AT356827B - Verfahren zur herstellung von neuen spirol- actonen - Google Patents

Verfahren zur herstellung von neuen spirol- actonen

Info

Publication number
AT356827B
AT356827B AT815577A AT815577A AT356827B AT 356827 B AT356827 B AT 356827B AT 815577 A AT815577 A AT 815577A AT 815577 A AT815577 A AT 815577A AT 356827 B AT356827 B AT 356827B
Authority
AT
Austria
Prior art keywords
actones
spirol
producing new
producing
new
Prior art date
Application number
AT815577A
Other languages
English (en)
Other versions
ATA815577A (de
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=5993550&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT356827(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Priority to AT0428979A priority Critical patent/AT366391B/de
Publication of ATA815577A publication Critical patent/ATA815577A/de
Application granted granted Critical
Publication of AT356827B publication Critical patent/AT356827B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/007—3 membered carbocyclic rings in position 6-7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT815577A 1976-11-16 1977-11-15 Verfahren zur herstellung von neuen spirol- actonen AT356827B (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT0428979A AT366391B (de) 1976-11-16 1979-06-18 Verfahren zur herstellung von neuen spirolactonen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2652761A DE2652761C2 (de) 1976-11-16 1976-11-16 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

Publications (2)

Publication Number Publication Date
ATA815577A ATA815577A (de) 1979-10-15
AT356827B true AT356827B (de) 1980-05-27

Family

ID=5993550

Family Applications (1)

Application Number Title Priority Date Filing Date
AT815577A AT356827B (de) 1976-11-16 1977-11-15 Verfahren zur herstellung von neuen spirol- actonen

Country Status (23)

