04-28
CA1101410A (en) 1981-05-19
DK146017C (da) 1983-10-24
JPS5356652A (en) 1978-05-23
CH625809A5 (en) 1981-10-15
CY1178A (en) 1983-06-10
DK146017B (da) 1983-05-24
GB1563638A (en) 1980-03-26
HU175218B (hu) 1980-06-28
AU2914877A (en) 1979-04-05
FR2366311B1 (da) 1982-12-03
DE2743069C2 (de) 1987-03-05
IL53012A (en) 1982-05-31
ES462763A1 (es) 1978-05-16
HK16683A (en) 1983-05-27
AT363203B (de) 1981-07-27
NL7710089A (nl) 1978-03-31
IE46047B1 (en) 1983-02-09
SG3383G (en) 1983-09-09
AT363202B (de) 1981-07-27
CH632279A5 (en) 1982-09-30
CH625808A5 (en) 1981-10-15
ATA691077A (de) 1980-12-15
CH631999A5 (en) 1982-09-15
CH624967A5 (en) 1981-08-31
SE7706673L (sv) 1978-03-30
ATA151379A (de) 1980-12-15
IL53012A0 (en) 1977-11-30
DE2743069A1 (de) 1978-03-30
JPS6214557B2 (da) 1987-04-02
ATA151279A (de) 1980-12-15
CH631998A5 (en) 1982-09-15
KE3258A (en) 1983-03-04
SE436751B (sv) 1985-01-21
LU75903A1 (da) 1978-05-16
MY8400092A (en) 1984-12-31
CH632000A5 (en) 1982-09-15
DD133150A5 (de) 1978-12-13
DK256977A (da) 1978-03-30
AU514200B2 (en) 1981-01-29
CH625810A5 (en) 1981-10-15

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Legal Events

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ELA Expired due to lapse of time