Country Link
US (1) US4129564A (de)
JP (2) JPS5363373A (de)
AT (1) AT356827B (de)
AU (1) AU512611B2 (de)
BE (1) BE860877A (de)
CA (1) CA1092094A (de)
CH (2) CH631463A5 (de)
CS (1) CS194823B2 (de)
DD (1) DD132968B3 (de)
DE (1) DE2652761C2 (de)
DK (1) DK141967C (de)
ES (1) ES464193A1 (de)
FR (1) FR2370755A1 (de)
GB (1) GB1550568A (de)
GR (1) GR65227B (de)
HU (1) HU174983B (de)
IE (1) IE46076B1 (de)
IL (1) IL53353A (de)
IT (1) IT1092262B (de)
LU (1) LU78514A1 (de)
NL (1) NL7711946A (de)
SE (1) SE436425B (de)
SU (2) SU695560A3 (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2922500A1 (de) * 1979-05-31 1980-12-04 Schering Ag 6 beta .7 beta
DE3022337A1 (de) * 1980-06-11 1982-01-07 Schering Ag Berlin Und Bergkamen, 1000 Berlin Praeparate zur kontrazeption und zur behandlung gynaekologischer stoerungen
DE3051166C2 (en) * 1980-06-11 1990-10-18 Schering Ag, 1000 Berlin Und 4709 Bergkamen, De Compsns. for contraception or treatment of gynaecological disorders
DE3111951A1 (de) * 1981-03-23 1982-09-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen 7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel
ATE15206T1 (de) * 1981-09-21 1985-09-15 Schering Ag 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-1 - one, ihre 3,15-trimethylessigsaeure-ester und ihre herstellung.
DE3213962A1 (de) * 1982-04-13 1983-10-13 Schering AG, 1000 Berlin und 4709 Bergkamen 1(alpha).2(alpha);6(beta).7(beta).15(beta).16(beta)-trimethylen-3-oxo-17(alpha)-pregn-4-en-21.17-carbolacton, dessen herstellung und verwendung als arzneimittel
DE3227598A1 (de) * 1982-07-22 1984-01-26 Schering AG, 1000 Berlin und 4709 Bergkamen 7(alpha)-acylthio-15.16-methylen-3-oxo-17(alpha)-pregna-1.4-dien-21,17-carbolactone, verfahren zu ihrer herstellung und verwendung als arzneimittel
DE3234972A1 (de) * 1982-09-17 1984-03-22 Schering AG, 1000 Berlin und 4709 Bergkamen 7(alpha)-alkyl-17(alpha)-pregn-4-en-21.17-carbolactone und -21-carbonsaeuresalze sowie verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3240510A1 (de) * 1982-10-29 1984-05-03 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 7(alpha)-acylthio-1(alpha),2(alpha)-methylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, deren herstellung und diese enthaltende arzneimittel
JPS59139400A (ja) * 1983-01-31 1984-08-10 Shionogi & Co Ltd 抗アルドステロン活性ステロイド誘導体
DE3306554A1 (de) * 1983-02-22 1984-08-23 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von 3-((delta)(pfeil hoch)4(pfeil hoch)-3-ketosteroid-17(alpha)-yl)-propionsaeurelactonen
FI77669C (fi) * 1983-04-13 1989-04-10 Ciba Geigy Ag 20-spiroxaner och analoger, som innehaoller en oeppen ring e, foerfarande foer deras framstaellning samt dessa innehaollande farmaceutiska preparat.
EP0134529B1 (de) * 1983-08-17 1990-03-21 Schering Aktiengesellschaft 7-alpha-Substituierte 3-Oxo-17alpha-pregn-4-en-21.17-carbolactone, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
DE3347510A1 (de) * 1983-12-27 1985-08-01 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von 3-oxo-17(alpha)-pregna-4,6-dien-21,17-carbolactonen
DE3402329A1 (de) * 1984-01-20 1985-08-01 Schering AG, 1000 Berlin und 4709 Bergkamen 6,6-ethylen-15,16-methylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US4670551A (en) * 1984-06-21 1987-06-02 Ciba-Geigy Corporation Epoxy steroids
JPS6248694A (ja) * 1985-08-28 1987-03-03 Shionogi & Co Ltd 抗アルドステロン活性ステロイド誘導体
DE3544661A1 (de) * 1985-12-13 1987-06-19 Schering Ag Verfahren zur herstellung von 7(alpha)-acetylthiosteroiden
JPS62132932U (de) * 1986-02-14 1987-08-21
US4837211A (en) * 1987-04-06 1989-06-06 Carolina Medical Products, Inc. Spironolactone composition
JPS6453026U (de) * 1987-09-29 1989-03-31
DE3916112A1 (de) * 1989-05-16 1990-11-22 Schering Ag Dihydrospirorenon als antiandrogen
DE4344462C2 (de) 1993-12-22 1996-02-01 Schering Ag Zusammensetzung für die Empfängnisverhütung
DE69620756T2 (de) * 1995-06-07 2002-11-14 G.D. Searle & Co., Chicago Kombinationstherapie zur behandlung des kongestiven herzversagens mit spironolacton und angiotensin ii-antagonist
DE19633685C1 (de) * 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
DE19651000A1 (de) * 1996-12-01 1998-06-04 Schering Ag Oxyiminopregnancarbolactone
EP1126880A2 (de) * 1998-11-06 2001-08-29 G.D. SEARLE & CO. Kombinationstherapie von angiotensin-konvertierendem enzym hemmer und aldosterone antagonist zur reduzierung des erkrankungs- und todesfallrisikos von kardiovaskuläre erkrankungen
US6787531B1 (en) * 1999-08-31 2004-09-07 Schering Ag Pharmaceutical composition for use as a contraceptive
RS50262B2 (sr) 1999-08-31 2018-10-31 Bayer Pharma AG Farmaceutska kombinacija etinilestradiola i drospirenona za primenu kao kontraceptivnog sredstva
EP2305267A3 (de) 1999-08-31 2011-08-17 Bayer Schering Pharma Aktiengesellschaft Pharmazeutische Kombination von Ethinylestradiol und Drospirenon zur Verwendung als Verhütungsmittel
SK287634B6 (sk) * 1999-08-31 2011-04-05 Bayer Schering Pharma Aktiengesellschaft Farmaceutická kompozícia obsahujúca drospirenón a etinylestradiol a farmaceutický prípravok
KR100913910B1 (ko) * 2000-01-18 2009-08-26 바이엘 쉐링 파마 악티엔게젤샤프트 호르몬 보충 요법용 드로스피렌온
US20020132801A1 (en) * 2001-01-11 2002-09-19 Schering Aktiengesellschaft Drospirenone for hormone replacement therapy
US6716829B2 (en) 2000-07-27 2004-04-06 Pharmacia Corporation Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders
EP1368009A2 (de) * 2000-07-27 2003-12-10 Pharmacia Corporation Aldosteron-blocker zur behandlung oder vorbeugung von entzündungsverwandten störungen
EP1216713A1 (de) 2000-12-20 2002-06-26 Schering Aktiengesellschaft Zusammensetzungen von Estrogen-Zyklodextrin Komplexe
EP1216712A1 (de) 2000-12-20 2002-06-26 Schering Aktiengesellschaft Einschlusskomplexe von Drospirenone und Cyclodextrinen
WO2003006027A1 (en) * 2001-07-13 2003-01-23 Schering Aktiengesellschaft Combination of drospirenone and an estrogen sulphamate for hrt
JP2005522466A (ja) * 2002-03-18 2005-07-28 ファルマシア・コーポレーション アルドステロン受容体アンタゴニスト、およびニコチン酸またはニコチン酸誘導体の組合わせ
MXPA04009039A (es) * 2002-03-18 2005-01-25 Pharmacia Corp Combinacion de un antagonista de los receptores de la aldosterona y un agente secuestrante de los acidos biliares.
ITMI20040367A1 (it) * 2004-03-01 2004-06-01 Ind Chimica Srl Processo per la preparazione di drospirenone
US20050220825A1 (en) * 2004-03-10 2005-10-06 Adrian Funke Molecular dispersions of drospirenone
HUP0402465A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main intermediates of the process
HUP0402466A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
US8617597B2 (en) 2006-07-06 2013-12-31 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
EP2057182A2 (de) * 2007-05-01 2009-05-13 Sicor, Inc. Verfahren zur herstellung von drospirenon und zwischenprodukten davon
FR2917975B1 (fr) 2007-06-26 2009-10-16 Ceva Sante Animale Sa Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains
US20090035374A1 (en) * 2007-07-31 2009-02-05 Katrin Mittmann Method of making a single-stage pharmaceutical preparation for oral therapy to regulate blood pressure and kit containing same
US20090035373A1 (en) * 2007-07-31 2009-02-05 Katrin Mittmann Pharmaceutical composition for contraception and blood pressure regulation, kit for contraception containing same and method of production of same
HUP0700826A3 (en) 2007-12-20 2010-03-29 Richter Gedeon Nyrt Coated tablet containing drospirenone and process for producing the same
WO2009111574A2 (en) * 2008-03-05 2009-09-11 Evestra, Inc. BISMETHYLENE-17α CARBOLACTONES AND RELATED USES
WO2010068500A2 (en) * 2008-11-25 2010-06-17 Evestra, Inc. PROGESTATIONAL 3-(6,6-ETHYLENE-17b-HYDROXY-3-OXO-17a-PREGNA-4-ENE-17a -YL) PROPIONIC ACID g-LACTONES
WO2010094624A1 (en) 2009-02-18 2010-08-26 Bayer Schering Pharma Aktiengesellschaft Particles comprising drospirenone encapsulated in a polymer
EP2398461A1 (de) 2009-02-18 2011-12-28 Bayer Pharma Aktiengesellschaft Formulierung mit drospirenon zur subkutanen oder intramuskulären verabreichung
US8334375B2 (en) * 2009-04-10 2012-12-18 Evestra, Inc. Methods for the preparation of drospirenone
ES2432063T3 (es) * 2009-06-16 2013-11-29 Crystal Pharma, S.A.U. Procedimiento para la obtención de 17-espirolactonas en esteroides
EP2977084B1 (de) 2010-05-10 2017-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren und zusammensetzungen zur behandlung von flüssigkeitsansammlung in und/oder unter der netzhaut
EP2582365B1 (de) 2010-06-16 2019-03-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Zusammensetzungen zur stimulierung der reepithelialisation während der wundheilung
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
CN102887934B (zh) * 2012-09-20 2015-05-27 杭州福斯特药业有限公司 一种屈螺酮的制备方法
WO2016063269A1 (en) 2014-10-20 2016-04-28 Prendergast Patrick T Use of antagonists to the nuclear steroid receptor alone or in combination as direct antiviral agents to inhibit alphavirus, togaviridae, arenaviridae, filoviridae, bunyaviridae, flaviviridae and rhabdoviridae
LT3313408T (lt) 2015-06-23 2024-03-12 Laboratorios Leon Farma Sa Kontraceptikas drospirenono pagrindu, skirtas pacientėms, turinčioms antsvorio
EP3108889A1 (de) 2015-06-23 2016-12-28 Philippe Perrin Drospirenonbasiertes verhütungsmittel für einen weiblichen übergewichtigen patienten
WO2017055248A1 (en) 2015-09-28 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of heart failure
JP6835836B2 (ja) 2015-10-13 2021-02-24 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 脈絡膜血管新生の処置のための方法及び医薬組成物
WO2018019843A1 (en) 2016-07-26 2018-02-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonist of mineralocorticoid receptor for the treatment of osteoarthritis
EP4134082A1 (de) 2021-08-12 2023-02-15 Chemo Research, S.L. Verfahren zur behandlung von endometriose und zur bereitstellung einer wirksamen empfängnisverhütung
EP4395785A1 (de) 2021-08-31 2024-07-10 Inserm (Institut National de la Santé et de la Recherche Scientifique) Verfahren zur behandlung von augenrosacea
WO2023152658A1 (en) 2022-02-10 2023-08-17 Lupin Limited Slow release drospirenone tablet composition
US20250186337A1 (en) 2022-03-01 2025-06-12 Chemo Research, S.L. Chewable oral contraceptive

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3257390A (en) * 1963-06-12 1966-06-21 Merck & Co Inc Ring a unsaturated 21-hydroxy-3-oxo-17alpha-pregnane-17-carboxylic acid lactone diuretic agents
NL166267C (nl) * 1968-03-22 1981-07-15 Merck & Co Inc Werkwijze ter bereiding van farmaceutische preparaten, de onder toepassing daarvan verkregen gevormde voort- brengselen, alsmede werkwijze ter bereiding van 6,7-methyleen-20-spirox-4-en-3-onderivaten met aldoste- ron remmende werking.
DE2237143A1 (de) * 1972-07-28 1974-02-14 Hoechst Ag Verfahren zur herstellung von beta(3-keto-7alpha-acetylthio-17beta-hydroxy4-androsten-17alpha-yl)-propionsaeuregamma-lacton und dessen 1-dehydro-derivat
CH601352A5 (de) * 1973-09-26 1978-07-14 Hoffmann La Roche

Also Published As

Publication number Publication date
JPS5363373A (en) 1978-06-06
DD132968A5 (de) 1978-11-22
DE2652761A1 (de) 1978-05-18
NL7711946A (nl) 1978-05-18
DK141967C (da) 1980-12-08
SU695560A3 (ru) 1979-10-30
CA1092094A (en) 1980-12-23
SE436425B (sv) 1984-12-10
ES464193A1 (es) 1978-09-01
DD132968B3 (de) 1991-03-28
US4129564A (en) 1978-12-12
IE46076B1 (en) 1983-02-09
JPS61218595A (ja) 1986-09-29
AU3050977A (en) 1979-05-17
LU78514A1 (de) 1978-03-20
AU512611B2 (en) 1980-10-16
IL53353A (en) 1982-04-30
JPS6156240B2 (de) 1986-12-01
FR2370755B1 (de) 1980-06-06
SE7712891L (sv) 1978-05-17
ATA815577A (de) 1979-10-15
JPH0242840B2 (de) 1990-09-26
IT1092262B (it) 1985-07-06
GR65227B (en) 1980-07-30
CS194823B2 (en) 1979-12-31
CH632774A5 (de) 1982-10-29
IE46076L (en) 1978-05-16
DK508077A (da) 1978-05-17
FR2370755A1 (fr) 1978-06-09
DK141967B (da) 1980-07-28
GB1550568A (en) 1979-08-15
IL53353A0 (en) 1978-01-31
BE860877A (fr) 1978-05-16
HU174983B (hu) 1980-04-28
SU743582A3 (ru) 1980-06-25
CH631463A5 (de) 1982-08-13
DE2652761C2 (de) 1985-11-21

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